scholarly journals Cardiac function profiling and its antidiabetic effect of Daphne mucronata in alloxan induced diabetic rabbits

2017 ◽  
pp. 125-131
Author(s):  
BASIT ALI
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Cardiac Function ◽  
Herbal Remedies ◽  
Elevated Plasma ◽  
Antidiabetic Effect ◽  
Chronic Hyperglycemia ◽  
Daphne Mucronata ◽  
Diabetic Rabbits ◽  
Alloxan Monohydrate

Diabetes mellitusis a chronic hyperglycemia associated with elevated plasma cholesterol.Natural and traditional herbal remedies are a source of new commercial products. Anti-diabetic potential of D. mucronata extracts (methanol) has been assessed in alloxan monohydrate diabetic induced rabbits.The extracts were given orally by 8 hours. Thedose rate was 12 mg, 125mg, 225 mg and 325mg/kg body weight respectively.At every 2 hours blood sample was collected, serum separated and glucose level was determined by kit method. The result suggests that the treatment of 325 mg/kg body weight significantly(p<0.05) decreased blood glucose and cholesterol level at 143 mg/dl and 166.33 mg/dl in the experimental group.Therefore, it is concluded that the D. mucronata possess significant anti-diabetic activity.

Effect of Crude Leaves Extract of Bersama Abyssinica on Blood Glucose Level and Serum Lipid Level of Streptozotocin-Induced Diabetic Mice: Evidence for In vivo Antidiabetic Activity

2021 ◽  
Vol 19 ◽  
Author(s):  
Zemene Demelash Kifle ◽  
Agumas Alemu Alehegn ◽  
Baye Yrga Adugna ◽  
Abebe Basazn Mekuria ◽  
Engidaw Fentahun Enyew
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Serum Lipid ◽  
Lipid Level ◽  
Serum Lipid Level ◽  
Diabetic Mice ◽  
Lipid Levels ◽  
Antidiabetic Effect ◽  
Bersama Abyssinica

Background: Diabetes mellitus is one of the major and common metabolic, and chronic disorders in the world. Several medicinal plants have been used globally for the management of diabetes mellitus. The current study aimed to study the anti-hyperglycemic and anti-hyperlipidemic effects of Bersama abyssinica. Methods: Antidiabetic effect of 80% methanolic crude extract of Bersama abyssinica was studied in repeated dose-treated STZ-induced diabetic mice model. The activities of Bersama abyssinica on serum lipid level and body weight were investigated on STZ-induced diabetic mice. Data were analyzed using one-way ANOVA and significant when the p-value was less than 0.05. Results: All doses of the crude 80% methanolic extract of Bersama abyssinica (100 mg/kg, 200 mg/kg, and 400 mg/kg) exhibited a noticeable BGL reduction when compared with baseline blood glucose level and diabetic control on the 7th and 14th days of administration. Moreover, the higher dose of the extract (at 400 mg/kg) significantly (p < 0.001, 54.3%) decreased the BGL in STZ-induced diabetic mice. The maximum decrement in fasting BGL was achieved at the 14th days: 34.92%, 41.10%, 54.30%, and 59.66%, respectively for BAC 100 mg/kg, BAC 200 mg/kg, BAC 400 mg/kg, and GLC 5 mg/kg treated groups. Bersama abyssinica also displayed a significant (p < 0.05) improvement of serum lipid levels and body weight. Conclusion: Bersama abyssinica crude extract exhibited a significant antidiabetic effect and prevented body weight loss in streptozotocin-induced diabetic mice. The finding also confirmed the valuable biochemical activity of Bersama abyssinica by improving serum lipid levels.

scholarly journals Study of blood glucose and SGPT lowering effects of Daphne Mucronata Royle in induced diabetic rabbits

2017 ◽  
pp. 132-143
Author(s):  
AZIZ ULLAH
Keyword(s):  
Blood Glucose ◽  
Glucose Level ◽  
Methanol Extract ◽  
Enzyme Level ◽  
Diabetic Control ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level ◽  
Reduction Effect ◽  
Daphne Mucronata ◽  
Diabetic Rabbits

This study was carried out to study Anti-diabetic effect of the plant Daphne mucronataextract in alloxan induced diabetic rabbits. To the first fifteen healthy rabbits taken and divided them into five groups as each group contains three numbers of rabbits. Group one kept in normal condition means no induction or treatment observed. Group second was given the diabetic control dose in quantity (12mg/kg). Group three also treated with the dose rate (125mg/kg) the D. Mucronata(methanol) extract. Similarly group no four was treat with the subject extract in the concentration of (225mg/kg). And the last fifth group of rabbits had the dosage of extract (325mg/kg). This mechanism of entrance was orally ingestion and the treatment duration was eight hours, after each of the next two hours from the start the blood samples were collected, serum separated and the glucose level determined by the method known by Kit method. After all the observations we reached to an impressive conclusion that the D. Mucronata(methanol) extract has significant potential to reduce blood glucose level and also recognized to be effective to reduce the blood SGPT enzyme level, so it can be suggested that this plant has such antidiabetic and SGPT reduction effect.

scholarly journals Hypoglycemic and Hypocholestrolemic study of Monothica boxifolia Falc. in induced diabetic Rabbits

2017 ◽  
pp. 144-151
Author(s):  
TAO SHIHENG
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Cholesterol Level ◽  
Glucose Level ◽  
Normal Control ◽  
Blood Test ◽  
Diabetic Control ◽  
The Body ◽  
Diabetic Rabbits

In the present examination, antidiabetic capability of Monothica separates (methanol) has been assessed in alloxan-prompted diabetic hares. Fifteen solid, bunnies were separated into four unique gatherings including, Normal control, Diabetic control , treated with Monothicamethanol remove, with 3 hares in each gathering. The concentrates were given orally for 24 hours, 100 mg, 200 mg, 300 mg extricate per bunny every day. At regular intervals blood test was gathered, serum isolated and absolute glucose level, cholesterol level was controlled by unit strategy. The body weight was recorded on like clockwork interim. The Monothecamethanol extricates lowered blood glucose and cholesterol level demonstrated greatest decrease adequately. The treatment with theseconcentrates additionally diminished the blood glucose and cholesterol. Along these lines, it is presumed that the Monothecapossessnoteworthy antidiabetic movement.

scholarly journals Screening of achillea santolina for anti-diabetic activity and its comparison with caralluma tuberculata.

2020 ◽  
Vol 27 (07) ◽  
pp. 1414-1419
Author(s):  
Muhammad Saleh Faisal ◽  
Asad Inayat ◽  
Muhammad Nabi ◽  
Waqar Hayat ◽  
Muhammad Sajid Khan ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Crude Extract ◽  
Glucose Levels ◽  
Cooking Oil ◽  
Blood Glucose Levels ◽  
Crude Extracts ◽  
Diabetic Rabbits ◽  
Medical University ◽  
Mean Blood Glucose

Objectives: The study was designed to investigate the hypoglycaemic effect of Achillea santolina and its comparison with Caralluma tuberculata. Study Design: Experimental study. Setting: Khyber Medical University, Peshawar. Period: July 2017 to February 2018. Material & Methods: Crude extract and carbon tetrachloride (CCl4) extract of Achillea santolina were prepared and administered to normal and alloxan treated diabetic rabbits. These extracts were given in capsule form as well as in cooking oil and their effects on blood glucose levels were observed at 0, 2, 4, 6, 8, 12 and 24 hours of administration. The results were compared with Caralluma tuberculata. Results: The crude extract 200 mg/kg body weight of Achillea santolina showed marked reduction in mean blood glucose level at 2, 4, 8 and 12 hours with significant (p<0.001) difference when compared with Caralluma tuberculata. The metformin 500 mg/kg body weight was also given to compare its effects with the plant crude extracts, which was more or less intermediate between the crude extracts of Achillea santolina and Caralluma tuberculata. The diabetic rabbits were treated with 100 mg/kg body weight CCl4 fraction of Achillea in capsule form. Blood glucose levels dropped markedly at 2 hours and further more at 4 hours as observed with Caralluma. Upon comparison with metformin, Achillea found to lower blood glucose levels but quite late than metformin. The diabetic rabbits were also treated with 100 mg/kg body weight CCl4 fraction of Achillea santolina in cooking oil and Caralluma was found to cause higher reduction in blood glucose levels than Achillea. Conclusion: Both Achillea santolina and Caralluma tuberculata lowered the blood glucose levels but the later turned out to be more significant in developing hypoglycaemia, particularly when taken with cooking oil.

scholarly journals Study of Blood Glucose and SGPT lowering effect of Eucalyptus Lanceolata Linn. in Induced Diabetic Rabbits

2015 ◽  
pp. 152-158
Author(s):  
MINGYUE YAOA
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
The Body ◽  
Antidiabetic Activity ◽  
Medicinal Uses ◽  
Diabetic Rabbit ◽  
Pharmaceutical Industries ◽  
Diabetic Rabbits ◽  
Plants Extract

The part of the plant to curing the diabetes mellitus and improves available data on plants with hypoglycemic effects. Antidiuretic potential of eucalyptus extracts has been evaluated in alloxan-induced diabetic rabbit. Here we used, plants extract about 256 kg were mix with 1000 ml methanol and keep in Flask. After filtering the extracts were exposed to rotary evaporator machine that methanol separated from plant extract. In the Nine rabbit were divided into three different groups. The body weight was recorded on every 6 days interval. The data obtained revealed that eucalyptus extracts reduced the glucose level effectively. Such treatment with extracts decreased the SGPT level. Therefore, it is concluded that the eucalyptus possesses significant antidiabetic activity. And finally, we recommend this plant for medicinal uses and for pharmaceutical industries to isolate pure drugs.

scholarly journals Synergistic Effect of Aqueous Extracts of Croton Zabensicus and Vernonia amygdalina Leaves as an Antihyperglycemic Agent in an Alloxan Induced Diabetic Albino Rats

2019 ◽  
pp. 1-6
Author(s):  
I. A. Hassan ◽  
I. Abdulraheem ◽  
H. O. Emun ◽  
D. M. Lawal
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
The Body ◽  
Albino Rats ◽  
Steady Increase ◽  
Vernonia Amygdalina ◽  
Standard Drug ◽  
Continuous Increase ◽  
Group B ◽  
Alloxan Monohydrate

Aims: This study was aimed at investigating the antihyperglycemic effect of a combined extract of Vernonia amygdalina and croton zabensicus compare with a hypoglycemic drug, glibenclamide. Methodology: Twenty 20 experimental animals were used (albino rats); the rats were divided equally into four groups of five rats each; namely A (control), B (glibenclamide 10 mg/kg body weight), C (synergetic treatment 1000 mg/kg body weight), D (synergetic treatment 500 mg/kg of body weight). Diabetes was induced intraperitoneal using Alloxan Monohydrate to all the animals and their blood glucose rise above 200 mg/dl. Results: It was observed that group B and group C treated with glibenclamide (10 mg/kg body weight) and synergetic aqueous extract (1000 mg/kg body weight) show significant decrease in the blood glucose level from 451.75 mg/dl to 64.50 mg/dl and 339.50 mg/dl to 182.50 mg/dl respectively compared with group D with 278.25 mg/dl to 194.75 mg/dl. However, a change was also observed in the body weight of the groups; Group A (Normal control) showed a continuous increase in the body weight, Group B, C and D were observed to have decreased in body weight from induction period, but a steady increase was observed as treatment commences. Conclusion: Hence this combined extract can be used as antihyperglycemic; only that it is slower in remediation compared with the glibenclamide; but without side effect, as may be in the case of most standard drug.

scholarly journals ANTIDIABETIC EFFECT OF MIKANIA SCANDENS ON ALLOXAN-INDUCED RAT MODEL

2018 ◽  
Vol 11 (3) ◽  
pp. 109
Author(s):  
Rimashree Baishya ◽  
Anjan Adhikari ◽  
Sharmistha Biswas ◽  
Soma Banerjee
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Standard Drug ◽  
Glucose Levels ◽  
Male Wistar Rats ◽  
Histopathological Studies ◽  
Alloxan Monohydrate

 Objective: The objective was to study the evaluation of antidiabetic and antioxidant activity of different doses ethanolic extract of Mikania scandens leaves.Methods: The rats were divided into five groups of six animals each (non-diabetic control, diabetic control, standard drug-treated, and plant treated groups (250 and 500 mg/kg body weight)). Diabetes was induced in the healthy male Wistar rats (150–200 g body weight, 4–6 weeks old) by the administration of alloxan monohydrate (150 mg/kg, i.p.). On the 0th, 3th, 7th, 11th, and 15th days, the blood samples were analyzed for blood glucose. The antioxidant and antidiabetic parameters were evaluated by standard protocol. The liver tissue was used for histopathological assessment of liver damage.Results: The ethanolic extract of leaves of M. scandens showed a significant reduction (p<0.001) in the blood glucose levels and the antioxidant levels, with 500 mg/kg of body weight in the alloxan-induced diabetic rats as compared to the controls. Histopathological studies provided evidence that the leaf extract possesses antidiabetic activity.Conclusions: The ethanolic extract of leaves of M. scandens showed potent antidiabetic and antioxidant abilities against alloxan-induced rats, which indicate the presence of hypoglycemic constituents in the plant.

scholarly journals Creating a Long-Term Diabetic Rabbit Model

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Jianpu Wang ◽  
Rong Wan ◽  
Yiqun Mo ◽  
Qunwei Zhang ◽  
Leslie C. Sherwood ◽  
...  
Keyword(s):  
Cell Damage ◽  
Rabbit Model ◽  
Good Health ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Chronic Hyperglycemia ◽  
One Year ◽  
Diabetic Rabbits ◽  
Alloxan Monohydrate

This study was to create a long-term rabbit model of diabetes mellitus for medical studies of up to one year or longer and to evaluate the effects of chronic hyperglycemia on damage of major organs. A single dose of alloxan monohydrate (100 mg/kg) was given intravenously to 20 young New Zealand White rabbits. Another 12 age-matched normal rabbits were used as controls. Hyperglycemia developed within 48 hours after treatment with alloxan. Insulin was given daily after diabetes developed. All animals gained some body weight, but the gain was much less than the age-matched nondiabetic rabbits. Hyperlipidemia, higher blood urea nitrogen and creatinine were found in the diabetic animals. Histologically, the pancreas showed marked beta cell damage. The kidneys showed significantly thickened afferent glomerular arterioles with narrowed lumens along with glomerular atrophy. Lipid accumulation in the cytoplasm of hepatocytes appeared as vacuoles. Full-thickness skin wound healing was delayed. In summary, with careful management, alloxan-induced diabetic rabbits can be maintained for one year or longer in reasonably good health for diabetic studies.

scholarly journals Evaluation of Antidiarheal and Antidiabetic Activities of Wrigthia arborea (Dennst.) Mabb.

2015 ◽  
Vol 16 (2) ◽  
pp. 211-216
Author(s):  
Ronok Zahan ◽  
Laizuman Nahar ◽  
Zahangir Alam ◽  
Mst Luthfun Nesa ◽  
M Ekramul Haque
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Castor Oil ◽  
Methanol Extract ◽  
Pharmaceutical Journal ◽  
Diabetic Rats ◽  
Deciduous Tree ◽  
Elevated Blood ◽  
Antidiabetic Effect ◽  
Elevated Blood Glucose Level

Wrigthia arborea (Dennst.) Mabb., locally known as Shet-kurchi, is a small deciduous tree. These species are important in the traditional healthcare, especially in menstrual and renal complaints. The present study was designed to investigate the antidiarheal and antidiabetic activities of methanol extract of W. arborea. The methanol extract was studied for antidiarrhoeal properties using castor oil and magnesium sulphate induced diarrhoeal model in mice. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the study period. Antidiabetic effect was also evaluated in normal and alloxan induced diabetic rats. Considerable drop of elevated blood glucose level was observed in the normoglycemic and alloxan induced diabetic rats at a dose of 150 and 300 mg/kg b.w. when the extract was given intraperitoneally. Altogether, these results suggest that the methanol extract could be used for treating diarrhea and diabetes. This is the first report of antidiarheal and antidiabetic potential of W. arborea. DOI: http://dx.doi.org/10.3329/bpj.v16i2.22306 Bangladesh Pharmaceutical Journal 16(2): 211-216, 2013

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