scholarly journals Some Aspects of Nutrition and Moderate Body Weight Reduction in Lithuanian Olympic Sport Centre Female Basketball Players

2018 ◽  
Vol 2 (81) ◽  
Author(s):  
Marius Baranauskas ◽  
Linas Tubelis ◽  
Rimantas Stukas ◽  
Edmundas Švedas ◽  
Laimutė Samsonienė ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Weight Reduction ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Basketball Players ◽  
Body Weight Reduction ◽  
Glucose Levels ◽  
Before And After ◽  
Amino Acid Methionine ◽  
Olympic Sport

Research background and hypothesis. Many athletes know the benefi ts of low carbohydrate diets these days, but recently healthcare specialists have paid much attention to high carbohydrate diets and safer methods of losing weight. Research aim was to investigate Lithuanian Olympic Sport Centre female basketball players’ (n = 10) actual and special nutrition and their physical condition. Research methods. Athletes’ food records were analyzed and assessed. We determined plasma triacylglycerol, total cholesterol, LDL cholesterol, HDL cholesterol, glucose. Physical Working Capacity (PWC 170 ) test was conducted to determine aerobic fi tness before and after moderate weight reduction. Research results showed that the basketball players received too little carbohydrates, linoleic acid, amino acid methionine and too much fat. Vitamins D, PP, B 1  and folic acid intakes were insuffi cient. During moderate bodyweight reduction basketball players signifi cantly decreased in their BW (–2.2 ± 0.3 kg, p < 0.05), BF (–1.6 ± 0.3 kg, p < 0.05) and minerals (–0.1 ± 0.4 kg, p < 0.05), but they non-signifi cantly decreased in BP (p > 0.05). Furthermore, lipid panels markers (triacylglycerol, total cholesterol, LDL cholesterol, HDL cholesterol) experienced non-signifi cant improvements while glucose levels (p < 0.05) and PWC 170  (p < 0.05) resulted in signifi cant decrease following a 12-day hipocaloric diet. Discussion and conclusions. The results indicate that hipoenergetic moderate weight loss at < 30 kcal· kg –1  · day –1 , < 5 g · kg –1  · day  –1  carbohydrate is not recommended for athletes as it can affect aerobic fi tness.Keywords: nutrition, female basketball, bodyweight reduction.

scholarly journals GLYCEMIC AND LIPIDEIC STATUS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

2014 ◽  
Vol 04 (01) ◽  
pp. 009-014
Author(s):  
A. Harish Rao
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Fasting Glucose ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Glucose Levels ◽  
Low Hdl ◽  
One Year

Abstract: Objective: to know the glycemic and lipidaemic status in patients with acute myocardial infarction, and with the secondary objective to know the effect of age, gender, diabetes, smoking, hypertension on fasting glucose and lipid levels. Methods and materials: The 74 patients admitted for acute myocardial infarction during the study period of one year were analysed for fasting glucose values and serum levels of total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Results: The mean serum concentrations of total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol were 233.28±45.34, 139.22±41.71, 171.43±36.53 and 27.07±36.53 respectively. Mean levels of total cholesterol, HDL cholesterol, triglycerides and fasting glucose values were not affected by age, gender, BMI, hypertension and smoking. BMI >30kg/m2 was associated with increased levels of total cholesterol(p=0.013) and LDL cholesterol(p=0.014). Also increase LDL cholesterol was seen in male gender(p=0.04). The prevalence of hypercholesterolemia, hypertriglyceridemia and low HDL cholesterol was 82.4%,77% and 78% respectively. Diabetes had no effect on lipid profile. Conclusion: our study highlighted the prevalence of dyslipidemias associated with myocardial infarction but not significant impact of fasting glucose levels.

scholarly journals Pengaruh propolis terhadap profil lipid plasma tikus model hiperkolesterolemia

2012 ◽  
Vol 8 (3) ◽  
pp. 106
Author(s):  
Krisnansari Diah ◽  
Ariadne Tiara Hapsari ◽  
Evy Sulistyoningrum ◽  
Agus Prastowo
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Sprague Dawley ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Group I ◽  
Before And After

Background: Nowadays, cardiovascular disease caused by hypercholesterolemia has become the main cause of death. Propolis has been used widely to reduce plasma cholesterol levels.Objective: The aims of this research was to study the effect of propolis on lipid profile of hypercholesterolemic Sprague Dawley rats.Method: This was an experimental study with pre-post test. Twenty four (24) male Sprague Dawley rats aged 12-16 week old, weighing 125-200 g were allocated into 4 groups. Group I received standard meal + aquadest-gavage; group II received high cholesterol meal + PTU 0,01 + aquadest gavage; group III received high cholesterol meal + PTU 0,01 + 0,027 g propolis gavage; group IV received high cholesterol meal + PTU 0,01 + 0,054 g propolis gavage. Total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol levels before and after treatment were measured. The data were then analyzed with One Way Anova.Results: The study showed that there were no significant differences in changes of body weight. There were significant differences in total cholesterol levels between all groups of treatment. Triglyceride levels were significantly different among all groups, except between group I and IV. Furthermore, the HDL cholesterol levels of group I vs III and group I vs IV were significantly different. However, there were no differences found in LDL cholesterol levels among all groups of treatment.Conclusion: Provision of 0,027 g and 0,054 g propolis improve lipid profile (total cholesterol, triglyceride and HDL cholesterol levels) of hypercholesterolemic rats.

scholarly journals The role of plant stanols in the primary prevention of hypercholesterolemia in patients with arterial hypertension

2019 ◽  
Vol 18 (3) ◽  
pp. 5-10
Author(s):  
A. S. Safaryan ◽  
T. V. Kamyshova ◽  
D. V. Nebieridze ◽  
V. D. Sargsyan
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Clinical Manifestations ◽  
Hdl Cholesterol ◽  
Average Level ◽  
Control Group ◽  
Study Group ◽  
Plant Stanols ◽  
Before And After ◽  
Lipid Parameters

Aim. To assess the efficacy and safety of plant stanols in patients with arterial hypertension (AH) and disorders of lipid metabolism, without clinical manifestations of atherosclerosis.Material and methods. The study included 40 patients — men at the age of 50-55 years, with AH (stage 1) and cholesterol above 5,0 mmol/l and LDL cholesterol above 3,0 mmol/l with low and medium risk (SCORE — 1-4%). Patients with coronary artery disease and other clinical manifestations of atherosclerosis, secondary hypertension, liver diseases, diabetes mellitus, secondary dyslipoproteinemia, cardiovascular diseases requiring constant therapy, bronchial asthma were excluded from the study. Patients were randomized into 2 groups of 20 people. In the study group of patients within 3 months received plant stanols (2 tab./day), in the control group — only healthy diet. In addition, patients with high blood pressure received antihypertensive therapy. Assessment of lipid parameters (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides) was performed at baseline and after 3 months. At the beginning of the study, after 3 months of the study patients underwent a full medical examination. Safety control of plant stanols was carried out by determination of liver enzymes (aspartic transaminase (AST), alanine transaminase (ALT)), before and after the completion of the study.Results. Patients of two groups were comparable in baseline characteristics (lipid parameters, blood pressure level). After 3 months of research beginning patients from study group have statistically significant decrease of total cholesterol and LDL cholesterol. The average level of total cholesterol before treatment was 5,8±0,32 mmol/l, and after treatment — 5,3±0,32 mmol/l, p<0,001. The average level of LDL cholesterol before treatment was 3,6±0,26 mmol/l, and after treatment — 3,3±0,25 mmol/l, p<0,001. According to other lipid parameters (HDL cholesterol, triglycerides) significant differences are not obtained. As a result, there was a significant reduction in the total risk from 4% to 3,1%. As for the control group, the dynamics of lipid parameters were practically not observed. For example, the average level of total cholesterol before treatment was 5,7±0,39 mmol/l, and after treatment — 5,6±0,42 mmol/l. The average level of LDL cholesterol before treatment was 3,6±0,21 mmol/l, and after treatment — 3,6±0,21 mmol/l. The differences between the study and control groups in the reduction of total and LDL cholesterol were highly significant (p<0,001). The study did not reveal the dynamics of liver enzymes. The level of AST before treatment in the study group was 28,4±6,54, and after treatment — 29,5±5,56. ALT levels were 32,3±7,38 and 33,9±5,65, before and after the study, respectively.Conclusion. The study shows the high efficacy and safety of plant stanols. We found a significant decrease of the two most important parameters of lipid metabolism — total cholesterol and LDL cholesterol.

scholarly journals Pengaruh jamur tiram putih (pleurotus ostreatus) terhadap kadar glukosa darah, profil lipid dan kadar MDA pada tikus (rattus norvegicus) diabetes melitus

2016 ◽  
Vol 4 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Purbowati Purbowati ◽  
Andrew Johan ◽  
RA Kisdjamiatun RMD
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Pleurotus Ostreatus ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Oyster Mushroom ◽  
Glucose Levels ◽  
Cholesterol Levels ◽  
Blood Glucose Levels

Background : Diabetes mellitus is a chronic disease caused by acquired deficiency in insulin production by the pancreas, or by the ineffectiveness of using the produced insulin. Oyster mushroom (Pleurotus ostreatus) can help lower blood glucose levels, improve lipid profile and reduce levels of MDA.Objective : to analyze the effect of oyster mushroom on blood glucose levels, lipid profile and MDA levels in STZ induced rats as type 1 DM model. Methods : thirty Sprague Dawley rats were randomly divided into 3 groups: one positive group (1) and two treated group which received 100 mg/kgBB (2) and 200 mg/kgBB (3) oyster mushroom extract, respectively. The interventions were carried out for 30 days. The examination of blood glucose levels, lipid profile and MDA levels was before and after the intervention. The differences inthe datapre-post interventions were analyzed by paired t-test, whereas the differences between the groups were analyzed by one-way ANOVA and kruskal wallis followed by post hoc analysis. Results : the treatment group experienced a decrease in blood glucose levels, total cholesterol, LDL cholesterol, triglycerides, MDA and an increase in HDL cholesterol levels post-intervention (p < 0,001). Oyster mushroom extract with the dose of 200 mg/kg was more effective in lowering blood glucose levels, MDA levels and improving lipid profiles (p < 0,001).Conclusion : Oyster mushrooms administration lowers blood glucose levels, total cholesterol, LDL cholesterol, triglycerides, MDA and increases HDL cholesterol levels. 

scholarly journals Substitution of whole cows’ milk with defatted milk for 4 months reduced serum total cholesterol, HDL-cholesterol and total apoB in a sample of Mexican school-age children (6–16 years of age)

2015 ◽  
Vol 114 (5) ◽  
pp. 788-795 ◽  
Author(s):  
Salvador Villalpando ◽  
Yaveth Lara Zamudio ◽  
Teresa Shamah-Levy ◽  
Verónica Mundo-Rosas ◽  
Alejandra Contreras Manzano ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Boarding Schools ◽  
Serum Total Cholesterol ◽  
School Age Children ◽  
Linear Regression Models ◽  
Whole Milk ◽  
Before And After ◽  
The Difference

AbstractWe carried out this study to compare the effect of consuming whole, partially defatted and defatted cows’ milk for 4 months on serum concentrations of blood indicators of cardiovascular risk (CVR) in Mexican children and adolescents. Children aged between 6 and 16 years living in indigenous boarding schools in Mexico and who were usual consumers of whole milk were recruited to this study. Totally, thirteen boarding schools were randomly selected to receive full supplies of whole, partially defatted and defatted cows’ milk for 4 months. Serum total cholesterol (TC), TAG, HDL-cholesterol, apoA and total apoB, and Lp(a) concentrations were measured before and after the intervention. Comparisons were made with multi-level mixed-effects linear regression models using the difference in differences approach. Compared with the whole milk group, TC, LDL-cholesterol, HDL-cholesterol and total apoB were lower in defatted milk consumers by –0·43, –0·28, –0·16 mmol/l and −0·05 g/l, respectively (allP<0·001). Compared with the whole milk group, the group that consumed partially defatted milk showed a significant decrease in the concentrations of LDL-cholesterol (−0·12,P=0·01), apoA (−0·05 g/l,P=0·01) and total apoB (−0·05 g/l,P=0·001). Defatted milk intake for 4 months reduced some of the serum indicators of CVR.

scholarly journals Effects of tibolone on the risk factors for cardiovascular diseases in postmenopausal women

2006 ◽  
Vol 63 (4) ◽  
pp. 387-391 ◽  
Author(s):  
Katarina Jeremic ◽  
Gordana Lazovic ◽  
Ivan Tulic ◽  
Miroslava Gojnic ◽  
Jelena Stojnic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Total Cholesterol ◽  
Postmenopausal Women ◽  
Ldl Cholesterol ◽  
Statistical Significance ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Before And After ◽  
The Difference

Background/Aim. Tibolone is a preparation that belongs to the group of steroidal substances. The effects of the use of the use of tibolone are the consequence of the activities of its metabolities, considering that their hormonal activity depends on the type of tissue in which they develop. The aim of this study was to evaluate the influence of the use of tibolone on risk factors for the development of cardiovascular diseases in postmenopausal women. Methods. A prospective observational stady included 94 patients who had the concentration of l7? estradiol < 50 pg/ml, and who was in menopause more than a year. Out of the total number of patients, 63 accepted to receive tibolone 2.5 mg daily (tibolone group), while 31 of the patients refused to take tibolone (control group). We measured the concentration of lipids (cholesterol, LDL cholesterol, HDL cholesterol, triglicerides), antitrombin III, fibrinogen, and C-reactive protein, before and after the treatment within a 6-month period. Then, we compared the difference between the values of concentrations and tested the statistical significance of the difference. We also evaluated the changes of values in the concentrations of the examinated parameters inside a 6-month period in the control group. Results. In 31 patients of the control group, from the control group there were no significant changes in the values of the defined parameters as compared to their initial values after six months. But there were changes of statistical significance (p < 0.001) in values of the concentrations of the exeminated parameters before and after the treatment in the tibolone group. In fact, we recorded decreases in the total cholesterol by 17.8%, HDL cholesterol by 27%, LDL cholesterol by 4% (without statistical significance p > 0.05) and triglicerids by 35%. There were no statistical differences in the concentrations of antitrombin III, fibrionogen, and C-reactive proteine in the tibolone group before and after the treatment. Conclusion. The use of tibolone dose decrease the concentration of the total cholesterol, triglicerides, HDL cholesterol, without a significant decrease of LDL cholesterol. Also, the use of tibolone does not have any significant effect on the concentrations of antitrombin III, fibrinogen and C-reactive proteine. The number of serum parameters measured in this study was limited, thus that was the reason to discuss only about the metabolism of lipids in the patients from the tibolone group. The final conclusion about the risk for cardiovascular diseases in the patients on tibolone, howerer, reqnires were extensive further clinical exeminations.

Reductive effect of body weight in C57BL/6J mice fed a high-fat diet by Saesaengmyung Diet

2005 ◽  
Vol 83 (2) ◽  
pp. 161-165
Author(s):  
Hyo-Jin An ◽  
Na-Hyung Kim ◽  
Yun-Kyung Kim ◽  
Yeoung-Su Lyu ◽  
Taekyun Shin ◽  
...  
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Standard Diet ◽  
High Fat ◽  
Glucose Levels

The Saesaengmyung Diet (SD) is a newly developed dietary product to help control weight. The aim of this study was to evaluate whether SD combined with a high-fat (HF) diet could influence body weight, fat accumulation, and glucose levels in blood. C57BL/6J mice were fed for 8 weeks with a standard diet, an HF diet, and an HF + 10% or HF + 20% SD diet. Body weight was recorded weekly, and plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and glucose were analyzed at the end of the study. Weight increases in the 10% or 20% SD group were significantly less than in the HF diet group (p < 0.05). Plasma total cholesterol level significantly decreased by 33.5% in the 10% SD group and 38.8% in the 20% SD group, but the LDL cholesterol, HDL cholesterol, and glucose levels in the SD groups were not significantly changed. Our findings indicate that SD may be beneficial to overweight individuals in the reduction of weight gain induced by an HF diet.Key words: Saesaengmyung Diet, high-fat diet, obesity, body weight, cholesterol, glucose.

scholarly journals Efectos de un programa de ejercicio físico durante tres años en niños obesos: un estudio de intervención (Effects of an exercise program during three years in obese boys: an intervention study)

Retos ◽  
2015 ◽  
pp. 10-13
Author(s):  
Antonio García-Hermoso ◽  
Yolanda Escalante ◽  
Ana M. Domínguez ◽  
José M. Saavedra
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Exercise Program ◽  
Hdl Cholesterol ◽  
Fat Free Mass ◽  
Model Assessment ◽  
Obese Children ◽  
Homeostasis Model Assessment ◽  
Glucose Levels

El objetivo del presente estudio fue determinar el efecto de un programa de ejercicio físico a largo plazo (3 años) sobre parámetros cineantropométricos y metabólicos en niños obesos. La muestra estuvo compuesta por ocho niños de edades entre 8 y 11 años, que llevaron a cabo un programa de ejercicio físico multideportivo (tres sesiones de 90 minutos por semana). Se llevó a cabo una valoración cineantropométrica, evaluando los siguientes parámetros: talla, peso, índice de masa corporal (IMC), zIMC, masa grasa y magra, y una valoración metabólica: colesterol total (CT), colesterol HDL, colesterol LDL, triglicéridos (TG), insulina, glucosa, homeostasis model assessment (HOMA-IR), índice LDL/HDL y CT/HDL. Tras la intervención se observaron cambios en el zIMC (dejando de ser obesos tras la intervención), colesterol total, LDL, índice colesterol total/HDL y niveles de glucosa a largo plazo, mostrando que intervenciones longitudinales generan beneficios positivos en niños obesos principalmente en su perfil lipídico.Palabra clave: obesidad, ejercicio físico, intervención longitudinal, colesterol, insulina.Abstract: The aim of this study was to determine the effect of a long-term exercise program (3 years) on kinanthopometric and metabolic in obese children. The sample consisted of eight boys between 8 and 11 years, who conducted a aerobic multi-sport exercise program (three sessions, 90 minutes per week). Carried out an assessment kinanthropometric assessing the following parameters: height, weight, body mass index (BMI), zBMI, fat mass and fat free mass, and a metabolic assessing: total cholesterol (TC), HDL cholesterol, LDL cholesterol, triglycerides (TG), insuline, glucose, Homeostasis Model Assessment (HOMA-IR), ratio LDL/HDL and TC/HDL. Following the intervention, changes were observed on zBMI (ceasing to be obese after the intervention), total cholesterol, LDL, and ratio total cholesterol/HDL) and glucose levels at the long term, showing that longitudinal interventions generate positive benefits on obese children mainly in the lipid profile. Key words: obesity, physical exercise, longitudinal intervention, cholesterol, insulin.

Effects of diacerein intake on cardiometabolic profiles in type 2 diabetics: a systematic review and meta-analysis of clinical trials.

2020 ◽  
Vol 27 ◽  
Author(s):  
Peyman Nowrouzi-Sohrabi ◽  
Reza Tabrizi ◽  
Mohammad Jalali ◽  
Navid Jamali ◽  
Shahla Rezaei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Body Weight ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Hdl Cholesterol ◽  
Cochrane Central Register ◽  
Statistical Heterogeneity

Introduction: A systematic review and meta-analysis of clinical trials was undertaken to evaluate the effect of diacerein intake on cardiometabolic profiles in patients with type 2 diabetes mellitus (T2DM). Methods: Electronic databases such as PubMed, EMBASE, Scopus, Web of Science, Google Scholar, and Cochrane Central Register of Controlled Trials were searched from inception to 31 July 2019. Statistical heterogeneity was evaluated using Cochran’s Q test and I-square (I2 ) statistic. Data were pooled using random-effect models and weighted mean difference (WMD). Results: From 1,733 citations, seven clinical trials were eligible for inclusion and meta-analysis. A significant reduction in hemoglobin A1c (HbA1c) (WMD -0.73; 95%CI -1.25 to -0.21; P= 0.006; I2 = 72.2%) and body mass index (BMI) (WMD -0.55; 95%CI -1.03 to -0.07; P= 0.026; I2 = 9.5%) were identified. However, no significant effect of diacerein intake was identified on fasting blood sugar (FBS) (WMD - 9.00; 95%CI -22.57 to 4.57; P= 0.194; I2 = 60.5%), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD 0.39; 95%CI 0.95 to 1.73; P= 0.569; I2 = 2.2%), body weight (WMD -0.54; 95%CI -1.10 to 0.02; P= 0.059), triglycerides (WMD -0.56; 95%CI -24.16 to 23.03; P= 0.963; I2 = 0.0%), total-cholesterol (WMD -0.21; 95%CI -12.19 to 11.78; P= 0.973; I2 = 0.0%), HDL-cholesterol (WMD -0.96; 95%CI -2.85 to 0.93; P= 0.321; I2 = 0.0%), and LDL-cholesterol levels (WMD -0.09; 95%CI -8.43 to 8.25; P= 0.983; I2 = 37.8%). Conclusion: Diacerein intake may reduce HbA1c and BMI; however, no evidence of effect was observed for FBS, HOMA-IR, body weight, triglycerides, total-cholesterol, HDL-cholesterol or LDL-cholesterol.

scholarly journals Plasma PCSK9 Concentrations Correlate with LDL and Total Cholesterol in Diabetic Patients and Are Decreased by Fenofibrate Treatment

2008 ◽  
Vol 54 (6) ◽  
pp. 1038-1045 ◽  
Author(s):  
Gilles Lambert ◽  
Nicolas Ancellin ◽  
Francesca Charlton ◽  
Daniel Comas ◽  
Julia Pilot ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Polyclonal Antibodies ◽  
Sandwich Elisa ◽  
Ldl Receptor ◽  
Hdl Cholesterol ◽  
Diabetic Patients ◽  
Plasma Triglycerides ◽  
Fenofibrate Treatment ◽  
Before And After ◽  
Fenofibrate Intervention

Abstract Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of the LDL receptor (LDLr) in hepatocytes, and its expression in mouse liver has been shown to decrease with fenofibrate treatment. Methods: We developed a sandwich ELISA using recombinant human PCSK9 protein and 2 affinity-purified polyclonal antibodies directed against human PCSK9. We measured circulating PCSK9 concentrations in 115 diabetic patients from the FIELD (Fenofibrate Intervention and Event Lowering in Diabetes) study before and after fenofibrate treatment. Results: We found that plasma PCSK9 concentrations correlate with total (r = 0.45, P = 0.006) and LDL (r = 0.54, P = 0.001) cholesterol but not with triglycerides or HDL cholesterol concentrations in that cohort. After 6 weeks of treatment with comicronized fenofibrate (200 mg/day), plasma PCSK9 concentrations decreased by 8.5% (P = 0.041 vs pretreatment). This decrease correlated with the efficacy of fenofibrate, as judged by a parallel reduction in plasma triglycerides (r = 0.31, P = 0.015) and LDL cholesterol concentrations (r = 0.27, P = 0.048). Conclusions: We conclude that this decrease in PCSK9 explains at least in part the LDL cholesterol–lowering effects of fenofibrate. Fenofibrate might be of interest to further reduce cardiovascular risk in patients already treated with a statin.

Sign in / Sign up

Export Citation Format

Share Document