scholarly journals Diagnostic Delay of Pulmonary Embolism in COVID-19 Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Federica Melazzini ◽  
Margherita Reduzzi ◽  
Silvana Quaglini ◽  
Federica Fumoso ◽  
Marco Vincenzo Lenti ◽  
...  

Pulmonary embolism (PE) is a frequent, life-threatening COVID-19 complication, whose diagnosis can be challenging because of its non-specific symptoms. There are no studies assessing the impact of diagnostic delay on COVID-19 related PE. The aim of our exploratory study was to assess the diagnostic delay of PE in COVID-19 patients, and to identify potential associations between patient- or physician-related variables and the delay. This is a single-center observational retrospective study that included 29 consecutive COVID-19 patients admitted to the San Matteo Hospital Foundation between February and May 2020, with a diagnosis of PE, and a control population of 23 non-COVID-19 patients admitted at our hospital during the same time lapse in 2019. We calculated the patient-related delay (i.e., the time between the onset of the symptoms and the first medical examination), and the physician-related delay (i.e., the time between the first medical examination and the diagnosis of PE). The overall diagnostic delay significantly correlated with the physician-related delay (p < 0.0001), with the tendency to a worse outcome in long physician-related diagnostic delay (p = 0.04). The delay was related to the presence of fever, respiratory symptoms and high levels of lactate dehydrogenase. It is important to rule out PE as soon as possible, in order to start the right therapy, to improve patient's outcome and to shorten the hospitalization.

2007 ◽  
Vol 35 (5) ◽  
pp. 771-772 ◽  
Author(s):  
B. P. Powell ◽  
D. Simes

Levosimendan has been used successfully in the treatment of ischaemic cardiac failure and myocardial stunning. There is growing evidence from both human and animal experiments that levosimendan has particularly favourable effects on the right ventricle. We describe a case of life-threatening pulmonary embolus supported by the use of levosimendan.


Author(s):  
Alwaleed Al-Dairy ◽  
Rahim Abo Kasem

Cardiac Hydatid Cysts are uncommonly encountered entity of hydatid disease. Presentation may be with non-specific symptoms and sometimes with life threatening events. We present a rare case of a 9-year-old female who was diagnosed with a Cardiac Hydatid Cyst in the right ventricle, and underwent successful surgical excision


2016 ◽  
Vol 48 (2) ◽  
pp. 555-557 ◽  
Author(s):  
Antonella Mameli ◽  
Maria Antonietta Palmas ◽  
Antonello Antonelli ◽  
Paolo Contu ◽  
Paolo Prandoni ◽  
...  

2017 ◽  
Vol 3 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Mihaela Dobra ◽  
Lehel Bordi ◽  
Tiberiu Nyulas ◽  
Alexandra Stănescu ◽  
Mirabela Morariu ◽  
...  

AbstractNew imaging tools have been developed in recent years to rapidly and accurately diagnose life-threatening diseases associated with high mortality rates, such as acute coronary syndromes, acute aortic dissection, or pulmonary embolism. The concept of using computed tomographic (CT) assessment in emergency settings is based on the possibility of excluding multiple acute pathologies within one scan. It can be used for patients complaining of acute chest pain of unclear etiology with the possible association of acute coronary dissection or pulmonary embolism, but only a low to moderate risk of developing an acute coronary syndrome. One of the benefits of this protocol is the possibility of decreasing the number of patients who are hospitalized for further investigations. The technique also allows the rapid triage of patients and the safe discharge of those who show negative results. The aim of this review is to summarize the current medical literature regarding the potential use of CT for the triple rule-out (TRO) of coronary etiologies.


2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Konstantinos Kiroplastis ◽  
Apostolos Kambaroudis ◽  
Apostolos Andronikou ◽  
Andromachi Reklou ◽  
Dimitris Kokkonis ◽  
...  

Purpose. Pheochromocytoma in association with pregnancy is a very rare, without specific symptoms, life-threatening condition, increasing both maternal and fetal mortality up to 50%. The present paper illustrates the case of a pregnant woman, diagnosed with pheochromocytoma, aiming to demonstrate and discuss the difficulties that arouse during the diagnosis and the problems concerning the treatment.Patient. A 34-year-old woman, in the 9th week of pregnancy, complained for headache, sweating, and a feeling of heavy weight on the right renal area. A tumor of 10 cm diameter at the site of the right adrenal was found. Twenty-four-hour urine catecholamine and VMA excretion levels were well raised.Results. Multidisciplinary approach treated the patient conservatively. Surgical resection of the tumor was performed after the 14th week of pregnancy at the completion of organogenesis. Neither postoperative complications occurred nor hypertension relapse was recorded. The fetus was delivered without complications at the 36th week.Conclusions. There are no consensus and guidelines for treating pheochromocytoma during pregnancy, especially when it is diagnosed in the first trimester. The week of pregnancy and a multidisciplinary approach will determine whether the pregnancy should be continued or not, as well as the time and the approach of surgical treatment.


Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-216324
Author(s):  
Gudula J A M Boon ◽  
Yvonne M Ende-Verhaar ◽  
Roisin Bavalia ◽  
Lahassan H El Bouazzaoui ◽  
Marion Delcroix ◽  
...  

Background The current diagnostic delay of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE) is unacceptably long, causing loss of quality-adjusted life years and excess mortality. Validated screening strategies for early CTEPH diagnosis are lacking. Echocardiographic screening among all PE survivors is associated with overdiagnosis and cost-ineffectiveness. We aimed to validate a simple screening strategy for excluding CTEPH early after acute PE, limiting the number of performed echocardiograms. Methods In this prospective, international, multicentre management study, consecutive patients were managed according to a screening algorithm starting 3 months after acute PE to determine whether echocardiographic evaluation of pulmonary hypertension (PH) was indicated. If the ‘CTEPH prediction score’ indicated high pretest probability or matching symptoms were present, the ‘CTEPH rule-out criteria’ were applied, consisting of ECG reading and N-terminalpro-brain natriuretic peptide. Only if these results could not rule out possible PH, the patients were referred for echocardiography. Results 424 patients were included. Based on the algorithm, CTEPH was considered absent in 343 (81%) patients, leaving 81 patients (19%) referred for echocardiography. During 2-year follow-up, one patient in whom echocardiography was deemed unnecessary by the algorithm was diagnosed with CTEPH, reflecting an algorithm failure rate of 0.29% (95% CI 0% to 1.6%). Overall CTEPH incidence was 3.1% (13/424), of whom 10 patients were diagnosed within 4 months after the PE presentation. Conclusions The InShape II algorithm accurately excluded CTEPH, without the need for echocardiography in the overall majority of patients. CTEPH was identified early after acute PE, resulting in a substantially shorter diagnostic delay than in current practice.


2021 ◽  
Author(s):  
HuiHua Hu ◽  
XiaoCong Wang

Abstract Background: Brain stem infarction and pulmonary embolism are both serious life-threatening diseases with extremely high mortality. Central respiratory failure caused bycerebral stem infarction was considered in the initial stage of the disease. Pulmonary embolism (trunk) may have been the second cause of respiratory failure during diagnosis and treatment. The patient improved obviously after active treatment. Although the patient's condition improved significantly after active treatment, it is worth reflecting that if we had detected the right main pulmonary embolism in a timely manner during the first CTA examination, we could have determined whether the patient could benefit more from thrombolysis of the right main pulmonary artery under interventional therapy. Therefore, in clinical work, we should consider the possible complications ofthe patient while focusing on the most life-threatening primary disease.Case presentation:The patient, a 53-year-old female, she was immediately transferred from the emergency department to the ICU. Physical examination: T 37°C, HR 109/min, R 10/min, BP 105/73 mmHg, SpO 2 79%, GCS score 5, E1V2M2, coma. T CTA examination of the cervical blood vessels and cerebral blood vessels was recommended. 2) CTA examination of the cervical blood vessels and craniocerebral blood vessels performed at 10 o'clock on March 23 suggested moderate and severe stenosis at the beginning of the right vertebral artery, severe stenosis at the middle and upper segments of the basilar artery, and severe stenosis at the beginning of the bilateral posterior cerebral artery. Consideration: high possibility of brainstem infarction. After discussion with the family members, they agreed to submit the patient to percutaneous craniography and thrombectomy. 3) Cerebral artery extraction was performed from 23:50 on March 23 to 01:20 on March 24. Intraoperative diagnosis: 1. Cerebral stem infarction. 2. Upper basilar artery occlusion. Postoperative angiography showed that the basilar artery was unobstructed, and the bilateral superior cerebellar artery and posterior cerebral artery had returned to normal. Tirofiban was given 4 ml/h postoperatively. 4) The CT diagnosis room on March 24 reported the results of the vascular CTA scan from 10 'clock on March 23: A filling defect of the right main pulmonary artery and the left lower pulmonary artery lumen was observed. Pulmonary embolism was considered. Color Doppler ultrasound examination of the heart and lower limb vessels was immediately performed, and the interventional department was consulted. Cardiac ultrasonography suggested that there was no obvious thrombus in the right atrium or right ventricle of the patient. she receive anticoagulant and antiplatelet therapy.Conclusions: Central respiratory failure caused bycerebral stem infarction was considered in the initial stage of the disease. Pulmonary embolism (trunk) may have been the second cause of respiratory failure during diagnosis and treatment. The patient improved obviously after active treatment. Although the patient's condition improved significantly after active treatment, it is worth reflecting that if we had detected the right main pulmonary embolism in a timely manner during the first CTA examination, we could have determined whether the patient could benefit more from thrombolysis of the right main pulmonary artery under interventional therapy. Therefore, in clinical work, we should consider the possible complications ofthe patient while focusing on the most life-threatening primary disease.


2008 ◽  
Vol 1 (2) ◽  
pp. 11
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
D Dimer ◽  

VASA ◽  
2019 ◽  
Vol 48 (5) ◽  
pp. 381-388 ◽  
Author(s):  
Katalin Mako ◽  
Attila Puskas

Summary. Iliac vein compression syndrome (May-Thurner syndrome – MTS) is an anatomically variable clinical condition in which the left common iliac vein is compressed between the right common iliac artery and the underlying spine. This anatomic variant results in an increased incidence of left iliac or iliofemoral vein thrombosis. It predominantly affects young women in the second or third decades of life with preponderance during pregnancy or oral contraceptive use. Although MTS is rare, its true prevalence is underestimated but it can be a life-threatening condition due to development of pulmonary embolism (PE). In this case based review the authors present three cases of MTS. All patients had been previously confirmed with PE, but despite they were admitted to hospital, diagnosed and correctly treated for PE and investigated for thrombophilia, the iliac vein compression syndrome was not suspected or investigated. With this presentation the authors would like to emphasize that MTS is mostly underdiagnosed, and it needs to be ruled out in left iliofemoral vein thrombosis in young individuals.


2015 ◽  
Vol 29 (4) ◽  
pp. 135-146 ◽  
Author(s):  
Miroslaw Wyczesany ◽  
Szczepan J. Grzybowski ◽  
Jan Kaiser

Abstract. In the study, the neural basis of emotional reactivity was investigated. Reactivity was operationalized as the impact of emotional pictures on the self-reported ongoing affective state. It was used to divide the subjects into high- and low-responders groups. Independent sources of brain activity were identified, localized with the DIPFIT method, and clustered across subjects to analyse the visual evoked potentials to affective pictures. Four of the identified clusters revealed effects of reactivity. The earliest two started about 120 ms from the stimulus onset and were located in the occipital lobe and the right temporoparietal junction. Another two with a latency of 200 ms were found in the orbitofrontal and the right dorsolateral cortices. Additionally, differences in pre-stimulus alpha level over the visual cortex were observed between the groups. The attentional modulation of perceptual processes is proposed as an early source of emotional reactivity, which forms an automatic mechanism of affective control. The role of top-down processes in affective appraisal and, finally, the experience of ongoing emotional states is also discussed.


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