scholarly journals APPENDECTOMY IN THE TIMES OF COVID-19: COMPARATIVE STUDY OF TWO GROUPS OF PATIENTS BETWEEN SIMILAR PERIODS OF TIME - 2019 VS 2020

2020 ◽  
Vol 2 (1) ◽  
pp. 6-11
Author(s):  
C. Ungureanu ◽  
R. Mirică ◽  
R. Iosifescu ◽  
M. Zamfir ◽  
M. Mardare ◽  
...  

Acute pathology of the cecal appendix - appendicitis, is a condition that does not take into account the pandemic period. The aim of this study is to retrospectively analyze the relationship of care for two groups of patients who underwent appendectomy in COVID-19 period and one year before, same period of time, in emergency hospital service. We performed a retrospective analysis on the patients admitted in our surgery center by comparing two groups for each period analysed: group A, for the period March-May 2019 and group B for the period March-May 2020 (corresponding to COVID-19 pandemic). We compared the groups analysing features that prove the change in age, incidence, grade (severity) of appendicitis, delay of surgery, length of surgery, postoperative complications and hospitalization time. CT scan was made for each patient. In the group B, PCR COVID-19 testing was made (all patients were negative for COVID-19). Our study consisted of 52 patients, group A-32 patients (61.53%) and group B-22 patients (38.47%). The Covid-19 pandemic influenced the incidence of appendicitis and we noted a delayed presentation which led to more complicated appendicitis than same period of the previous year. The impact also was noted on length of surgery, due to use of PPE (personal protective equipment) and also modified anatomy of the region related to inflammation. The severity of appendicitis was higher in the COVID-19 period when compared to 2019 similar period of time. Further research is required to draw more conclusions on this period.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15650-e15650
Author(s):  
Kehe Chen ◽  
Haiming Wei ◽  
Tianqi Liu ◽  
Zhenxiang Chen ◽  
Deng Pan ◽  
...  

e15650 Background: Hepatocellular carcinoma (HCC) is one of the most common prevalent fatal cancers worldwide with poor prognosis due to high incidence of recurrence. For patients with HCC, surgical treatment is a potentially cutative therapy. However, the puzzle in the therapy was the rapid recurrence after surgery. The purpose of this study was to integrate the impact of different immune context present in HCC microenvironment on patients’ prognosis, provide the molecular prediction clue of HCC recurrence. Methods: RNA targeted sequencing was performed on 12 primary tumor specimens from HCC patients. Transcripts of 395 immune related genes expressed in FFPE tumor samples were analyzed. The lima package was used to analyze the different expressed genes (DEGs) between patients with different prognosis. The gene set variance analysis (GSVA) analysis was performed to explore gene sets enrichment related to the recurrence post-resection. Results: 15 DEGs were detected in tissue samples between the two groups (group A: patients who relapsed within one year after surgery; group B: patients who hadn't relapsed beyond two years after surgery). The Antigen processing pathway enrichment may associate with the favorable prognosis (p < 0.05). HLA-A gene expression in group A was lower than that in group B; The gene expression of IL23A, TP63, ALOX15B, BUB1, CXCR2, CCL20, CLEC4C, PTK7, MPO, IL1B, MMP9, GAGE2C, GAGE2A, GAGE2E, DMBT1, FOXM1 in group A was higher than that in group B. Additionally, the combination of 3 genes (TP63, IL23A and BUB1) can distinguish the patients recurrent within 1 year or beyond 2 years post-resection. The joint diagnostic equation is logit (Y = 1) = 0.073 +0.740 *(TP63) + 0.589 * (IL23A)+0.959(BUB1), (Optimal threshold: 0.667, specificity: 1, sensitivity: 0.833). Conclusions: Our results suggest that RNA-seq of immune related genes from FFPE sample can effectively profile the specific landscape of tumor immune microenvironment and predict the survival of HCC. 3 genes’ expression (TP63, IL23A and BUB1) might correlate with recurrence in HCC patients after surgery.


2014 ◽  
Vol 919-921 ◽  
pp. 820-823
Author(s):  
Xi Rong Wu ◽  
Li Li Zhu

Selection of five typical loess in Shanxi Province, the paper adopt the indoor test methods to prepares the different compaction and different moisture content specimens which were used to test CBR value and rebound module, analyzes the impact of compactness and moisture content on the CBR value and resilient modulus and establishes the relationship of CBR and moisture content. The result shows that the level of moisture content has great impact on CBR value and rebound module. The CBR value is maximal under optimum moisture content and maximum degree of compaction condition. The times of compaction have little effect on the improvement of CBR with increasing water content. The relationship of the soaking CBR,resilient modulus and the moisture content shows a certain regularity.Key words: Loess filler;the CBR;resilient modulus;compactness;moisture content;relationship


Author(s):  
Kirollos Wagdy Bandry ◽  
Hisham Abou-Taleb ◽  
Gehan S. Seifeldein ◽  
Mohamad Gaber Taha ◽  
Omran Khodary Qenawy

Abstract Background Postmenstrual spotting has recently been related to a discontinuation of the myometrium at the site of a previous cesarean section called "CS scar niche". There was no consensus regarding the gold standard method for the assessment of the niche. Recently, Magnetic resonance imaging (MRI) has shown promise in the evaluation of the niche. Our study aims to assess the role of MRI in the evaluation of the CS scar niche characters and its association with post-menstrual spotting. Results A total of 65 patients with CS niche were prospectively included in this study and subdivided into two groups, according to presence or absence of postmenstrual spotting (Group A; 34 patients with postmenstrual spotting and Group B; 31 patients without spotting). All patients were examined using a 1.5 T MRI unit. CS scar niche volume was significantly higher among women with post-menstrual spotting (0.57 ± 0.07 vs. 0.07 ± 0.05 (cm3); P < 0.001). Also, women with post-menstrual spotting have significantly higher scar length (9.38 ± 3.06 vs. 5.02 ± 2.10 (mm); P < 0.001), scar depth (6.95 ± 3.16 vs. 3.23 ± 0.99 (mm); P < 0.001), scar width (15.78 ± 3.94 vs. 9.87 ± 1.84 (mm); P < 0.001) in comparison to those without post-menstrual spotting. Scar depth (> 7.4 mm) had 81% sensitivity and 97% specificity for prediction of post-menstrual spotting with overall accuracy was 88.7%. While scar width (> 12.8 mm) had 71% sensitivity and 97% specificity for prediction of post-menstrual spotting with overall accuracy was 83.3%. Scar volume (> 0.15 cm3) had 97% sensitivity and 100% specificity for prediction of post-menstrual spotting with overall accuracy was 98.4%. Conclusion MRI measures (CS scar volume, depth, and width) are predictors for postmenstrual spotting in patients with CS scar niche, and scar volume is the most powerful predictor.


2014 ◽  
Vol 2 (1) ◽  
pp. 41-50
Author(s):  
Mohammad Ali Arab Zouzani

This study was conducted in to investigate the relationship of cohesive chains and chain interaction to the coherence of texts. To do this, the following procedure was followed. First, 95 EFL students were asked to write a composition on a particular topic. These texts were scored by three experienced raters based on their perceived degree of coherence. The texts were then ordered from high to low. Thirty high-rated texts were labeled as group A, and thirty low-rated texts were labeled as group B. These texts were analyzed for the presence and frequency of cohesive chain and chain interaction based on the model proposed by Hassan (1989). After collecting the data and statistically analyzing them, the results showed that the texts getting higher coherence scores had a higher proportion of relevant tokens to peripheral ones and a higher proportion of central tokens to non-central ones in comparison to the low-rated texts. Therefore, cohesive chain and chain interaction can be used as an indicator of coherence and has pedagogical and theoretical implications.  


2020 ◽  
Vol 16 (3) ◽  
pp. 291-302
Author(s):  
Jingyan Song ◽  
Tianqi Wang ◽  
Jiayin Guo ◽  
Ying Guo ◽  
Xiaoming Wang ◽  
...  

Background: The complexity of follicular fluid metabolome presents a huge challenge for qualitative and quantitative metabolite profiling and discovery of the comprehensive biomarkers. Objective: In order to address this challenge, novel SWATHtoMRM metabolomics method was used for providing broad coverage and excellent quantitative capability to discover the human follicular fluid metabolites related to age and evaluate their relationship with pregnancy outcome and oocyte senescence. Methods: The patients were divided into four groups according to age, including group A (28 cases, 21- 27 years old), group B (42 cases, 28-34 years old), group C (31 cases, 35-41 years old), and group D (24 cases, 42-48 years old). Follicular fluid samples from 125 IVF patients were analyzed. The differential ions among the four groups were identified by principal components analysis according to accurate mass, isotope ratio, and tandem mass spectroscopic spectra. Then, the differential metabolic pathways were further identified by a KEGG cluster analysis. Results: A total of 18 metabolites in the follicular fluid differed among the four groups, including amino acids, lipids, hormones, and vitamins. A total of 15 metabolites, including 6-oxohexanoate, phenylalanine, proline, hexadecanoic acid, linoleate, arachidonate, oleic acid, docosahexaenoic acid, LysoPC(16:1), LysoPC(20:5), LysoPC (20:3), 25-hydroxyvitamin D3, 5-dehydroepisterol, 27- hydroxycholesterol, and 5beta-cholestane-3alpha,7alpha,12alpha,23,25-pentol, were down-regulated with age and 3 metabolites, including LysoPC(18:3), LysoPC(18:1), and 13,14-dihydroretinol, were upregulated with age. Conclusion: Our study provides useful information for revealing the relationship between age and female reproductive capability.


2017 ◽  
Vol 8 (2) ◽  
pp. 101
Author(s):  
Manssour Ras'n M. Habbash

Electronic reference tools viz. dictionaries, wikis, explorers, translators etc. tender a great support to the EFL learners in understanding different aspects of the lexical, syntactical, phonological and semantic complexities. In view of the usefulness of online reference tools, it is hypothesized that extensive use of the tools in classrooms expedites the acquisition of the language. In an effort to establish the correlation between the effective use of the tools and the acquisition of English as a foreign language, it is proposed to take up a study that aims at finding out the impact of using Electronic reference tools in EFL classrooms. The study was conducted with two groups of learners of English as a foreign language who completed their yearlong English language course that is mandatory for continuing their bachelors’ course. By using purposive sampling method the participants of the study were selected and were divided into group A and group B based on the levels of success in their acquisition of English required for continuing their bachelor’s courses. The levels of success were determined based on a diagnostic test conducted at the end of their one-year English language program, and graded in light of the Interagency Language Round Table Scale (ILRS). The students who obtained ILRS +3 level and above in the test were included in group A, and the students who obtained below ILRS 3 level are included in group B. The final sample of the students in both the groups were provided with a questionnaire of Likert scale that is followed by face-to-face interviews. By employing mixed method model of research, the correlation between their use of online reference tools and their level of success in learning the language were established. The results show a positive correlation that confirms the use of online and electronic reference tools is an essential learning strategy both within and out of the classroom learning as well as for expediting the learning process. 


2020 ◽  
Vol 81 (05) ◽  
pp. 387-391
Author(s):  
Nikhil Jain ◽  
Shankar Acharya ◽  
Nitin Maruti Adsul ◽  
Mukesh Kumar Haritwal ◽  
Manoj Kumar ◽  
...  

Abstract Background Although spinal canal narrowing is thought to be the defining feature for the clinical diagnosis of lumbar canal stenosis, the degree of spinal canal stenosis necessary to elicit neurologic symptoms is not clear. Several studies have been performed to detect an association between a narrow spinal canal and clinical symptoms. Through our prospective study, we compared the radiologic criteria with the clinical criteria using the Oswestry Disability Index (ODI) and assessed how they correlate. Materials and Methods We used the qualitative grading (morphological classification system on magnetic resonance imaging [MRI]) system, dural sac cross-sectional area (DSCA), and sedimentation sign on MRI images and compared them with the Self-Paced Walking Ability (Self-Paced Walking Test) and ODI of the patients in the study. The systems were applied to 85 patients divided into three groups: group A: 43 patients with neurogenic claudication and able to walk < 30 minutes; group B: 11 patients with neurogenic claudication and able to walk > 30 minutes; and group C: 31 patients with simple back pain and no signs of neurologic claudication. Results The mean ODI was 21.19 in group C, 46.50 in group B, and 61.95 in group A. The difference was statistically significant. The mean DSCA was 164.42 mm2 in group C, 49.94 mm2 in group B, and 35.07 mm2 in group A. The difference was statistically significant. The sedimentation sign was negative in 96.8% patients in group C, 54.5% patients in group B, and 32.6% patients in group A. The difference was statistically significant. Group C had 9.3% patients in morphology grade A3, 51.6% in grade A2, and 38.7% patients in grade A1. Group B had 63.6% patients in grade C, 18.2% patients in grade B, 9.1% in grade A4, and 9.1% in grade A3. Group A had 18.6% patients in grade D, 39.5% in grade C, 27.9% in grade B, 11.6% in grade A4, and 2.3% in grade A3. The mean DSCA of group C was significantly different from group A and group B, but the difference of the mean DSCA between group A and group B was not statistically significant. The relationship of ODI to DSCA, ODI to sedimentation sign, and ODI to morphological grading for group C and group A was not statistically significant. The relationship of morphological grading to DSCA was statistically significant for all three groups. Conclusion DSCA, morphological grading, and sedimentation sign are good to excellent radiologic indicators differentiating patients with simple back pain from those with lumbar spinal stenosis. Clinically, ODI is an excellent indicator of the severity of stenosis. But ODI statistically has no significant correlation to any of these radiologic parameters.


2020 ◽  
Vol 10 (3) ◽  
pp. 68 ◽  
Author(s):  
Alla Belousova ◽  
Yulia Mochalova

The thinking of a manager is conditioned by their motivational features which determine their personal professional success and the effectiveness of the organization’s activities. In this study, we assumed that two groups of sales and advertising managers had differences in the relationships between thinking style and their motivational qualities, as well as their individual need for achievement. We used the following sources: The methodology of A. Belousova for the diagnosis of thinking styles, the “scale of control over action” by J. Kuhl, and “the need for achievement” by Yu.A. Orlov. The selection consisted of 61 people, 25 to 30 years of age, of which 41 were men and 20 were women, from organizations engaged in the sale of a technical group of goods (also known as Group A) and advertising services (also known as Group B), in Rostov-on-Don. The Spearman rank correlation method was used for quantitative data processing. In group Group A, the analysis showed the presence of statistically significant connections. A critical style of thinking has a significant relationship with the level of clarity about the need for achievements and practical thinking is statistically significantly interrelated with control over action in a situation of failure. Whereas, in Group B, an initiative, managerial, and practical style of thinking has a significant correlation with the need for achievement.


2020 ◽  
Author(s):  
YUEPING LI ◽  
Juan Ding ◽  
Wei Zhang

Abstract Purpose: To investigate the improvement of binocular summation (BiS) for the high (100%) contrast and different low contrasts (10%, 5%, 2.5%) and the relationship of BiS with stereopsis and central fusion in patients with intermittent exotropia (IXT) after strabismic surgeries.Design: Prospective studyParticipants: Seventy-six patients with IXT aging 9 to 40 years with poor control at distance before strabismus surgeries. Methods: To analyze preoperative and postoperative BiS records and the proportions of patients with different BiS for the high (100%) contrast and the low contrasts (10%, 5%, 2.5%). The score of visual acuity (log Mar) was recorded when patient recognizing the full line with full refraction correction. BiS was classified into three situations depending on whether binocular visual acuity (BVA) was better, worse or equal to that of the better-seeing eye . The results of distant random dots stereograph(RDS) were grouped into A, unable to recognize; B, moderate, 200”≤RDS≤400” and C, good, RDS<200”.Results: The patients with binocular summation were increased from 9.2% to 40.8% for 100%contrast, from 17.1% to 53.9% for 10% contrast, from 21.1% to 76.1% for 5% contrast, from 21.1% to 72.4% for 2.5% contrast after surgeries, respectively. Tested using 2.5% contrast, (1) more patients presented binocular summation in the groups B and C ; (2) postoperative improvements of BVA in group B(1.5±1.03 lines) and group C (1.57±1.26 lines) differed significantly with that in the group A (0.74±1.00 line); (3)more patients presented binocular summation and the improvement of BVA was 1.43±1.16 lines in the group with central fusion after surgeries.Conclusions: BiS for high contrast and different low contrasts can be improved in IXT after successful surgical treatment. It may be associated with obtaining central fusion, recovering stereopsis at distance and good alignment after the surgeries. BiS for 2.5% contrast was improved significantly and sensitive to the good stereopsis and central fusion. Improvement of BiS, particularly for low contrast, has benefit for the daily activities in the real environment. BiS could be as supplementary assessment of binocular function for the patients with IXT before and after treatment.


2014 ◽  
Vol 41 (5) ◽  
pp. 341-344 ◽  
Author(s):  
Thiago de Paula Bon ◽  
Patrícia Frascari ◽  
Marcos de Assis Moura ◽  
Marcus Vinicius Dantas de Campos Martins

Objective: To retrospectively analyze the relationship of time of care, combined with possible post-appendectomy complications, with the promptness of transfer of patients seen in Emergency Care Units (UPA) to the emergency hospital.Methods: We analyzed patients with preoperative diagnosis of acute appendicitis undergoing appendectomy from January to July 2012. Patients were divided into two groups according to the site of the first care. Group A included patients who received initial care directly in the emergency department of the Lourenço Jorge County Hospital (HMLJ) and group B consisted of patients seen in the UPA and forwarded to HMLJ to undergo surgical treatment.Results: the average time between initial treatment and surgery in group A was 29 hours (SD = 21.95) and 54 hours in group B (SD = 54.5). Considering the onset of symptoms, the patients in group A were operated on average 67 hours after (SD = 42.55), while group B, 90 hours (SD = 59.58). After the operation, patients in group A were hospitalized, on average, for 94 hours (SD = 73.53) and group B, 129 hours (SD = 193.42).Conclusion: there was no significant difference in the time elapsed between the onset of symptoms, initial treatment and early surgical treatment, or time elapsed between surgery and discharge.


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