scholarly journals The evaluation of Serum Copper Level in Hemodialysis Patients with and without anemia Compared with Healthy Controls

2014 ◽  
Vol 14 (1) ◽  
pp. 43-48
Author(s):  
Abbasali Zeraati ◽  
Sajad Ataei Azimi ◽  
Seyed Mahdi Pakdaman Shahri ◽  
Farzaneh Sharifipour ◽  
Reza Hekmat ◽  
...  
Keyword(s):  
Venous Blood ◽  
Medical Science ◽  
Hemodialysis Patients ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Healthy Controls ◽  
Inverse Regression ◽  
Serum Copper Level ◽  
Significant Difference

Introduction: Anemia is a common complication of ESRD with different etiologies. The most common cause of anemia in such patients is insufficient production of erythropoietin by kidneys. Another possible reason is copper deficiency, thus, this study is aimed to evaluate the serum copper level among hemodialysis patients with and without anemia and to compare them to healthy controls. Material and Methods: A total number of 56 patients who underwent regular hemodialysis due to their ESRD were enrolled and divided into two groups of 28 according to their Hgb results including patients with anemia (Hgb<11 gr/dl) and patients without anemia (Hgb>11 gr/dl). Also, 28 healthy individuals participated as the control group. Venous blood samples were collected from patients prior to hemodialysis. Spectrophotometry employed for copper measurements. Data were analyzed using t-test and Pearson regression analysis. Results: Mean age of patients was 44.36±15.80 years. No significant difference was present among the three groups with regarding to age and gender. Mean and SD of serum copper in patients with anemia, without anemia, and controls were 180.11±54.48, 139.66±35.57 and 155.82±42.06 µg/dl respectively. Serum copper level was significantly higher in hemodialysis patients with anemia compared with those without anemia (p<0.03). Also a significant inverse regression between serum copper and Hgb was present in all hemodialysis patients (p=0.02, r=-0.37). Conclusion: Higher levels of serum copper in anemic patients could be a result of restraining role of high serum copper on iron absorption that has a negative effect on the production of Hgb. However, complementary studies are required. DOI: http://dx.doi.org/10.3329/bjms.v14i1.16853 Bangladesh Journal of Medical Science Vol.14(1) 2015 p.43-48

scholarly journals Does copper deficiency predispose children to otitis media with effusion?

2018 ◽  
Vol 4 (5) ◽  
pp. 1147
Author(s):  
Maryam Amizadeh ◽  
Sareh Molaei Moghbeli ◽  
Hamed Reihani-Kermani ◽  
Amir Reihani
Keyword(s):  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Graphite Furnace ◽  
Serum Levels ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Serum Selenium ◽  
Cross Sectional ◽  
Significant Difference

<p class="abstract"><strong>Background:</strong> Both otitis media with effusion (OME) and copper or selenium have been associated to the immune system, hence it could be proposed that cooper and/or selenium deficiency predisposes children to OME through immune cells dysfunction. The aim of this study was to determine the serum levels of Copper and Selenium in an immundeficient-linked disease - OME – in childhood.</p><p class="abstract"><strong>Methods:</strong> This cross-sectional study was conducted between July 2015 and December 2016 including 80 patients age 1 to 8 years old who were divided into two groups: otitis media with effusion (OME) consisted of 40 patients and the control (n=40). Patients who did not recover after three months conservative treatments were included. Serum levels of Copper and Selenium were measured using graphite furnace atomic absorption spectrometry.  </p><p class="abstract"><strong>Results:</strong> Statistical analysis showed no significant differences regarding age and sex were noted between groups. Patients with OME had significantly lower serum copper levels than the control group (p=0.007). However, there was no statistically significant difference in serum selenium levels between groups. The analysis also showed a significant positive correlation between serum copper level and age (correlation coefficient=0.348, p=0.028), whereas, there was no correlation between the measured selenium level and age.</p><p class="abstract"><strong>Conclusions:</strong> The results of the present study showed that serum level of copper might play a role on development of otitis media with effusion in childhood.</p>

scholarly journals The Effects of Antiepileptic Drugs (AED) on Serum Copper Level in Children with Epilepsy

2019 ◽  
pp. 1-7
Author(s):  
Shamim-Ara-Sarkar . ◽  
Habibur Rahman ◽  
Israt Jahan ◽  
Md. Ranzu Ahmed
Keyword(s):  
Antiepileptic Drugs ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Case Group ◽  
Serum Copper Level ◽  
Unusual Behavior ◽  
Epileptic Child ◽  
Multiple Drugs

Background: Epilepsy is a central nervous system disorder in which brain activity becomes irregular, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness. Serum copper level may change due to long term use of antiepileptic drugs. Objective: The purpose of the present study was to assess the serum copper level in childhood epilepsy treated with long-term Anti-Epileptic Drug (AED). Methodology: This cross-sectional study was carried out in the Department of Paediatric Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU) during March to August’ 2013. Sample size was one hundred, among these fifty were case (epileptic child who had received  anti-epileptic drugs (Carbamazepine and/or Valproic acid) for more than three months) and rest fifty were control (newly diagnosed epileptic child, who yet not received antiepileptic drug). Result: The mean copper level was 1.11±0.32 µg/ml in case group and 0.96±0.20 µg/ml in control group, which was statistically significant (p<0.05). Conclusion: The use of one drug or multiple drugs in the treatment of epileptic patients may play significant role in increasing copper serum level.

scholarly journals Serum Alpha-(1, 3)-Fucosyltransferase IV, Copper, and Zinc Levels in Patients with Colorectal Cancer and Healthy Controls

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Roya Abbasi Natajomrani ◽  
Durdi Qujeq ◽  
Vahid Hosseini ◽  
Reza Hajihosseini
Keyword(s):  
Colorectal Cancer ◽  
Clinical Symptoms ◽  
Venous Blood ◽  
Serum Copper ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Controls ◽  
Copper And Zinc ◽  
The Mean ◽  
Zinc Levels

Background: Colorectal cancer (CRC) has no significant clinical symptoms at the early stages, and the molecular differences in the serum of the patients and healthy subjects could be assessed to identify the biological markers that indicate the detection of this cancer at the levels of the biological system. Objectives: The present study aimed to assess the concentrations of the alpha-(1, 3)-fucosyltransferase IV (FUT4) enzyme and copper (Cu) and zinc (Zn) as biological elements. Methods: This case-control study was conducted on 40 patients with CRC, including 20 men and 20 women. A metal-free sterile tube was used to collect five milliliters of venous blood. The enzyme-linked immunosorbent assay (ELISA) based on the Biotin double-antibody sandwich technology was used to measure the human FUT4 in the sera. In addition, plasma zinc and copper values were determined using Zist Chem Diagnostics kits. Results: The mean FUT4 levels in the CRC patients was slightly higher than the control group (P = 0.17), and the mean serum copper and zinc levels of these patients were lower than the control group with a significance difference in this regard (P < 0.001). In addition, the AUC of FUT4, copper, and zinc was 0.58, 0.80, and 0.77, respectively. Conclusions: According to the results, the altered levels of FUT4, copper, and zinc in the serum of the CRC patients compared to the healthy controls could be an indicator associated with the CRC disease course. Furthermore, the unusual changes in the FUT4, copper, and zinc levels may signify CRC development, which plays a key role in the diagnosis and monitoring of this cancer.

scholarly journals Quantitative Assessment of Serum Copper Status in Children with Thalassemia Major

2020 ◽  
pp. 94-100
Author(s):  
Subir Nandy ◽  
A. K. M. Amirul Morshed ◽  
Tanzina Iveen Chowdhury ◽  
Shahnoor Islam ◽  
Bijoy K. Paul ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Serum Copper ◽  
Dietary Factors ◽  
Chemistry Laboratory ◽  
Beta Thalassemia ◽  
Copper Level ◽  
Control Group ◽  
Normal Children ◽  
Beta Thalassemia Major ◽  
Significant Difference

Objective: Support of ordinary degrees of copper, has a significant influence in reducing the morbidities related with thalassemia major. Levels of this component has been seen as modified in this incessant transfusion subordinate infection from everywhere throughout the world, however with broadly factor results. Other than rehashed blood transfusions and utilization of chelating operators, the level of copper in thalassemia patients are influenced by hereditary and dietary factors likewise, convincing us to embrace this investigation in our population. The Objectives of this study was to appraise of serum levels of copper in children with beta-thalassemia major. Methods: In this observational comparative research design, all children between 5 to 15 years affected by beta thalassemia major (30 patients) and 30 normal children were evaluated for serum copper levels in the Department of Pediatrics, DMCH and attended at Thalassemia Center, DSH (Dhaka Shishu Hospital). Serum measurements for copper were performed using Atomic Absorption Spectrophotometer (Varian, AA 240 FS, USA) in Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Centre, Dhaka, Bangladesh. Results: The minimum, maximum, and the mean concentration of serum copper in patients were 103.50, 239.94, and 147.55 ± 35.17 µg/dl and in control group, those were 58.75, 192.43, and 123.85± 33.19 µg/dl respectively. There was no significant difference in serum copper level in the β thalassemia group and the control group (p=0.54) (P=0.3). Conclusion: This investigation revealed that there is no copper inadequacy. Further assessment in such manner is suggested.

scholarly journals Histogenous Hypoxia and Acid Retention in Schizophrenia: Changes in Venous Blood Gas Analysis and SOD in Acute and Stable Schizophrenia Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Xingbing Huang ◽  
Qiu-Ling Lu ◽  
Xiu-Mei Zhu ◽  
Yi-Bin Zeng ◽  
Yun Liu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Venous Blood ◽  
Fasting Blood Glucose ◽  
Downward Trend ◽  
Control Group ◽  
Healthy Controls ◽  
Blood Gas ◽  
Stable Period ◽  
Significant Difference ◽  
Venous Blood Gas

Background: Oxidative stress may play an important role in the pathogenesis of schizophrenia (SCH), and there is considerable indirect evidence that hypoxia is closely related to SCH, but direct evidence of hypoxia in SCH has never been found.Methods:In this study, superoxide dismutase (SOD), venous blood gas, and Positive and Negative Syndrome Scale (PANSS) were examined in 40 SCH patients and compared with those of 40 healthy controls. The patients were treated with combination of atypical antipsychotics and Ditan Huayu Lishen decoction (a Chinese medicine decoction) and examined in the acute and stable period, respectively. Comparisons of indicators between two groups were performed using an independent-samples t-test, comparison of indicators between the acute and stable periods in the SCH group was performed using paired-samples t-test. Pearson correlation and multiple linear regression analyses were performed to investigate the relationships between the effect indicators.Results: Higher venous pH, PvO2, and fasting blood glucose levels and lower SOD, lactic acid, and PvCO2 levels were found in SCH patients compared with the control group; SOD was negatively correlated with the general psychopathology subscale score (PANSS-G), and PvO2 levels were closely related to venous pH in SCH and related to PvCO2 in the control group. It was also found that SOD activity showed no significant difference in acute and stable period, whereas PvO2 showed a downward trend, and venous pH was decreased significantly after treatment. Both the venous pH and PvO2 were higher in patients with SCH than that in healthy controls.Conclusion: It suggests that histogenous hypoxia and acid retention exist in relation to SCH, and there is an improvement of acid retention and a downward trend in histogenous hypoxia after combination treatment. Venous pH, PvO2, and PvCO2 are trait variables, but not state variables of SCH. The theory of histogenous hypoxia and acid retention can well explain the decrease in pH value and the increase in lactic acid in brain tissue of patients with SCH. Histogenous hypoxia and acid retention closely related to glucose metabolism. So they may play an important role in pathophysiology for SCH.

scholarly journals Assessment of Serum Copper Level among Sudanese Patients with vitiligo

2020 ◽  
Author(s):  
Mehad Muawia ◽  
Suad H H ◽  
Gad Allah Modawe
Keyword(s):  
Family History ◽  
Serum Level ◽  
Patient Group ◽  
Serum Copper ◽  
Unknown Etiology ◽  
Copper Level ◽  
Control Group ◽  
Serum Copper Level ◽  
Number Of Patients ◽  
One Year

Background: Vitiligo is a common skin disease of unknown etiology characterized clinically by depigmented patches, which can be localized or generalized; it usually runs a chronic course with an un predictable outcome and failure of complete cure in many affected individuals. Many communities consider it a contagious disease which leads to a great psychological and social stigma for patients; previous studies showed that copper might be associated with the pathogenesis of vitiligo. The aim of this study was to assess copper level in Sudanese vitiligo patients. Methods: This is a case-control study conducted in dermatology clinics in Khartoum state during the period from November 2018 to February 2019. Blood samples were obtained from 100 participants, 50 from vitiligo patients and 50 from non-vitiligo subjects representing a control  group. Serum copper was measured by mind-ray (automation). Results: A highly significant increase (P-value = 0.000) in the copper level was seen in vitiligo patients compared with the control group. Of the total number of patients, 17 (34%) were females and 33 (66%) were males. According to the duration of the disease, the copper level was significantly increased in patient group with a disease duration of > one year compared to the patient group six months–one year and patient group < 6 months; we found no significance of the family history, 18% of the case group had a family history while 42 (82%) had no family history. Discussion: The relationship between the serum level of copper and vitiligo has been assessed by many studies. Copper is one of the trace elements that was found to be important for tyrosinase enzyme that catalyzes the first steps in melanin synthesis in the skin. Some studies showed that the disease was associated with low serum levels of copper and since vitiligo is a disease that is characterized clinically by white areas of skin with no melanin, these studies seem to be logical. However, in this study, the serum level of copper was found to be high in vitiligo patients which might be justified by the release of copper from the destroyed melanocytes. Another justification might be a defect in the carrier protein for copper. Conclusion: The study found that the serum copper was significantly increased in vitiligo patients compared to the control and it is recommended that serum copper level and copper profile should be assessed routinely in vitiligo patients. Keywords: vitiligo, depigmentation, copper, Sudanese

scholarly journals Utility of Serum Copper Level Estimation in Patients Suffering from Alzheimer’s Disease

2017 ◽  
Vol 33 (2) ◽  
pp. 96-102
Author(s):  
Dewan Mushfiqur Rahman ◽  
SK Mahbub Alam ◽  
Shamshad B Quraishi ◽  
Imran Sarker ◽  
Md Rafiqul Islam ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Copper ◽  
High Serum ◽  
Total Serum ◽  
Copper Level ◽  
Control Group ◽  
Serum Copper Level ◽  
Control Groups ◽  
And Control

Background: Alzheimer’s disease is the most common cause of dementia. Metals such as zinc , copper, iron are likely involved in the neurodegeneration of Alzheimer’s disease . Copper can catalyze a flux of reactive oxygen species that can damage functional and structural macromolecules in brain. Most studies found association of high serum copper level with Alzheimer’s disease but also some studies did not. Methods: Total 48 patients of Alzheimer’s disease who were diagnosed according to NIA-AA ( National institute of Aging – Alzheimer’s Association) recommendation ( revised NINCDS-ADRDA) criteria were taken as study population purposively and 42 age and sex matched control were selected. Fasting serum copper level were done for both groups. Comparison of serum copper level of Alzheimer’s patients with that of the control group were done to see association. Results : A total of 28 male and 20 female with mean age of 66.20 ± 9.42 (mean±SD) years, 22 male and 20 female with mean age of 63.54 ± 9.74 (mean±SD) years constituted as case and control groups, respectively. The mean of serum copper in case and control groups were 0.95 ± 0.37 versus 0.92 ± 0.25 mg/L (P > 0.05). The present study found that serum copper levels are non-significantly higher in patients with AD than control group, however it did not show a significant relationship with severity of dementia. Conclusion: So our suggestion was to perform a study work including total serum copper level , serum ceruloplasmin level and free serum copper level comparing between a large Alzheimer’s Disease patients group and age , sex matched apparently healthy control group to understand the copper dyshomeostasis in Alzheimer’ Disease. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 96-102

scholarly journals Evaluation Serum Copper Levels in Preeclampsia and Healthy Pregnant Women

2019 ◽  
Vol 9 (1) ◽  
pp. 18-22
Author(s):  
Nilima Baral ◽  
Rezwana Haque ◽  
Farzana Akonjee Mishu
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Case Group ◽  
Second Trimester ◽  
Serum Copper Level ◽  
Third Trimester

Background: Preeclampsia is a fatal medical disorder of pregnancy. It has been associated with adverse course and outcome of the pregnancy resulting in increased maternal and infant mortality and morbidity. As the pathogenesis of preeclampsia is not completely understood, prevention remains a complex issue. In recent times, there has been an increasing prevalence in the incidence of preeclampsia globally. The aim of this study is to determine the states of the copper in pregnant women with preeclampsia. Methods: This case-control study was carried out in the Department of Biochemistry, Mymensingh Medical College, Mymensingh, from July 2013 to June 2014. The subjects were selected on the basis of inclusion and exclusion criteria by purposive method. This study included 73 patients with preeclampsia as case (Gr.I) classified into two subgroups according to the gestational age: Gr.I(a); preeclampsia in the second trimester (n = 35), and Gr.I(b); preeclampsia in the third trimester (n = 38). Copper levels were analyzed and results were compared with 73 apparently healthy pregnant control (Gr.II), and the corresponding gestational age subgroups [Gr.II(a); normal pregnancy of second trimester (n = 35) and Gr.II(b), normal pregnancy of third trimester (n = 38)]. Results: The mean serum copper level was significantly (p<0.001) lower in case group than that of control group. Similar extent of reduction was observed in serum copper level at different gestational age groups of preeclamptic women when compared with corresponding control groups. Conclusion: Estimation of serum copper level should be incorporated in pre eclamptic patients for prevention of complications. Birdem Med J 2019; 9(1): 18-22

Serum Copper Level and Polycystic Ovarian Syndrome: A Meta-Analysis

2021 ◽  
pp. 1-8
Author(s):  
Qingtao Jiang ◽  
Feng Zhang ◽  
Lei Han ◽  
Baoli Zhu ◽  
Xin Liu
Keyword(s):  
Large Scale ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Copper Status ◽  
Plasma Copper ◽  
Mean Differences ◽  
Ovarian Syndrome

<b><i>Introduction:</i></b> The association of serum copper with polycystic ovarian syndrome (PCOS) has been studied for years, but no definite conclusion is drawn. Therefore, we conducted a meta-analysis to investigate serum copper concentrations in PCOS subjects compared with healthy controls. <b><i>Methods:</i></b> Electronic search was performed in PubMed, Google Scholar, and Scopus up to June 30, 2020, without any restriction. Standardized mean differences (SMDs) with corresponding 95% CIs in serum copper levels were employed with random-effects model. <i>I</i><sup>2</sup> was applied to evaluate heterogeneity among studies. <b><i>Results:</i></b> Nine studies, measuring plasma copper levels in 1,168 PCOS patients and 1,106 controls, were included. Pooled effect size suggested serum copper level was significantly higher in women with PCOS (SMD = 0.51 μg/mL, 95% CI = [0.30, 0.72], <i>p</i> &#x3c; 0.0001). The overall heterogeneity was not connected with subgroups of the country, but derived from the opposite result of 1 study. <b><i>Conclusion:</i></b> Our research generally indicated circulating copper level in PCOS sufferers was significantly higher than normal controls. Large-scale studies are still needed to elucidate the clear relation between copper status and etiology of PCOS.

scholarly journals Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients

2021 ◽  
Author(s):  
Frank Faltraco ◽  
Denise Palm ◽  
Adriana Uzoni ◽  
Lena Borchert ◽  
Frederick Simon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dermal Fibroblast ◽  
Sleep Onset ◽  
Dermal Fibroblasts ◽  
Control Group ◽  
Adhd Group ◽  
Healthy Controls ◽  
Circadian Gene ◽  
Significant Difference ◽  
Circadian Preference

AbstractA link between dopamine levels, circadian gene expression, and attention deficit hyperactivity disorder (ADHD) has already been demonstrated. The aim of this study was to investigate the extent of these relationships by measuring circadian gene expression in primary human-derived dermal fibroblast cultures (HDF) after dopamine exposure. We analyzed circadian preference, behavioral circadian and sleep parameters as well as the circadian gene expression in a cohort of healthy controls and participants with ADHD. Circadian preference was evaluated with German Morningness-Eveningness-Questionnaire (D-MEQ) and rhythms of sleep/wake behavior were assessed via actigraphy. After ex vivo exposure to different dopamine concentrations in human dermal fibroblast (HDF) cultures, the rhythmicity of circadian gene expression (Clock, Bmal1, Per1-3, Cry1) was analyzed via qRT-PCR. We found no statistical significant effect in the actigraphy of both groups (healthy controls, ADHD group) for mid-sleep on weekend days, mid-sleep on weekdays, social jetlag, wake after sleep onset, and total number of wake bouts. D-MEQ scores indicated that healthy controls had no evening preference, whereas subjects with ADHD displayed both definitive and moderate evening preferences. Dopamine has no effect on Per3 expression in healthy controls, but produces a significant difference in the ADHD group at ZT24 and ZT28. In the ADHD group, incubation with dopamine, either 1 µM or 10 µM, resulted in an adjustment of Per3 expression to control levels. A similar effect also was found in the expression of Per2. Statistical significant differences in the expression of Per2 (ZT4) in the control group compared to the ADHD group were found, following incubation with dopamine. The present study illustrates that dopamine impacts on circadian function. The results lead to the suggestion that dopamine may improve the sleep quality as well as ADHD symptoms by adjustment of the circadian gene expression, especially for Per2 and Per3.

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