PRP application in dermatology: review of current approaches

2021 ◽  
pp. 55-58
Author(s):  
V. V. Bondarenko
Keyword(s):  
Growth Factors ◽  
Blood Plasma ◽  
Tissue Repair ◽  
Skin Diseases ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Biologically Active ◽  
Tissue Repair And Regeneration ◽  
Positive Results ◽  
Active Substances

In recent years, the possibilities of a dermatologist in the treatment of patients with chronic dermatoses have significantly expanded due to the emergence of new highly effective methods, such as autologous blood plasma enriched with platelet-rich-growth factors (platelet-rich-plasma, PRP). The positive results of using this technology due to its constituent growth factors, cytokines and other biologically active substances, which have a pronounced normalizing effect on the processes of tissue repair and regeneration, expands the possibilities of its use in such skin diseases as erosive and ulcerative lichen planus, scleroatrophic lichen, acne and post-acne. The aim of this review was to analyze the literature on the mechanisms of PRP action in patients with dermatological diseases.

scholarly journals A boomy century of periodontal regeneration with biological mediators

2021 ◽  
Vol 7 (3) ◽  
pp. 103-117
Author(s):  
Deepak Grover ◽  
Navneet Kaur ◽  
Gurpreet Kaur
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Periodontal Regeneration ◽  
Transforming Growth Factor Β ◽  
Tissue Repair And Regeneration ◽  
Plasma Fraction

With the advanced and improved knowledge of bone regeneration on the molecular level, some of key molecules that alter the complicated physiological method were identified, and are already in scientific use or beneath research to enhance bone restore. Of those molecules, BMPs were the maximum considerably studied, as they are robust osteoinductive elements. They result in the mitogenesis of mesenchymal stem cells (MSCs) and different osteoprogenitors, and their differentiation in the direction of osteoblasts. Other growth factors except BMPs which have been implicated through out the bone regeneration, with one-of-a-kind features with respect of cell proliferation, chemotaxis and angiogenesis, are also being investigated or are presently getting used to reinforce bone restore, which include platelet-derived growth factor, transforming growth factor- β, insulin-like growth factor-1, vascular endothelial growth factor and fibroblast growth factor, amongst others. One present day technique to enhance bone regeneration and soft-tissue recovery with the aid of using nearby application of growth factors is the use of platelet-rich plasma, an extent of the plasma fraction of autologous blood with platelet concentrations above baseline, that is wealthy in most of the aforementioned molecules. This overview focuses and target on the biological mediators that regulates key cellular events which have a capacity to induce the method of tissue repair and regeneration.

scholarly journals Role of Growth Factors-rich Plasma (Activated Platelet-rich Plasma) in Androgenic Alopecia: Literature Review and Suggested Treatment Protocol

2021 ◽  
Vol 3 (1) ◽  
pp. 16-23
Author(s):  
Sheher Bano ◽  
Tariq Mehmood Dar
Keyword(s):  
Growth Factors ◽  
Cosmetic Surgery ◽  
Platelet Rich Plasma ◽  
Standard Procedure ◽  
Treatment Protocol ◽  
Biologically Active ◽  
Attractive Alternative ◽  
Androgenic Alopecia ◽  
Tissue Repair And Regeneration

Androgenetic alopecia (AGA) has become a prevalent hair fall dysfunction due to genetic as well as hormonal effects distinguished by androgen-related gradual weakening of the scalp hair with a sequence. Around turn 60, 45 percent of males and 35 percent of females come down with AGA. Owing to the small number of successful AGA therapies, Platelet-rich Plasma (PRP) has been an attractive alternative therapeutic approach. Platelet-rich plasma (PRP) is being proposed for the incorporation of greater levels of growth factors and certain other biologically active substances in wounded lesions to achieve the specific healing objectives. PRP is already being included in dentistry and cosmetic surgery for about four decades. Even the usefulness of this autologous substance in both these fields seems to be well known. Notably, in treating different cosmetic procedures, PRP is already progressively seen because its high constituents of platelet-derived growth factors and cytokines may improve the biochemical mechanisms correlated with tissue repair and regeneration. After activation, platelets within the PRP secrete various growth factors that exhibit the results of hair regeneration. However, PRP may be prepared with different protocols and procedures. Differences could influence the character and possible effectiveness of the end PRP product in the availability of RBCs and WBCs, the introduction of thrombin or calcium chloride to trigger fibrin initiation, and pH-altering substances. A standard procedure for PRP preparation and application and a framework to assess results have not been developed, though many research works have been published. Thereby, the subsequent research article presents a proposed treatment protocol for AGA by platelets-rich plasma (PRP), which has been confirmed after reviewing different studies performed by researchers that exhibit PRP's efficacy in AGA.

scholarly journals ROLE OF PLATELET RICH PLASMA IN TREATMENT OF CHRONIC NON-HEALING VENOUS ULCER

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Firdaus A. Dekhaiya ◽  
Jignesh K. Joshi ◽  
Sarav Bamania
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Healing Process ◽  
Venous Ulcer ◽  
Lower Limbs ◽  
Venous Ulcers ◽  
Autologous Platelet Rich Plasma ◽  
Adhesive Proteins ◽  
Autologous Platelet

Introduction: Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the lower limbs. Considering that PRP is a source of growth factors, and consequently has mitogenic, angiogenic, and chemotactic properties, it represents an adjunctive treatment for recalcitrant wounds. Moreover, PRP provides the wound with adhesive proteins, such as fibrinogen, which are important in wound healing. PRP contain more amount of platelets, cytokines and growth factors which are dispersed in a very small amount of plasma which can be prepared from a sample of centrifuged autologous blood. Application of PRP has been reported to be effective in both acute as well as chronic non healing venous ulcers. Aim and Objective: To evaluate the efficacy of autologous platelet rich plasma in the management of chronic venous ulcer. Material and Method: A Prospective study conducted on 100 patients of chronic venous ulcers admitted in Sir T. Hospital Bhavnagar from June 2018 to June 2019 after fulfilled our inclusion and exclusion criteria. PRP then injected intalesionally inside and around the periphery of the wound/ulcer. This process was done once/week for 12 weeks. At every week, the area and volume of ulcer was calculated and photographs were taken. Result: All the patients showed healing of the ulcer with reduction in size of ulcer more than 90% was observed in 72 patients, followed by 80–90% reduction in wound size in 18 patients after the 12 weeks follow-up. Overall, significant reduction in size of ulcer was observed in all the treated patients. Conclusion: Autologous platelet rich plasma (PRP) as an autologous method, it is biocompatible, simple, safe, affordable and less expensive procedure in the treatment of chronic venous ulcers. PRP is found to be useful in improving and enhancing the healing process in chronic venous leg ulcers without any side effect. Keywords:  Venous ulcer, Platelet rich plasma

Platelets, inflammation and tissue regeneration

2011 ◽  
Vol 105 (S 06) ◽  
pp. S13-S33 ◽  
Author(s):  
Alan Nurden
Keyword(s):  
Skin Diseases ◽  
Platelet Rich Plasma ◽  
Blood Platelets ◽  
Blood Stream ◽  
Cellular Growth ◽  
Biologically Active ◽  
Wide Range ◽  
The Central Nervous System ◽  
Membrane Budding ◽  
And Function

SummaryBlood platelets have long been recognised to bring about primary haemostasis with deficiencies in platelet production and function manifesting in bleeding while upregulated function favourises arterial thrombosis. Yet increasing evidence indicates that platelets fulfil a much wider role in health and disease. First, they store and release a wide range of biologically active substances including the panoply of growth factors, chemokines and cytokines released from α-granules. Membrane budding gives rise to microparticles (MPs), another active participant within the blood stream. Platelets are essential for the innate immune response and combat infection (viruses, bacteria, micro-organisms). They help maintain and modulate inflammation and are a major source of pro-inflammatory molecules (e.g. P-selectin, tissue factor, CD40L, metalloproteinases). As well as promoting coagulation, they are active in fibrinolysis; wound healing, angiogenesis and bone formation as well as in maternal tissue and foetal vascular remodelling. Activated platelets and MPs intervene in the propagation of major diseases. They are major players in atherosclerosis and related diseases, pathologies of the central nervous system (Alzheimers disease, multiple sclerosis), cancer and tumour growth. They participate in other tissue-related acquired pathologies such as skin diseases and allergy, rheumatoid arthritis, liver disease; while, paradoxically, autologous platelet-rich plasma and platelet releasate are being used as an aid to promote tissue repair and cellular growth. The above mentioned roles of platelets are now discussed.

Biologically Active Blood Plasma-Based Biomaterials as a New Paradigm for Tissue Repair Therapies

2013 ◽  
Vol 1 (3) ◽  
pp. 127-137 ◽  
Author(s):  
Jason D. Smith ◽  
Lee E. Weiss ◽  
James E. Burgess ◽  
Alan I. West ◽  
Phil G. Campbell
Keyword(s):  
Blood Plasma ◽  
Tissue Repair ◽  
Biologically Active ◽  
New Paradigm

Platelets – an important element of the immune system

2013 ◽  
Vol 16 (2) ◽  
pp. 407-413 ◽  
Author(s):  
A. Trzeciak-Ryczek ◽  
B. Tokarz-Deptuła ◽  
W. Deptuła
Keyword(s):  
Endothelial Cells ◽  
Growth Factors ◽  
Immune System ◽  
Inflammatory Response ◽  
Immunological Response ◽  
Biologically Active ◽  
Effector Cells ◽  
Cytokines And Chemokines ◽  
Active Substances ◽  
Monocytes And Lymphocytes

Abstract Platelets are anucleate cells derived from the megakaryocyte series, and have long been considered only as cells responsible for coagulation and the fibrinolysis process. However, recently more data shows that they are also effector cells in the inflammatory response and important elements of the immunological response. Platelets store and release many biologically active substances, including growth factors, cytokines and chemokines (tab. 1), which actively affect i.a. elements of the immune system, and thus become regulators of immunity and mediators of inflammatory response. Their impact on the immune system cells is also associated with the induction of leucocytes and progenitor cells to the site of pathogen permeation or vascular injury inflow, as well as endothelial cells. Interacting with neutrophils, monocytes and lymphocytes, they not only activate them, but also form platelet-leukocyte aggregates that immobilise pathogens and prevent their spreading. Furthermore, platelets are capable of absorbing pathogens, affecting anti-infection immunity of the system. It is also assumed that the presence of receptors on their surface, such as Toll-like receptors (TLRs), affects their initiation and activity of the immunological response.

scholarly journals Research of biologically active compounds of catalpa (Catalpa bignonioides Walt.)

2020 ◽  
pp. 52-58
Author(s):  
O. V. Demeshko ◽  
S. V. Romanova ◽  
V. V. Kovalyov ◽  
I. I. Batiuchenko
Keyword(s):  
Acetic Acid ◽  
Phenolic Compounds ◽  
Chromatographic Analysis ◽  
Skin Diseases ◽  
Biologically Active Compounds ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Compounds ◽  
Chromatographic Paper ◽  
Active Substances

Catalpa bignonioides Walt. (catalpa) the family Bignoniaceae – a tree, which originates from North America. Catalpa bark contains resins and tannins. Monoterpene glycosides were found in the leaf. Catalpa seeds contain up to 30% of eleostearic acid. Decoctions are made of the bark of the tree. They serve as a gastric agent and have an anthelmintic effect. Decoction of the bark exhibits bronchodilator action, is used in the complex treatment of cancer. The leaves are used to treat skin diseases. The infusion of fruits has anti-herpetic and hypoglycemic properties. The aim of the work is to investigate biologically active compounds of the leaves of catalpa bignini. The object of the study was the leaves of common catalpa harvested in the summer of 2018 in Sevastopol. Chemical identification reactions and methods of chromatographic analysis were used to determine the major groups of biologically active substances of the leaves of the catalpa (chromatographic paper Filtrak FN No. 4, Munktell, Czech Republic). Chromatography was performed in pre-selected solvent systems: n-butanol‒acetic acid‒water (BAW) (4:1:2) ‒ I direction and 15% acetic acid ‒ II direction. Identification reactions were performed with aqueous and aqueous-alcoholic extracts of catalpa leaves. The qualitative composition of the phenolic compounds was investigated by paper chromatography. The content of the sum of phenolic compounds, hydroxycyclic acids and flavonoids was determined by the spectrophotometric method. Based on the held reactions and chromatographic analysis, by the characteristic fluorescence in the filtered UV light before and after treatment with chromogenic reagents and the values of Rf in the raw material the presence of the following groups of biologically active substances were determined: flavonoids, phenol glycosides, hydroxycoric acids. According to the chromatographic analysis, at least 9 substances of phenolic nature have been detected in the alcohol-aqueous extracts. For the first time, the presence of the following groups of biologically active substances: hydroxycoric acids, phenologic glycosides, flavonoids was determined in the leaves of catalpa. Quantitative content of natural compounds in the leaves of common catalpa: the sum of phenolic compounds (4,76 ± 0,04%), of hydroxycoric acids (3,42 ± 0,02%), of flavonoids (1,88 ± 0,02%). The results of the study will be used in the development of the draft quality control methods for medicinal plant raw materials.

STUDY OF WOUND-HEALING EFFECTS OF EXTRACTS OF CERTAIN PLANTS OF THE ARID ZONE

2021 ◽  
Vol 1 (3) ◽  
pp. 335-342
Author(s):  
A.S. Baimukhambetova ◽  
◽  
M.A. Egorov ◽  
A.K. Azhikova ◽  
D.K. Magzanova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plant Species ◽  
Tissue Repair ◽  
Arid Zone ◽  
Glycyrrhiza Glabra ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
White Rats ◽  
Glycyrrhiza Glabra L ◽  
Active Substances

In an experiment on white rats, the regenerating effect of biologically active substances of plant species growing in the Astrakhan region was shown: Achillea micrantha Willd., Helichrysum arenarium, Glycyrrhiza glabra L., Helichrysum nogaicum Tzvel. The article presents data from planimetric studies of damaged skin. The results obtained make it possible to consider extracts as the basis of tissue repair stimulants, as well as to recommend them as anti-inflammatory and wound healing agents.

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