scholarly journals MHD on Convective Mass Transfer in Annular Flow: Catheter Based Drug Release

2021 ◽  
Vol 12 (5) ◽  
pp. 6699-6709
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Mass Transfer ◽  
Biomedical Applications ◽  
The Body ◽  
Convective Mass Transfer ◽  
Diffusive Mass Transfer ◽  
Tissue Region ◽  
Physical Phenomena ◽  
The Magnetic Field

In the present study, convective diffusive mass transfer is considered, along with effects of particle drag under the influence of a magnetic field concerning drug delivery in the presence of the catheter. A concentric annular region is created by the presence of a catheter, and the effects of which on mass transfer are considered. A model on the hydrodynamics of the fluid, blood flow, and convective diffusive mass transfer of the species is presented. Here, an attempt is made to analyze a drug delivery method for delivering a drug to a specific site in the body and for this analysis, considered a channel bounded by the tissue region where the drug is targeted. The magnetic field induces pulsatile flow, which affects the mass transfer. The graphs predict that the mass transfer increases from the lumen region to the tissue region. Peclet number and magnetic parameter are the parameters that significantly affect carrying drugs towards the tissue. The results are well agreed with the physical phenomena of the problem as well as many biomedical applications.

Magnetic Nano-Systems in Drug Delivery and Biomedical Applications

2021 ◽  
pp. 663-695
Author(s):  
Saritha R. Shetty ◽  
Archana Upadhya
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Targeted Delivery ◽  
Biomedical Applications ◽  
Magnetic Hyperthermia ◽  
Effective Utilization ◽  
Engineering Sciences ◽  
Nanoscale Science ◽  
The Magnetic Field ◽  
Unique Ability

Nanotechnology is that sphere of technology that involves the participation of biology, chemistry, physics, and engineering sciences. Nanoscale science defines the chemistry and physics of structures lying in the range of 1-100 nm. Among the nanosystems researched, magnetic nanosystems are highlighted due their unique ability, which enables their targeting to specific locations on application of an external magnetic field. The exhibited property of these magnetic nanosystems being super-paramagnetism, there is no retention of magnetic property on removal of the magnetic field, thus enabling a reversion of the targeting process. For effective utilization of these nanosystems, they should be reduced to nanosizes, layered with biocompatible entities, stabilized, and functionalized. In the chapter, synthesis and functionalization and stabilization are elucidated. The biomedical applications such as targeted delivery, MRI, magnetic hyperthermia, tissue engineering, gene delivery, magnetic immunotherapy, magnetic detoxification, and nanomagnetic actuation are discussed.

Magnetic Nano-Systems in Drug Delivery and Biomedical Applications

2018 ◽  
pp. 157-191 ◽  
Author(s):  
Saritha R. Shetty ◽  
Archana Upadhya
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Targeted Delivery ◽  
Biomedical Applications ◽  
Magnetic Hyperthermia ◽  
Effective Utilization ◽  
Engineering Sciences ◽  
Nanoscale Science ◽  
The Magnetic Field ◽  
Unique Ability

Nanotechnology is that sphere of technology that involves the participation of biology, chemistry, physics, and engineering sciences. Nanoscale science defines the chemistry and physics of structures lying in the range of 1-100 nm. Among the nanosystems researched, magnetic nanosystems are highlighted due their unique ability, which enables their targeting to specific locations on application of an external magnetic field. The exhibited property of these magnetic nanosystems being super-paramagnetism, there is no retention of magnetic property on removal of the magnetic field, thus enabling a reversion of the targeting process. For effective utilization of these nanosystems, they should be reduced to nanosizes, layered with biocompatible entities, stabilized, and functionalized. In the chapter, synthesis and functionalization and stabilization are elucidated. The biomedical applications such as targeted delivery, MRI, magnetic hyperthermia, tissue engineering, gene delivery, magnetic immunotherapy, magnetic detoxification, and nanomagnetic actuation are discussed.

Monte Carlo calculation of the energy parameters and spatial distribution of the cathodic arc ions while passing through the macro-particles filters

2018 ◽  
Vol 1 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Alexey Chernogor ◽  
Igor Blinkov ◽  
Alexey Volkhonskiy
Keyword(s):  
Magnetic Field ◽  
Mass Transfer ◽  
Monte Carlo ◽  
Monte Carlo Calculation ◽  
Inhomogeneous Magnetic Field ◽  
Flow Energy ◽  
Wide Range ◽  
Field Concentrator ◽  
Cathodic Arc ◽  
The Magnetic Field

The flow, energy distribution and concentrations profiles of Ti ions in cathodic arc are studied by test particle Monte Carlo simulations with considering the mass transfer through the macro-particles filters with inhomogeneous magnetic field. The loss of ions due to their deposition on filter walls was calculated as a function of electric current and number of turns in the coil. The magnetic field concentrator that arises in the bending region of the filters leads to increase the loss of the ions component of cathodic arc. The ions loss up to 80 % of their energy resulted by the paired elastic collisions which correspond to the experimental results. The ion fluxes arriving at the surface of the substrates during planetary rotating of them opposite the evaporators mounted to each other at an angle of 120° characterized by the wide range of mutual overlapping.

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

COMPARISON OF CARDIAC MAGNETIC FIELD DISTRIBUTIONS DURING DEPOLARIZATION AND REPOLARIZATION

2003 ◽  
Vol 13 (12) ◽  
pp. 3783-3789 ◽  
Author(s):  
F. E. SMITH ◽  
P. LANGLEY ◽  
L. TRAHMS ◽  
U. STEINHOFF ◽  
J. P. BOURKE ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Field Strength ◽  
Magnetic Field Strength ◽  
Field Distribution ◽  
Normal Subjects ◽  
The Body ◽  
Magnetic Field Distribution ◽  
T Wave ◽  
High Magnetic Field Strength ◽  
The Magnetic Field

Multichannel magnetocardiography measures the magnetic field distribution of the human heart noninvasively from many sites over the body surface. Multichannel magnetocardiogram (MCG) analysis enables regional temporal differences in the distribution of cardiac magnetic field strength during depolarization and repolarization to be identified, allowing estimation of the global and local inhomogeneity of the cardiac activation process. The aim of this study was to compare the spatial distribution of cardiac magnetic field strength during ventricular depolarization and repolarization in both normal subjects and patients with cardiac abnormalities, obtaining amplitude measurements by magnetocardiography. MCGs were recorded at 49 sites over the heart from three normal subjects and two patients with inverted T-wave conditions. The magnetic field intensity during depolarization and repolarization was measured automatically for each channel and displayed spatially as contour maps. A Pearson correlation was used to determine the spatial relationship between the variables. For normal subjects, magnetic field strength maps during depolarization (R-wave) showed two asymmetric regions of magnetic field strength with a high positive value in the lower half of the chest and a high negative value above this. The regions of high R-wave amplitude corresponded spatially to concentrated asymmetric regions of high magnetic field strength during repolarization (T-wave). Pearson-r correlation coefficients of 0.7 (p<0.01), 0.8 (p<0.01) and 0.9 (p<0.01) were obtained from this analysis for the three normal subjects. A negative correlation coefficient of -0.7 (p<0.01) was obtained for one of the subjects with inverted T-wave abnormalities, suggesting similar but inverted magnetic field and current distributions to normal subjects. Even with the high correlation values in these four subjects, the MCG was able to identify differences in the distribution of magnetic field strength, with a shift in the T-wave relative to the R-wave. The measurement of cardiac magnetic field distribution during depolarization and repolarization of normal subjects and patients with clinical abnormalities should enable the improvement of theoretical models for the explanation of the cardiac depolarization and repolarization processes.

scholarly journals Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

2018 ◽  
Author(s):  
Mahendran Subramanian ◽  
Arkadiusz Miaskowski ◽  
Stuart Iain Jenkins ◽  
Jenson Lim ◽  
Jon Dobson
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Field Gradient ◽  
Biomedical Applications ◽  
Magnetic Field Gradient ◽  
Field Source ◽  
Remote Manipulation ◽  
Cancer Cell Death ◽  
The Magnetic Field

AbstractThe manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been demonstrated to be useful in various biomedical applications. Some techniques have evolved utilizing this non-invasive external stimulus but the scientific community widely adopts few, and there is an excellent potential for more novel methods. The primary focus of this study is on understanding the manipulation of MNPs by a time-varying static magnetic field and how this can be used, at different frequencies and displacement, to manipulate cellular function. Here we explore, using numerical modeling, the physical mechanism which underlies this kind of manipulation, and we discuss potential improvements which would enhance such manipulation with its use in biomedical applications, i.e., increasing the MNP response by improving the field parameters. From our observations and other related studies, we infer that such manipulation depends mostly on the magnetic field gradient, the magnetic susceptibility and size of the MNPs, the magnet array oscillating frequency, the viscosity of the medium surrounding MNPs, and the distance between the magnetic field source and the MNPs. Additionally, we demonstrate cytotoxicity in neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells in vitro. This was induced by incubation with MNPs, followed by exposure to a magnetic field gradient, physically oscillating at various frequencies and displacement amplitudes. Even though this technique reliably produces MNP endocytosis and/or cytotoxicity, a better biophysical understanding is required to develop the mechanism used for this precision manipulation of MNPs, in vitro.

scholarly journals Magnetic micropump embedded in contact lens for on-demand drug delivery

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Cong Wang ◽  
Jungyul Park
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Drug Release ◽  
Contact Lens ◽  
Tear Film ◽  
Check Valve ◽  
Drug Diffusion ◽  
On Demand ◽  
The Magnetic Field

AbstractIn this paper, we report a thin magnetic micropump embedded in contact lens, which is capable of on-demand one-directional drug delivery. The proposed micropump can be actuated by the external magnetic field whenever needed without the need of battery. A micro check valve was integrated with the micropump for one-directional drug delivery from the micropump to the post-lens tear film. With actuation of the external magnetic field, the micro check valve is opened, and on-demand drug release can be realized. On the contrary, without an external magnetic field, the micro check valve is closed, and the undesired drug diffusion can be prevented. Through the control of the strength and the frequency of the magnetic field pulse, on-demand drug release and controlled dose can be realized.

scholarly journals Magnetic field disturbances in the sheath region of a super-sonic interplanetary magnetic cloud

2008 ◽  
Vol 26 (10) ◽  
pp. 3153-3158 ◽  
Author(s):  
E. Romashets ◽  
M. Vandas ◽  
S. Poedts
Keyword(s):  
Magnetic Field ◽  
Geomagnetic Storms ◽  
Magnetic Cloud ◽  
The Body ◽  
Magnetic Clouds ◽  
Shock Surface ◽  
Sheath Region ◽  
Magnetic Field Magnitude ◽  
The Magnetic Field ◽  
Magnetic Disturbances

Abstract. It is well-known that interplanetary magnetic clouds can cause strong geomagnetic storms due to the high magnetic field magnitude in their interior, especially if there is a large negative Bz component present. In addition, the magnetic disturbances around such objects can play an important role in their "geo-effectiveness". On the other hand, the magnetic and flow fields in the CME sheath region in front of the body and in the rear of the cloud are important for understanding both the dynamics and the evolution of the interplanetary cloud. The "eventual" aim of this work is to calculate the magnetic field in this CME sheath region in order to evaluate the possible geo-efficiency of the cloud in terms of the maximum |Bz|-component in this region. In this paper we assess the potential of this approach by introducing a model with a simplified geometry. We describe the magnetic field between the CME shock surface and the cloud's boundary by means of a vector potential. We also apply our model and present the magnetic field distribution in the CME sheath region in front of the body and in the rear of the cloud formed after the event of 20 November 2003.

Relation between wave speeds in the crust of dense magnetic stars

1978 ◽  
Vol 364 (1719) ◽  
pp. 537-552 ◽  
Keyword(s):  
Magnetic Field ◽  
Initial Pressure ◽  
The Body ◽  
Perfect Conductor ◽  
Initial State ◽  
Wave Speeds ◽  
Magnetic Stars ◽  
Arbitrary Strength ◽  
The Magnetic Field ◽  
Relativistic Framework

By studying, within the relativistic framework, the propagation of so-called infinitesimal discontinuities throughout a magnetized elastic perfect conductor in an initial state of high hydrostatic pressure p 0 and in the presence of a magnetic field of arbitrary strength, it is proven that there hold universal relations (i. e., that do not depend on the exact equation of state of the body) between the speeds U f and U s of so-called fast and slow magnetoelastic modes. These results, which should hold true in the crust of dense magnetic stars, have the following form. If A 0 is the relativistic Alfvén number of the initial state and a 0 is the sound speed of a fictitious relativistic perfect fluid whose law of compression would yield the initial pressure p o , then (with nondimensional speeds) U 2 / f = 4/3[ U 2 s (1+ A 2 0 ]+( a 2 0 -4/3 A 2 0 ) for a propagation along the magnetic field and U 2 f (1+ A 2 0 )=4/3 U 2 s +( a 2 0 + A 2 0 ) for a propagation in a direction orthogonal to the magnetic field. These results generalize previous results obtained in relativistic elasticity by Carter and Maugin.

Targeting Magnetic Nanoparticles in High Magnetic Fields for Drug Delivery Purposes

2004 ◽  
Vol 820 ◽  
Author(s):  
Ramazan Asmatulu ◽  
Richard.O. Claus ◽  
Judy S. Riffle ◽  
Michael Zalich
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Magnetic Particles ◽  
Guidance System ◽  
Test Results ◽  
Test Parameters ◽  
Magnetic Guidance ◽  
The Magnetic Field

AbstractBiodegradable magnetic nanoparticles were synthesized using Poly(L-Lactic Acid) and magnetite nanoparticles (∼14 nm) at different dosages, and then these nanaoparticles (nanocomposites) and pure magnetic particles were targeted in external magnetic fields by changing the test parameters. The magnetic field test results showed that magnetic saturation, fluid speed, magnetic field distance and particle size were extremely effective for a magnetic guidance system that is needed for an effective drug delivery approach. Thus, it is assumed that such nanoparticles can carry drugs (chemotherapy) to be able to cure cancer tumors as well as many other diseases.

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