scholarly journals Deployment of a Mobile Laboratory for the Control and Monitoring of High-Consequence Infectious Diseases: An Illustration With the Ebola Virus, the Biowarfare Agents, and the COVID-19

2020 ◽  
Vol 3 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Russel J Reiter ◽  
Qiang Ma ◽  
Ramaswamy Sharma

This review summarizes published reports on the utility of melatonin as a treatment for virus-mediated diseases. Of special note are the data related to the role of melatonin in influencing Ebola virus disease. This infection and deadly condition has no effective treatment and the published works documenting the ability of melatonin to attenuate the severity of viral infections generally and Ebola infection specifically are considered. The capacity of melatonin to prevent one of the major complications of an Ebola infection, i.e., the hemorrhagic shock syndrome, which often contributes to the high mortality rate, is noteworthy. Considering the high safety profile of melatonin, the fact that it is easily produced, inexpensive and can be self-administered makes it an attractive potential treatment for Ebola virus pathology.  


Author(s):  
Cécile Viboud ◽  
Hélène Broutin ◽  
Gerardo Chowell

Disentangling the spatial-temporal dynamics of infectious disease transmission is important to address issues of disease persistence, epidemic growth and optimal control. In this chapter, we review key concepts relating to the spatial-temporal dynamics of infectious diseases in meta-populations, whereby geographically separate subpopulations are connected by migration or mobility rates. We review the dynamics of colonization, persistence and extinction of emerging and recurrent pathogens in meta-populations; the role of demographic and environmental factors; and geographic heterogeneity in epidemic growth rate. We illustrate theoretical concepts by reviewing the spatial dynamics of childhood diseases and other acute infections in low- and middle-income countries, and provide a detailed description of the spatial-temporal dynamics of the 2014–16 Ebola epidemic in West Africa. We further discuss how increased availability of empirical data and recent methodological developments provide a deeper mechanistic understanding of transmission processes in space and time, and make recommendations for future work.


2016 ◽  
Vol 10 (05) ◽  
pp. 537-543 ◽  
Author(s):  
Giulia Bertoli ◽  
Marco Mannazzu ◽  
Giordano Madeddu ◽  
Riccardo Are ◽  
Alberto Muredda ◽  
...  

Since the onset of the worst epidemic of Ebola virus disease in December 2013, 28,637 cases were reported as confirmed, probable, or suspected. Since the week of 3 January 2016, no more cases have been reported. The total number of deaths have amounted to 11,315 (39.5%). In developed countries, seven cases have been diagnosed: four in the United States, one in Spain, one in the United Kingdom, and one in Italy. On 20 July 2015, Italy was declared Ebola-free. On 9 May 2015, an Italian health worker came back to Italy after a long stay in Sierra Leone working for a non-governmental organization. Forty-eight hours after his arrival, he noticed headache, weakness, muscle pains, and slight fever. The following day, he was safely transported to the Infectious Diseases Unit of University Hospital of Sassari. The patient was hospitalized for 19 hours until an Italian Air Force medical division transferred him to Rome, to the Lazzaro Spallanzani Institute. Nineteen people who had contacts with the patient were monitored daily for 21 days by the Public Health Office of Sassari and none presented any symptoms. So far, neither vaccine nor treatment is available to be proposed on an international scale. Ebola is considered a re-emerging infectious disease which, unlike in the past, has been a worldwide emergency. This case study aimed to establish a discussion about the operative and logistic difficulties to be faced and about the discrepancy arising when protocols clash with the reality of facts.


2018 ◽  
Vol 80 (7) ◽  
pp. 493-500
Author(s):  
Derek Dube ◽  
Tracie M. Addy ◽  
Maria R. Teixeira ◽  
Linda M. Iadarola

Throughout global history, various infectious diseases have emerged as particularly relevant within an era. Some examples include the Bubonic plague of the fourteenth century, the Spanish Influenza pandemic of 1918, the HIV epidemic of the 1980s, and the Zika virus outbreak in 2015–16. These instances of emerging infectious disease represent ideal opportunities for timely, relevant instruction in natural and health science courses through case studies. Such instructional approaches can promote student engagement in the material and encourage application and higher-order thinking. We describe here how the case study approach was utilized to teach students about emerging infectious diseases using the 2014–16 Ebola virus outbreak as the subject of instruction. Results suggest that students completing the case study not only had positive perceptions of the mode of instruction, but also realized learning gains and misconception resolution. These outcomes support the efficacy of case pedagogy as a useful teaching tool in emerging infectious diseases, and augment the paucity of literature examining Ebola virus knowledge and misconceptions among undergraduate students within United States institutions.


2020 ◽  
Vol 38 (8) ◽  
pp. 820-824 ◽  
Author(s):  
Seung-Whee Rhee

With the rapid spread of coronavirus disease 2019 (COVID-19), the amount of used personal protective equipment (PPE) including face masks and protective clothes has significantly increased. This used PPE in a hospital can lead to the indirect infection by COVID-19. Accordingly, it has been recognized that the management of used PPE is very important to prevent the spread of COVID-19. Through the experience of spreading some infectious diseases such as severe acute respiratory syndrome, Middle East respiratory syndrome and Ebola virus in South Korea (Republic of Korea), a safe management method of waste related to infectious diseases has been developed. In addition, regarding waste related to COVID-19, the Ministry of Environment, SK, proposed special measures to strengthen the management process of waste related to COVID-19 based on principles such as sustainability, transparency and safety.


2021 ◽  
Vol 9 ◽  
Author(s):  
Patrice Debré ◽  
Marie Neunez ◽  
Michel Goldman

Ebola virus disease is one of the deadliest infections in the world today. The microbe to blame is the Ebola virus. It has already caused numerous outbreaks in Africa, in the regions located south of the Sahara. This article describes the main characteristics of this infectious disease as well as the currently available treatments, namely vaccines and antibodies. Antibodies are produced by the human body when it is infected by a microbe. Antibodies can be collected from the blood of infected humans or animals and purified or manufactured in a laboratory to produce drugs. While vaccines have demonstrated their effectiveness in preventing infectious diseases, antibodies are effective in stopping the progression of several infectious diseases. In this article, you will discover that the stimulation of the immune system, either by the vaccine or by antibodies, is essential to tackle Ebola virus disease.


Author(s):  
Stephen B. Kennedy ◽  
John B. Dogba ◽  
Christine L. Wasunna ◽  
Philip Sahr ◽  
Candace B. Eastman ◽  
...  

Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of effective and sustainablelaboratory services in Liberia. However, in a resource-limited environment such as Liberiaprogress regarding the rebuilding of the health system can be relatively slow, while efforts tosustain the transient gains remain a key challenge for the Ministry of Health. In this paper, wedescribe the pre-Ebola virus disease laboratory system in Liberia and its prevailing efforts toaddress future emerging infectious diseases, as well as current Infectious diseases, all of whichare exacerbated by poverty. We conclude that laboratory and diagnostic services in Liberiahave encountered numerous challenges regarding its efforts to strengthen the healthcaredelivery system. These challenges include limited trained human resource capacity, inadequateinfrastructure, and a lack of coordination. As with most countries in sub-Saharan Africa, whencomparing urban and rural settings, diagnostic and clinical services are generally skewedtoward urban health facilities and private, faith-based health facilities. We recommend thatstructured policy be directed at these challenges for national institutions to develop guidelinesto improve, strengthen and sustain diagnostic and curative laboratory services to effectivelyaddress current infectious diseases and prepare for future emerging and re-emerging infectiousdiseases.


2017 ◽  
Vol 70 (11-12) ◽  
pp. 385-390
Author(s):  
Dajana Lendak ◽  
Tomislav Preveden ◽  
Nadica Kovacevic ◽  
Slavica Tomic ◽  
Maja Ruzic ◽  
...  

Introduction. The end of 20th and beginning of 21st century is marked by the discovery of new, supercontagious and fast spreading viral diseases. Since 1967, more than 40 new agents have been identified, including human immunodeficiency virus, Ebola, Marburg fever, severe acute respiratory syndrome, hepatitis C, hepatitis E viruses and Zika virus. Modern lifestyle, availability and speed of air traffic, migrations, as well as climate changes, enable faster spreading of infectious diseases from the regions that were hardly reachable. We selected a few diseases that raised the greatest attention among experts and public in general. Ebola. Ebola virus raises anxiety due to high mortality and fast spreading by using inter-human contact. Zika virus. Zika virus, that most often causes mild symptoms, is potentially responsible for microcephaly in neonates. Dengue. Dengue virus is an ?old story?, but in last decades incidence has multiplied by 30. West Nile virus. Although discovered in 1937, West Nile virus has been found exclusively in rural parts of Africa, while nowadays it represents one of the most important etiological factors of viral meningo-encephalitis all over the world. Hepatitis E. Today it is well-known that hepatitis E virus can cause not only acute viral hepatitis but also potentially blood-transmitted chronic hepatitis in immunocompromised, as well as some neurological disorders. Conclusion. One of the scientific challenges in the future will certainly be the discovery of available and cost-effective diagnostic tests, as well as efficient and safe vaccines for these diseases. Up to now, efficient prophylaxis is available only for Denga virus.


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