scholarly journals Analysis of the Prevalence of Digestive System Diseases in the Republic of Karakalpakstan

2019 ◽  
Vol 5 (5) ◽  
pp. 83-88
Author(s):  
S. Nurpolatova ◽  
J. Jaibergenova ◽  
G. Karimov
Keyword(s):  
Ulcerative Colitis ◽  
Gastrointestinal Tract ◽  
Digestive System ◽  
Medical Center ◽  
Development Stage ◽  
Chronic Cholecystitis ◽  
Initial Development ◽  
Number Of Patients ◽  
Digestive System Diseases ◽  
The Republic

The analysis of the incidence rate associated with disorders in the gastrointestinal tract among the population of the Republic of Karakalpakstan for the period 2016–2017 is presented. Patients who received treatment in the Department of Gastroenterology of the Khalmuratov Republican Multidisciplinary Medical Center. Studies have shown an increase in the number of patients with a diagnosis of ulcerative colitis, chronic cholecystitis, chronic pancreatitis, chronic hepatitis, cirrhosis of the liver. In order to prevent diseases of the gastrointestinal tract, it is necessary to carry out measures for early diagnosis using the latest technologies and treatment of diseases at the initial development stage

scholarly journals CLINICAL AND LABORATORY MARKERS OF DIGESTIVE SYSTEM DISEASES IN HIV-INFECTED PATIENTS FOR FAMILY MEDICINE PRACTICE

2020 ◽  
Vol 73 (9) ◽  
pp. 1909-1914
Author(s):  
Olga A. Golubovska ◽  
Volodymyr I. Vysotskyi
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Digestive System ◽  
Gastrointestinal Disease ◽  
Medical Center ◽  
Clinical Stage ◽  
Blood Parameters ◽  
System Disease ◽  
Elevated Liver Enzymes ◽  
Digestive System Diseases

The aim: To identify clinical and laboratory signs of digestive system disease in HIV-infected patients for helping family physicians. Materials and methods: Research was conducted at five regional HIV / AIDS centers in Ukraine during 2017-2019. Randomly selected 342 adult HIV-infected patients were divided into two groups, with concomitant digestive system diseases and without concomitant digestive system disease. Statistical analysis was performed using the software package EZR 1.41 (Saitama Medical Center, Jichi Medical University, Japan). Results: The incidence of digestive system disease in patients with HIV clinical stages II, III and IV was significantly higher than in patients with HIV clinical stage I. Gastrointestinal disease was also significantly associated with the incidence of tuberculosis, candidiasis, kidney disease and HIV encephalopathy. Incidence of asthenic-vegetative and dyspeptic syndromes, weight loss, anemia and leukopenia, elevated liver enzymes, low CD4 counts and detectable viral load levels in patients on antiretroviral therapy were significantly more common in HIV-infected patients with gastrointestinal pathologies. HIV patients with digestive system disease significantly more often had changes to their therapy regiment, interruptions in treatment and more often experienced side effects. Conclusions: Digestive system disease becomes more common with the progression of HIV infection. Comorbidity of HIV infection and digestive system disease is characterized by changes in general clinical, biochemical and immunological blood parameters and patients with digestive system comorbidities more often have a poor virological response to antiretroviral therapy.

scholarly journals Accumulation of Mast Cells in the Lesions and Effects of Antiallergic Drugs on the Patients with Inflammatory Bowel Disease

Ulcers ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Motohiro Kurosawa ◽  
Hiroichi Nagai
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Mast Cells ◽  
Bowel Disease ◽  
Inflammatory Lesions ◽  
Eosinophilic Colitis ◽  
Number Of Patients ◽  
Antiallergic Drug ◽  
Inflammatory Bowel

The pathomechanism of inflammatory bowel disease (IBD) has not yet been fully demonstrated. However, it is well known that mast cells are present in the gastrointestinal tract, suggesting that mast cells may take part in it. So, we investigated the number of mast cells in IBD, such as ulcerative colitis (UC) and eosinophilic colitis, and showed that the number of mast cells was increased in the inflammatory lesions. We also presented a case of UC which was treated successfully with an antiallergic drug, tranilast. Furthermore, possible new approaches to treating the disease with immunomodulators including suplatast are introduced. However, our investigations were performed with a limited number of patients with IBD, and additional further studies are required to confirm the findings.

scholarly journals Two Cases of Diffuse Duodenitis Associated with Ulcerative Colitis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Katsuya Endo ◽  
Masatake Kuroha ◽  
Hisashi Shiga ◽  
Yoichi Kakuta ◽  
Seiichi Takahashi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gastrointestinal Tract ◽  
Target Organ ◽  
Upper Gastrointestinal Tract ◽  
Histological Findings ◽  
Gastrointestinal Involvement ◽  
Case Patient ◽  
Free Condition ◽  
Number Of Patients ◽  
Upper Gastrointestinal

The upper gastrointestinal tract is not generally considered a target organ in ulcerative colitis (UC). However, several cases showing upper gastrointestinal involvement in UC have been reported. In this report, we present 2 rare cases of diffuse duodenitis accompanying pancolonic UC. Case patient 1 was a 44-year-old man who developed diffuse duodenitis shortly after colectomy and was successfully treated with mesalazine. Case patient 2 was a 25-year-old woman who developed diffuse duodenitis under a steroid-free condition and was successfully treated with prednisolone. The 2 patients hadHelicobacter pylori-negative duodenitis that resembled colonic lesions of UC in both the endoscopic and histological findings. No evidence of Crohn’s disease was found in these cases. We diagnosed both cases as typical UC-associated diffuse duodenitis. The occurrence of gastrointestinal involvement in UC has been attracting attention because such lesions could potentially open a new window for studying the etiology and pathogenesis of UC. Further studies involving a large number of patients are needed to clarify whether the upper gastrointestinal tract is a target organ in UC.

scholarly journals Prevalence of Allergic and Pulmonological Diseases in the Republic of Karakalpakstan

2020 ◽  
Vol 6 (3) ◽  
pp. 140-155
Author(s):  
S. Nurpulatova ◽  
Z. Kunnazarova
Keyword(s):  
Medical Center ◽  
Allergic Diseases ◽  
The Body ◽  
Chronic Obstructive ◽  
Early Prevention ◽  
Contact Allergens ◽  
Obstructive Pulmonary Disease ◽  
Number Of Patients ◽  
The Family ◽  
The Republic

The incidence rate among the population of the Republic of Karakalpakstan for the period 2017–2018 is presented. Patients who received treatment at the Department of Pulmonology and Allergology of the Republican Multidisciplinary Medical Center named after U. Halmuratov were examined. Studies have shown an increase in the number of patients with a diagnosis of chronic obstructive pulmonary disease, asthma, chronic bronchitis, pneumonia, bronchiectatic disease, interstitial lung disease, urticaria, allergic dermatitis, Quincke’s edema, lung cancer. In order to prevent allergic diseases, early prevention consists of an informative method — the installation of an allergic history in the family and relatives. If patients have a hereditary predisposition to allergic diseases, it is recommended to exclude in the last trimester products with a high allergenic effect (chocolate, nuts, citrus fruits, contact allergens), minimize drug intake, abandon bad habits, general hardening of the body, prevention of seasonal respiratory diseases.

Digestive system diseases associated with Turner's syndrome in 3 pediatric cases

2018 ◽  
Author(s):  
Lamia Gargouri ◽  
Faten Hadjkacem ◽  
Dorra Ghorbel ◽  
Faiza Safi ◽  
Manel Hsairi ◽  
...  
Keyword(s):  
Digestive System ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Digestive System Diseases

Features of the complex treatment of ulcerative colitis in clinical practice

2020 ◽  
pp. 6-11
Author(s):  
Svetlana Svetlana ◽  
Mikhail Klimentov ◽  
Olga Neganova ◽  
Alina Nazmieva ◽  
Anastasiya Kochurova
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Practice ◽  
Statistical Study ◽  
Age Groups ◽  
Length Of Hospital Stay ◽  
Unknown Etiology ◽  
Number Of Patients ◽  
First Republic ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Nowadays there are certain difficulties in the early diagnosis of ulcerative colitis, proceeding with minimal intestinal symptoms. The etiology of the disease remains unclear to this day; there is no exact information about the prevalence of the disease due to the large number of latent forms and the low number of patients seeking medical help. This article presents the results of a retrospective analysis of the incidence of ulcerative colitis in the coloproctology department of the First Republic Clinical Hospital of Izhevsk. The study was conducted to assess the frequency of occurrence and determine the internal picture of ulcerative colitis. To achieve this goal, we selected 34 patients with ulcerative colitis. A statistical study was conducted on the following criteria: gender composition, age groups, forms of the disease, localization, complications, and main complaints. The length of hospital stay often was not more than 20 days. The literature on this pathology was also studied and presented in the form of a theoretical basis, which consisted of the determination and etiology of inflammatory bowel diseases. Due to the unknown etiology, insufficiently studied pathogenesis, difficult differential diagnosis with other intestinal diseases and insufficiently perfect treatment methods, there are a large number of unresolved problems in the field of ulcerative colitis. That is why, in this article we tried to reveal the problem of the features of the course and complex therapy of that disease in clinical practice.

A Review of the Bioactive Ingredients, Pharmacological Functions and Mechanisms of Inonotus obliquus

2020 ◽  
Vol 17 ◽  
Author(s):  
Gulinigaer Anwaier ◽  
Cong Wen ◽  
Yi-ni Caoili ◽  
Rong Qi
Keyword(s):  
Digestive System ◽  
Treatment Strategies ◽  
Research Progress ◽  
Chemical Components ◽  
Separation And Purification ◽  
Active Components ◽  
Inonotus Obliquus ◽  
Global Issues ◽  
Medicinal Fungus ◽  
Digestive System Diseases

: As a medicinal fungus, Inonotus obliquus (IO) has been widely used in the treatment of cancer and digestive system diseases. Despite the progress that has been made in the studies of IO and its active compounds, their applications in other important clinical diseases, such as cardiovascular diseases, which are major global issues with limited treatment strategies, are seldom reported. This review summarizes the separation and purification methods of chemical components of IO, the advances in their applications, and research progress on the pharmacological effects and related mechanisms of IO in disease prevention. This review will help researchers and clinicians to further understand the pharmacological functions and mechanisms of IO and its active components, which may extend their medical applications in the prevention and treatment of other diseases in addition to tumors and digestive system diseases in the near future.

The Causative Organisms of Bacterial Meningitis and their Antimicrobial Resistance Profiles in Iranian Children in 2011-2016

2020 ◽  
Vol 20 (2) ◽  
pp. 229-236
Author(s):  
Sepideh Keshavarz Valian ◽  
Shima Mahmoudi ◽  
Babak Pourakbari ◽  
Maryam Banar ◽  
Mohammad Taghi Haghi Ashtiani ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Bacterial Meningitis ◽  
Medical Center ◽  
Blood Cultures ◽  
Gram Positive ◽  
Gram Negative ◽  
Number Of Patients ◽  
Resistance Patterns ◽  
Iranian Children ◽  
Surgery Department

Objective: The study aimed to describe the identity and antimicrobial resistance patterns of the causative agents of bacterial meningitis in children referred to Children’s Medical Center (CMC) Hospital, Tehran, Iran. Methods: This retrospective study was performed at CMC Hospital during a six-year period from 2011 to 2016. The microbiological information of the patients with a diagnosis of bacterial meningitis was collected and the following data were obtained: patients’ age, sex, hospital ward, the results of CSF and blood cultures, and antibiotic susceptibility profiles of isolated organisms. Results: A total of 118 patients with bacterial meningitis were admitted to CMC hospital. Sixty-two percent (n=73) of the patients were male. The median age of the patients was ten months (interquartile range [IQR]: 2 months-2 years) and the majority of them (n=92, 80%) were younger than two years of age. The highest number of patients (n=47, 40%) were admitted to the surgery department. Streptococcus epidermidis was the most frequent isolated bacterium (n=27/127, 21%), followed by Klebsiella pneumoniae (n=20/127, 16%), and Staphylococcus aureus (n=16/127, 12.5%). Blood culture was positive in 28% (n=33/118) of patients. Ampicillin-sulbactam and imipenem were the most effective antibiotics against Gram-negative bacteria isolated from CSF cultures. In the case of Gram-positive organisms, ampicillinsulbactam, vancomycin, and linezolid were the best choices. Imipenem was the most active drug against Gram-negative blood pathogens. Also, ampicillin and vancomycin had the best effect on Gram-positive bacteria isolated from blood cultures. Conclusion: Results of this study provide valuable information about the antibiotic resistance profiles of the etiologic agents of childhood meningitis, which can be used for prescription of more effective empirical therapies.

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