Prevalence of Liver Cancer in Isfahan Province, Iran

Background: Liver cancer remains to grow worldwide. We aimed to describe the period prevalence (PP) and incidence rates (Irs) for liver cancer in Isfahan Province that is located in the center of Iran and ranked as the third province in terms of population.Methods: Information related to the Surveillance, Epidemiology, and End Results; (SEER) was collected from the Isfahan Cancer Registry. Period prevalence (PP) was calculated per 100,000 people. The cancer sites studied were defined according to the International Classification of Diseases (ICD-O; Third Edition) and recorded by topography code (C22).Result: Among all registered liver cancer patients, 57% of the 920 cases were male. The mean age of the patients was 65.9 ± 16.8 years. Reported age in 13% of the patients was less than 50 years and as high as 84% were in between 50 to 90 years. With a total PP of 18.5 per 100,000 people, this value was 24.4% higher in males when compared to females (16.8 vs. 20.9). In the previous years, incidences were 3.9 (2011-2012), 5.3 (2012-2013), 4.9 (2013-2014) and 4.2 (2014-2015) per 100,000 people. There were 89% reported deaths among the total population.Conclusion: The PP for liver cancer in male population was approximately 24.4% higher than females. There was a 7.7% increase in the Irs over the study period. Further study toward estimation of the proportion of the causes of liver cancer and deaths due to infection of hepatitis B and C virus, exposure to aflatoxin, alcohol drinking and smoking seem to be advantageous. Therefore, the plan of healthcare system should focus on greater effort toward strategic evidence-based pharmacotherapy in Isfahan province/Iran.

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Investigation of Genital System Cancers Prevalencein Isfahan, Iran

Indonesian Journal of Cancer ◽

10.33371/ijoc.v13i2.631 ◽

2019 ◽

Vol 13 (2) ◽

pp. 25 ◽

Cited By ~ 2

Author(s):

Zahra Tolou-Ghamari

Keyword(s):

Cancer Control ◽

International Classification Of Diseases ◽

Genital System ◽

Period Prevalence ◽

Isfahan Province ◽

Care Plans ◽

Genital Cancer ◽

Chi Squared ◽

Classification Of Diseases ◽

The Usa

Background: Previous publication reported a significant disparity of genital cancer incidence between genders. The aim of this study is to investigate period prevalence (PP) and incidence (Irs) of genital cancer in Isfahan/Iran. Methods: Information equivalent to those collected by the USA Surveillance, Epidemiology, and End Results (SEER) program was obtained from the Isfahan Cancer Registry. Period prevalence (PP) was calculated per 100.000 persons. The cancer sites studied were defined according to the International Classification of Diseases (ICD-O; Third Edition) and recorded by topography code. Results: Between the years 2011 to 2015, among all registered cases (3024 cases), 60% applied to the male genital system. The mean (SD) age at diagnosis was higher for men 69.4 (14.7) than women 57.8 (15) (t-test; P<0.006). The calculated PP was significantly (Chi-squared test; P<0.001) higher in males (71.5) than females (49.6) per 100.000 in Isfahan Province. Conclusions: The PP for ovarian cancer in female and prostate cancer in male was higher than for other genital tumors. To facilitate early diagnosis for better management, we recommend that health-care plans for Isfahan Province/Iran place a greater focus on pharmacotherapy and environmental factors in cancer control.

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Updating and Validating the U.S. Veterans Affairs Frailty Index: Transitioning From ICD-9 to ICD-10

The Journals of Gerontology Series A ◽

10.1093/gerona/glab071 ◽

2021 ◽

Author(s):

David Cheng ◽

Clark DuMontier ◽

Cenk Yildirim ◽

Brian Charest ◽

Chelsea E Hawley ◽

...

Keyword(s):

Frailty Index ◽

International Classification Of Diseases ◽

Veterans Affairs ◽

Administrative Claims ◽

Before And After ◽

Classification Of Diseases ◽

Icd 10 ◽

National Cohort ◽

The Mean

Abstract Background The Veterans Affairs Frailty Index (VA-FI) is an electronic frailty index developed to measure frailty using administrative claims and electronic health records data in Veterans. An update to ICD-10 coding is needed to enable contemporary measurement of frailty. Method International Classification of Diseases, ninth revision (ICD-9) codes from the original VA-FI were mapped to ICD-10 first using the Centers for Medicaid and Medicare Services (CMS) General Equivalence Mappings. The resulting ICD-10 codes were reviewed by 2 geriatricians. Using a national cohort of Veterans aged 65 years and older, the prevalence of deficits contributing to the VA-FI and associations between the VA-FI and mortality over years 2012–2018 were examined. Results The updated VA-FI-10 includes 6422 codes representing 31 health deficits. Annual cohorts defined on October 1 of each year included 2 266 191 to 2 428 115 Veterans, for which the mean age was 76 years, 97%–98% were male, 78%–79% were White, and the mean VA-FI was 0.20–0.22. The VA-FI-10 deficits showed stability before and after the transition to ICD-10 in 2015, and maintained strong associations with mortality. Patients classified as frail (VA-FI > 0.2) consistently had a hazard of death more than 2 times higher than nonfrail patients (VA-FI ≤ 0.1). Distributions of frailty and associations with mortality varied with and without linkage to CMS data and with different assessment periods for capturing deficits. Conclusions The updated VA-FI-10 maintains content validity, stability, and predictive validity for mortality in a contemporary cohort of Veterans aged 65 years and older, and may be applied to ICD-9 and ICD-10 claims data to measure frailty.

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Addressing the Gaps in Post-Stroke Sexual Activity Rehabilitation: Patient Perspectives

Healthcare ◽

10.3390/healthcare7010025 ◽

2019 ◽

Vol 7 (1) ◽

pp. 25 ◽

Cited By ~ 2

Author(s):

Sarah Prior ◽

Nicole Reeves ◽

Gregory Peterson ◽

Linda Jaffray ◽

Steven Campbell

Keyword(s):

Sexual Activity ◽

International Classification Of Diseases ◽

Public Hospitals ◽

Post Stroke ◽

Classification Of Diseases ◽

Icd 10 ◽

The Mean ◽

To Receive ◽

Activity Information

Sexual dysfunction is common but often under-recognised or neglected after stroke. This study sought to identify the existing methods for providing information and discussion on post-stroke sexual activity, and perceived gaps from the patient perspective. A sample of 1265 participants who had been admitted to any of the four major public hospitals in Tasmania, Australia, with stroke (International Classification of Diseases (ICD-10) group B70) were mailed a survey assessing their experiences with, and opinions about, receipt of post-stroke sexual activity education. One hundred and eighty-three participants (14.5%) responded; of these, 65% were male and the mean age was 69.1 years. The results indicated that, whilst over 30% or participants wanted to receive information related to post-stroke sexual activity, only a small proportion of participants (8.2%) had received this. In terms of the method of receiving this information, participants preferred to receive this from a doctor in a private discussion with or without their partner present. The delivery of post-stroke sexual activity information and education is inconsistent and fails to meet patient needs within major Tasmanian hospitals, highlighting the importance of developing sound, routine, post-stroke education and information processes.

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Epidemiology and Medication Pattern Change of Psoriatic Diseases in Taiwan from 2000 to 2013: A Nationwide, Population-based Cohort Study

The Journal of Rheumatology ◽

10.3899/jrheum.170516 ◽

2018 ◽

Vol 45 (3) ◽

pp. 385-392 ◽

Cited By ~ 9

Author(s):

James Cheng-Chung Wei ◽

Lin-Hong Shi ◽

Jing-Yang Huang ◽

Xue-Fen Wu ◽

Rui Wu ◽

...

Keyword(s):

Anatomical Therapeutic Chemical ◽

International Classification Of Diseases ◽

Population Based ◽

Incidence Rates ◽

Research Database ◽

Chi Square ◽

Classification Code ◽

Classification Of Diseases ◽

Taiwan National Health Insurance

Objective.To analyze the trend of prevalence and incidence rates for psoriatic arthritis (PsA) and psoriasis in Taiwan, and to determine the changes in medication patterns.Methods.Data were collected from the Taiwan National Health Insurance Research Database, which covered at least 95% of the population from 2000 to 2013. International Classification of Diseases, 9th edition (ICD-9) was used to identify PsA (ICD-9 696.0) and other psoriasis (ICD-9 696.1). Medications were identified by Anatomical Therapeutic Chemical Classification code. We calculated the annual age standardized prevalence and incidence rate of PsA and psoriasis in individuals aged ≥ 16 years from 2000 to 2013, and used the Poisson regression to test the trends by Wald chi-square statistic.Results.The prevalence (per 100,000 population) of psoriatic diseases between 2000 and 2013 increased from 11.12 to 37.75 for PsA, and from 179.2 to 281.5 for psoriasis. The incidence (per 100,000 person-yrs) increased from 3.64 to 6.91 in PsA, while there was no significant change in psoriasis. Prevalence and incidence in PsA were more rapidly increased than in psoriasis. Sex ratio (men to women) of PsA decreased from 2.0 to 1.5 in 2000 and 2013, respectively. There was an increase in the use of disease-modifying antirheumatic drugs (DMARD), especially biologics, which is significantly different from topical therapies.Conclusion.The prevalence and incidence rates of psoriatic disease, especially PsA, were increasing in Taiwan. The medication pattern showed an increase in DMARD and biologics, while use of topical therapies decreased.

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Incidence of COVID-19 in patients exposed to chloroquine and hydroxychloroquine: results from a population-based prospective cohort in Catalonia, Spain, 2020

Eurosurveillance ◽

10.2807/1560-7917.es.2021.26.9.2001202 ◽

2021 ◽

Vol 26 (9) ◽

Author(s):

Rosa Maria Vivanco-Hidalgo ◽

Israel Molina ◽

Elisenda Martinez ◽

Ramón Roman-Viñas ◽

Adrián Sánchez-Montalvá ◽

...

Keyword(s):

Care Service ◽

International Classification Of Diseases ◽

Population Based ◽

Health Administration ◽

Risk Of Infection ◽

Control Cohort ◽

Male Population ◽

Classification Of Diseases

Background Several clinical trials have assessed the protective potential of chloroquine and hydroxychloroquine. Chronic exposure to such drugs might lower the risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or severe coronavirus disease (COVID-19). Aim To assess COVID-19 incidence and risk of hospitalisation in a cohort of patients chronically taking chloroquine/hydroxychloroquine. Methods We used linked health administration databases to follow a cohort of patients with chronic prescription of hydroxychloroquine/chloroquine and a control cohort matched by age, sex and primary care service area, between 1 January and 30 April 2020. COVID-19 cases were identified using International Classification of Diseases 10 codes. Results We analysed a cohort of 6,746 patients (80% female) with active prescriptions for hydroxychloroquine/chloroquine, and 13,492 controls. During follow-up, there were 97 (1.4%) COVID-19 cases in the exposed cohort and 183 (1.4%) among controls. The incidence rate was very similar between the two groups (12.05 vs 11.35 cases/100,000 person-days). The exposed cohort was not at lower risk of infection compared with controls (hazard ratio (HR): 1.08; 95% confidence interval (CI): 0.83–1.44; p = 0.50). Forty cases (0.6%) were admitted to hospital in the exposed cohort and 50 (0.4%) in the control cohort, suggesting a higher hospitalisation rate in the former, though differences were not confirmed after adjustment (HR: 1·46; 95% CI: 0.91–2.34; p = 0.10). Conclusions Patients chronically exposed to chloroquine/hydroxychloroquine did not differ in risk of COVID-19 nor hospitalisation, compared with controls. As controls were mainly female, findings might not be generalisable to a male population.

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DIAGNOSES MADE BY LEADERS OF EMERGENCY MEDICA L SERVICES TEAMS WITHIN THE OPERAT ION AREA OF THE EMERGENCY MEDICA L SERVICES STAT ION IN MINSK MAZOWIECKI IN 2013-2017

Emergency Medical Service ◽

10.36740/emems202002105 ◽

2020 ◽

Vol 7 (2) ◽

pp. 103-112

Author(s):

Krzysztof Mitura ◽

Beata Łaziuk ◽

Daniel Celiński ◽

Agnieszka Hawrylewicz-Łuka ◽

Leszek Szpakowski ◽

...

Keyword(s):

International Classification Of Diseases ◽

Medical Data ◽

Team Leaders ◽

Aim Analysis ◽

State Of Emergency ◽

Classification Of Diseases ◽

Icd 10 ◽

The Mean ◽

Mean Time

Introduction: The activities of the Emergency Medical Services (EMS) Station in Minsk Mazowiecki are based on the provision of medical aid to persons in a state of emergency. The aim: Analysis of interventions of EMS teams operating in the structure of the EMS Station in Minsk Mazowiecki, including diagnoses made by team leaders based on the International Classification of Diseases. Material and methods: The study was retrospective. The analysis covered 39,027 dispatches of EMS teams in Minsk Mazowiecki in the period from January 1, 2013 to December 31, 2017. The study was conducted on the basis of medical data collected in SP ZOZ RM-MEDITRANS computer systems in Siedlce. Results: The results indicated an increase in the number of interventions performed by EMS teams working in the EMS Station in Minsk Mazowiecki (by 30.80%) in the period from 2013 to 2017. In that period, interventions in code 2 (69.12%) dominated. The EMS teams reached the event site much faster in code 1 than in code 2. The mean time needed to reach the event site was noticeable. Most interventions took place in the patient’s home (73.14%). The leaders of EMS teams made diagnoses mainly on the basis of a group of ICD-10 codes regarding symptoms and disease features (37.39%), followed by injuries, poisoning, external factors (20.58%) and cardiovascular diseases (15.64%). Of all interventions, 68.60% of patients were transported to hospitals, and 23.97% remained at the place of call. Conclusions: The analysis of interventions of EMS teams in Minsk Mazowiecki indicated an increase in the society’s demand for services in the field of EMS, while the optimization of their use and verification of the legitimacy of their interventions is warranted. In addition, EMS team leaders made diagnoses mainly on the basis of a group of ICD-10 codes regarding symptoms and disease features.

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Cancer Mortality Patterns in Tanzania: A Retrospective Hospital-Based Study, 2006-2015

JCO Global Oncology ◽

10.1200/jgo.19.00270 ◽

2020 ◽

pp. 224-232 ◽

Cited By ~ 2

Author(s):

Emanuel P. Lyimo ◽

Susan F. Rumisha ◽

Irene R. Mremi ◽

Chacha D. Mangu ◽

Coleman Kishamawe ◽

...

Keyword(s):

Cancer Mortality ◽

International Classification Of Diseases ◽

Incidence Rates ◽

Public Hospitals ◽

Hospital Death ◽

Awareness Campaigns ◽

Classification Of Diseases ◽

Cancer Types ◽

Diagnostic Capabilities

PURPOSE This retrospective study sought to determine the type, burden, and pattern of cancer deaths in public hospitals in Tanzania from 2006 to 2015. METHODS This study analyzed data on cancer mortality in 39 hospitals in Tanzania. Data on the age and sex of the deceased and type of cancer were extracted from hospital death registers and report forms. Cancer types were grouped according to the 10th revision of the International Classification of Diseases. Age-standardized mortality rates and cancer mortality patterns were analyzed. A χ2 test was used to examine the association between common cancers and selected covariates. RESULTS A total of 12,621 cancer-related deaths occurred during the 10-year period, which translates to an age-standardized hospital-based mortality rate of 47.8 per 100,000 population. Overall, the number of deaths was notably higher (56.5%) among individuals in the 15- to 59-year-old age category and disproportionately higher among females than males ( P = .0017). Cancers of the cervix, esophagus, and liver were the 3 major causes of death across all study hospitals in Tanzania. Cancers of the cervix, esophagus, and liver were the largest contributors to mortality burden among females. Among males, cancers of the esophagus, liver, and prostate were the leading cause of mortality. CONCLUSION There is an increasing trend in cancer mortality over recent years in Tanzania, which differs with respect to age, sex, and geographic zones. These findings provide a basis for additional studies to ascertain incidence rates and survival probabilities, and highlight the need to strengthen awareness campaigns for early detection, access to care, and improved diagnostic capabilities.

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Gastrointestinal perforations in patients with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs in Sweden: a nationwide cohort study

RMD Open ◽

10.1136/rmdopen-2020-001201 ◽

2020 ◽

Vol 6 (2) ◽

pp. e001201 ◽

Cited By ~ 1

Author(s):

Andrei Barbulescu ◽

Bénédicte Delcoigne ◽

Johan Askling ◽

Thomas Frisell

Keyword(s):

Cohort Study ◽

General Population ◽

Treatment Guidelines ◽

International Classification Of Diseases ◽

Incidence Rates ◽

Classification Of Diseases ◽

Icd 10 ◽

Population Controls ◽

Necrosis Factor

ObjectivesTo compare incidence rates of gastrointestinal (GI) perforations between patients with RA and the general population, and between patients treated with tumour necrosis factor inhibitors (TNFi) and non-TNFi biologics.MethodsIn this nationwide cohort study, a total of 63 532 patients with RA, with 26 050 biological treatment episodes (TNFi, rituximab, abatacept or tocilizumab) and 76 304 general population controls, were followed between 2009 and 2017 until the first outcome event. The main outcome was hospitalisation or death due to lower GI perforations, identified according to a prespecified list of ICD-10 (International Classification of Diseases, 10th revision) codes. Inverse probability of treatment weighting was used for adjustment.ResultsThe sex-standardised and age-standardised incidence rates of lower GI perforations were 1.1 (95% CI 1.0 to 1.3) events per 1000 person-years among general population controls, 1.6 (1.5–1.7) among bionaïve patients and ranged from 1.8 (1.4–3.6) (TNFi) to 4.5 (2.7–10.4) (tocilizumab) among biologics-treated patients. After adjustment for glucocorticoid use, the risk in bionaïve, TNFi-treated, abatacept-treated or rituximab-treated patients with RA was no longer different from the general population, while for tocilizumab it remained significantly higher. Comparing tocilizumab to TNFi, the adjusted HR for lower GI perforations was 2.2 (1.3–3.8), corresponding to one additional GI perforation per 451 patient-years treated with tocilizumab instead of TNFi.ConclusionTocilizumab was associated with a higher risk of lower GI perforations compared with alternative biologics. In absolute numbers, the risk remained low on all biologics commonly used to treat RA, but the accumulated evidence across settings and outcome definitions supports that this risk should be considered in treatment guidelines for RA.

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Prevalence of Chronic Kidney Disease, Thrombotic Cardiovascular Events, and Use of Oral P2Y12 Inhibitors among Veterans

American Journal of Nephrology ◽

10.1159/000486647 ◽

2018 ◽

Vol 47 (2) ◽

pp. 67-71 ◽

Cited By ~ 3

Author(s):

Manisha Singh ◽

Deepa Raghavan ◽

James S. Williams ◽

Bradley C. Martin ◽

Teresa J. Hudson ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Patient Population ◽

International Classification Of Diseases ◽

Period Prevalence ◽

P2y12 Inhibitors ◽

Classification Of Diseases ◽

Pharmacy Data ◽

Cost Differences

Background: Contemporary prevalence of chronic kidney disease (CKD) and thrombotic cardiovascular (CV) events remains unclear in Veterans enrolled in the Veterans Affairs Health Care System (VA) care. Although oral P2Y12 inhibitors (P2Y12i) are increasingly being prescribed to this patient population, the overall prescription trend for P2Y12i remains unclear. Methods: Using national VA corporate warehouse data, we used International Classification of Diseases-9 codes to identify Veterans with CKD, dialysis-dependent CKD, and CV events. VA pharmacy data were used to count P2Y12i prescriptions for the federal fiscal years (FY) 2011 through 2015. Results: The period prevalence of Veterans with CKD was 378,233 (6.1%). The point prevalence of CKD increased by 49% from 132,979 (2.30%) in FY11 to 213,444 (3.42%) in FY15. The period prevalence of Veterans with dialysis-dependent CKD was 150,298 (2.4%). In all, 128,703 (56.7%) CV events occurred in Veterans with CKD. Veterans with CKD were given 50.1% of prescriptions for clopidogrel, 49.3% for prasugrel, and 60.4% for ticagrelor. In this patient population, year-to-year increases in P2Y12i prescriptions were observed with a dramatic increase in ticagrelor prescriptions. Conclusion: CKD is common among Veterans and its true prevalence is likely being underestimated. The prevalence of dialysis-dependent CKD is higher among Veterans than the non-Veteran US population. CV events are widely co-prevalent and these patients are commonly prescribed P2Y12i. The recent increase in ticagrelor prescriptions in this patient population and large cost differences between the 3 P2Y12i underline the need for future studies to identify the preferred P2Y12i for these patients.

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Descriptive Epidemiology of Primary Biliary Cirrhosis in the Province of Quebec

Canadian Journal of Gastroenterology ◽

10.1155/1991/712802 ◽

1991 ◽

Vol 5 (5) ◽

pp. 174-178 ◽

Cited By ~ 12

Author(s):

Jean-Pierre Villeneuve ◽

Daphna Fenyves ◽

Claire Infante-Rivard

Keyword(s):

Primary Biliary Cirrhosis ◽

Western Europe ◽

International Classification Of Diseases ◽

Discharge Summary ◽

Biliary Cirrhosis ◽

Short Term ◽

Classification Of Diseases ◽

The Mean ◽

Secondary Biliary Cirrhosis

Primary biliary cirrhosis (PBC) is a rare disease, but is usually recognized because of the characteristic clinical picture and the diagnostic specificity of antimitochondrial antibody (AMA) determination. Information on the epitlemiology of PBC is limited. The authors have examined the incidence and prevalence of PBC in the province of Quebec, where all short term hospitals are required to classify discharge summary diagnoses according to theInternational Classification of Diseases. Code 571.6 designates primary or secondary biliary cirrhosis. The authors reviewed the charts of all patients to whom this code was assigned during a six year period (1980-86). Two hundred and twenty-eight subjects satisfied predetermined diagnostic criteria for PBC. The mean annual incidence rate was 3.9 per 106 population, and the point prevalence in 1986 was 25.4 per 106 population. Ninety-two patients were female, with a mean age at the time of diagnosis of 55.7 years; 89.4% had positive AMA, and 10.5% were asymptomatic. As of January 1, 1989, 126 patients were alive, 91 had died, and 11 had undergone liver transplantation. Cumulative five and 10 year survivals from the time of initial diagnosis were 69% and 49%, respectively. In patients with serum bilirubins greater than 100 μmol/L (n=66), cumulative two year survival was 5.5%. These data indicate that the incidence and prevalence of PBC in Quebec arc similar to chose reported in Ontario and at the lower end of the range of chose reported in western Europe. The clinical features and evolution of PBC are also similar, and serum bilirubin is a major prognostic factor.

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