scholarly journals Thrombocytosis as a Predictor of Serious Bacterial Infection in Febrile Infants

2019 ◽  
Vol 16 (41) ◽  
pp. 401-404
Author(s):  
Deepak Mishra ◽  
Amit Kumar Das ◽  
Ram Hari Chapagain ◽  
Nitu Kumari Jha ◽  
Ganesh Kumar Rai
Keyword(s):  
Bacterial Infection ◽  
Bacterial Infections ◽  
Diagnostic Marker ◽  
Common Finding ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Young Infants

Background: Most of the febrile infants <90 days old will have no more than a mild viral infection but there is a substantial minority that will be diagnosed as having serious bacterial infection at a reported prevalence of 10–14%. A simple, readily available, inexpensive diagnostic marker that yields results quickly and also accurately identifies bacterial infections in febrile infants would be of great value in management of these infants. This study aims to assess the role of thrombocytosis in predicting serious bacterial infection in young febrile infants beyond neonatal period.Methods: A hospital based cross-sectional observational study was conducted from May 2016 to April 2017 on 76 febrile infants of age group 29-90 days in Kanti Children’s Hospital.Results: The incidence of serious bacterial infection was found 43 (56.6%). Thrombocytosis, elevated C-reactive protein and pyuria were significantly higher in serious bacterial infection cases (p value <0.05). Thrombocytosis alone had the sensitivity of only 53.5%, but had specificity of 90.9%. Elevated C-reactive protein had the best sensitivity (81.4%). Combination of leukocytosis, elevated C-reactive protein, pyuria and thrombocytosis had better sensitivity (93.0%) than these parameters alone. The overall ability of platelet count to identify infants with SBI was only moderate (AUC: 0.722). Elevated C-reactive protein was found to have better ability to identify infants with serious bacterial infection (AUC: 0.846).Conclusions: Thrombocytosis is a common finding in young infants diagnosed with serious bacterial infection. It has however, moderate ability in identifying infants with serious bacterial infection. Combining thrombocytosis with elevated C-reactive protein, leukocytosis and pyuria has better sensitivity in diagnosing serious bacterial infection than these individual parameters alone. Hence, combining these parameters may help in early prediction of febrile young infants at risk of serious bacterial infection.Keywords: Febrile young infants; serious bacterial infection; thrombocytosis.

scholarly journals Serum procacitonin as a diagnostic marker of bacterial infection in febrile children

2017 ◽  
Vol 4 (4) ◽  
pp. 1381
Author(s):  
Brindha K. ◽  
Kumar Manickam ◽  
Santhakumari Ulagaratchagan ◽  
Mohan Kumar ◽  
Sowmya Sampath ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Bacterial Infections ◽  
Operating Characteristic ◽  
Diagnostic Marker ◽  
Characteristic Curve ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Hs Crp ◽  
Better Than

Background: Early and accurate diagnosis of bacterial infections in children is important as the outcome is dependent on it. Various tests and biomarkers have been used for this among which serum procalcitonin shows a lot of promise. The aim of the study was to determine the role of serum procalcitonin as a diagnostic marker of bacterial infection in febrile children.Methods: All acutely febrile children between 6 months to 12 years of age were enrolled in this prospective study. The efficacy of procalcitonin (PCT), highly sensitive C-reactive protein (hs CRP) and absolute neutrophil count (ANC) in diagnosing bacterial infections was compared.Results: Among the three parameters, PCT has the highest area under the receiver operating characteristic curve (AUC) (O.755), followed by CRP (AUC 0.717) and ANC (AUC 0.628).Conclusions: In summary, our study showed that PCT performs better than hs CRP and ANC in detecting bacterial infection in febrile children. 

scholarly journals C-reactive protein velocity discriminates between acute viral and bacterial infections in patients who present with relatively low CRP concentrations

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Daniel Bernstein ◽  
Dan Coster ◽  
Shlomo Berliner ◽  
Itzhak Shapira ◽  
David Zeltser ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Retrospective Cohort ◽  
Bacterial Infections ◽  
Viral Infections ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Acute Infections ◽  
The Mean ◽  
Acute Bacterial Infections

Abstract Background To assess the utility of C-reactive protein (CRP) velocity to discriminate between patients with acute viral and bacterial infections who presented with relatively low CRP concentrations and were suspected of having a bacterial infection. Methods We analyzed a retrospective cohort of patients with acute infections who presented to the emergency department (ED) with a relatively low first CRP measurement (CRP1) ≤ 31.9 mg/L and received antibiotics shortly after. We then calculated C-reactive protein velocity (CRPv), milligram per liter per hour, for each patient based on CRP1 and the second CRP value (CRP2) measured within the first 24 h since admission. Finally, we compared CRPv between patients with bacterial and viral infections. Results We have presently analyzed 74 patients with acute bacterial infections and 62 patients with acute viral infections at the mean age of 80 and 66 years respectively, 68 male and 68 female. CRP1 did not differ between both groups of patients (16.2 ± 8.6 and 14.8 ± 8.5 for patients with viral and bacterial infections respectively, p value = 0.336). However, the CRP2 was significantly different between the groups (30.2 ± 21.9 and 75.6 ± 51.3 for patients with viral and bacterial infections respectively, p-value < 0.001) and especially the CRPv was much higher in patients with acute bacterial infections compared to patients with acute viral infections (0.9 ± 1.2 and 4.4 ± 2.7 respectively, p-value < 0.001). Conclusion CRPv and CRP2 are useful biomarkers that can discriminate significantly between patients who present with acute bacterial and viral infections, and relatively low CRP concentration upon admission who were suspected of having a bacterial infection.

scholarly journals A STUDY TO ASSESS PREDICTIVE ROLE OF C-REACTIVE PROTEIN IN EARLY PREGNANCY AMONG WOMEN

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Neeti Mahla ◽  
Mukesh Choudhary
Keyword(s):  
Early Pregnancy ◽  
Quantitative Estimation ◽  
First Trimester ◽  
Normal Pregnancy ◽  
P Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Predictive Role ◽  
The Difference

Background: To Assess Predictive Role of C-Reactive Protein In Early Pregnancy among Women Methods: Hospital based comparative analysis was conducted on Women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy. C-reactive protein (CRP) quantitative estimation is done by turbi-diametric method. Collected samples were sent to a designated lab of our hospital. Results: The mean c-reactive protein level in cases 2.31 with min-max value ranging from 0.80-3.91mg/dl while in controls mean c-reactive protein value came to be 9.12 with min-max range from 3.21-24.16 mg/dl. The difference between the two groups is significant as p value is less than 0.001. Conclusion: Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies. Keywords: CRP, Pregnancy, Women

scholarly journals The role of education in the association between self-rated health and levels of C-reactive protein: a cross-sectional study in rural areas of China

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e027659 ◽  
Author(s):  
Raoping Tu ◽  
Kuan-Yu Pan ◽  
Guoxi Cai ◽  
Taro Yamamoto ◽  
Hui-Xin Wang
Keyword(s):  
Rural Areas ◽  
Protein A ◽  
Cross Sectional Study ◽  
Linear Regression Models ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Self Rated Health

ObjectivesThis study aims to examine the association between self-rated health (SRH) and levels of C-reactive protein (CRP) among adults aged 45 to 101 years old in rural areas of China, and to explore the role of education in the association.DesignCross-sectional study.SettingThe study population was derived from two databases in China: Nanping project (NP) and the China Health and Retirement Longitudinal Study (CHARLS).ParticipantsThere were 646 participants from a rural area of Nanping (NP) and 8555 rural participants from a national representative sample of China (CHARLS).MethodsCRP was measured using a high sensitivity sandwich enzyme immunoassay in the NP and immunoturbidimetric assay in the CHARLS. SRH was assessed by SRH questionnaires and categorised into good and poor. Education was measured by the maximum years of schooling and dichotomised into illiterate and literate. Multivariate linear regression models were used to study the associations.ResultsCompared to people with good SRH, those with poor SRH had higher levels of CRP in NP (β=0.16, 95% CI −0.02 to 0.34) and in CHARLS (β=0.07, 95% CI 0.02 to 0.11) after adjusting for potential confounders. Similar findings were observed in the pooled population (β=0.08, 95% CI 0.03 to 0.12), especially in men (β=0.13, 95% CI 0.06 to 0.20) and in literate people (β=0.12, 95% CI 0.06 to 0.18).ConclusionPoor SRH may be a predicator of elevated levels of CRP among middle-aged and older people in rural areas, especially in men and literate people.

scholarly journals Role of procalcitonin and C-reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia

2011 ◽  
Vol 5 (6) ◽  
pp. 398-403 ◽  
Author(s):  
Shin Ahn ◽  
Won Young Kim ◽  
Sung-Han Kim ◽  
SangBum Hong ◽  
Chae-Man Lim ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Viral Pneumonia ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
2009 H1n1

scholarly journals Impact of inflammation on the biomarkers of iron status in a cross-sectional survey of Lao women and children

2013 ◽  
Vol 110 (12) ◽  
pp. 2285-2297 ◽  
Author(s):  
Jacqueline Knowles ◽  
David I. Thurnham ◽  
Bounthom Phengdy ◽  
Keonakhone Houamboun ◽  
Khamseng Philavong ◽  
...  
Keyword(s):  
Iron Status ◽  
Lao Pdr ◽  
C Reactive Protein ◽  
Nutrition Survey ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Reactive Protein ◽  
National Nutrition Survey ◽  
Women And Children

Anaemia is prevalent in South East Asia and Fe deficiency (ID) is considered to be the main cause, but the role of subclinical inflammation in the aetiology is uncertain. In the present study, we determined the influence of inflammation on the biomarkers of Fe status in women and children, and herein, we discuss the proportion of anaemia associated with ID. As part of the 2006 Lao People's Democratic Republic (The Lao PDR) National Nutrition Survey, blood collected from 482 young children and 816 non-pregnant women was analysed. Plasma ferritin, transferrin receptor (sTfR), Hb, C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) concentrations were measured. ID was assessed using ferritin concentrations ( < 12 (children) or < 15 (adults) μg/l), sTfR concentrations (>8·3 mg/l) and body Fe stores (BIS < 0). Elevated CRP (>5 mg/l) and/or AGP (>1 g/l) concentrations were used to categorise inflammation status in order to correct the Fe biomarkers for inflammation. Inflammation was present in 14 % of adults and 43 % of children. Anaemia was present in 37·6 % of both women (Hb concentrations < 120 g/l) and children (Hb concentrations < 110 g/l). Correcting ferritin concentrations for inflammation increased the prevalence of ID from 24·3 to 26 % for women and from 18 to 21 % for children (P< 0·001 for both). Ferritin concentrations were more helpful in detecting ID than sTfR concentrations or BIS, but regression analysis found that sTfr concentrations explained more of the variance in Hb concentrations in both women (20 %) and children (17 %) than ferritin concentrations (5 and 1·4 %, respectively). Nevertheless, the total variance in Hb concentrations explained was only 26 and 18 % in women and children, respectively, and other factors may be more important than ID in contributing to anaemia in The Lao PDR.

scholarly journals Relationship of root canal treatment to C-reactive protein as an inflammatory marker for cardiovascular disease

2010 ◽  
Vol 2 (1) ◽  
pp. 11 ◽  
Author(s):  
Bruce Arroll ◽  
Divya Dhar ◽  
Mary Cullinan
Keyword(s):  
Cardiovascular Disease ◽  
Root Canal ◽  
Periodontal Diseases ◽  
Inflammatory Marker ◽  
Root Canal Treatment ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Serum Crp

INTRODUCTION: Periodontal disease and elevated C-reactive protein (CRP) tests both are positively correlated with cardiovascular disease (CVD) in many studies. Some health practitioners have concerns that root canal treatment may provide a source for inflammation and hence increase the risk for CVD. AIM: To explore the relationship between CRP as a marker of inflammation and presence and number of root canal treatments in primary care patients. METHODS: Cross-sectional questionnaire about dental care followed by a blood test for serum CRP in patients from two New Zealand urban family practices. RESULTS: One hundred and 34 patients participated. The study showed no significant association between CRP and root canal treatment on multivariate analysis controlling for socioeconomic status, age, gender and smoking. The CRP level for those with =3 root-treated teeth was 1.68 while the level for those with <3 was 2.36, but the p-value was not statistically significant (p=0.198). Age, missing teeth and smoking were all significantly related to CRP levels so the sample has biological validity. DISCUSSION: Root canal treatment was not associated with higher CRP levels. The CRP levels were non-significantly lower in those with higher numbers of root-treated teeth. While there are a number of potential biases in this paper, the dataset appears to be biologically valid and consistent with known facts. These findings do not support the hypothesis that root canal treatment is associated with higher levels of inflammation. At this point patients should not consider having their root canal teeth removed. KEYWORDS: Periodontal diseases; C-reactive protein; inflammation; cardiovascular diseases; gingivitis; root canal treatment

scholarly journals Thrombocytosis as an additional predictor of serious bacterial infection in febrile young infants

2017 ◽  
Vol 4 (3) ◽  
pp. 1027
Author(s):  
Merin Eapen ◽  
Sreelatha P. R. ◽  
Jayakumar C.
Keyword(s):  
Platelet Count ◽  
Bacterial Infection ◽  
Soft Tissues ◽  
Early Recognition ◽  
Tertiary Care ◽  
White Blood Cells ◽  
C Reactive Protein ◽  
High Power Field ◽  
Reactive Protein ◽  
Young Infants

Background: To estimate the incidence of Reactive Thrombocytosis among febrile young infants and to assess the utility of platelet count as a potential predictor of Serious bacterial infection (SBI).Methods: This study was conducted as a prospective study between January 2014 to September 2015 at the tertiary care pediatric unit, Alappuzha, India. The participants were all infants 30 to 89 days of age, admitted with rectal temperature >38°C. The results of the sepsis evaluation on admission were recorded. SBI included cases of occult bacteremia, urinary tract infection, bacterial meningitis, pneumonia, bacterial gastroenteritis and infections of the soft tissues and bones.Results: Of the 120 infants studied, 24 (28%) had SBI. Platelet count was significantly higher in infants with SBI compared to those without {Platelet count ≥ 4.5lakhs /mm3 in SBI (70.3%) vs. Non SBI (30.2%). Mean platelet count 4.82±1.4 in SBI vs. 3.9±1.2 in non SBI which was statistically significant (p<0.05). Thrombocytosis had moderate ability in predicting SBI (Area under curve area under the curve: 0.720). The combination of platelet count ≥450,000/mm3, WBC ≥15,000/mm3, C-reactive protein ≥1 mg/dl, pyuria ≥5 White blood cells (WBC) per High power field (HPF) and erythrocyte sedimentation rate (ESR) >30mm/hr resulted in identification of all infants with SBI.Conclusions: Thrombocytosis in combination with leukocytosis, elevated C-reactive protein, ESR, and pyuria, may help in early recognition of febrile young infants at risk for SBI. 

scholarly journals C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1195
Author(s):  
Jiong Yu ◽  
Xiaowei Shi ◽  
Jing Ma ◽  
Ronggao Chen ◽  
Siyi Dong ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Bacterial Infection ◽  
Systemic Inflammation ◽  
Bacterial Infections ◽  
Cox Regression ◽  
Prognostic Models ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Clinically Significant ◽  
The Relationship

The relationship between aseptic systemic inflammation and postoperative bacterial infection is unclear. We investigated the correlation of systemic inflammation biomarkers with 30-day clinically significant bacterial infections (CSI) after liver transplantation (LT). This retrospective study enrolled 940 patients who received LT and were followed for 30 days. The primary end point was 30-day CSI events. The cohort was divided into exploratory (n = 508) and validation (n = 432) sets according to different centers. Area under the receiver operated characteristic (AUROC) and Cox regression models were fitted to study the association between baseline systemic inflammation levels and CSI after LT. A total of 255 bacterial infectious events in 209 recipients occurred. Among systemic inflammation parameters, baseline C-reactive protein (CRP) was independently associated with 30-day CSI in the exploratory group. The combination of CRP and organ failure number showed a good discrimination for 30-day CSI (AUROC = 0.80, 95% CI, 0.76–0.84) and the results were confirmed in an external verification group. Additionally, CRP levels were correlated with bacterial product lipopolysaccharide. In conclusion, our study suggests that pre-transplantation CRP is independent of other prognostic factors for 30-day CSI post-LT, and can be integrated into tools for assessing the risk of bacterial infection post-LT or as a component of prognostic models.

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