scholarly journals Fully Integrated PET/MR Imaging for the Assessment of the Relationship Between Functional Connectivity and Glucose Metabolic Rate

2020 ◽  
Vol 14 ◽  
Author(s):  
Lalith Kumar Shiyam Sundar ◽  
Shahira Baajour ◽  
Thomas Beyer ◽  
Rupert Lanzenberger ◽  
Tatjana Traub-Weidinger ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Mr Imaging ◽  
Metabolic Rate ◽  
Fully Integrated ◽  
Glucose Metabolic Rate ◽  
The Relationship

scholarly journals Glutamate connectivity associations converge upon the salience network in schizophrenia and healthy controls

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert A. McCutcheon ◽  
Toby Pillinger ◽  
Maria Rogdaki ◽  
Juan Bustillo ◽  
Oliver D. Howes
Keyword(s):  
Functional Connectivity ◽  
Frontal Cortex ◽  
Network Connectivity ◽  
Resonance Spectroscopy ◽  
Salience Network ◽  
Healthy Controls ◽  
1H Mrs ◽  
Before And After ◽  
Functional Brain Networks ◽  
The Relationship

AbstractAlterations in cortical inter-areal functional connectivity, and aberrant glutamatergic signalling are implicated in the pathophysiology of schizophrenia but the relationship between the two is unclear. We used multimodal imaging to identify areas of convergence between the two systems. Two separate cohorts were examined, comprising 195 participants in total. All participants received resting state functional MRI to characterise functional brain networks and proton magnetic resonance spectroscopy (1H-MRS) to measure glutamate concentrations in the frontal cortex. Study A investigated the relationship between frontal cortex glutamate concentrations and network connectivity in individuals with schizophrenia and healthy controls. Study B also used 1H-MRS, and scanned individuals with schizophrenia and healthy controls before and after a challenge with the glutamatergic modulator riluzole, to investigate the relationship between changes in glutamate concentrations and changes in network connectivity. In both studies the network based statistic was used to probe associations between glutamate and connectivity, and glutamate associated networks were then characterised in terms of their overlap with canonical functional networks. Study A involved 76 individuals with schizophrenia and 82 controls, and identified a functional network negatively associated with glutamate concentrations that was concentrated within the salience network (p < 0.05) and did not differ significantly between patients and controls (p > 0.85). Study B involved 19 individuals with schizophrenia and 17 controls and found that increases in glutamate concentrations induced by riluzole were linked to increases in connectivity localised to the salience network (p < 0.05), and the relationship did not differ between patients and controls (p > 0.4). Frontal cortex glutamate concentrations are associated with inter-areal functional connectivity of a network that localises to the salience network. Changes in network connectivity in response to glutamate modulation show an opposite effect compared to the relationship observed at baseline, which may complicate pharmacological attempts to simultaneously correct glutamatergic and connectivity aberrations.

scholarly journals Heritability and interindividual variability of regional structure-function coupling

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zijin Gu ◽  
Keith Wakefield Jamison ◽  
Mert Rory Sabuncu ◽  
Amy Kuceyeski
Keyword(s):  
Functional Connectivity ◽  
Structure Function ◽  
Regional Differences ◽  
Regional Scale ◽  
Brain Regions ◽  
Diffusion Weighted Mri ◽  
Regional Structure ◽  
Human Connectome Project ◽  
Structural Connections ◽  
The Relationship

AbstractWhite matter structural connections are likely to support flow of functional activation or functional connectivity. While the relationship between structural and functional connectivity profiles, here called SC-FC coupling, has been studied on a whole-brain, global level, few studies have investigated this relationship at a regional scale. Here we quantify regional SC-FC coupling in healthy young adults using diffusion-weighted MRI and resting-state functional MRI data from the Human Connectome Project and study how SC-FC coupling may be heritable and varies between individuals. We show that regional SC-FC coupling strength varies widely across brain regions, but was strongest in highly structurally connected visual and subcortical areas. We also show interindividual regional differences based on age, sex and composite cognitive scores, and that SC-FC coupling was highly heritable within certain networks. These results suggest regional structure-function coupling is an idiosyncratic feature of brain organisation that may be influenced by genetic factors.

The Relationship of Mode and Intensity of Training on Resting Metabolic Rate in Women

2001 ◽  
Vol 11 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Heidi K. Byrne ◽  
Jack H. Wilmore
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Women Subjects ◽  
Present Cross Sectional Study ◽  
Significant Difference ◽  
Level Of Training ◽  
The Relationship ◽  
Aerobically Trained

The present cross-sectional study was designed to investigate the relationship between exercise training and resting metabolic rate (RMR). The focus of this investigation was to compare RMR in aerobically trained (AT), resistance trained (RT), and untrained (UNT) women. Subjects were also classified as highly trained (HT), moderately trained (MT), or untrained (UNT) in order to examine the relationship between RMR and level of training. Sixty-one women between the ages of 18 and 46 years volunteered to serve as subjects in this study. Each subject completed measurements of body composition, maximal oxygen uptake (V̇O2max), and two consecutive measurements of RMR. The data presented show that there was no significant difference in resting metabolic rate between resistance-trained, aerobically trained, and control subjects. However, when grouped by intensity of training, there was a trend for an increased resting metabolic rate (kcal/day) in the highly trained subjects, regardless of mode of training.

Effects of Television on Metabolic Rate: Potential Implications For Childhood Obesity

PEDIATRICS ◽  
1993 ◽  
Vol 91 (2) ◽  
pp. 281-286
Author(s):  
Robert C. Klesges ◽  
Mary L. Shelton ◽  
Lisa M. Klesges
Keyword(s):  
Energy Expenditure ◽  
Metabolic Rate ◽  
Television Viewing ◽  
Resting Energy Expenditure ◽  
Normal Weight ◽  
Laboratory Setting ◽  
Obese Children ◽  
Two Measures ◽  
The Relationship ◽  
Resting Energy

The effects of television viewing on resting energy expenditure (metabolic rate) in obese and normal-weight children were studied in a laboratory setting. Subjects were 15 obese children and 16 normal-weight children whose ages ranged from 8 to 12 years. All subjects had two measures of resting energy expenditure obtained while at rest and one measurement of energy expenditure taken while viewing television. Results indicated that metabolic rate during television viewing was significantly lower (mean decrease of 211 kcal extrapolated to a day) than during rest. Obese children tended to have a larger decrease, although this difference was not statistically significant (262 kcal/d vs 167 kcal/d, respectively). It was concluded that television viewing has a fairly profound lowering effect of metabolic rate and may be a mechanism for the relationship between obesity and amount of television viewing.

scholarly journals Cardiorespiratory Fitness and Body Composition in Postmenopausal Women

2014 ◽  
Vol 43 (1) ◽  
pp. 139-148 ◽  
Author(s):  
Helena Moreira ◽  
Betânia Passos ◽  
Josiane Rocha ◽  
Vivianne Reis ◽  
André Carneiro ◽  
...  
Keyword(s):  
Body Composition ◽  
Oxygen Uptake ◽  
Metabolic Rate ◽  
Postmenopausal Women ◽  
Aerobic Fitness ◽  
Basal Metabolic Rate ◽  
Visceral Fat ◽  
Central Adiposity ◽  
Visceral Fat Area ◽  
The Relationship

Abstract The object of the study was to analyze the relationship between aerobic fitness and body composition in postmenopausal women. We hypothesized that postmenopausal women that had higher adiposity had lower cardiorespiratory capacity, regardless of the characteristics of menopause. The sample included 208 women (57.57 ± 6.62 years), whose body composition and the basal metabolic rate were evaluated by octopolar bioimpedance (InBody 720) and the oxygen uptake by the modified Bruce protocol. Most of the sample showed obesity and a high visceral fat area. The visceral fat area and the basal metabolic rate explained 30% of the variation of oxygen uptake, regardless of age, time, nature or hormone therapy. The values of the latter variables were reduced in the presence of high central adiposity (-6.16 ml/kg/min) and the basal metabolic rate of less than 1238 kcal/day (-0.18 ml/kg/min). The women with oxygen uptake above 30.94 ml/kg/min showed lower values of total and central adiposity when compared with other groups. With an increase of aerobic fitness, there was a growing tendency of the average values of the soft lean mass index, with differences between the groups low-high and moderate-high. These results suggest worsening of the cardiorespiratory condition with an increase of central adiposity and a decrease of the BMR, regardless of age and menopause characteristics.

scholarly journals Glucose metabolic rate and progression of illness in Alzheimer's disease

1995 ◽  
Vol 10 (8) ◽  
pp. 659-667 ◽  
Author(s):  
Benjamin V. Siegel ◽  
Monte S. Buchsbaum ◽  
Arnold Starr ◽  
Richard C. Mohs ◽  
Dirceu C. Neto
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metabolic Rate ◽  
Glucose Metabolic Rate
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