scholarly journals An experimental study on effects of wheatgrass (Triticum aestivum) juice on low density lipoprotien (LDL) level in blood of experimentally induced hypercholesterolaemic male long Evans rat

2015 ◽  
Vol 30 (2) ◽  
pp. 18-24
Author(s):  
Rokhsana Dil Afroz ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Md Ismail Khan ◽  
Tuhin Jahan
Keyword(s):  
Experimental Study ◽  
Triticum Aestivum ◽  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Serum Total Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Cholesterol Levels ◽  
Long Evans ◽  
Experimentally Induced

An experimental study was done to observe the hypocholesterolaemic effect of wheatgrass (Triticum aestivum) juice on experimentally induced hypercholesterolaemic rats, especially on serum low density lipoprotein (LDL) level, which was carried out in the Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka, between July, 2009 and June, 2010. A total number of 48 healthy adult male Long Evans rats (Norwegian strain) were used for the present study. 6 rats were taken in each group of total 8 groups treated differently with 1 control group. Rats of the first 5 groups were sacrificed at 29th day and their serum total cholesterol levels were measured. The rest of the rats were sacrificed at 57th day and their serum total cholesterol levels were measured. The mean serum LDL of 10ml/kg grass juice fed normal rats was decreased by 11.64% than that of the laboratory diet fed control group (P<0.01). Serum LDL of the group of rats treated with 10ml/kg grass juice and1% cholesterol diet were decreased by 36.59% than that of the hypercholesterolaemic control group (P<0.001). Serum LDL of the hypercholesterolaemic rats treated with 10ml/kg grass juice for 28 days were decreased by 29.10%, and in hypercholesterolaemic rats treated with 20ml/kg grass juice for 28 days were decreased by 39.46% (P<0.001). Reduction of LDL as evident on hypercholesterolaemic rats treated with 20ml/kg grass juice, which was similar to hypercholesterolaemic rats treated with 0.14mg/kg Atorvastatin for 28 days. DOI: http://dx.doi.org/10.3329/bjpp.v30i2.22678 Bangladesh J Physiol Pharmacol 2014; 30(2): 18-24

Effects of Wheatgrass (Triticum aestivum) Juice on Serum Cholesterol of Experimentally Induced Hypercholesterolaemic Male Long Evans Rat

2014 ◽  
Vol 27 (1-2) ◽  
pp. 21-27
Author(s):  
Rokhsana Dil Afroz ◽  
Abu Sadat Mohammad Nurunabbi ◽  
Md Ismail Khan
Keyword(s):  
Triticum Aestivum ◽  
Total Cholesterol ◽  
Serum Total Cholesterol ◽  
Control Group ◽  
Medical College ◽  
Cholesterol Levels ◽  
Healthy Adult Male ◽  
The Mean ◽  
Long Evans ◽  
Experimentally Induced

An experimental study was designed to observe the hypocholesterolaemic effect of wheatgrass (Triticum aestivum) juice on experimentally induced hypercholesterolaemic rats, which was carried out in the Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka, from July, 2009 to June, 2010. A total number of 48 healthy adult male Long Evans rats (Norwegian strain), age ranging from 2-3 months, and weighing from 140-200 grams were used for the present study. 6 rats were taken in each group of total 8 groups treated differently with 1 control group. Rats of the first 5 groups were sacrificed at 29th day and their serum total cholesterol levels were measured. Rest of the rats were sacrificed at 57th day and their serum total cholesterol levels were measured. The mean serum concentration of total cholesterol of 10ml/kg grass juice fed normal rats was decreased by 11.64% than that of the laboratory diet fed control group (P<0.01). The total cholesterol of the group of rats treated with 10ml/kg grass juice and1% cholesterol diet were decreased by 36.59% than that of the hypercholesterolaemic control group (P<0.001). The mean total cholesterol of the hypercholesterolaemic rats treated with 10ml/kg grass juice for 28 days were decreased by 29.10%, and in hypercholesterolaemic rats treated with 20ml/kg grass juice for 28 days were decreased by 39.46% (P<0.001). The mean total cholesterol of the hypercholesterolaemic rats treated with 0.14mg/kg atorvastatin for 28 days were found to be decreased by 38.86% than that of hypercholesterolemic control group, which was statistically significant (P<0.001). DOI: http://dx.doi.org/10.3329/bjpp.v27i1-2.20070 Bangladesh J Physiol Pharmacol 2011; 27(1&2):21-27

Electroacupuncture Therapy for Weight Loss Reduces Serum Total Cholesterol, Triglycerides, and LDL Cholesterol Levels in Obese Women

2005 ◽  
Vol 33 (04) ◽  
pp. 525-533 ◽  
Author(s):  
Mehmet Tuǧrul Cabıoǧlu ◽  
Neyhan Ergene
Keyword(s):  
Total Cholesterol ◽  
Weight Reduction ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
The Body ◽  
Serum Total Cholesterol ◽  
Control Group ◽  
Obese Women ◽  
Diet Restriction ◽  
Cholesterol Levels

Our purpose in this study was to investigate the effect of acupuncture therapy on body weight and on levels of the serum total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol in obese women. Fifty-five women were studied in three groups as follows: (1) control group ( n = 12; mean age = 43.3 ± 4.3, and mean body mass index { BMI } = 32.2 ± 3.4); (2) electroacupuncture (EA) ( n = 22; mean age = 39.8 ± 5.3, and BMI = 34.8 ± 3.3); and (3) diet restriction ( n = 21; mean age = 42.7 ± 3.9, and BMI = 34.9 ± 3.3). EA was performed using the ear points, Sanjiao (Hungry) and Shen Men (Stomach), and the body points, LI 4, LI 11, St 25, St 36, St 44 and Liv 3, once daily, for 30 minutes, for 20 days, whereas patients on diet restriction had a 1425 Kcal diet program, that consisted of 1425 Kcal daily for 20 days. There was a 4.8% weight reduction in patients with EA application, whereas patients on diet restriction had a 2.5% weight reduction. There were significant decreases in total cholesterol and triglyceride levels in EA and diet groups compared with the control group ( p < 0.05 in both cases). Furthermore, there was a decrease in LDL levels in the EA group compared with the control group ( p < 0.05). No significant changes could be found in HDL levels among the three groups. Our results suggest that EA application in obese women may decrease the serum total cholesterol, triglyceride, and LDL cholesterol levels by increasing the serum beta endorphin level. This lipolytic effect of EA may also reduce the morbidity of obesity by mobilizing the energy stores that result in weight reduction.

Serum Total Cholesterol Screening for the Detection of Elevated Low-Density Lipoprotein in Children and Adolescents: The Bogalusa Heart Study

PEDIATRICS ◽  
1990 ◽  
Vol 85 (4) ◽  
pp. 472-479
Author(s):  
Barbara A. Dennison ◽  
David A. Kikuchi ◽  
Sathanur R. Srinivasan ◽  
Larry S. Webber ◽  
Gerald S. Berenson
Keyword(s):  
Children And Adolescents ◽  
Total Cholesterol ◽  
Screening Tool ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Total Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Cholesterol Levels

The use of serum total cholesterol measurement was evaluated as a screening tool to predict elevated levels of low-density lipoprotein cholesterol in 2857 children and adolescents, aged 5 to 17 years, examined in 1981 and 1982. Subjects were from the biracial community of Bogalusa, Louisiana. For selected serum total cholesterol values (150 to 210 mg/dL, 3.88 to 5.43 mmol/L), sensitivities were higher for blacks than whites and higher for females than males, whereas the positive predictive values were higher for whites than blacks and higher for males than females. With the age-, race-, and sex-specific 95th percentiles of serum total cholesterol levels as cutoff points, only 44% to 50% of subjects with elevated low-density lipoprotein cholesterol levels (≥95th percentile) were detected, and approximately 50% of those identified had false-positive results. Lowering the serum total cholesterol cutoff point increased the sensitivity, but decreased the specificity and positive predictive value. At the 75th percentiles of serum total cholesterol levels, sensitivities were 92% to 95% for females and 100% for males and specificities were 78% to 79%, but the false-positive results increased to 81% to 84%. The low cost and ease of obtaining serum total cholesterol measurements contribute to its appeal as a screening tool for hyperlipidemia. However, its poor test characteristics make serum total cholesterol measurement inefficient as a screening tool for detecting elevated levels of low-density lipoprotein cholesterol in children and adolescents.

scholarly journals Evaluation of antiatherogenic effect of Alternanthera brasiliana Linn kuntz in rats on atherogenic diet

2019 ◽  
Vol 8 (6) ◽  
pp. 1172
Author(s):  
Urmi Choudhury ◽  
Tarali Devi ◽  
Asha Borah
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Methanolic Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Serum Total Cholesterol ◽  
Low Density ◽  
High Fat

Background: Hypercholesterolaemia is a major risk factor for systemic atherosclerosis and a well-known etiological factor for cardiovascular diseases and its complications which is a leading cause of mortality worldwide. In a recent study, the antihyperlipidemic activity of dried leaves extract of Alternanthera brasiliana has been evaluated. Hence, the present study was undertaken to investigate the anti-atherosclerotic potential of the methanolic extract of the leaves of Alternanthera brasiliana L. Kuntz (MEAB) in high fat diet induced hypercholesterolemic rat model.Methods: Thirty (30) wistar albino rats of either sex were randomly divided into five groups: first two groups received normal diet and high fat diet respectively and the remaining three groups received high fat diet supplemented with methanolic extract of Alternanthera brasiliana (MEAB) administered orally daily at two different doses: 200 mg/kg and 400 mg/kg and Atorvastatin 10 mg/kg/day orally as standard respectively. Serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) was estimated after 12 weeks. Atherogenic index was calculated from the results of lipid profile. At the end, the aorta was removed for assessment of atherosclerotic plagues.Results: Our results showed that MEAB possessed significant cholesterol lowering potency as indicated by decrease in serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) accompanied by an increase in serum high density lipoprotein (HDL-C) and reduces the atherosclerotic lesion of aorta (p <0.05).Conclusions: These results strongly suggests that MEAB can prevent the progress of atherosclerosis likely due to the effect of A. brasiliana on serum lipoproteins and its antioxidant and anti-inflammatory properties. It could be a potential therapy for the prevention and treatment of atherosclerosis.

scholarly journals Two Weeks Of Western Diet Disrupts Liver Molecular Markers Of Cholesterol Metabolism In Rat

2020 ◽  
Author(s):  
Roxane St-Amand ◽  
Emilienne T. Ngo Sock ◽  
Samantha Quinn ◽  
Jean-Marc Lavoie ◽  
David H. St-Pierre
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Metabolism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Plasma Total Cholesterol ◽  
Cholesterol Levels ◽  
Density Lipoprotein Receptor ◽  
Element Binding Protein

Abstract Background: The present study was designed to test the hypothesis that in the liver, excessive fat accumulation impairs cholesterol metabolism mainly by altering the low-density lipoprotein-receptor (LDL-R) pathway. Method: Young male Wistar rats were fed standard (SD), high fat (HFD; 60% kcal) or Western (WD; 40% fat + 35% sucrose (17.5% fructose)) diets for 2 or 6 weeks. Results: Weight gain (~ 40g) was observed only following 6 weeks of the obesogenic diets (P < 0.01). Compared to the 2-week treatment, obesogenic diets tripled fat pad weight (~ 20 vs 7 g) after 6 weeks. Hepatic triglyceride (TG) levels were greater in response to both the WD and HFD compared to the SD (P < 0.01) at 2 and 6 weeks and their concentrations were greater (P < 0.05) in WD than HFD at 2 weeks. Plasma total cholesterol levels were higher (P < 0.05) in animals submitted to WD. After 2 and 6 weeks, liver expression of LDL-R, proprotein convertase subtilisin/kexin 9 (PCSKk9) and sterol regulatory element binding protein 2 (SREBP2), involved in LDL-cholesterol uptake, was lower in animals submitted to WD than in others treated with HFD or SD (P < 0.01). Similarly, low-density lipoprotein-receptor-related protein 1 (LRP1) and acyl-CoA cholesterol acyltransferase-2 (ACAT-2) mRNA levels were lower (P < 0.01) among WD compared to SD-fed rats. Expression of the gene coding the main regulator of endogenous cholesterol synthesis, 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCoAR) was reduced in response to WD compared to SD and HFD at 2 (P < 0.001) and 6 (P < 0.05) weeks. Being enriched in fructose, the WD strongly promoted the expression of carbohydrate-response element binding protein (ChREBP) and acetyl-CoA carboxylase (ACC), two key regulators of de novo lipogenesis. Conclusion: These results show that the WD promptly increased TG levels in the liver by potentiating fat storage. This impaired the pathway of hepatic cholesterol uptake via the LDL-R axis, promoting a rapid increase in plasma total cholesterol levels. These results indicate that liver fat content is a factor involved in the regulation of plasma cholesterol.

scholarly journals Effect of Wheatgrass (Triticum aestivum) Juice on High Density Lipoprotein (HDL) Level in Experimentally Induced Dyslipidaemic Male Long Evans Rat

2015 ◽  
Vol 3 (1) ◽  
pp. 18-24
Author(s):  
Rokhsana Dil Afroz ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Md Ismail Khan ◽  
Tuhin Jahan
Keyword(s):  
Triticum Aestivum ◽  
Lipid Profile ◽  
Cholesterol Level ◽  
Hdl Cholesterol ◽  
High Density ◽  
Lipid Lowering ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Long Evans ◽  
Experimentally Induced

Background: Evidence shows that high density lipoproteins (HDLs) may exert multiple anti-atherogenic and anti-thrombotic effects that together decrease the risk of cardiovascular morbidity in hyperlipidaemic state. Experimental studies showed that fresh wheatgrass (Triticum aestivum Linn.) juice exerts lipid lowering effect as well as increases HDL-cholesterol level in rats. Objective: The present study was done to observe the effect of wheatgrass juice on serum HDL-cholesterol on experimentally induced dyslipidaemic rats evident by reduced HDL-cholesterol level. Materials and method: This experimental study was carried out in the Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka, from July 2009 to June 2010. A total number of 48 healthy adult male Long Evans rats, age ranging from 2-3 months, and weighing from 140-200 grams were used for the present study. Six rats were taken in each group of total 8 groups treated differently with 1 control group. Rats of the first 5 groups were sacrificed at 29th day and their lipid profile was measured. Rests of the rats were sacrificed at 57th day and their lipid profile was measured. Results: Mean HDL-cholesterol of the group of rats treated with 10 mL/kg grass juice and 1% cholesterol diet, with 10 mL/kg grass juice and with 20 mL/kg grass juice were significantly increased (P<0.05, P<0.05, P<0.01 respectively). The mean HDL-cholesterol of the group treated with Atorvastatin for 28 days were also significantly increased (P<0.001).Conclusion: The present experiment showed that HDL-cholesterol level is increased by ingestion of wheat grass juice in experimental animals. Therefore, it provides the initial step for demonstrating cardio-protective effect of wheatgrass juice by increasing HDL-cholesterol level in blood in dyslipidaemic state. DOI: http://dx.doi.org/10.3329/dmcj.v3i1.22235 Delta Med Col J. Jan 2015; 3(1): 18-24

Cigarette Smoking-Associated Changes in Blood Lipid and Lipoprotein Levels in the 8-to 19-Year-Old Age Group: A Meta-Analysis

PEDIATRICS ◽  
1990 ◽  
Vol 85 (2) ◽  
pp. 155-158
Author(s):  
Wendy Y. Craig ◽  
Glenn E. Palomaki ◽  
A. Myron Johnson ◽  
James E. Haddow
Keyword(s):  
Total Cholesterol ◽  
Old Age ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Low Density ◽  
Age Group ◽  
Cholesterol Levels

In this meta-analysis it was demonstrated that, when compared with nonsmokers of similar age, smokers in the 8- to 19-year-old age group have significantly higher serum levels of triglyceride (+11.8%), very-low-density lipoprotein (VLDL)-cholesterol (+12.4%) and low-density lipoprotein (LDL)-cholesterol (+4.1%) and significantly lower serum levels of high-density lipoprotein (HDL)-cholesterol (-8.5%) and total cholesterol (-3.7%). All of these smoking-associated changes are in the same direction as those found in adults, with the exception of total cholesterol levels, which are significantly increased in adult smokers. The extent to which mean triglyceride, LDL-cholesterol, and HDL-choles-terol levels are shifted is significantly greater in the 8-to 19-year-old smokers than in adult smokers. The changes in mean total cholesterol levels among smokers in both age groups represent only the net shifts in the lipoprotein fractions and are therefore likely to be a less sensitive indicator of the possible lipid-related excess coronary artery disease risk in smokers.

Effect of a Long-Term Fat-Modified Diet on Serum Lipoprotein Levels of Cholesterol and Triglyceride in Patients on Home Haemodialysis

1981 ◽  
Vol 60 (1) ◽  
pp. 81-86 ◽  
Author(s):  
V. J. Wass ◽  
R. J. Jarrett ◽  
V. Meilton ◽  
M. K. Start ◽  
M. Mattock ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Low Density ◽  
Home Haemodialysis ◽  
Cholesterol Levels ◽  
Modified Diet

1. Changes in serum total and lipoprotein fraction triglyceride and cholesterol levels were studied in 24 adults on home haemodialysis. Half the patients were randomly allocated to a low cholesterol (mean 200 mg/day), fat-modified diet (mean polyunsaturated/saturated fat ratio of 1.0 with a mean of 43% of the total energy content derived from fat). 2. Before dietary manipulation, triglyceride levels in all lipoprotein fractions were significantly higher (P < 0.02) than in a control group of age and sex matched normal subjects. Total cholesterol, very-low-density-lipoprotein (VLDL) and low-density-lipoprotein (LDL) cholesterol were also significantly raised (P < 0.02), but high-density-lipoprotein (HDL) cholesterol was normal. In the patients on a fat-modified diet triglyceride levels did not alter in any of the lipoprotein fractions. Total cholesterol and LDL cholesterol levels fell significantly into the normal range (P < 0.002 and < 0.001 respectively) but VLDL and HDL cholesterol levels did not change. 3. Hypertriglyceridaemia is the most common lipid abnormality in patients with renal failure and a long-term fat-modified diet is, therefore, of limited therapeutic importance in these patients unless there is a low HDL/LDL cholesterol ratio.

scholarly journals Relationship between Smoking and Concentrations of Some Biochemical Parameters in Blood of Young Smokers

2019 ◽  
pp. 65-70
Author(s):  
Khalid Shaalan Sahab
Keyword(s):  
Cigarette Smoking ◽  
Total Cholesterol ◽  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Total Serum ◽  
Control Group ◽  
Low Density ◽  
Young Smokers

Cigarette smoking is main cause of lung cancer and one of the major causes for cardiovascular problems. Smoking causes changes to some blood contents. The study aimed to identifying the influence of cigarette smoking on concentrations of glucose, total cholesterol, triglycerides, high density lipoprotein (HDL-C), glucose, low density lipoprotein (LDL-C) and bilirubin in blood of young smokers. The study conducted among 30 subjects of young smokers and compared with 20 non-smoker volunteers as control group. The biochemical parameters of blood among all subjects have been determined by using available commercial kits. The results have been showed that the mean of the total serum bilirubin levels were lower in smokers when compared with controls but with significant (P > 0.05). Serum fasting blood glucose (FBG) and total cholesterol (TC) levels were found to be higher in smokers as compared to controls (P ≤ 0.05). The comparison between the estimated levels of triglycerides (TG) and low density lipoprotein-c (LDL-C) in smokers and healthy controls subjects showed no significant increased (P > 0.05). Also there are no significant decrease in levels of HDL-C in smoking subjects as compared to controls Conclusion: The conclusion from results, that smoke of cigarette can influence on biochemical parameters such as glucose, total cholesterol and bilirubin in early stages of smoking and produce a problems to cardiovascular system in early ages.

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