scholarly journals Sleep and Aging: Endocrine and Epigenetic Aspects

2020 ◽  
Vol 6 (8) ◽  
pp. 65-96
Author(s):  
S. Bulgakova ◽  
N. Romanchuk

Along with many physiological changes during normal aging, sleep also changes. Age-related changes in sleep include: a decrease in the duration of night sleep, an increase in the frequency of falling asleep during the day, an increase in the number of night awakenings and time spent without sleep during the night, a decrease in the phase of slow sleep, etc. Most of these changes occur between the young and the middle and remain unchanged in the elderly. In addition, the circadian system and homeostatic sleep mechanisms become less stable with aging. The level and nature of the secretion of hormones acting on sleep change during normal aging, which affects the processes of sleep and wakefulness. Sleep indicators are interrelated and/or dependent on lifestyle, polymorbidity (somatic, psychological), polypharmacy, epigenetic (social, economic, environmental, etc.) factors. Increased average human life expectancy and neuroendocrine changes in physiological and pathological aging, on the one hand, epigenetic factors and electromagnetic information load/overload, on the other hand, made a significant contribution to the circadian nature of human brain neural network interaction with artificial intelligence.

Author(s):  
Andri Setyorini ◽  
Niken Setyaningrum

Background: Elderly is the final stage of the human life cycle, that is part of the inevitable life process and will be experienced by every individual. At this stage the individual undergoes many changes both physically and mentally, especially setbacks in various functions and abilities he once had. Preliminary study in Social House Tresna Wreda Yogyakarta Budhi Luhur Units there are 16 elderly who experience physical immobilization. In the social house has done various activities for the elderly are still active, but the elderly who experienced muscle weakness is not able to follow the exercise, so it needs to do ROM (Range Of Motion) exercise.   Objective: The general purpose of this research is to know the effect of Range Of Motion (ROM) Active Assitif training to increase the range of motion of joints in elderly who experience physical immobility at Social House of Tresna Werdha Yogyakarta unit Budhi Luhur.   Methode: This study was included in the type of pre-experiment, using the One Group Pretest Posttest design in which the range of motion of the joints before (pretest) and posttest (ROM) was performed  ROM. Subjects in this study were all elderly with impaired physical mobility in Social House Tresna Wreda Yogyakarta Unit Budhi Luhur a number of 14 elderly people. Data analysis in this research use paired sample t-test statistic  Result: The result of this research shows that there is influence of ROM (Range of Motion) Active training to increase of range of motion of joints in elderly who experience physical immobility at Social House Tresna Wredha Yogyakarta Unit Budhi Luhur.  Conclusion: There is influence of ROM (Range of Motion) Active training to increase of range of motion of joints in elderly who experience physical immobility at Social House Tresna Wredha Yogyakarta Unit Budhi Luhur.


Author(s):  
В. С. Мякотных ◽  
А. П. Сиденкова ◽  
Е. С. Остапчук ◽  
И. А. Кулакова ◽  
Н. А. Белых ◽  
...  

Высокий риск когнитивных расстройств у лиц пожилого и старческого возраста заставляет, с одной стороны, искать их причины, с другой - возможности профилактики. В связи с этим в последние годы получило распространение понятие когнитивного резерва, подразумевающего совокупность количественных параметров головного мозга и его способности сохранять высокую функциональную активность в процессе старения и на фоне связанной с возрастом патологии головного мозга. Представленный в статье материал на основе обзора научной литературы освещает два основных момента, касающихся возможности сохранения когнитивного резерва, - гендерный и образовательный факторы. Указывается на разные возможности женщин и мужчин, связанные со структурными и функциональными особенностями ЦНС у представителей разного пола, и на особую роль поддерживаемого в течение всей жизни образовательного процесса. Обозначена авторская позиция о необходимости разделения понятий образования и образованности, то есть уровня общей культуры и создания удобного инструмента для определения последнего. Это, в свою очередь, помогло бы в разработке модели когнитивного резерва, нацеленной на предотвращение трансформации физиологического когнитивного старения в патологическое. The high risk of cognitive disorders in the elderly and senile age makes, on the one hand, to look for their causes, on the other - the possibility of prevention. In this regard, in recent years, the concept of cognitive reserve has become widespread, implying a set of quantitative parameters of the brain and its ability to maintain high functional activity in the process of aging and against the background of age-related brain pathology. The material presented in the article on the basis of the review of scientific literature highlights two main points concerning the possibility of preserving the cognitive reserve-gender and educational factors. It is pointed to the different opportunities of women and men associated with the structural and functional characteristics of the Central nervous system in representatives of different sexes and the special role of the educational process supported throughout life. The author’s position on the need to separate the concepts of education and the level of General culture, and the creation of a convenient tool for determining the latter is indicated. This, in turn, would help in the development of a cognitive reserve model aimed at preventing the transformation of physiological cognitive aging into pathological aging.


2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Anna M. Schneider ◽  
Mihriban Özsoy ◽  
Franz A. Zimmermann ◽  
René G. Feichtinger ◽  
Johannes A. Mayr ◽  
...  

Aging is an important and inevitable biological process in human life, associated with the onset of chronic disease and death. The mechanisms behind aging remain unclear. However, changes in mitochondrial function and structure, including reduced activity of the mitochondrial respiratory chain and increased production of reactive oxygen species—thus oxidative damage—are believed to play a major role. Mitochondria are the main source of cellular energy, producing adenosine triphosphate (ATP) via oxidative phosphorylation. Accumulation of damaged cellular components reduces a body’s capacity to preserve tissue homeostasis and affects biological aging and all age-related chronic conditions. This includes the onset and progression of classic degenerative diseases such as cardiovascular disease, kidney failure, neurodegenerative diseases, and cancer. Clinical manifestations of intestinal disorders, such as mucosal barrier dysfunction, intestinal dysmotility, and chronic obstipation, are highly prevalent in the elderly population and have been shown to be associated with an age-dependent decline of mitochondrial function. This review summarizes our current understanding of the role of mitochondrial dysfunction in intestinal aging.


2019 ◽  
Vol 9 ◽  
pp. 107-116
Author(s):  
Monika Mucha

Fashion: A factor determining or excluding the participation of seniors on the market?  Fashion is an inseparable element of contemporary human life. In general, clothing choices are determined by age, gender and material factors. In terms of age, however, these decisions differ significantly, which is especially evident among the elderly. In consumer choices older consumers are usually guided by rationality. Seniors are currently a specific group of consumers on the market. On the one hand, they are marginalized because of their age and earnings, but on the other hand, it is a social group that begins to dominate the market, which in the near future will become a group of target recipients, including clothing products. When discussing fashion, there are also important characteristics of consumers that influence the fact of whether a given person is an active partici­pant on the market or is an individual excluded from it. The purpose of this article is to try to define fashion as a factor determining or excluding the participation of seniors in the market. The paper presents an analysis of secondary research and the results of pilot studies on the attitude of seniors in the context of fashion. 


2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1881-1887
Author(s):  
Sushma B ◽  
Karthik Ganesh Mohanraj

In the present modern mechanical world, humans are living like a machine without proper food at the right time, without sleep at the right time or even without any relaxation. There is a concept that even food stands next to sleep for a human's life. Sleep plays a major role in human life for the proper functioning of the brain. Any disturbances in sleep for prolonged duration or period may create serious effects in the body and its functioning. Sleeplessness is known clinically as insomnia, a sleep-related disorder wherein the affected people have problems in sleeping. They may have difficulty falling asleep or staying asleep as long as desired. Hypersomnia, on the other hand, is a neurological disorder of excessive times spent sleeping or excessive sleep. It can have many possible causes and problems with functioning. The study setting is done using online Google forms, including 100 participants. The sampling method is a random sampling method. Well-structured questionnaires were prepared and circulated among those 100 participants. According to the results, 74% of the adults who took the survey are aware that insomnia is sleeplessness. More than 50% of the adults feel that insomnia and hypersomnia lead to death, and 53% of the adults believe that insomnia and hypersomnia are age-related. It can be concluded that awareness of such sleep disorders can be helpful for future generations.


2019 ◽  
Vol 13 (4) ◽  
pp. 444-449 ◽  
Author(s):  
Zahra Babaei ◽  
Zahra Ghayoumi-Anaraki ◽  
Behrooz Mahmoodi-Bakhtiari

ABSTRACT The growth in the elderly population has posed a social, economic and health challenge for the twenty-first century. Objective: Aging is often characterized by changes in cognitive functions which affect the receptive and expressive capabilities of language. Since language plays a significant role in human life, we evaluate the existence of age-related differences in narrative and persuasive discourses. Methods: The narrative discourse of 91 adults and persuasive discourse of 92 adults,aged from 19 to 75 years and stratified into four age groups,were examined. Results: There was a statistically significant difference between coherence in the elderly group and each of the other three age groups for both types of discourse. There was also a significant difference for the cohesion variable between the elderly and the first age group for narrative discourse only. Conclusion: The results of this study demonstrate that discourse is influenced by aging and type (genre) of discourse task. Therefore, it is essential for clinicians to take into account the linguistic needs of elderly and incorporate these into their clinical programs. Also, this finding can help clinicians to distinguish between discourses of normal aging and other neurologic disorders (for example dementia, right hemisphere damage, aphasia).


2020 ◽  
Vol 2 (2) ◽  
pp. 47-54
Author(s):  
Ilona Zakowicz

in every given period one can observe different attitudes towards old age, death and the elderly, which are shown through varied stances and ideas about this specific period of human life. The reality of the xxicentury often regarded as “vision-centric” is dominated by the cult of beauty and youth which creates increasingly demanding requirements, rela-ted mainly to the attractiveness of appearance, of the body – especially the one belonging to the elderly. The increase in the number of senior citizens compared to the rest of the society that can be witnessed nowadays leads to the elderly being amore carefully examined social group. Mediated by the media discourse the images of the elderly are becoming more common and therefore the author’s attempt at reconstructing the postmodern strategy of the rendering of late adulthood seems to be an interesting and important topic to consider.


Author(s):  
Irina B. Durakova ◽  
Ekaterina V. Mayer

Introduction. The improvement of the efficiency of older employees is based on the successful ageing paradigm, i.e. the ability to make up for age-related losses by means of selection, compensation, and optimisation. However, all the players on the labour market face an obstacle in the form of a common stereotype that older people are of ill health, unable to learn, apathetic, and lack motivation. Therefore, the implementation of a strategy for the protection of interests of the elderly in Russia requires studying the stages of the human life cycle with regard to the efficiency of employees. Purpose. The purpose of our study was to provide scientific justification for specifying the stages of the human life cycle and the possibility for older employees to remain efficient. The latter is ensured by the coordination of the organisation’s requirements and individual challenges and demands of the employees. Methodology. In our study, we used historical and logical approach to the analysis of theories suggested by Russian and international scholars, as well as major works and other publications on the topic. The analysis allowed us to determine the essence of the studied phenomenon not restricted by any particular form. We then synthesised the parts and dependencies determined via the analysis of the stages of the human life cycle. Such synthesis allowed us to focus on the development of a basis that can be used to slow down the ageing of human resources and maintain the efficiency of older employees. The other methods used in the study were induction, deduction, analogy, generalisation, comparative analysis, and systems analysis. Results. The article describes a basic research platform for studying the human life cycle, which differentiates between the stages of development, establishment, and deterioration with regard to the ability to perform job functions. It also substantiates the idea of the employee life cycle from the point of view of both employers and employees. The article specifies the three stages of the life cycle and summarises the existing approaches taking into account the new ageing paradigm. Conclusions. A paradigm is a way of perceiving the reality and viewing it as a new norm, which should be controlled, whenever possible. By controlling successful ageing through studying the content, specifics, and dynamics of the stages of the life cycle, we can extend the effective working stage of the human life cycle and ensure a good balance between effective work and private life, which over the years is filled with new sense and new difficulties. I.e. A phenomenon we could call a “sandwich effect”. The scientific approach to the problem allowed us to study both the theoretical basis of successful ageing and the practical side involving the healthcare system, the employer, and the employee.


2009 ◽  
Vol 21 (2) ◽  
pp. 372-389 ◽  
Author(s):  
Grégoria Kalpouzos ◽  
Gaël Chételat ◽  
Brigitte Landeau ◽  
Patrice Clochon ◽  
Fausto Viader ◽  
...  

This study set out to establish the relationship between changes in episodic memory retrieval in normal aging on the one hand and gray matter volume and 18FDG uptake on the other. Structural MRI, resting-state 18FDG-PET, and an episodic memory task manipulating the depth of encoding and the retention interval were administered to 46 healthy subjects divided into three groups according to their age (young, middle-aged, and elderly adults). Memory decline was found not to be linear in the course of normal aging: Whatever the retention interval, the retrieval of shallowly encoded words was impaired in both the middle-aged and the elderly, whereas the retrieval of deeply encoded words only declined in the elderly. In middle-aged and elderly subjects, the reduced performance in the shallow encoding condition was mainly related to posterior mediotemporal volume and metabolism. By contrast, the impaired retrieval of deeply encoded words in the elderly group was mainly related to frontal and parietal regions, suggesting the adoption of inefficient strategic processes.


2020 ◽  
Vol 4 (5) ◽  
pp. 449-452
Author(s):  
Alan MacLeod ◽  
Nicola Spence

COVID 19 has raised the profile of biosecurity. However, biosecurity is not only about protecting human life. This issue brings together mini-reviews examining recent developments and thinking around some of the tools, behaviours and concepts around biosecurity. They illustrate the multi-disciplinary nature of the subject, demonstrating the interface between research and policy. Biosecurity practices aim to prevent the spread of harmful organisms; recognising that 2020 is the International Year of Plant Health, several focus on plant biosecurity although invasive species and animal health concerns are also captured. The reviews show progress in developing early warning systems and that plant protection organisations are increasingly using tools that compare multiple pest threats to prioritise responses. The bespoke modelling of threats can inform risk management responses and synergies between meteorology and biosecurity provide opportunities for increased collaboration. There is scope to develop more generic models, increasing their accessibility to policy makers. Recent research can improve pest surveillance programs accounting for real-world constraints. Social science examining individual farmer behaviours has informed biosecurity policy; taking a broader socio-cultural approach to better understand farming networks has the potential to change behaviours in a new way. When encouraging public recreationists to adopt positive biosecurity behaviours communications must align with their values. Bringing together the human, animal, plant and environmental health sectors to address biosecurity risks in a common and systematic manner within the One Biosecurity concept can be achieved through multi-disciplinary working involving the life, physical and social sciences with the support of legislative bodies and the public.


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