How to Control Covid-19 with a Nanobiotherapy?

Distress Syndrome ◽

Multiple Organ ◽

World Health ◽

Shortness Of Breath ◽

The World ◽

Health Organization ◽

Muscle Ache

The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. In a recent study of Nanshan Chen et al., on patients of Wuhan Jinyintan Hospital, Wuhan, China, from the 99 patients with SARSCoV-2 infection, 51% had chronic diseases and they had symptoms of fever (83%), cough (82%) shortness of breath (31%), muscle ache (11%), fatigue (9%), headache (8%), sore throat (5%), rhinorrhea (4%), chest pain (2%), diarrhea (2%), and nausea and vomiting (1%) [1, 2]. The majority of patients can recover, however, about 25% of patients will progress into severe complications including acute respiratory distress syndrome (ARDS), which may worsen rapidly into respiratory failure, need an intensive care unit (ICU) and even cause multiple organ failure [3]. Depending on the pathophysiological mechanisms supposed to be involved in the development of the various clinical forms of the disease, various types of treatment have been tested with varying degrees of success. We have developed a nanotherapy to block the entry of the virus into the host cell, to reduce its potential for replication and to regulate the immune response against the microbial aggressor [4].

OBESITY IN SARS-COV-2 INFECTION: LITERATURE REVIEW

10.36106/2709661 ◽

2021 ◽

pp. 19-23

Author(s):

Donizete Tavares Da Silva ◽

Priscila De Sousa Barros Lima ◽

Renato Sampaio Mello Neto ◽

Gustavo Magalhães Valente ◽

Débora Dias Cabral ◽

...

Keyword(s):

Public Health ◽

Gastrointestinal Tract ◽

Severe Acute Respiratory Syndrome ◽

Distress Syndrome ◽

Circulatory System ◽

World Health ◽

Global Public Health ◽

The World ◽

In March 2020, the World Health Organization (1) declared COVID-19 as a pandemic and a threat to global public health (2). The virus mainly affects the lungs and can cause acute respiratory distress syndrome (ARDS). In addition, coronavirus 2 severe acute respiratory syndrome (SARSCOV2) also has devastating effects on other important organs, including the circulatory system, brain, gastrointestinal tract, kidneys and liver

COVID-19- or Tramadol-induced Seizure: A Differential Diagnosis in Young People

International Journal of Medical Toxicology and Forensic Medicine ◽

10.32598/ijmtfm.v10i4.32009 ◽

2020 ◽

Vol 10 (4) ◽

pp. 32009.1-32009.2

Author(s):

Solmaz Nekoueifard ◽

◽

Mohammad Majidi ◽

Keyword(s):

Myocardial Infarction ◽

Acute Kidney Injury ◽

Differential Diagnosis ◽

Distress Syndrome ◽

Kidney Injury ◽

World Health ◽

The World ◽

Life Threatening ◽

Coronavirus disease 2019 (COVID-19) was first declared in December 2019 from Wuhan, China [1, 2]. It then has been reported a pandemic in March 2020 by the World Health Organization [3]. Clinical features of COVID-19 are different from asymptomatic to mild to moderate symptoms, such as fever, headache, myalgia, sore throat, anosmia, cough, fatigue headache, hemoptysis, and dyspnea to the life-threatening complications, including shock, pneumonia, acute respiratory distress syndrome, myocarditis, myocardial infarction, acute kidney injury, multi-organ failure, and even death [1, 2].

Pathomorphological Changes In The Lungs Of COVID-19 Patients

Journal of Asian Medical Students' Association ◽

10.52629/jamsa.v9i1.259 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Zeshan Ali

Keyword(s):

Respiratory Failure ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Multiple Organ ◽

World Health ◽

Severe Respiratory Failure ◽

Novel Virus ◽

In December 2019, a novel virus was discovered in China causing severe acute respiratory distress syndrome and the virus was designated as SARS-CoV-2 [1]. On 11th March 2020, the Corona Virus (SARS-CoV-2) was declared a pandemic by World Health Organization (WHO) [2]. Millions of people worldwide have been affected by this virus [3]. Most of the patients shows mild symptoms. Severe cases lead to the death of patients due to severe respiratory failure. Multiple organ failure has been seen in many patients suffering from COVID-19

Multiorgan Involvement in COVID-19 and Possible Therapies

Journal of Cardiac Critical Care TSS ◽

10.1055/s-0040-1714151 ◽

2020 ◽

Vol 04 (01) ◽

pp. 20-24

Author(s):

Prachee Sathe ◽

Vijay Sundar Singh

Keyword(s):

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

World Health Organization ◽

Distress Syndrome ◽

Respiratory Illness ◽

World Health ◽

The World ◽

Novel Coronavirus ◽

AbstractIn late 2019, China reported cases of respiratory illness in humans, which involved a novel Coronavirus SARS-CoV-2 (also known as 2019-nCoV). The World Health Organization (WHO) termed the disease COVID-19 (i.e., Coronavirus disease 2019). Most of the morbidity and mortality from COVID-19 is largely due to acute viral pneumonitis that leads to acute respiratory distress syndrome (ARDS). This article will discuss the clinical features of the multiorgan involvement in COVID-19 as well as the management of patients who become critically ill due to COVID-19.

Cytokine Storm and Immunomodulation in COVID-19: a Review

Coronaviruses ◽

10.2174/2666796702666210913100327 ◽

2021 ◽

Vol 02 ◽

Author(s):

Amir Mohammad Arsh ◽

Suhana Mishra ◽

Vishwas Tripathi ◽

Amaresh Mishra

Keyword(s):

Immune Response ◽

Multiple Organ ◽

World Health ◽

Cytokine Storm ◽

Review Of The Literature ◽

Global Pandemic ◽

The World ◽

The Subject ◽

Health Organization ◽

Immunomodulatory Therapies

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has taken over the world, and more than 38 lakh deaths have been reported till now due to this infectious disease. It has been declared a global pandemic by the world health organization. SARS-CoV-2 causes coronavirus disease of 2019 (COVID-19), and the major problem called "Cytokine storm" is reported, which may lead to death among the COVID-19 patients. This study aimed to review the Cytokine storm and its mechanism along with few immunomodulatory therapies for SARS-CoV-2 infection suppression effectively. Methods: The recently published works of literature were selected and reviewed based on the subject of this study. The databases, including Pubmed, ScienceDirect, Scopus, and Google Scholar, were searched extensively. Results: The review of the literature showed that an uncontrolled immune response causes excess inflammation. Evidence from recent trials has demonstrated that cytokine storms can be an important factor in the COVID-19 severity, leading to multiple organ failure and death. Conclusion: This study reviewed immunomodulatory therapies and strategies for SARS-CoV-2 infected patients to suppress the immune response. Ultimately, the cytokine storm can prove to be a boon and reduce the significant death tolls to SARS-CoV-2 infection.

Prospects of plasmapheresis for patients with severe COVID-19

European Journal of Translational Myology ◽

10.4081/ejtm.0.9165 ◽

2020 ◽

Author(s):

Ilmira R. Gilmutdinova ◽

Maksim Yu. Yakovlev ◽

Petr S. Eremin ◽

Anatoliy D. Fesun

Keyword(s):

Respiratory Failure ◽

Distress Syndrome ◽

International Committee ◽

World Health ◽

Cytokine Storm ◽

Positive Experience ◽

Cytokine Levels ◽

The World ◽

On February 11, 2020, the World Health Organization officially named the infection caused by the new coronavirus “Coronavirus disease 2019” (COVID-19). On February 11, 2020, the International Committee on Taxonomy of Viruses (ICTV) officially named the infectious matter “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). Emergence of severe complications with new coronavirus disease is due to the development of hypercytokinaemia, also known as “cytokine storm”. These complications comprise acute respiratory distress syndrome (ARDS), respiratory failure and death. Emerging data point to the logic of using extracorporeal haemocorrection to normalise cytokine levels and reduce the severity of organ disorders. The analysis of the literature indicates that to date, a certain positive experience has been accumulated in the world in the application of extracorporeal methods in clinical practice in patients with COVID-19.

Prospects of plasmapheresis for patients with severe COVID-19

European Journal of Translational Myology ◽

10.4081/ejtm.2020.9165 ◽

2020 ◽

Vol 30 (3) ◽

Author(s):

Ilmira R. Gilmutdinova ◽

Maksim Yu. Yakovlev ◽

Petr S. Eremin ◽

Anatoliy D. Fesun

Keyword(s):

Respiratory Failure ◽

Distress Syndrome ◽

International Committee ◽

World Health ◽

Cytokine Storm ◽

Positive Experience ◽

Cytokine Levels ◽

The World ◽

Markers Associated with COVID-19 Susceptibility, Resistance, and Severity

Viruses ◽

10.3390/v13010045 ◽

2020 ◽

Vol 13 (1) ◽

pp. 45

Author(s):

Aisha D. Fakhroo ◽

Asmaa A. Al Thani ◽

Hadi M. Yassine

Keyword(s):

Mortality Rate ◽

Distress Syndrome ◽

Immune Reaction ◽

Severe Infection ◽

World Health ◽

Cytokine Storm ◽

Factors Associated ◽

The World ◽

In December 2019, the latest member of the coronavirus family, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, leading to the outbreak of an unusual viral pneumonia known as coronavirus disease 2019 (COVID-19). COVID-19 was then declared as a pandemic in March 2020 by the World Health Organization (WHO). The initial mortality rate of COVID-19 declared by WHO was 2%; however, this rate has increased to 3.4% as of 3 March 2020. People of all ages can be infected with SARS-CoV-2, but those aged 60 or above and those with underlying medical conditions are more prone to develop severe symptoms that may lead to death. Patients with severe infection usually experience a hyper pro-inflammatory immune reaction (i.e., cytokine storm) causing acute respiratory distress syndrome (ARDS), which has been shown to be the leading cause of death in COVID-19 patients. However, the factors associated with COVID-19 susceptibility, resistance and severity remain poorly understood. In this review, we thoroughly explore the correlation between various host, viral and environmental markers, and SARS-CoV-2 in terms of susceptibility and severity.

TIRYAQ-E-ARBA (A POLY HERBAL UNANI FORMULATION) IN FIGHTING AGAINST COVID 19 LIKE CONDITIONS – UNANI PERSPECTIVE

Indian Journal of Unani Medicine ◽

10.53390/ijum.v13i1.3 ◽

2020 ◽

Vol 13 (1) ◽

Author(s):

Nafisa Qibriya Khan ◽

A. H. Farooqui ◽

Syed Ayesha Fatima ◽

Jalil Ahmad ◽

Tausif S. Khan

Keyword(s):

Respiratory Infections ◽

Transmission Rate ◽

Multiple Organ ◽

World Health ◽

Upper Respiratory Tract ◽

Health Crisis ◽

Unani Medicine ◽

The World ◽

Health Organization ◽

Almost All

Coronavirus disease 2019 (COVID-19) is a pandemic disease of modern time with unique and rapid transmission rate and affected almost all the nations without respecting any border. Coronavirus disease 2019 (COVID-19) is arguably the biggest health crisis the world has faced in 21st century. It is an infectious disease and declared pandemic by the World Health Organization. The coronavirus disease 2019 (COVID-19) outbreak, which originated in Wuhan, China, has now spread to 192 countries and administrative regions infecting nearly 800,000 individuals of all ages as of 31 March 2020. Though most infected individuals exhibit mild symptoms including fever, upper respiratory tract symptoms, shortness of breath, and diarrhoea, or are asymptomatic altogether, severe cases of infection can lead to pneumonia, multiple organ failure, and death. Globally, at least 7900 deaths have been directly attributed to COVID19, and this number is expected to rise with the ongoing epidemic. This is particularly crucial as the current outbreak involves a new pathogen (SARS-CoV-2), on which limited knowledge exists of its infectivity and clinical profile. Research is in progress on therapeutic efficacy of various agents including anti-malarials (Chloroquine and Hydroxychloroquine), antiviral drugs, and convalescent serum of recovered patients. Unani system of medicine is one of the traditional systems of medicine which is being explored for providing preventive, supportive and rehabilitative care to patients. Unani system of medicine has a detailed description of drugs that are utilized in many infectious diseases, including respiratory infections. Immune response is essential to eliminate virus and to preclude disease progression to severe stages. Therefore, it is important to summarize the evidence regarding the preventive measures, control options such as immune-stimulator and prophylactic treatment in Unani medicine against Covid19. This review summarizes various pharmacological actions of Unani formulation Tiryaq-e-Arba in Unani literature and various reported pharmacological activities which can possibly provide prevention, control and reduction of complications of this deadly disease.

The Pandemic Hits Us Hard, but We Don’t Lose Hope

The Hip and Knee Journal ◽

10.46355/hipknee.v2i1.72 ◽

2021 ◽

Vol 2 (1) ◽

pp. 1-4

Author(s):

Krisna Yuarno Phatama ◽

Sholahuddin Rhatomy, MD ◽

Asep Santoso ◽

Nicolaas C. Budhiparama

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

World Health Organization ◽

Distress Syndrome ◽

World Health ◽

Global Pandemic ◽

New Variant ◽

At the end of 2019, we faced a new variant of the coronavirus that can cause pneumonia and acute respiratory distress syndrome-like symptoms. It started in Wuhan, Hubei Province, China, and spread quickly to the whole world.This new virus is called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and can manifest as a disease called coronavirus disease 2019 (COVID-19). On March 13th, 2020 World Health Organization (WHO) declared COVID-19 as a global pandemic, and the story of frightening pandemic begin.