scholarly journals Lipid profile and nutritional status of a pediatric population with sickle cell anemia: differences between gender and association with severity markers

2021 ◽  
Vol 10 (10) ◽  
pp. e344101018934
Author(s):  
Nilcemar Rodrigues Carvalho Cruz ◽  
Thaisa Netto Souza Valente ◽  
Fernanda Oliveira Ferreira ◽  
Leandro Roberto de Macedo ◽  
Andreza da Silva Brito Rocha ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lactate Dehydrogenase ◽  
Vitamin A ◽  
Body Mass ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Blood Cells ◽  
Pediatric Population ◽  
White Blood Cells ◽  
Apolipoprotein A

Objective: To investigate the associations between nutritional status and lipid profile with biomarkers of hemolysis and inflammation in sickle cell anemia, in addition to considering gender differences. Methods: This cross-sectional study analyzed nutritional, and biochemical data of pediatric patients carrying sickle cell anemia. Results: Vitamin A, apolipoprotein B, total cholesterol, low-density lipoprotein, and non-high-density lipoprotein cholesterol were lower in boys. Hemoglobin was significantly lower, and the white blood cells and lactate dehydrogenase were higher in boys. Body mass index, vitamin A, and triglycerides were associated with hemoglobin levels, while apolipoprotein A-I was associated with white blood cells and total bilirubin. Additionally, body mass index and vitamin A were associated with lactate dehydrogenase. Vitamin A showed significant predictive power in hemoglobin alteration and lactate dehydrogenase, while apolipoprotein A-I was able to predict high white blood cells values and total bilirubin. Conclusion: This study found in a pediatric population with sickle cell anemia that body mass index, vitamin A, triglycerides, and apolipoprotein A-I were associated with biomarkers of hemolysis and inflammation. Boys exhibited the greater nutritional deficit and severity of the disease.

scholarly journals Male Gender, Increased Blood Viscosity, Body Mass Index and Triglyceride Levels Are Independently Associated with Systemic Relative Hypertension in Sickle Cell Anemia

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66004 ◽  
Author(s):  
Yann Lamarre ◽  
Marie-Laure Lalanne-Mistrih ◽  
Marc Romana ◽  
Nathalie Lemonne ◽  
Daniele Mougenel ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Blood Viscosity ◽  
Male Gender

scholarly journals Iron Chelation Reduces DNA Damage in Sickle Cell Anemia

2021 ◽  
Vol 27 ◽  
pp. 107602962110472
Author(s):  
Rawan S. Al-Khateeb ◽  
Hanan S. Althagafy ◽  
Mohammad Zaki ElAssouli ◽  
Dunya A. Nori ◽  
Mohammed AlFattani ◽  
...  
Keyword(s):  
Dna Damage ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Blood Cells ◽  
Hematological Parameters ◽  
Fluorescent Microscopy ◽  
White Blood Cells ◽  
Iron Chelation ◽  
Target Group ◽  
Hemoglobin F

Sickle cell anemia (SCA) is a blood condition that causes severe pain. One of the therapeutic agents used for the treatment of SCA is hydroxyurea, which reduces the episodes of pain but causes DNA damage to white blood cells. The aim of this study was to evaluate the efficacy of the combination of hydroxyurea and iron chelation therapy in relation to the extent of DNA-associated damage. Blood samples were collected from 120 subjects from five groups. Various hematological parameters of the obtained serum were analyzed. The amount of damage caused to their DNA was detected using the comet assay and fluorescent microscopy techniques. The percentage of DNA damage in the group that was subjected to the combination therapy (target group) was 1.32% ± 1.51%, which was significantly lower ( P < .05) than that observed in the group treated with hydroxyurea alone (6.36% ± 2.36%). While the target group showed comparable levels of hemoglobin F and lactate dehydrogenase compared to the group that was treated with hydroxyurea alone, highly significant levels of transferrin receptors and ferritin were observed in the target group. The results of this study revealed that the administration of iron chelation drugs with hydroxyurea may help improve patients’ health and prevent the DNA damage caused to white blood cells due to hydroxyurea. Further studies are needed to better understand the underlying mechanisms that are involved in this process.

scholarly journals Long working hours, anthropometry, lung function, blood pressure and blood-based biomarkers: cross-sectional findings from the CONSTANCES study

2018 ◽  
Vol 73 (2) ◽  
pp. 130-135 ◽  
Author(s):  
Marianna Virtanen ◽  
Linda Magnusson Hansson ◽  
Marcel Goldberg ◽  
Marie Zins ◽  
Sari Stenholm ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Blood Cells ◽  
White Blood Cells ◽  
Working Hours ◽  
Cross Sectional ◽  
Long Working Hours ◽  
Anthropometric Markers

BackgroundAlthough long working hours have been shown to be associated with the onset of cardiometabolic diseases, the clinical risk factor profile associated with long working hours remains unclear. We compared the clinical risk profile between people who worked long hours and those who reported being never exposed to long hours.MethodsA cross-sectional study in 22 health screening centres in France was based on a random population-based sample of 75 709 participants aged 18–69 at study inception in 2012–2016 (the CONSTANCES study). The data included survey responses on working hours (never, former or current exposure to long working hours), covariates and standardised biomedical examinations including anthropometry, lung function, blood pressure and standard blood-based biomarkers.ResultsAmong men, long working hours were associated with higher anthropometric markers (Body Mass Index, waist circumference and waist:hip ratio), adverse lipid levels, higher glucose, creatinine, white blood cells and higher alanine transaminase (adjusted mean differences in the standardised scale between the exposed and unexposed 0.02–0.12). The largest differences were found for Body Mass Index and waist circumference. A dose–response pattern with increasing years of working long hours was found for anthropometric markers, total cholesterol, glucose and gamma-glutamyltransferase. Among women, long working hours were associated with Body Mass Index and white blood cells.ConclusionIn this study, men who worked long hours had slightly worse cardiometabolic and inflammatory profile than those who did not work long hours, especially with regard to anthropometric markers. In women, the corresponding associations were weak or absent.

Height, weight, body mass index and ocular biometry in patients with sickle cell disease

2009 ◽  
Vol 29 (2) ◽  
pp. 189-198 ◽  
Author(s):  
Ebi Peter Osuobeni ◽  
Iheanyi Okpala ◽  
Tom H. Williamson ◽  
Peter Thomas
Keyword(s):  
Body Mass Index ◽  
Sickle Cell Disease ◽  
Body Mass ◽  
Sickle Cell ◽  
Cell Disease ◽  
Ocular Biometry

Analysis of Body Mass Index (BMI) Trends Among a Pediatric Dental Patient Population: A Pilot Study. (Preprint)

2021 ◽  
Author(s):  
Tengfei Su ◽  
Mac Jackson ◽  
Keaton Sacry ◽  
Karl Kingsley MPH
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Low Income ◽  
Patient Population ◽  
Pediatric Population ◽  
Primary Care Providers ◽  
Overweight And Obesity ◽  
Dental School ◽  
Care Providers ◽  
Over Time

BACKGROUND Over the past few decades, a growing trend of overweight and obesity has emerged among the pediatric population. This is a cause of significant concern as these are significantly correlated to other negative oral and systemic health outcomes over time. Although measurement of body mass index (BMI) is common among pediatric physicians and primary care providers, few studies have explored the feasibility of BMI measurement and analysis from pediatric dental providers. OBJECTIVE The primary objective of this study was to compile and analyze pediatric BMI measurements taken from a pediatric dental school patient population. METHODS This study was a retrospective analysis of previously collected data of pediatric patients between 2012 and 2019 (N=451), which was reviewed and approved by the Institutional Review Board (IRB). Descriptive statistics and trend analysis were compiled to determine the trends in pediatric BMI over time. RESULTS Nearly equal percentages of females and males were represented in the study (P=0.432), with the overwhelming majority identified as racial/ethnic minorities (84.5%), P=0.0075. These data revealed that pediatric BMI increased significantly from 25.6 in 2012 to 31.3 in 2018 (22.1%), P=0.031. No significant differences between males and females were observed (P=0.4824) or between minority and non-minority patients (P=0.8288). CONCLUSIONS This study provides significant novel temporal information regarding pediatric BMI among this low-income, minority patient population and highlights the need for expanding the dental school (and pediatric dental residency) curriculum to include more topics related to measuring and tracking overweight and obese children and the most appropriate methods for use in the pediatric dental office.

scholarly journals Elastic property of sickle cell anemia and sickle cell trait red blood cells

2021 ◽  
Vol 26 (09) ◽  
Author(s):  
Endris Muhammed ◽  
James Cooper ◽  
Daniel Devito ◽  
Robert Mushi ◽  
Maria del Pilar Aguinaga ◽  
...  
Keyword(s):  
Elastic Property ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Blood Cells ◽  
Sickle Cell Trait

scholarly journals The prevalence of leukocyte abnormalities among Sudanese patients with sickle cell disease

2021 ◽  
Vol 9 (1) ◽  
pp. 262-267
Author(s):  
Tarig Osman Khalafallah Ahmed ◽  
Ekhlas Alrasheid Abu Elfadul ◽  
Ahmed A. Agab Eldour ◽  
Omer Ibrahim Abdallah Mohammed
Keyword(s):  
Sickle Cell Disease ◽  
Cell Volume ◽  
Sickle Cell ◽  
Blood Cells ◽  
White Blood Cells ◽  
Blood Film ◽  
Cell Disease ◽  
Mean Cell Volume ◽  
Blood Disorder ◽  
Age Range

Sickle cell disease (SCD) is an inherited blood disorder that affects red blood cells. The study was conducted in Elobied town during the period May 2011 to September 2011. The aim of this study is to detect the abnormalities of leucocytes among sickle cell anemic patients. 40 sickle cell anemic patients; age range between 8 months to 23 years. Blood sample was taken for all patients and the laboratory investigation were performed using automated estimation for: hemoglobin (Hb), Packed cell volume (PCV), red cell count (RBCs), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell concentration (MCHC), and total white blood cells, comment on blood film using manual methods. The conclusion of this study there is increase in total white blood cells with shift to left in neutrophil precursor in sickle cell patients with complications ,the most immature cells are band form, myelocytes and metamyelocytes, and there also lymphocytosis and neutrophilia which has been increases in response to infections.

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