scholarly journals Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature

2021 ◽  
Vol 12 ◽  
Author(s):  
Matteo Spaziani ◽  
Chiara Tarantino ◽  
Natascia Tahani ◽  
Daniele Gianfrilli ◽  
Emilia Sbardella ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cancer Survival ◽  
Transition Period ◽  
Hormone Deficiency ◽  
Therapeutic Success ◽  
Clinical Diagnostic ◽  
Final Stature ◽  
Definition Of ◽  
The Relationship

The role of growth hormone (GH) during childhood and adulthood is well established. Once final stature is reached, GH continues to act during the transition, the period between adolescence and adulthood in which most somatic and psychological development is obtained. The achievement of peak bone mass represents the most relevant aspect of GH action during the transition period; however, equally clear is its influence on body composition and metabolic profile and, probably, in the achievement of a complete gonadal and sexual maturation. Despite this, there are still some aspects that often make clinical practice difficult and uncertain, in particular in evaluating a possible persistence of GH deficiency once final stature has been reached. It is also essential to identify which subjects should undergo re-testing and, possibly, replacement therapy, and the definition of unambiguous criteria for therapeutic success. Moreover, even during the transition phase, the relationship between GH substitution therapy and cancer survival is of considerable interest. In view of the above, the aim of this paper is to clarify these relevant issues through a detailed analysis of the literature, with particular attention to the clinical, diagnostic and therapeutic aspects.

Biomarkers of Acromegaly and Growth Hormone Action

2020 ◽  
Vol 27 (12) ◽  
pp. 1231-1245
Author(s):  
Filippo Maffezzoni ◽  
Teresa Porcelli ◽  
Andrea Delbarba ◽  
Letizia Pezzaioli ◽  
Carlo Cappelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Biological Markers ◽  
Clinical Care ◽  
Hormone Deficiency ◽  
Surrogate Outcomes ◽  
Current State ◽  
Growth Hormone Action ◽  
Igf I ◽  
Definition Of

: Biological markers (biomarkers) play a key role in drug development, regulatory approval and clinical care of patients and are linked to clinical and surrogate outcomes. : Both acromegaly and Growth Hormone Deficiency (GHD) are pathological conditions related to important comorbidities that, in addition to having stringent diagnostic criteria, require valid markers for the definition of treatment, treatment monitoring and follow-up. GH and insulin-like growth factor-I (IGF-I) are the main biomarkers of GH action in children and adults while, in acromegaly, both GH and IGF-I are established biomarkers of disease activity. : However, although GH and IGF-I are widely validated biomarkers of GHD and acromegaly, their role is not completely exhaustive or suitable for clinical classification and follow-up. Therefore, new biological markers for acromegaly and GH replacement therapy are strongly needed. : The aim of this paper is to review and summarize the current state in the field pointing out new potential biomarkers for acromegaly and GH use/abuse.

scholarly journals Language in social reproduction: Sociolinguistics and sociosemiotics

2009 ◽  
Vol 37 (1/2) ◽  
pp. 43-81
Author(s):  
Patrizia Calefato
Keyword(s):  
Social Reproduction ◽  
Social Dimension ◽  
The Social ◽  
The Sixties ◽  
Roman Jakobson ◽  
New Type ◽  
General Linguistics ◽  
Definition Of ◽  
The Relationship

This paper focuses on the semiotic foundations of sociolinguistics. Starting from the definition of “sociolinguistics” given by the philosopher Adam Schaff, the paper examines in particular the notion of “critical sociolinguistics” as theorized by the Italian semiotician Ferruccio Rossi-Landi. The basis of the social dimension of language are to be found in what Rossi-Landi calls “social reproduction” which regards both verbal and non-verbal signs. Saussure’s notion of langue can be considered in this way, with reference not only to his Course of General Linguistics, but also to his Harvard Manuscripts.The paper goes on trying also to understand Roland Barthes’s provocative definition of semiology as a part of linguistics (and not vice-versa) as well as developing the notion of communication-production in this perspective. Some articles of Roman Jakobson of the sixties allow us to reflect in a manner which we now call “socio-semiotic” on the processes of transformation of the “organic” signs into signs of a new type, which articulate the relationship between organic and instrumental. In this sense, socio-linguistics is intended as being sociosemiotics, without prejudice to the fact that the reference area must be human, since semiotics also has the prerogative of referring to the world of non-human vital signs.Socio-linguistics as socio-semiotics assumes the role of a “frontier” science, in the dual sense that it is not only on the border between science of language and the anthropological and social sciences, but also that it can be constructed in a movement of continual “crossing frontiers” and of “contamination” between languages and disciplinary environments.

scholarly journals Deliberate Practice and Expertise in Martial Arts: The Role of Context in Motor Recall

1998 ◽  
Vol 20 (3) ◽  
pp. 260-279 ◽  
Author(s):  
Thana Hodge ◽  
Janice M. Deakin
Keyword(s):  
General Theory ◽  
Martial Arts ◽  
Recall Performance ◽  
Deliberate Practice ◽  
Expert Performance ◽  
Novice Group ◽  
Definition Of ◽  
The Relationship

This study used participants from the martial arts (karate) to examine the influence of context in the acquisition of novel motor sequences and the applicability of Ericsson, Krampe, and Tesch-Romer's (1993) theory of deliberate practice in this athletic domain. The presence of context did not benefit recall performance for the experts. The performance of the novice group was hindered by the presence of context. Evaluation of the role of deliberate practice in expert performance was assessed through retrospective questionnaires. The findings related to the relationship between relevance and effort, and relevance and enjoyment diverged from Ericsson et al.'s (1993) definition of deliberate practice, suggesting that adaptations should be made if it is to be considered general theory of expertise.

scholarly journals Interrelation of management accounting and internal control systems

2021 ◽  
pp. 176-182
Author(s):  
Vera V. Krainova Krainova
Keyword(s):  
Internal Control ◽  
Management Accounting ◽  
Information Support ◽  
Accounting System ◽  
Model Of Management ◽  
Definition Of ◽  
Control And Management ◽  
The Relationship ◽  
Management Accounting System

The article substantiates the relationship between internal control and management accounting. In the course of the substantiation, the content of the definition of "management accounting" is specified in the context of the study of the role of the management accounting system in the information support of internal control; on the example of shipping companies, the information of management accounting for the purposes of internal control is systematized. A conceptual model of management accounting is constructed, the system-forming elements of the management accounting system are identified and clarified, each of which has control elements "embedded" in it.

Legal change for child health: Report on a conference

PEDIATRICS ◽  
1977 ◽  
Vol 60 (2) ◽  
pp. 251-253
Author(s):  
Henry M. Seidel
Keyword(s):  
Middle Ages ◽  
Children And Youth ◽  
Frank Lloyd Wright ◽  
Conference Participant ◽  
Health Report ◽  
Points Of View ◽  
Definition Of ◽  
Relationship Of ◽  
The Relationship

"Physically and politically powerless, children have always gotten the short end of the stick. In earlier times, the surplus, especially females, were legally and deliberately killed; in the Middle Ages and until recently children were chattels; in Dickensian England they starved in workhouses or were exploited as beggars a la Oliver Twist...." Louise Raggio, Conference Participant The building Frank Lloyd Wright called Wingspread served as the setting for a discussion concerning the relationship of the health of the young to their legal needs and the role of the pediatrician in these regards. Men and women from medicine, the law, and social work shared their points of view, seeking a firm definition of advocacy for children, attempting to highlight some manageable priorities among the legal needs so that pediatricians might move to a partnership with others in the community which might facilitate access to a better life for all children and youth.

The role of cyadox and recombinant growth hormone (rGH) on the promotion of growth through epigenetics

2020 ◽  
Author(s):  
Aimei Liu ◽  
Feng Zhu ◽  
Xiaohui Zhu ◽  
Yulian Wang ◽  
Awais Ihsan ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Chromatin Structure ◽  
Dna Methyltransferases ◽  
Promoter Regions ◽  
Recombinant Growth Hormone ◽  
Animal Growth ◽  
Growth Promoting ◽  
The Relationship ◽  
Accessible Chromatin

Abstract Background: Cyadox is an effective growth-promoting antibiotic, which is similar to the role of recombinant growth hormone (rGH). Current studies have shown that cyadox can promote animal growth through altering intestinal microflora, improving protein utilization and increasing protein synthesis. Increasing evidence suggests that epigenetics are also closely related to growth. However, the potential role of epigenetics in the cyadox for growth has not been explored. Results: Here, we used recombinant growth hormone (rGH) and cyadox to study the relationship between growth and changes in epigenetics including DNA methylation, histone modification and chromatin structure. Bisulfite DNA sequencing (BSP) assay suggested that cyadox and rGH treatments increased IGF-1 expression partially by hypomethylation at CpG sites within the promoter region of IGF-1, which was regulated by DNA methyltransferases (DNMTs). We also observed an enrichment of H3K4me3 and H3K27ac at the promoter regions of IGF-1 by ChIP-qPCR assay, which contributed to an increase in IGF-1 transcription. In addition, immunofluorometric assay displayed cellular accessible chromatin structure following the treatment of cyadox and rGH, facilitating the combination of transcription factors and DNA and thus enhancing gene transcription. Conclusions: Taken together, our findings indicated that cyadox and rGH promote cell growth partially through epigenetic changes, providing a prospect for the development of animal growth-promoting drugs in the future.

scholarly journals Religion, civil society and conflict: What is it that religion does for and to society?

2011 ◽  
Vol 67 (3) ◽  
Author(s):  
Jaco Beyers
Keyword(s):  
Civil Society ◽  
Sociology Of Religion ◽  
Multiple Realities ◽  
Moral Discernment ◽  
Sense Of Reality ◽  
Definition Of ◽  
Role Of Religion ◽  
The Relationship ◽  
Insight Into

Human consciousness instinctively tries to make sense of reality. Different human interpretations of reality lead to a world consisting of multiple realities. Conflict occurs when differing realities (worldviews) encounter one another. Worldviews are socially created and determine human behaviour and, as such, most often find expression in religion. The discussion of conflict and the role of religion in civil society take place within the discourse of the sociology of religion. Religion is socially determined. Peter Berger’s insight into the sociology of religion therefore plays an important role in establishing the relationship between religion and civil society as one that takes on different forms. Thus, a clear definition of both civil society and religion was needed to understand the nature of these relationships. The role of religion in civil society with regard to the presence of conflict in society was further investigated in this article. The conditions under which conflict in society occurs were discussed, as were the conditions for tolerance in society, for religion ultimately becomes the provider of moral discernment when conflict occurs in civil society.

The relationship between the serum free light chain assay and serum immunofixation electrophoresis, and the definition of concordant and discordant free light chain ratios

Blood ◽  
2009 ◽  
Vol 114 (1) ◽  
pp. 38-39 ◽  
Author(s):  
Seema Singhal ◽  
Eric Vickrey ◽  
Jairam Krishnamurthy ◽  
Veerpal Singh ◽  
Sharon Allen ◽  
...  
Keyword(s):  
Light Chain ◽  
Normal Serum ◽  
Free Light Chain ◽  
Serum Free ◽  
Serum Free Light Chain ◽  
Immunofixation Electrophoresis ◽  
Serial Samples ◽  
Definition Of ◽  
The Relationship

Abstract“Stringent” complete remission in myeloma has been defined by a normal serum free light chain ratio (SFLCR) in addition to the standard criteria for CR. 2648 serial samples from 122 IgG or IgA myeloma patients were studied to explore the relationship between SFLCR and serum immunofixation electrophoresis (SIFE). SFLCR was normal in 34% of cases with positive SIFE and abnormal in 66%. SFLCR was normal in 69% of cases with negative SIFE and abnormal in 31%. When evaluated with SIFE as the benchmark, the sensitivity of SFLCR was 66% and specificity was 69%. These findings were unchanged when abnormal SFLCR values were classified as concordant (< 0.26 for λ disease and > 1.65 for κ) or discordant (< 0.26 for κ disease and > 1.65 for λ). Additional studies are required to determine the temporal relationship between SFLCR normalization and paraprotein clearance. Until then, the role of SFLCR in defining response remains controversial.

The nature and role of morality in situational action theory

2020 ◽  
pp. 147737082097709
Author(s):  
Jennifer Barton-Crosby
Keyword(s):  
Human Nature ◽  
Action Theory ◽  
Moral Rule ◽  
Personal Morality ◽  
Rule Breaking ◽  
Situational Action Theory ◽  
Definition Of ◽  
The Relationship ◽  
Perception Of Action

For situational action theory (SAT), morality is key to the definition of crime and the explanation for why and how acts of crime happen: acts of crime are acts of moral rule-breaking and personal morality guides individuals’ perception of moral rule-breaking as an option before controls become relevant. However, the nature and role of morality in SAT can be misread. Within this article I respond to misinterpretations of the theory by elaborating and adding further context to the concept of morality in SAT. I contend that the root of misunderstanding is grounded in alternative assumptions regarding human nature: SAT assumes a fundamentally rule-guided human nature, whereas the prevailing view within criminology is that people are primarily self-interested. In this article I delineate SAT’s assumption of a rule-guided human nature and set out how this assumption informs the definition of crime and personal morality in the theory. I further specify the nature and role of morality in the perception of action alternatives, and in so doing distinguish SAT from theories that view constraint as the measure of morality. Finally, I develop and clarify SAT’s position on the relationship between morality and the law.

scholarly journals Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice

Endocrinology ◽  
2020 ◽  
Vol 161 (4) ◽  
Author(s):  
Elizabeth A Jensen ◽  
Jonathan A Young ◽  
Zachary Jackson ◽  
Joshua Busken ◽  
Edward O List ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gut Microbiome ◽  
Hormone Deficiency ◽  
Microbial Profile ◽  
Host Growth ◽  
Folate Biosynthesis ◽  
Host Metabolism ◽  
Mouse Lines ◽  
Acetate Butyrate

Abstract The gut microbiome has been implicated in host metabolism, endocrinology, and pathophysiology. Furthermore, several studies have shown that gut bacteria impact host growth, partially mediated through the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. Yet, no study to date has examined the specific role of GH on the gut microbiome. Our study thus characterized the adult gut microbial profile and intestinal phenotype in GH gene-disrupted (GH-/-) mice (a model of GH deficiency) and bovine GH transgenic (bGH) mice (a model of chronic, excess GH action) at 6 months of age. Both the GH-/- and bGH mice had altered microbial signatures, in opposing directions at the phylum and genus levels. For example, GH-/- mice had significantly reduced abundance in the Proteobacteria, Campylobacterota, and Actinobacteria phyla, whereas bGH mice exhibited a trending increase in those phyla compared with respective controls. Analysis of maturity of the microbial community demonstrated that lack of GH results in a significantly more immature microbiome while excess GH increases microbial maturity. Several common bacterial genera were shared, although in opposing directions, between the 2 mouse lines (e.g., decreased in GH-/- mice and increased in bGH mice), suggesting an association with GH. Similarly, metabolic pathways like acetate, butyrate, heme B, and folate biosynthesis were predicted to be impacted by GH. This study is the first to characterize the gut microbiome in mouse lines with altered GH action and indicates that GH may play a role in the growth of certain microbiota thus impacting microbial maturation and metabolic function.

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