scholarly journals Immunity-Boosting Natural Herbs to Combat COVID-19 Pandemic: A Narrative Review

2021 ◽  
Vol 4 (4) ◽  
pp. 260-272
Author(s):  
Saurabh Nimesh ◽  
Muhammad Akram ◽  
Md. Iftekhar Ahmad ◽  
Arshad Ahmad ◽  
Pratibha Kumari ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Immune Responses ◽  
South Asian ◽  
Respiratory Infections ◽  
Folk Medicine ◽  
World Health ◽  
Potential Treatment ◽  
The World ◽  
Upper Respiratory ◽  
Health Organization

Coronaviruses cause some severe forms of respiratory infections such as Severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and Coronavirus disease 2019 (Covid-19). These viruses cause diarrhea in pigs and cows and upper respiratory disease in chickens, while other symptoms may differ. In humans, a total of six coronaviruses have been identified HCoVs-NL63, HCoVs-OC43, HCoVs-229E, HCoVs-HKU1, MERS-CoV, and SARS-CoV. The world health organization (WHO) has done a great deal of hard work regarding combating the monstrous effects of this virus. So far, no specific antiviral drugs have been developed for the treatment of Covid-19. Therefore, the medicinal plants used for the previous epidemic outbreaks are getting attention for their potential treatment against the virus. It has been reported that 70 to 80% of people in developing countries depend on medicinal plants or phytomedicine compared to allopathic drugs for their primary healthcare. The south Asian subcontinents have used almost up to 25,000 formulations and extracts obtained from medicinal plants for treatment in folk medicine. The present review discusses an overview of the coronavirus, its immune responses, and some immunity-boosting herbs to combat Covid-19.

scholarly journals Building a COVID-19 Vulnerability Index

2020 ◽  
Author(s):  
Dave DeCapprio ◽  
Joseph Gartner ◽  
Carol J. McCall ◽  
Thadeus Burgess ◽  
Sarthak Kothari ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Vulnerability Index ◽  
Mortality Rates ◽  
World Health ◽  
Acute Respiratory Disease ◽  
Upper Respiratory Infections ◽  
The World ◽  
Upper Respiratory ◽  
Health Organization

AbstractCOVID-19 is an acute respiratory disease that has been classified as a pandemic by the World Health Organization. Characterization of this disease is still in its early stages; however, it is known to have high mortality rates, particularly among individuals with preexisting medical conditions. Creating models to identify individuals who are at the greatest risk for severe complications due to COVID-19 will be useful for outreach campaigns to help mitigate the disease’s worst effects. While information specific to COVID-19 is limited, a model using complications due to other upper respiratory infections can be used as a proxy to help identify those individuals who are at the greatest risk. We present the results for three models predicting such complications, with each model increasing predictive effectiveness at the expense of ease of implementation.

Natural products from the traditional Moroccan pharmacopoeia: A potential lead for the prevention and treatment of COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1278-1285
Author(s):  
Mohamed Yafout ◽  
Amine Ousaid ◽  
Ibrahim Sbai El Otmani ◽  
Youssef Khayati ◽  
Amal Ait Haj Said
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Molecular Mechanisms ◽  
Scientific Literature ◽  
Treatment Protocol ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Promising Source

The new SARS-CoV-2 belonging to the coronaviruses family has caused a pandemic affecting millions of people around the world. This pandemic has been declared by the World Health Organization as an international public health emergency. Although several clinical trials involving a large number of drugs are currently underway, no treatment protocol for COVID-19 has been officially approved so far. Here we demonstrate through a search in the scientific literature that the traditional Moroccan pharmacopoeia, which includes more than 500 medicinal plants, is a fascinating and promising source for the research of natural molecules active against SARS-CoV-2. Multiple in-silico and in-vitro studies showed that some of the medicinal plants used by Moroccans for centuries possess inhibitory activity against SARS-CoV or SARS-CoV-2. These inhibitory activities are achieved through the different molecular mechanisms of virus penetration and replication, or indirectly through stimulation of immunity. Thus, the potential of plants, plant extracts and molecules derived from plants that are traditionally used in Morocco and have activity against SARS-CoV-2, could be explored in the search for a preventive or curative treatment against COVID-19. Furthermore, safe plants or plant extracts that are proven to stimulate immunity could be officially recommended by governments as nutritional supplements.

TIRYAQ-E-ARBA (A POLY HERBAL UNANI FORMULATION) IN FIGHTING AGAINST COVID 19 LIKE CONDITIONS – UNANI PERSPECTIVE

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Nafisa Qibriya Khan ◽  
A. H. Farooqui ◽  
Syed Ayesha Fatima ◽  
Jalil Ahmad ◽  
Tausif S. Khan
Keyword(s):  
Respiratory Infections ◽  
Transmission Rate ◽  
Multiple Organ ◽  
World Health ◽  
Upper Respiratory Tract ◽  
Health Crisis ◽  
Unani Medicine ◽  
The World ◽  
Health Organization ◽  
Almost All

Coronavirus disease 2019 (COVID-19) is a pandemic disease of modern time with unique and rapid transmission rate and affected almost all the nations without respecting any border. Coronavirus disease 2019 (COVID-19) is arguably the biggest health crisis the world has faced in 21st century. It is an infectious disease and declared pandemic by the World Health Organization. The coronavirus disease 2019 (COVID-19) outbreak, which originated in Wuhan, China, has now spread to 192 countries and administrative regions infecting nearly 800,000 individuals of all ages as of 31 March 2020. Though most infected individuals exhibit mild symptoms including fever, upper respiratory tract symptoms, shortness of breath, and diarrhoea, or are asymptomatic altogether, severe cases of infection can lead to pneumonia, multiple organ failure, and death. Globally, at least 7900 deaths have been directly attributed to COVID19, and this number is expected to rise with the ongoing epidemic. This is particularly crucial as the current outbreak involves a new pathogen (SARS-CoV-2), on which limited knowledge exists of its infectivity and clinical profile. Research is in progress on therapeutic efficacy of various agents including anti-malarials (Chloroquine and Hydroxychloroquine), antiviral drugs, and convalescent serum of recovered patients. Unani system of medicine is one of the traditional systems of medicine which is being explored for providing preventive, supportive and rehabilitative care to patients. Unani system of medicine has a detailed description of drugs that are utilized in many infectious diseases, including respiratory infections. Immune response is essential to eliminate virus and to preclude disease progression to severe stages. Therefore, it is important to summarize the evidence regarding the preventive measures, control options such as immune-stimulator and prophylactic treatment in Unani medicine against Covid19. This review summarizes various pharmacological actions of Unani formulation Tiryaq-e-Arba in Unani literature and various reported pharmacological activities which can possibly provide prevention, control and reduction of complications of this deadly disease.

scholarly journals How to Help Children and Adolescents with Austism SprectrumDisorder during Covid-19 Pandemic

2020 ◽  
Keyword(s):  
Social Isolation ◽  
Social Communication ◽  
Respiratory Infections ◽  
Autism Spectrum ◽  
World Health ◽  
Behavioral Strategies ◽  
Daily Lives ◽  
The Social ◽  
The World ◽  
Health Organization

The Autism Spectrum Disorder(ASD) are distinguished by persistent deficits in social communication and social interaction and restricted and repetitive patterns of behavior. Coronaviruses are an extremely common cause of colds and other upper respiratory infections. COVID-19, short for “coronavirus disease 2019”. The fast spread of the virus that causes COVID-19 has sparked alarm worldwide. The World Health Organization (WHO) has declared this rapidly spreading coronavirus outbreak a pandemic. Most of the countries around the world are adopting social distancing to slow the spread of coronavirus. There are several possible impacts of this pandemic on the daily lives of individuals with ASD, such as worsening of dysfunctional behaviors and regression of skills already acquired in different domains of development due to the social isolation. The objective of this article is to provide guidance to parents, health and education professionals that live or work with ASD individuals during the social isolation, on how to manage interventions that can be executed in the home environment, like remote training in language and social communication skills, behavioral strategies and sensory integration activities

scholarly journals A review of post infectious pulmonary fibrosis in the era of COVID-19 and potential treatment options

2021 ◽  
Vol 9 (40) ◽  
pp. 37-46
Author(s):  
Medha Ghose ◽  
Maehali Patel
Keyword(s):  
Risk Factors ◽  
Pulmonary Fibrosis ◽  
Treatment Options ◽  
World Health ◽  
Potential Treatment ◽  
Pulmonary Injury ◽  
The World ◽  
Health Organization ◽  
Post Infectious

On March 11, 2020, the World Health Organization (WHO) released a statement characterizing COVID-19 as a pandemic that has, as of October 2020, caused almost 36 million confirmed global cases and over 1 million deaths. One of the long-term complications suggested by researchers is fibrosis. It has been hypothesized that the combination of ongoing pulmonary injury caused by COVID-19 and the inability to promptly repair damage results in interstitial matrix widening and eventual compression and destruction of alveoli and capillaries. Here we focus on pathogenesis, risk factors, different infectious causes of fibrosis along with COVID-19, and potential treatment options that might reduce its effects. Key words: COVID-19, pulmonary fibrosis, mechanism, treatment

scholarly journals The Relationship Between the Global Burden of Influenza From 2017 to 2019 and COVID-19: Descriptive Epidemiological Assessment (Preprint)

2020 ◽  
Author(s):  
Stefan David Baral ◽  
Katherine Blair Rucinski ◽  
Jean Olivier Twahirwa Rwema ◽  
Amrita Rao ◽  
Neia Prata Menezes ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Temporal Trends ◽  
Sub Saharan Africa ◽  
World Health ◽  
Respiratory Pathogens ◽  
Modes Of Transmission ◽  
The World ◽  
Influenza Activity ◽  
Sub Saharan ◽  
Health Organization

BACKGROUND SARS-CoV-2 and influenza are lipid-enveloped viruses with differential morbidity and mortality but shared modes of transmission. OBJECTIVE With a descriptive epidemiological framing, we assessed whether recent historical patterns of regional influenza burden are reflected in the observed heterogeneity in COVID-19 cases across regions of the world. METHODS Weekly surveillance data reported by the World Health Organization from January 2017 to December 2019 for influenza and from January 1, 2020 through October 31, 2020, for COVID-19 were used to assess seasonal and temporal trends for influenza and COVID-19 cases across the seven World Bank regions. RESULTS In regions with more pronounced influenza seasonality, COVID-19 epidemics have largely followed trends similar to those seen for influenza from 2017 to 2019. COVID-19 epidemics in countries across Europe, Central Asia, and North America have been marked by a first peak during the spring, followed by significant reductions in COVID-19 cases in the summer months and a second wave in the fall. In Latin America and the Caribbean, COVID-19 epidemics in several countries peaked in the summer, corresponding to months with the highest influenza activity in the region. Countries from regions with less pronounced influenza activity, including South Asia and sub-Saharan Africa, showed more heterogeneity in COVID-19 epidemics seen to date. However, similarities in COVID-19 and influenza trends were evident within select countries irrespective of region. CONCLUSIONS Ecological consistency in COVID-19 trends seen to date with influenza trends suggests the potential for shared individual, structural, and environmental determinants of transmission. Using a descriptive epidemiological framework to assess shared regional trends for rapidly emerging respiratory pathogens with better studied respiratory infections may provide further insights into the differential impacts of nonpharmacologic interventions and intersections with environmental conditions. Ultimately, forecasting trends and informing interventions for novel respiratory pathogens like COVID-19 should leverage epidemiologic patterns in the relative burden of past respiratory pathogens as prior information.

Bioactive Natural Medicinal Plants in South Indian Western Ghats and Their Pharmacological Importance

2020 ◽  
Vol 6 (2) ◽  
pp. 62-69
Author(s):  
M. Tamizharasi ◽  
R. Rajila ◽  
D. Beula Shiny ◽  
J. Vijila Jasmin ◽  
T. Kumaran
Keyword(s):  
Medicinal Plants ◽  
Western Ghats ◽  
New Drugs ◽  
World Health ◽  
Plant Resources ◽  
Medical Products ◽  
Primary Health ◽  
South Indian ◽  
The World ◽  
Health Organization

Awareness of traditional knowledge and medicinal plants can play a key role in the utilization and discovery of natural plant resources. Plants became the basis of medicine system throughout the world for thousands of years and continue to provide mankind with new remedies. Researchers generally agree that natural products from plants and other organisms have been the most consistently successful source for ideas for new drugs. The world health organization estimates that 80% of the population living in the developing countries relies exclusively on traditional medicine for their primary health care. More than half of the world's population still relies entirely on plants for medicines, and plants supply the active ingredients of most traditional medical products. The review shows the south Indian medicinal plant products has been used by people to treat various health ailments.

scholarly journals Determination of essential and non-essential elements in Xylanthemum macropodum of Balochistan, Pakistan

2021 ◽  
Vol 2 (02) ◽  
pp. 94-103
Author(s):  
Maria Bibi ◽  
Samiullah Khan ◽  
Attiq-Ur-Rehman Kakar ◽  
Naqeebullah Khan ◽  
Abdul Hakeem Tareen ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Atomic Absorption ◽  
Essential Elements ◽  
Permissible Limit ◽  
World Health ◽  
Home Remedy ◽  
The World ◽  
Health Organization

Background: Medicinal plants have been used to treat various diseases for several years throughout the world. Xylanthemum macropodum is a medicinal plant with a vast application as a home remedy in Balochistan. Objective: The current study was conducted to determine the levels of essential and non-essential elements in Xylanthemum macropodum collected from Quetta (Balochistan, Pakistan). Methods: Analysis was conducted for eleven elements by using atomic absorption spectrophotometer and flame photometer. Results: The essential and non-essential elements that were detected in Xylanthemum macropodum are K, Na, Ca, Fe, Cu, Co, Ni, Mn, Cr, Cd and Pb, respectively. The result of the concentration of determined elements are in the order of K> Na> Ca> Fe> Cu> Co> Ni> Mn> Cd> Cr> Pb in Xylanthemum macropodum 3000> 1600> 790.25> 92.36> 85.31> 49.24> 40.94> 20.94> 6.655> 1.61> 1.18 µg/g respectively. Conclusions: Mn, Na and Pb were found within the permissible limit given by World Health Organization, while Ca, Cu, Fe, Ni, Cd and Cr were beyond the permissible limits. However, there is no permissible limit for K and Co.

scholarly journals Medicinal Plants for Prevention and Treatment of Coronavirus Disease

2021 ◽  
pp. 74-85
Author(s):  
Onder Otlu ◽  
Ceyhun Bereketoglu ◽  
Tugba Raika Kiran ◽  
Aysun Bay Karabulut
Keyword(s):  
Medicinal Plants ◽  
Virus Disease ◽  
White Blood Cells ◽  
Antioxidant Properties ◽  
Antiviral Agent ◽  
World Health ◽  
Chronic Infections ◽  
Corona Virus ◽  
The World ◽  
Health Organization

The 2019-nCoV (new Corona Virus) outbreak was announced by the World Health Organization (WHO), the International Emergency Public Health Organization, on January 30, 2020, and WHO reported the 2019-nCoV pathogen to SARSCoV-2 and Corona virus Disease 2019 on 12 February. (COVID2019). COVID-19 was officially recognized as a Pandemic by WHO on March 11, 2020. Plants have been used all over the world as traditional medicine for centuries to treat many chronic infections, including viral diseases. In recent years, scientists have been trying to verify the potential of functional compounds to protect human health and cure diseases with their research on functional and nutraceutical foods. Traditional medicinal plants have a long history supported by many researches such as maintaining a healthy life, toxins taken in daily life, fighting and preventing diseases, and longevity. Studies on the antiviral, antiinflammatory and antioxidant properties of ethnomedical plants and natural phytochemicals can be considered as a great potential drug source against various ailments as well as Covid-19 treatment. Based on this study, plant extracts increase immunity with the increase in the number of white blood cells and lymphocytes in viral infections such as Covid-19, which can lead to fatal consequences, regulating the production and release of proinflammatory cytokines, showing an anti-inflammatory effect with a decrease in the C-reactive protein and erythrocyte sedimentation rate, It appears to have a positive effect such as interfering with the development and potential antiviral agent activity. In this study, phytochemicals and effects associated with COVID-19 infection were reviewed.

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