A Role of Variance in Interferon Genes to Disease Severity in COVID-19 Patients

The rapid rise and global consequences of the novel coronavirus disease 19 (COVID-19) have again brought the focus of the scientific community on the possible host factors involved in patient response and outcome to exposure to the virus. The disease severity remains highly unpredictable, and individuals with none of the aforementioned risk factors may still develop severe COVID-19. It was shown that genotype-related factors like an ABO Blood Group affect COVID-19 severity, and the risk of infection with SARS-CoV-2 was higher for patients with blood type A and lower for patients with blood type O. Currently it is not clear which specific genes are associated with COVID-19 severity. The comparative analysis of COVID-19 and other viral infections allows us to predict that the variants within the interferon pathway genes may serve as markers of the magnitude of immune response to specific pathogens. In particular, various members of Class III interferons (lambda) are reviewed in detail.

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RNA Coronaviruses’ Outbreaks: Recent Progress on the SARS-CoV-2 Pandemic Diagnostic Tests, Vaccination and Therapeutics

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557521666210422113915 ◽

2021 ◽

Vol 21 ◽

Author(s):

Ghadeer A. R. Y. Suaifan ◽

Bayan A. Alkhawaja ◽

Aya A. M. Mohammed

Keyword(s):

Viral Infections ◽

Rna Virus ◽

Infectious Agent ◽

The Novel ◽

Clinical Prognosis ◽

High Profile ◽

Intervention Measures ◽

Diagnostic Approaches ◽

Novel Coronavirus

: Coronaviruses are RNA-infective viruses that could be considered principal players in universal high-profile outbreaks, namely the Severe Acute Respiratory Syndrome (SARS, 2002-2003), the Middle East Respiratory Syndrome (MERS, 2012) and the continuing novel coronavirus disease (COVID-19, 2019) pandemic. RNA coronaviruses infections raise public health concerns with infections’ severity ranging from serious pandemics and highly contagious infections to common influenza episodes. With a wide consensus concerning the seminal role of early detection of the infectious agent on the clinical prognosis, recent technological endeavors have facilitated the rapid, sensitive and specific diagnosis of viral infections. Given that the burst of confirmed cases of the novel coronavirus disease 2019 (COVID-19) are climbing steeply, and we are amid this pandemic, this work will center at the respiratory RNA-viruses outbreaks, including the three coronaviruses-related pandemics, emphasizing on the approved diagnostic approaches, outlining therapeutic clinical trials as well as vaccine candidates. Based on the accumulated data and knowledge on the previous RNA-virus outbreaks, this review aspires to link the current intervention measures against SARS-CoV-2 infection with the previous interventions and to provide a roadmap for any possible future measures.

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A commentary on podiatry during the Covid-19 pandemic

Journal of Foot and Ankle Research ◽

10.1186/s13047-020-00425-9 ◽

2020 ◽

Vol 13 (1) ◽

Author(s):

Paul Chadwick ◽

Lawrence Ambrose ◽

Ross Barrow ◽

Martin Fox

Keyword(s):

Viral Infections ◽

The Novel ◽

Post Discharge ◽

Foot Health ◽

The United Kingdom ◽

Reduce Risk ◽

The Many ◽

Novel Coronavirus ◽

The Uk

Abstract Background The arrival of the novel coronavirus (SARS-CoV-2) has impacted the many aspects of modern life, especially, in the immediate term, the delivery of healthcare. Context This commentary examines the profession of podiatry and how it has adapted and responded to the emerging crisis. It focusses on but is not exclusive to the position in the United Kingdom (UK) and the edicts and direction from the UK Government. Podiatry roles during the pandemic It describes the role of podiatry in the pandemic and highlights the deployment of podiatry resources to fight the pandemic beyond traditional podiatric practice. It also looks at the shift from conventional consultation to digital solutions for managing patients in an effort to achieve the goals of maintenance of foot health whilst reducing the spread of the virus. The commentary summarises the emerging data related to a possible foot related presentation of the coronavirus. Conclusion The podiatry profession proved its flexibility and adaptability during the pandemic, to adjust rapidly to ensure that patients were able to access treatment to reduce risk of infection, ulceration and amputation. Dermatological presentations on the feet have been associated with Covid-19 in adolescents as is often the case in viral infections. CPD webinars to support clinicians and manage and prevent the spread of Covid-19 have been widely disseminated along with algorithms to ensure that patients that need treatment are being treated appropriately. Podiatrists have embraced remote technology to ensure that patients are correctly and safely triaged and, signposted and given appropriate self-care advice. MSK podiatrists have the ability to play an intrinsic role within the post discharge rehabilitation pathway.

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Role of Vyadhikshamatva (Immunity) in COVID19

National Journal of Research in Ayurved Science ◽

10.52482/ayurlog.v9i02.858 ◽

2021 ◽

Vol 9 (02) ◽

Author(s):

Mayur D. Patel ◽

Archana Gharge

Keyword(s):

Supportive Care ◽

Viral Infections ◽

Antiviral Agent ◽

The Novel ◽

Research Papers ◽

Secondary Infections ◽

The World ◽

Data Source ◽

Novel Coronavirus

Objective: The world was confronted with an illness 'COVID-19', caused by the novel coronavirus SARS-cov-2. This novel coronavirus is highly contagious and in just a few months has become a serious threat to human health all over the world. The mainstay in the management of corona viral infections has been supportive care, nutrition, and preventing secondary infections in the absence of any antiviral agent or vaccine. The best way of preventing COVID-19 infection is by enhancing an individual's body immunity. Hence the main objective of this study is to bring forward to the concept of immunity in Ayurveda for preventing COVID-19. Data Source: Different Ayurvedic Samhitas and textbooks, modern medical books, research papers in different journals and internet sources were referred to understand the concept of ojas, immunity and COVID-19 Review Methods: To compile the available literature on immunity and COVID-19. To compile the importance of ojas and vyadhikshamatva. To compile the importance of the Ayurvedic concept of immunity in the prevention of COVID-19. Results and Conclusion: The best way of preventing COVID-19 infection is by enhancing an individual's body immunity. Ojas is considered responsible for Vyadhikshamatva (immunity). An adequate exposition of the concept of ojas concerning immunity is essential during this COVID-19 pandemic.

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SARS-COV2 virus and Coronavirus disease (COVID-19)

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3401 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 977-982

Author(s):

Mohamed J. Saadh ◽

Bashar Haj Rashid M ◽

Roa’a Matar ◽

Sajeda Riyad Aldibs ◽

Hala Sbaih ◽

...

Keyword(s):

Close Contact ◽

Antiviral Agents ◽

Health Concern ◽

The Novel ◽

Global Public Health ◽

Fatal Disease ◽

Mild Disease ◽

Life Threatening ◽

Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

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The role and relationship of mindreading and social attunement in HRI – position statements of interdisciplinary researchers. Workshop HRI'20

10.31234/osf.io/3p6cd ◽

2020 ◽

Author(s):

Agnieszka Wykowska ◽

Jairo Pérez-Osorio ◽

Stefan Kopp

Keyword(s):

Mental States ◽

Human Robot Interaction ◽

Human Interaction ◽

Artificial Agents ◽

The Novel ◽

Robot Interaction ◽

Novel Coronavirus ◽

Relationship Of ◽

The Relationship

This booklet is a collection of the position statements accepted for the HRI’20 conference workshop “Social Cognition for HRI: Exploring the relationship between mindreading and social attunement in human-robot interaction” (Wykowska, Perez-Osorio & Kopp, 2020). Unfortunately, due to the rapid unfolding of the novel coronavirus at the beginning of the present year, the conference and consequently our workshop, were canceled. On the light of these events, we decided to put together the positions statements accepted for the workshop. The contributions collected in these pages highlight the role of attribution of mental states to artificial agents in human-robot interaction, and precisely the quality and presence of social attunement mechanisms that are known to make human interaction smooth, efficient, and robust. These papers also accentuate the importance of the multidisciplinary approach to advance the understanding of the factors and the consequences of social interactions with artificial agents.

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The Abstruse Side of Type I Interferon Immunotherapy for COVID-19 Cases with Comorbidities

Journal of Respiration ◽

10.3390/jor1010005 ◽

2021 ◽

Vol 1 (1) ◽

pp. 49-59

Author(s):

Selvakumar Subbian

Keyword(s):

Infectious Diseases ◽

Disease Severity ◽

Type I Interferon ◽

Host Factors ◽

Type I ◽

The Novel ◽

Inflammatory Drugs ◽

Precautionary Measures ◽

Inducible Genes

The Coronavirus Disease-2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has claimed 1.2 million people globally since December 2019. Although the host factors underpinning COVID-19 pathology are not fully understood, type I interferon (IFN-I) response is considered crucial for SARS-CoV-2 pathogenesis. Perturbations in IFN-I signaling and associated interferon-inducible genes (ISG) are among the primary disease severity indicators in COVID-19. Consequently, IFN-I therapy, either alone or in- combination with existing antiviral or anti-inflammatory drugs, is tested in many ongoing clinical trials to reduce COVID-19 mortality. Since signaling by the IFN-I family of molecules regulates host immune response to other infectious and non-infectious diseases, any imbalance in this family of cytokines would impact the clinical outcome of COVID-19, as well as other co-existing diseases. Therefore, it is imperative to evaluate the beneficial-versus-detrimental effects of IFN-I immunotherapy for COVID-19 patients with divergent disease severity and other co-existing conditions. This review article summarizes the role of IFN-I signaling in infectious and non-infectious diseases of humans. It highlights the precautionary measures to be considered before administering IFN-I to COVID-19 patients having other co-existing disorders. Finally, suggestions are proposed to improve IFN-I immunotherapy to COVID-19.

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The Role of Spices with reference Novel Coronavirus Covid 19

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.4038 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 1655-1661

Author(s):

Roshna Sukheoji Bhutada ◽

Kritika Umate

Keyword(s):

Viral Infections ◽

The Body ◽

Common People ◽

Supplementary Food ◽

Long Time ◽

Novel Coronavirus ◽

The Right ◽

Common Spices ◽

Physiological Reactions

The need of the day is a brisk lift to the resistant framework to keep it fit, battling today pandemic infections, for example, Covid — 19. One should get the right amount of nutrients from the diet, supplementation regimen to boost the immune system. These spices are always there to make tasty food as well as to protect the body from infectious diseases by building the immunity strong Ayurveda approaches to develop physiological reactions to facilitate immunity. Planning of diet is most important to boost immunity. As per many types of research to provide supplementary food which contains Zinc, Vitamin C, Vitamin D and immunity boosting food such as dealing with plenty of spices for a very long time. These spices include some rare to very common spices which we can found near us. The concern is that these viral infections are very prone to attack weak immunity and take the chance to affect the country to the globe. So the very common spices available will be always helpful to get through this Regular use of a few spices in the very simple form proves its importance as a medicine. In this article a review of spices is done which we are available near us, we are using it in our daily life and we are getting the benefit of these which a common people might not be fully aware of about role of immunity building of the body.

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The Impact of Vitamin C, Vitamin D, and Zinc on Immune Function Against Viral Infections, Particularly Those Caused by the Novel Coronavirus, SARS-CoV-2

Analytical Chemistry Letters ◽

10.1080/22297928.2021.1992297 ◽

2021 ◽

Vol 11 (6) ◽

pp. 792-800

Author(s):

Sony Ahmed ◽

Md. Shafiul Islam ◽

Mohua Ghosh ◽

Kazi Nazira Sharmin ◽

Ashley Tubbs

Keyword(s):

Vitamin D ◽

Vitamin C ◽

Immune Function ◽

Viral Infections ◽

The Novel ◽

Novel Coronavirus ◽

The Impact

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Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)

10.21203/rs.3.rs-29037/v2 ◽

2020 ◽

Author(s):

Xingyi Guo ◽

Zhishan Chen ◽

Yumin Xia ◽

Weiqiang Lin ◽

Hongzhi Li

Keyword(s):

Genetic Variation ◽

The Novel ◽

S Protein ◽

Angiotensin Converting Enzyme 2 ◽

Missense Variants ◽

Catalytic Metal ◽

Using Data ◽

Novel Coronavirus ◽

Insight Into

Abstract Background: The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiotensin-converting enzyme 2 (ACE2) in humans. However, it remains unclear how genetic variations in ACE2 may affect its function and structure, and consequently alter the recognition by SARS-CoV-2. Methods: We have systemically characterized missense variants in the gene ACE2 using data from the Genome Aggregation Database (gnomAD; N = 141,456). To investigate the putative deleterious role of missense variants, six existing functional prediction tools were applied to evaluate their impact. We further analyzed the structural flexibility of ACE2 and its protein-protein interface with the S-protein of SARS-CoV-2 using our developed Legion Interfaces Analysis (LiAn) program.Results: Here, we characterized a total of 12 ACE2 putative deleterious missense variants. Of those 12 variants, we further showed that p.His378Arg could directly weaken the binding of catalytic metal atom to decrease ACE2 activity and p.Ser19Pro could distort the most important helix to the S-protein. Another seven missense variants may affect secondary structures (i.e. p.Gly211Arg; p.Asp206Gly; p.Arg219Cys; p.Arg219His, p.Lys341Arg, p.Ile468Val, and p.Ser547Cys), whereas p.Ile468Val with AF = 0.01 is only present in Asian.Conclusions: We provide strong evidence of putative deleterious missense variants in ACE2 that are present in specific populations, which could disrupt the function and structure of ACE2. These findings provide novel insight into the genetic variation in ACE2 which may affect the SARS-CoV-2 recognition and infection, and COVID-19 susceptibility and treatment.

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