scholarly journals Host Immune Response to Malaria

2021 ◽  
Vol 2 (2) ◽  
pp. 67-71
Author(s):  
Reqgi First Trasia
Keyword(s):  
Immune Response ◽  
Plasmodium Falciparum ◽  
Malaria Control ◽  
Malaria Vaccine ◽  
Control Strategies ◽  
World Health ◽  
Human Immune System ◽  
The World ◽  
Human Immune ◽  
Health Organization

Malaria is still a health threat, especially for children and pregnant women in endemic areas. The World Health Organization (WHO) reports 228 million cases of malaria occur worldwide and an estimated 405,000 deaths from malaria globally in 2018. A series of malaria control efforts according to WHO recommendations have been carried out widely. However, these programs face obstacles. Therefore, the existence of an effective malaria vaccine is absolutely necessary in a series of malaria control strategies. Development of a malaria vaccine requires a basic concept regarding the host's immune response to malaria. Unfortunately, only a few in Indonesia have reviewed how the immune response is. This article will present an understanding of how the human immune system responds to Plasmodium falciparum.

scholarly journals Review Study on Sciencedirect Library Based on Coronavirus Covid-19

2020 ◽  
Vol 4 (2) ◽  
pp. 46
Author(s):  
Muzhir Shaban Al-Ani ◽  
Dimah Mezher Al-Ani
Keyword(s):  
Research Work ◽  
The United States ◽  
World Health ◽  
Key Factors ◽  
Human Immune System ◽  
Research Papers ◽  
The World ◽  
The Subject ◽  
Human Immune ◽  
Health Organization

Several years ago, China and the United States of America began experimenting with the coronavirus, which lives in the bat. It is not known until now how the virus spread and how it extended to all countries of the world. However, it is certain that this virus first appeared and spread was at the end of 2019 and in the Chinese city of Wuhan, especially in markets close to laboratories that are working on this virus. At the beginning of the year 2020, this virus began to spread very widely all over the world and began killing thousands of people every day. The world economy was destroyed until the World Health Organization considered it a pandemic. As for the research aspect, the researchers started the research work on this pandemic from many aspects, including medical, statistical, managerial, healthcare, and others. A statistical analysis depends many key factors that have been studied. This study was conducted on April 11, 2020, where a large number of research papers were downloaded using the keywords coronavirus disease (COVID)-19, which were applied in the Sciencedirect library that was examined on 100 research papers only. The obtained results indicated that most of the research papers that worked on the subject of COVID-19 confirmed that this virus infects the human respiratory system, which in turn leads to shortness of breath and death. Here, it must be noted that the human immune system has a major role in the process of overcoming this virus and gradual recovery. The obtained analysis indicated that the main fields of coronavirus are: Medicine 42%, statistics 21%, healthcare 19%, and management 18%. Through this study, it became clear that China is the first country in terms of the number of researchers and also in terms of the number of research papers related to the COVID-19.

INTERNATIONAL NEWS AND REPORTS

PEDIATRICS ◽  
1948 ◽  
Vol 2 (4) ◽  
pp. 499-504
Keyword(s):  
Child Health ◽  
Malaria Control ◽  
Venereal Disease ◽  
World Health ◽  
International News ◽  
World Health Assembly ◽  
The World ◽  
Health Organization ◽  
First World ◽  
And Child Health

The First World Health Assembly convened in Geneva, Switzerland, on June 24, 1948, and remained in session until July 24. Fifty-four nations sent delegates. The work of this First Assembly centered around the development of a program of action for the World Health Organization. After discussions of a long list of possible activities, the Assembly adopted a program which established certain priorities for the work of the Organization during the coming year. Malaria control, maternal and child health, tuberculosis and venereal disease control, nutrition and environmental sanitation were placed in the top priority. To carry out these priority programs the WHO authorized the appointment of expert committees and the establishment of appropriate sections of work in the secretariat of the Organization.

scholarly journals How to Control Covid-19 with a Nanobiotherapy?

2020 ◽  
Keyword(s):  
Intensive Care Unit ◽  
Immune Response ◽  
Acute Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Multiple Organ ◽  
World Health ◽  
Shortness Of Breath ◽  
The World ◽  
Health Organization ◽  
Muscle Ache

The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. In a recent study of Nanshan Chen et al., on patients of Wuhan Jinyintan Hospital, Wuhan, China, from the 99 patients with SARSCoV-2 infection, 51% had chronic diseases and they had symptoms of fever (83%), cough (82%) shortness of breath (31%), muscle ache (11%), fatigue (9%), headache (8%), sore throat (5%), rhinorrhea (4%), chest pain (2%), diarrhea (2%), and nausea and vomiting (1%) [1, 2]. The majority of patients can recover, however, about 25% of patients will progress into severe complications including acute respiratory distress syndrome (ARDS), which may worsen rapidly into respiratory failure, need an intensive care unit (ICU) and even cause multiple organ failure [3]. Depending on the pathophysiological mechanisms supposed to be involved in the development of the various clinical forms of the disease, various types of treatment have been tested with varying degrees of success. We have developed a nanotherapy to block the entry of the virus into the host cell, to reduce its potential for replication and to regulate the immune response against the microbial aggressor [4].

A comparison of malarial antigens from human and Aotus monkey blood infected with Plasmodium falciparum

Parasitology ◽  
1972 ◽  
Vol 64 (2) ◽  
pp. 191-195 ◽  
Author(s):  
R. J. M. Wilson ◽  
A. Voller
Keyword(s):  
Plasmodium Falciparum ◽  
Great Britain ◽  
Human Blood ◽  
Research Council ◽  
Medical Research Council ◽  
Financial Assistance ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Overseas Development

An extract of blood from Aotus monkeys infected with Plasmodium falciparum contained all the clones of malaria precipitins so far identified in human blood.We are grateful to the Medical Research Council and Overseas Development Administration of Great Britain and to the World Health Organization for their financial assistance.

Immunization

2020 ◽  
pp. 706-712
Author(s):  
David Goldblatt ◽  
Mary Ramsay
Keyword(s):  
Infectious Diseases ◽  
The Body ◽  
World Health ◽  
Human Immune System ◽  
Edible Vaccines ◽  
Poor Countries ◽  
Medical Interventions ◽  
Human Immune ◽  
Set Up ◽  
Health Organization

Immunization is one of the most successful medical interventions ever developed: it prevents infectious diseases worldwide. The basis for its success is that the human immune system can respond to vaccines by producing pathogen-specific antibody and memory cells (both B and T cells) which protect the body should the pathogen be encountered. Most currently licensed vaccines contain live or killed bacterial or viral constituents, bacterial polysaccharides, or bacterial toxoids, while new types of vaccines are being developed that contain DNA. Most vaccines are delivered directly into skin or muscle via needles, or they are administered orally. New edible vaccines and vaccines delivered via the skin without the use of needles are being developed. The Expanded Programme on Immunization, set up by the World Health Organization to define which vaccines should be delivered in resource-poor countries, has done much to increase vaccination coverage among infants most at risk of infectious diseases.

scholarly journals Subunit Vaccine Against Sars-Cov-2 Using CTL and HTL Epitopes

2021 ◽  
Author(s):  
Laila zahra ◽  
Yaser Daanial Khan
Keyword(s):  
B Cells ◽  
Subunit Vaccine ◽  
World Health ◽  
Effective Vaccine ◽  
Human Immune System ◽  
Th Cells ◽  
Short Period ◽  
The World ◽  
Precautionary Measures ◽  
Health Organization

Severe Acute Respiratory Syndrome coronavirus 2 which is widely known as Sars-Cov-2 is a deadly virus that is the main cause of Coronavirus Disease (COVID-19). This plague affects the human immune system badly and adversely affects the human body. This disease emerged from Wuhan, China, and spread all over the world in a very short period. The World Health Organization (WHO) has warned the world about its dire consequences and directed all the countries to take strict precautionary measures and still, there are lots of things that need to be done. This study focuses on the in silico methods which use immunoinformatic approaches to build epitope-based subunit vaccine for SARS-COV-2 that is used to produce several positive immune responses within the host cell. Various B-cells, Tc cells, and Th cells containing different epitopes are considered for the inhibition of spike of SARS-COV-2. By following different approaches, eventually, the structure of the proposed vaccine consists of Tc, Th cells, and B-cells joined by different linkers was designed. Currently having B-cell as well as IFN-y made epitopes confirm the humoral and cell-mediated immune response developed by the proposed vaccine. An online server, PSIPRED is used to develop the model of vaccine. 15 antigenic epitopes were chosen from Spike protein to develop an effective vaccine. This vaccine was antiviral, non?allergic, and less toxic. The sequence of vaccine structure was then validated by different computational methods like Molecular Docking, RMSD, RMSF, and Molecular Dynamic Simulation. Java Codon adaption tool also known as JCat is used for maximal optimization of vaccine expression with vector.<br>

scholarly journals A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant Parasites

2021 ◽  
Author(s):  
Henriette Bosson-Vanga ◽  
Nicolas Primas ◽  
Jean-François Franetich ◽  
Catherine Lavazec ◽  
Lina Gomez ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Chemical Structure ◽  
World Health ◽  
Mosquito Vector ◽  
First Line ◽  
Human Malaria Parasite ◽  
Content Type ◽  
The World ◽  
Sexual Stages ◽  
Health Organization

This work reports a new chemical structure that (i) displays activity against the human malaria parasite Plasmodium falciparum at 3 stages of the parasitic cycle (blood stage, hepatic stage, and sexual stages), (ii) remains active against parasites that are resistant to the first-line treatment recommended by the World Health Organization (WHO) for the treatment of severe malaria (artemisinins), and (iii) reduces transmission of the parasite to the mosquito vector in a mouse model. This new molecule family could open the way to the conception of novel antimalarial drugs with an original multistage mechanism of action to fight against Plasmodium drug resistance and block interhuman transmission of malaria.

scholarly journals The Durability, Functionality and Acceptability of Novel Screened Doors and Windows After Four Years of Use in A Gambian Village: A Cross-Sectional Survey

2021 ◽  
Author(s):  
Fiona C. Shenton ◽  
Musa Jawara ◽  
Majo Carrasco-Tenezaca ◽  
Jakob Knudsen ◽  
Umberto D'Alessandro ◽  
...  
Keyword(s):  
Malaria Control ◽  
Scale Up ◽  
World Health ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
The World ◽  
Trained Staff ◽  
Window Blinds ◽  
Health Organization

Abstract Background: The World Health Organization recommends house screening as a tool for malaria control, yet evidence of the long-term durability, functionality and acceptability of this intervention is lacking. Here we examined the sustainability and use of novel types of screened doors and windows four years after installation in a Gambian village. Methods: A survey of 31 houses, each with two screened doors and two screened windows, was conducted in the rainy season. There were four types of screened door and two types of screened window. Trained staff carried out the survey and interviews of room owners were conducted in the local language before translation into English.Results: Structurally, the manufactured doors and windows were highly durable and in excellent condition. Most doors shut smoothly 50/61 (82%), although only 25/61 (41%) shut fully automatically with the latch slotting into the hole on the frame and holding fast. Door locks were less robust, with only (24/61) 39% present and working. Blinds proved especially flimsy, with only 4/109 (4%) of door blinds and 10/56 (18%) of window blinds present and in working order. Householders hung curtains inside most doors 50/61 (82%) and in 26/61 (43%) of the windows. Front doors were commonly found propped open 21/31 (68%) and 23/27 (85%) of those with a front door curtain, put their curtains down at night. Doors and windows were well liked, 19/31 (61%) of respondents were happy with them because they kept mosquitoes out 14/31 (45%) and provided security 12/31 (39%). The main reason given for the use of curtains was to provide privacy 26/28 (93% of those with curtains), especially while the door was open or had ‘see-through’ panels.Conclusions: Overall, the screened doors and windows were in excellent condition after four years of use. Improvements to the lock design are needed before scale-up. Installation of screening in buildings should be accompanied with health messaging recommending that at night, doors and windows be closed and curtains lifted or drawn to one side - to improve ventilation and keep the house cool.

scholarly journals China’s fight against COVID-19: What we have done and what we should do next?

2020 ◽  
Author(s):  
Sixiang Cheng ◽  
Yuxin Zhao ◽  
Atipatsa Chiwanda Kaminga ◽  
Pingxin Zhang ◽  
Huilan Xu
Keyword(s):  
Public Health ◽  
Social Epidemiology ◽  
Control Strategies ◽  
World Health ◽  
Director General ◽  
Chinese Government ◽  
Positive Direction ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

AbstractBackgroundOn 12 March, the World Health Organization Director-General declared that “the threat of a global pandemic has become a reality”, and the disease caused by the novel coronavirus, known as COVID-19, has become a global concern. Chinese efforts in curbing the virus have widely been recognized. Even the WHO has lauded the efforts of the Chinese government and advised the world to learn from China in fighting the disease. Since the outbreak of COVID-19, to curb the spread of the epidemic, the Chinese government has implemented unprecedented prevention interventions at the nationwide level. Currently, the outbreak in Wuhan is changing in a positive direction and has been effectively controlled. However, it is not clear what these measures were and how these measures changed to curb the outbreak of COVID-19 quickly. This study explored the characteristics and identified that China’s control strategies have changed the epidemiological curve of rapidly rising new confirmed cases of COVID-19. This study also seeks to expand the experiences and lessons from this outbreak.MethodsWe collected public health interventions measures from Jan 20, 2020, to 5 March 2020, and data from COVID-19 daily newly confirmed cases and daily cumulates cases to compare the control effects and changing trends. We performed a retrospective description of these intervention strategies from three stages. Besides, from the perspective of public health, the experiences and lessons exposed by this outbreak were roughly summarized.ResultsThese non-pharmacology interventions measures adopted by the Chinese government by the instruction and spirit of President Xi Jinping were timely and efficient.ConclusionsThe present study was conducted to comprehensively analyze from a social epidemiology context. The results confirmed that these radical interventions taken by the Chinese government were effective, ambitious, and agile. However, we must be aware that the epidemic situation in Wuhan is still challenging.

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