scholarly journals IGFBP-2 Signaling in the Brain: From Brain Development to Higher Order Brain Functions

2019 ◽  
Vol 10 ◽  
Author(s):  
Shumsuzzaman Khan
Keyword(s):  
Brain Development ◽  
Higher Order ◽  
Brain Functions ◽  
The Brain

scholarly journals Evolutionary modifications in human brain connectivity associated with schizophrenia

Brain ◽  
2019 ◽  
Vol 142 (12) ◽  
pp. 3991-4002 ◽  
Author(s):  
Martijn P van den Heuvel ◽  
Lianne H Scholtens ◽  
Siemon C de Lange ◽  
Rory Pijnenburg ◽  
Wiepke Cahn ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Connectivity ◽  
Brain Evolution ◽  
Higher Order ◽  
Brain Functions ◽  
Human Brain Evolution ◽  
The Brain

See Vértes and Seidlitz (doi:10.1093/brain/awz353) for a scientific commentary on this article. Is schizophrenia a by-product of human brain evolution? By comparing the human and chimpanzee connectomes, van den Heuvel et al. demonstrate that connections unique to the human brain show greater involvement in schizophrenia pathology. Modifications in service of higher-order brain functions may have rendered the brain more vulnerable to dysfunction.

Dissecting the regional diversity of glial cells by applying -omic technologies

e-Neuroforum ◽  
2015 ◽  
Vol 21 (3) ◽  
Author(s):  
Daniela C. Dieterich ◽  
Moritz J. Rossner
Keyword(s):  
Glial Cells ◽  
Brain Function ◽  
Recent Progress ◽  
Higher Order ◽  
Cell Populations ◽  
Cellular Activity ◽  
Regional Diversity ◽  
Brain Functions ◽  
Exploratory Approach ◽  
The Brain

AbstractNeuronal as well as glial cells contribute to higher order brain functions. Many observations show that neurons and glial cells are not only physically highly intermingled but are physiologically tightly connected and mutually depend at various levels on each other. Moreover, macroglia classes like astrocytes, NG2 cells and oligodendrocytes are not at all homogenous cell populations but do possess a markedly heterogeneity in various aspects similar to neurons. The diversity of differences in morphology, functionality and, cellular activity has been acknowledged recently and will be integrated into a concept of brain function that pictures a neural rather than a puristical neuronal world. With the recent progress in “omic” technologies, an unbiased and exploratory approach toward an enhanced understanding of glial heterogeneity has become possible. Here, we provide an overview on current technical transcriptomic and proteomic approaches used to dissect glial heterogeneity of the brain.

TEORI KECERDASAN, PENDIDIKAN ANAK, DAN KOMUNIKASI DALAM KELUARGA

1970 ◽  
Vol 6 (1) ◽  
Author(s):  
Muskinul Fuad
Keyword(s):  
Multiple Intelligences ◽  
Educational Activity ◽  
Howard Gardner ◽  
Human Beings ◽  
Brain Functions ◽  
Starting Point ◽  
The Family ◽  
Education Today ◽  
The Brain ◽  
Spatial Logics

The education system in Indonesia emphasize on academic intelligence, whichincludes only two or three aspects, more than on the other aspects of intelligence. For thatreason, many children who are not good at academic intelligence, but have good potentials inother aspects of intelligence, do not develop optimally. They are often considered and labeledas "stupid children" by the existing system. This phenomenon is on the contrary to the theoryof multiple intelligences proposed by Howard Gardner, who argues that intelligence is theability to solve various problems in life and produce products or services that are useful invarious aspects of life.Human intelligence is a combination of various general and specific abilities. Thistheory is different from the concept of IQ (intelligence quotient) that involves only languageskills, mathematical, and spatial logics. According to Gardner, there are nine aspects ofintelligence and its potential indicators to be developed by each child born without a braindefect. What Gardner suggested can be considered as a starting point to a perspective thatevery child has a unique individual intelligence. Parents have to treat and educate theirchildren proportionally and equitably. This treatment will lead to a pattern of education that isfriendly to the brain and to the plurality of children’s potential.More than the above points, the notion that multiple intelligences do not just comefrom the brain needs to be followed. Humans actually have different immaterial (spiritual)aspects that do not refer to brain functions. The belief in spiritual aspects and its potentialsmeans that human beings have various capacities and they differ from physical capacities.This is what needs to be addressed from the perspective of education today. The philosophyand perspective on education of the educators, education stakeholders, and especially parents,are the first major issue to be addressed. With this step, every educational activity andcommunication within the family is expected to develop every aspect of children'sintelligence, especially the spiritual intelligence.

scholarly journals (Ascorb)ing Pb Neurotoxicity in the Developing Brain

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1311
Author(s):  
Faraz Ahmad ◽  
Ping Liu
Keyword(s):  
Ascorbic Acid ◽  
Animal Studies ◽  
Redox Homeostasis ◽  
Special Role ◽  
Developmental Exposure ◽  
Brain Functions ◽  
Brain States ◽  
Pb Exposure ◽  
The Brain ◽  
Potent Therapeutic Agent

Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies.

Simulation of sports movement training based on machine learning and brain-computer interface

2020 ◽  
pp. 1-12
Author(s):  
Linuo Wang
Keyword(s):  
Machine Learning ◽  
Time Series ◽  
Joint Learning ◽  
Scientific Methods ◽  
Learning Framework ◽  
Brain Functions ◽  
Movement Training ◽  
Practical Effect ◽  
Machine Interface ◽  
The Brain

Injuries and hidden dangers in training have a greater impact on athletes ’careers. In particular, the brain function that controls the motor function area has a greater impact on the athlete ’s competitive ability. Based on this, it is necessary to adopt scientific methods to recognize brain functions. In this paper, we study the structure of motor brain-computer and improve it based on traditional methods. Moreover, supported by machine learning and SVM technology, this study uses a DSP filter to convert the preprocessed EEG signal X into a time series, and adjusts the distance between the time series to classify the data. In order to solve the inconsistency of DSP algorithms, a multi-layer joint learning framework based on logistic regression model is proposed, and a brain-machine interface system of sports based on machine learning and SVM is constructed. In addition, this study designed a control experiment to improve the performance of the method proposed by this study. The research results show that the method in this paper has a certain practical effect and can be applied to sports.

Effects of the SNAP25 on Integration Ability of Brain Functions in Children With ADHD

2020 ◽  
pp. 108705472096456
Author(s):  
Yue Yang ◽  
Gang Peng ◽  
Hongwu Zeng ◽  
Diangang Fang ◽  
Linlin Zhang ◽  
...  
Keyword(s):  
Time Window ◽  
Precentral Gyrus ◽  
Children With Adhd ◽  
Brain Functions ◽  
Lingual Gyrus ◽  
Window Method ◽  
Central Gyrus ◽  
The Right ◽  
The Brain ◽  
Insight Into

Objective: The present study aimed to examine the effects of SNAP25 on the integration ability of intrinsic brain functions in children with ADHD, and whether the integration ability was associated with working memory (WM). Methods: A sliding time window method was used to calculate the spatial and temporal concordance among five rs-fMRI regional indices in 55 children with ADHD and 20 healthy controls. Results: The SNAP25 exhibited significant interaction effects with ADHD diagnosis on the voxel-wise concordance in the right posterior central gyrus, fusiform gyrus and lingual gyrus. Specifically, for children with ADHD, G-carriers showed increased voxel-wise concordance in comparison to TT homozygotes in the right precentral gyrus, superior frontal gyrus, postcentral gyrus, and middle frontal gyrus. The voxel-wise concordance was also found to be related to WM. Conclusion: Our findings provided a new insight into the neural mechanisms of the brain function of ADHD children.

scholarly journals Emergence Of Consciousness And Qualia From A Complex Brain

Folia Medica ◽  
2014 ◽  
Vol 56 (4) ◽  
pp. 289-296
Author(s):  
Jakob Korf
Keyword(s):  
System Theory ◽  
General System ◽  
Resolution Power ◽  
Brain Functions ◽  
Scientific Exploration ◽  
Brain Changes ◽  
Higher Brain Functions ◽  
The Brain

Abstract Qualia are private conscious experiences of which the associated feelings can be reported to other people. Whether qualia are amenable to scientific exploration has often been questioned, which is challenged by the present article. The following arguments are given: 1. the configuration of the brain changes continuously and irreversibly, because of genetic and environmental influences and interhuman communication; 2. qualia and consciousness are processes, rather than states; 3. private feelings, including those associated with qualia, should be positioned in the context of a personal brain as being developed during life; 4. consciousness and qualia should be understood in the context of general system theory, thus concluding that isolated, in vitro, properties of neurons and other brain constituents might marginally contribute to the understanding of higher brain functions, mind or qualia; 5. current in vivo approaches have too little resolution power - in terms of space and time - to delineate individual and subjective brain processes. When subtle personalized properties of the nervous system can be assessed in vivo or in vitro, qualia can scientifically be investigated. We discuss some approaches to overcome these barriers.

Bone-brain crosstalk and potential associated diseases

2016 ◽  
Vol 28 (2) ◽  
Author(s):  
Audrey Rousseaud ◽  
Stephanie Moriceau ◽  
Mariana Ramos-Brossier ◽  
Franck Oury
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Development ◽  
Cognitive Functions ◽  
Intimate Relationship ◽  
Whole Body ◽  
Reciprocal Relationships ◽  
Skeletal Homeostasis ◽  
The Central Nervous System ◽  
The Brain

AbstractReciprocal relationships between organs are essential to maintain whole body homeostasis. An exciting interplay between two apparently unrelated organs, the bone and the brain, has emerged recently. Indeed, it is now well established that the brain is a powerful regulator of skeletal homeostasis via a complex network of numerous players and pathways. In turn, bone via a bone-derived molecule, osteocalcin, appears as an important factor influencing the central nervous system by regulating brain development and several cognitive functions. In this paper we will discuss this complex and intimate relationship, as well as several pathologic conditions that may reinforce their potential interdependence.

Neurodevelopment in the first three years: implications for child development, professional practice and policy

2014 ◽  
Vol 9 (2) ◽  
pp. 154-164 ◽  
Author(s):  
Danya Glaser
Keyword(s):  
Brain Development ◽  
Brain Activity ◽  
Brain Maturation ◽  
Policy And Practice ◽  
Content Type ◽  
Key Issues ◽  
And Function ◽  
The Relationship ◽  
The Brain ◽  
Brain Connections

Purpose – The purpose of this paper is to outline brain structure and development, the relationship between environment and brain development and implications for practice. Design/methodology/approach – The paper is based on a selected review of the literature and clinical experience. Findings – While genetics determine the sequence of brain maturation, the nature of brain development and functioning is determined by the young child's caregiving environment, to which the developing brain constantly adapts. The absence of input during sensitive periods may lead to later reduced functioning. There is an undoubted immediate equivalence between every mind function – emotion, cognition, behaviour and brain activity, although the precise location of this in the brain is only very partially determinable, since brain connections and function are extremely complex. Originality/value – This paper provides an overview of key issues in neurodevelopment relating to the development of young children, and implications for policy and practice.

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