scholarly journals Tubulin and Tubulin Posttranslational Modifications in Alzheimer’s Disease and Vascular Dementia

2021 ◽  
Vol 13 ◽  
Author(s):  
Estibaliz Santiago-Mujika ◽  
Ruth Luthi-Carter ◽  
Flaviano Giorgini ◽  
Raj N. Kalaria ◽  
Elizabeta B. Mukaetova-Ladinska
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Older People ◽  
Vascular Dementia ◽  
Posttranslational Modifications ◽  
Binding Proteins ◽  
Neuronal Loss ◽  
Morphological Features ◽  
Potential Intervention ◽  
Dementia Therapy

Alzheimer’s disease (AD) and vascular dementia (VaD) are the two most common forms of dementia in older people. Although these two dementia types differ in their etiology, they share many pathophysiological and morphological features, including neuronal loss, which is associated with the microtubule (MT) destabilization. Stabilization of MTs is achieved in different ways: through interactions with MT binding proteins (MTBP) or by posttranslational modifications (PTMs) of tubulin. Polyglutamylation and tyrosination are two foremost PTMs that regulate the interaction between MTs and MTBPs, and play, therefore, a role in neurodegeneration. In this review, we summarize key information on tubulin PTMs in relation to AD and VaD and address the importance of studying further the tubulin code to reveal sites of potential intervention in development of novel and effective dementia therapy.

scholarly journals Islington study of dementia subtypes in the community

2002 ◽  
Vol 180 (3) ◽  
pp. 270-276 ◽  
Author(s):  
Tim Stevens ◽  
Gill Livingston ◽  
Ginnette Kitchen ◽  
Monica Manela ◽  
Zuzana Walker ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Older People ◽  
Vascular Dementia ◽  
Diagnostic Criteria ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Epidemiological Studies ◽  
Prevalence Data ◽  
Screening Criteria

BackgroundEpidemiological studies of dementia subtypes have revealed widely varying distribution rates. There are almost no published community prevalence data for dementia with Lewy bodies (DLB) or the frontal lobe dementias (FLD).AimsTo identify the distribution of dementia subtypes in a representative community population of older people.MethodPeople aged ⩾65 years in randomised enumeration districts in Islington, north London, were screened using a reliable and valid questionnaire. People screened as having dementia were assessed in detail and diagnoses were made according to standard diagnostic criteria.ResultsOf 1085 people interviewed, 107 (9.86%) met screening criteria for dementia. Diagnoses were made for 72 people (67.3%). Distribution of subtypes varied according to the criteria used; the best-validated criteria yielding: Alzheimer's disease 31.3%; vascular dementia 21.9%; DLB 10.9%; and FLD 7.8%.ConclusionsAlzheimer's disease is confirmed as the most common cause of dementia in older people, followed by vascular dementia. However, DLB and FLD occur sufficiently often to be seen frequently in clinical practice and should be incorporated into future editions of standard diagnostic criteria.

SPECIFIC PROPERTIES OF TUBULIN IN THE PREFRONTAL CORTEX IN CONTROL, SCHIZOPHRENIA AND VASCULAR DEMENTIA

2020 ◽  
pp. 65-71
Author(s):  
Burbaeva G.Sh. ◽  
Androsova L.V. ◽  
Vorobyeva E.A. ◽  
Savushkina O.K.
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prefrontal Cortex ◽  
Vascular Dementia ◽  
Binding Activity ◽  
Nephelometric Method ◽  
Rate Of Polymerization ◽  
Mental Diseases ◽  
And Control ◽  
The Brain

The aim of the study was to evaluate the rate of polymerization of tubulin into microtubules and determine the level of colchicine binding (colchicine-binding activity of tubulin) in the prefrontal cortex in schizophrenia, vascular dementia (VD) and control. Colchicine-binding activity of tubulin was determined by Sherlinе in tubulin-enriched extracts of proteins from the samples. Measurement of light scattering during the polymerization of the tubulin was carried out using the nephelometric method at a wavelength of 450-550 nm. There was a significant decrease in colchicine-binding activity and the rate of tubulin polymerization in the prefrontal cortex in both diseases, and in VD to a greater extent than in schizophrenia. The obtained results suggest that not only in Alzheimer's disease, but also in other mental diseases such as schizophrenia and VD, there is a decrease in the level of tubulin in the prefrontal cortex of the brain, although to a lesser extent than in Alzheimer's disease, and consequently the amount of microtubules.

Recent Updates on the Association Between Alzheimer's Disease and Vascular Dementia

2016 ◽  
Vol 12 (3) ◽  
pp. 226-237 ◽  
Author(s):  
Ghulam M. Ashraf ◽  
Sandesh Chibber ◽  
. Mohammad ◽  
Syed K. Zaidi ◽  
Shams Tabrez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia
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