scholarly journals Reduction of Pressure Pain Sensitivity as Novel Non-pharmacological Therapeutic Approach to Type 2 Diabetes: A Randomized Trial

2021 ◽  
Vol 15 ◽  
Author(s):  
Jens Faber ◽  
Ebbe Eldrup ◽  
Christian Selmer ◽  
Caroline Pichat ◽  
Sofie Korsgaard Hecquet ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Nervous System ◽  
Treatment Group ◽  
Glucose Metabolism ◽  
Active Treatment ◽  
Pain Sensitivity ◽  
Active Treatment Group ◽  
Control Group ◽  
Pressure Pain

BackgroundAutonomic nervous system dysfunction (ANSD) is known to affect glucose metabolism in the mammalian body. Tradition holds that glucose homeostasis is regulated by the peripheral nervous system, and contemporary therapeutic intervention reflects this convention.ObjectivesThe present study tested the role of cerebral regulation of ANSD as consequence of novel understanding of glucose metabolism and treatment target in type 2 diabetes (T2D), suggested by the claim that the pressure pain sensitivity (PPS) of the chest bone periosteum may be a measure of cerebral ANSD.DesignIn a randomized controlled trial of 144 patients with T2D, we tested the claim that 6 months of this treatment would reduce PPS and improve peripheral glucose metabolism.ResultsIn the active treatment group, mean glycated hemoglobin A1c (HbA1c) declined from 53.8 to 50.5 mmol/mol (intragroup p = 0.001), compared with the change from 53.8 to 53.4 mmol/mol in the control group, with the same level of diabetes treatment but not receiving the active treatment (between group p = 0.036). Mean PPS declined from 76.6 to 56.1 units (p < 0.001) in the active treatment group and from 77.5 to 72.8 units (p = 0.02; between group p < 0.001) in the control group. Changes of PPS and HbA1c were correlated (r = 0.37; p < 0.001).ConclusionWe conclude that the proposed approach to treatment of T2D is a potential supplement to conventional therapy.Clinical Trial Registration:www.clinicaltrials.gov (NCT 03576430).

scholarly journals Effectiveness of an app for perinatal home visitation by nurses in preventing infant abuse in Japan

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Isumi ◽  
S Doi ◽  
T Fujiwara
Keyword(s):  
Public Health ◽  
Treatment Group ◽  
Child Maltreatment ◽  
Active Treatment ◽  
Intervention Study ◽  
Home Visitation ◽  
Active Treatment Group ◽  
Health Centers ◽  
Public Health Nurses ◽  
Control Group

Abstract Background In Japan, public health nurses provide home visitation with pregnant women who are at high risk for child maltreatment, but its effectiveness in preventing child maltreatment has not been evaluated because contents and quality of home visitation vary from municipality to municipality. This study aims to evaluate whether the tablet app developed to standardize and assist perinatal home visitation by public health nurses is effective in preventing child maltreatment. Methods An intervention study was conducted in 2018 in Adachi City, Tokyo, Japan. Public health nurses at two public health centers used the tablet app when they support high-risk pregnant women through home visitation and interviews, while public health nurses at the other three public health centers provided support as in the past. Because two public health centers were different in usage of the app, the treatment group was further divided into two groups: active and inactive. As fatal abuse among infants, frequency of shaking and smothering was assessed as an outcome through a self-reported questionnaire at the 4-month health check, and compared between the active treatment group, inactive treatment group, and control group, using multiple logistic regression (N = 5,651). Results Prevalence of infant abuse was 0.82% in the active treatment group, 1.34% in the inactive treatment group, and 1.50% in the control group. When adjusted for parental demographics and parenting situations, mothers in the active treatment group were less likely to shake or smother their baby than those in the control group (Odds ratio: 0.51, p = 0.093). Conclusions It possibly suggests that the tablet app developed to assist perinatal home visitation by public health nurses was effective in preventing infant abuse. Key messages An intervention study was conducted at public health centers in Adachi City, Tokyo, Japan, using the tablet app developed to standardize and assist perinatal home visitation by public health nurses. The finding suggested that the tablet app may be effective in preventing shaking and smothering among 4-month old infants.

scholarly journals Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia

2020 ◽  
Author(s):  
Xiaomeng Sun ◽  
Jia Liu ◽  
Guang Wang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treatment Group ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Diabetic Patients ◽  
Fenofibrate Treatment

Abstract Background: This study was to research the efficacy of fenofibrate in the treatment of microalbuminuria in the patients with type 2 diabetes mellitus (T2DM) and hypertriglyceridemia. Methods: Type 2 diabetic patients (56) with microalbuminuria and hypertriglyceridemia aged 30 to 75 were randomly divided into the fenofibrate treatment group(n=28) and the control group (n=28) for 180 days. Urinary microalbumin /creatinine ratio (UACR) and other metabolic parameters were compared at baseline, during treatment and after treatment. Results: After 180 days, the reduction of levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in two groups were no differences. In treatment group, uric acid (UA) (296.42 ± 56.41 vs 372.46 ± 72.78), triglyceride (TG) [1.51(1.17, 2.06) vs 3.04(2.21, 3.29)], and UACR [36.45 (15.78,102.41) vs 129.00 (53.00, 226.25)] were significantly decreased compared with the baseline. The high-density lipoprotein cholesterol (HDL-C) levels were significantly increased (1.22 ± 0.26 vs 1.09 ± 0.24) compared with the baseline. The decrease in UACR [-44.05(-179.47, -12.16) vs -8.15(-59.69, 41.94)]in treatment group was significantly higher compared with the control group. The decrease in UACR was positively associated with the decreases in TG ( r = 0.447, P = 0.042) and UA ( r = 0.478, P = 0.024) after fenofibrate treatment. Conclusion: In the patients with hypertriglyceridemia and type 2 diabetes mellitus, fenofibrate can improve microalbuminuria and do not increase the deterioration of glomerular filtration rate

scholarly journals Habenula lesions improve glucose metabolism in rats with type 2 diabetes by increasing insulin sensitivity and inhibiting gluconeogenesis

2020 ◽  
Vol 8 (1) ◽  
pp. e001250
Author(s):  
Peng Qu ◽  
Yachun Wang ◽  
Lei Liu ◽  
Mengmeng Qi ◽  
Yimeng Sun ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Nervous System ◽  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Sham Group ◽  
Adrenal Glands ◽  
Tolerance Test ◽  
Lesion Group

IntroductionThe habenular nucleus (Hb), a famous relay station in the midbrain, is vital for controlling many physiological functions of vertebrates. The role of Hb in the pathogenesis of depression has been thoroughly studied, but whether it functions in the pathogenesis of diabetes remains unknown. In this study, we found that Hb lesions could improve glucose metabolism in type 2 diabetes mellitus (T2DM) by inhibiting the peripheral sympathetic nervous system and hepatic glucose production.Research design and methodsT2DM rats were induced by a high-carbohydrate and fat diet combined with streptozotocin. Electrical lesion method was applied to suppress the function of Hb. Serum and tissue samples of rats in the control group, T2DM group, sham group, and Hb lesion group were detected by ELISA, western blotting, and biochemical methods.ResultsCompared with the sham group, the expression levels of AMPK phosphorylation and insulin receptor (IR) were significantly increased, whereas glucose-6-phosphatase and phosphoenolpyruvate carboxylated kinase were reduced in the liver of the Hb lesion group. In the glucose tolerance test and pyruvate tolerance test, the lesion group showed stronger glucose tolerance and lower hepatic gluconeogenesis than the sham. These results suggest that Hb lesions not only effectively increase insulin sensitivity and improve insulin resistance but also inhibit gluconeogenesis in T2DM rats. Moreover, Hb lesions increase the expression of brain-derived neurotrophic factor, tropomyosin receptor kinase B, glucocorticoid receptor, and IR in the hippocampus. In this study, we also found that Hb lesions increase the content of acetylcholine in the adrenal glands and reduce the content of epinephrine in both the adrenal glands and the liver, which may be the main reason for the Hb lesions to regulate glucose metabolism in the liver.ConclusionHb is an important neuroanatomical target for the regulation of glucose metabolism in the central nervous system of diabetic rats.

scholarly journals Pengaruh Therapeutic Exercise Walking terhadap Sirkulasi Darah Perifer pada Pasien Diabetes Melitus Tipe 2 di Kelurahan Gebang Kecamatan Patrang Kabupaten Jember. (The Effect of Therapeutic Exercise Walking on Pheripheral Blood Circulation in Patients wit

2020 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Erti Ikhtiarini Dewi ◽  
Amadea Yollanda ◽  
Nur Widayati ◽  
Rondhianto Rondhianto
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treatment Group ◽  
Peripheral Blood ◽  
Blood Circulation ◽  
Control Group ◽  
Therapeutic Exercise ◽  
Peripheral Blood Circulation

Pathological change experienced by patients with type 2 diabetes mellitus is impaired peripheralblood circulation, especially in the lower limbs and feet. Peripheral blood circulation can be examinedby measuring Ankle Brachial Index (ABI). Therapeutic exercise walking is one of physical activitieswhich can improve blood circulation. This research goal was to analyze the effect of therapeuticexercise walking on peripheral blood circulation in patients with type 2 diabetes mellitus. Theresearch design was randomized control group pretest-posttest design. The sample size was 15respondents as control group and 15 respondents as treatment group. Data was analyzed by usingdependent t-test and independent t-test with significant level of 0.05. This result showed a significantincrease of ABI after therapeutic exercise walking in the treatment group (p= 0.001). However therewas a significant decrease of ABI between pretest and posttest in control group (p=0.010).Independent t-test indicated a significant difference of ABI between treatment group and controlgroup (p=0.000). So, it can be concluded that there is an influence of therapeutic exercise walking onthe peripheral blood circulation in patients with type 2 diabetes mellitus. Nurses should applytherapeutic exercise walking to improve peripheral blood circulation in patients with type 2 diabetesmellitus.Keywords: type 2 diabetes mellitus, therapeutic exercise walking, ankle brachial index

scholarly journals A Web-Based Transdiagnostic Intervention for Affective and Mood Disorders: Randomized Controlled Trial

2018 ◽  
Vol 5 (2) ◽  
pp. e36 ◽  
Author(s):  
Bogdan Tudor Tulbure ◽  
Andrei Rusu ◽  
Florin Alin Sava ◽  
Nastasia Sălăgean ◽  
Todd J Farchione
Keyword(s):  
Treatment Group ◽  
Emotional Disorders ◽  
Active Treatment ◽  
Active Treatment Group ◽  
Self Report ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Web Based ◽  
Transdiagnostic Treatment

Background Research increasingly supports a transdiagnostic conceptualization of emotional disorders (ie applying the same underlying treatment principles across mental disorders, without tailoring the protocol to specific diagnoses), and many international researchers are currently investigating this issue. Objective The aim of this study was to evaluate the efficacy and acceptability of a Web-based transdiagnostic program using a sample of Romanian adults diagnosed with anxiety and/or depression. Methods Volunteer participants registered for the study and completed a series of online self-report measures. Participants who fulfilled basic inclusion criteria on these measures were contacted for a telephone diagnostic interview using the Structural Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Axis I Disorders (SCID-I). Enrolled participants were randomized to either the active treatment group (N=69) or the wait-list control group (N=36) using a 2:1 ratio. The transdiagnostic treatment was based on the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al, 2011) that addresses common underlying mechanisms of anxiety and depression. Participants randomized to the active treatment condition received 10 weeks of Web-based treatment based on the UP. Throughout treatment, graduate students in clinical psychology provided guidance that consisted of asynchronous written communication on a secure Web platform. After the intervention, participants in both study conditions were invited to complete a set of self-report measures and a postintervention SCID-I interview conducted by a different team of graduate students blinded to participants’ group and diagnostic status. Six months later, participants in the active treatment group were invited to complete an online follow-up assessment. Results During the intervention, active treatment participants completed on average 19 homework assignments (SD 12.10), and we collected data from 79.0% (83/105) at postintervention and 51% (35/69) at follow-up for self-report measures. Postintervention SCID-I interviews were collected from 77.1% (81/105) participants. Relative to the wait-list control group, the transdiagnostic intervention yielded overall medium to large effect sizes for the primary outcome measures (within-group Hedges g=0.52-1.34 and between-group g=0.39-0.86), and also for anxiety sensitivity (g=0.80), symptom interference (g=0.48), and quality of life (g=0.38). Significant within-groups effects only were reported for the active treatment group on Panic Disorder Severity Scale-Self Report (PDSS-SR, g=0.58-0.65) and Yale-Brown Obsessive Compulsive Scale (Y-BOCS, g=0.52-0.58). Conclusions Insignificant between-group differences for the Y-BOCS and PDSS-SR could be explained by the small number of participants with the associated primary diagnostic (eg, only 3 participants with obsessive compulsive disorder) by the choice of outcome measure (PDSS-SR was not rated among the evidence-based measures) and by the fact that these disorders may be more difficult to treat. However, the overall results suggest that the transdiagnostic intervention tested in this study represents an effective treatment option that may prove easier to disseminate through the use of Web-based delivery systems. Trial Registration ClinicalTrials.gov CT02739607; https://clinicaltrials.gov/ct2/show/study/NCT02739607 (Archived by WebCite at http://www.webcitation.org/6yY1VeYIZ)

scholarly journals The Effect of Tempe Dietary Intake on Plasma Glucose Level in Elderly Patients with Type 2 Diabetes Mellitus

2017 ◽  
Vol 1 (6) ◽  
Author(s):  
Grace Puspasari ◽  
Drupadi Dillon ◽  
Budiman Budiman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treatment Group ◽  
Glucose Level ◽  
Plasma Glucose ◽  
Plasma Glucose Level ◽  
Daily Intake ◽  
Control Group

The aim of the study was to investigate  the effect of daily intake of 100 grams tempe for four weeks on plasma glucose level in elderly patients with type 2 diabetes mellitus. This study was a parallel randomized clinical trial. Subjects were 30 diabetic elderly living in four nursing homes in Jakarta. In the study subjects were assigned to two groups using block randomization. All subjects had to take diabetic regiment with calorie and macronutrient following diabetic recommendation diet. The treatment group (n=16) received tempe, while control group (n=14) received legumes other than tempe. Fasting plasma glucose level (FPG) was assessed before and after intervention. Unpaired t test and Mann Whitney were used to analyzed data with the 5% significance level. There were 27 subjects completed the study: 15 of treatment group and 12 of control group. Both group were comparable in age, gender, BMI, calorie and macronutrient intake before treatment. Fat, fiber, and isoflavone intake were significantly higher in treatment group compare to control group. Decrease in FPG after intervention were observed but were statisticaly insignificant. In conclusion daily intake of 100 grams tempe for four weeks did not decrease FPG.  Keywords: elderly, plasma glucose level, tempe, type 2 diabetes

scholarly journals THE EFFECT OF PUGUNTANO (CURANGA FEL-TERRAE [LOUR.]) EXTRACT ON ADIPONECTIN RECEPTOR (ADIPOR) IN RATS WITH TYPE 2 DIABETES MELLITUS

2019 ◽  
pp. 551-553
Author(s):  
DHARMA LINDARTO ◽  
YETTY MACHRINA ◽  
SANTI SYAFRIL ◽  
AWALUDDIN SARAGIH
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Treatment Group ◽  
Control Group ◽  
Model Assessment ◽  
Anti Inflammatory

Objective: This study aimed to determine whether the antidiabetic effects of puguntano (Curanga fel-terrae [Lour.]) extract involve anti-inflammatory effects mediated through adiponectin receptors (AdipoRs). Methods: Type 2 diabetes mellitus (T2DM) Wistar rats were induced by a combination of high-fat diet for 5 weeks and injection small dose streptozotocin 30 mg/kg bw/rat. This study was conducted in 48 T2DM rats, which were randomly assigned into two weight-matched groups (n=24, each). Only the treatment group received 0.2 mg/g bw of puguntano extract suspension through oral for 10 days. The clinical characteristics of T2DM and AdipoR were assessed before and after the treatment period. Results: The treatment group demonstrated significantly lower body weight, fasting blood glucose, and homeostasis model assessment-insulin resistance (HOMA-IR) but higher AdipoR than the control group (all, p<0.001). Furthermore, there were also negative correlations between AdipoR to body weight and HOMA-IR (all, p<0.05). Conclusion: Our data suggest that puguntano could improve glucose metabolism and ameliorate insulin resistance and have anti-inflammatory effects mediated through AdipoR in T2DM.

scholarly journals Effectiveness of chiropractic manipulation versus sham manipulation for recurrent headaches in children aged 7-14 years. A randomised clinical trial

2020 ◽  
Author(s):  
Susanne Lynge ◽  
Kristina Boe Dissing ◽  
Werner Vach ◽  
Henrik Wulf Christensen ◽  
Lise Hestbaek
Keyword(s):  
Clinical Trial ◽  
Treatment Group ◽  
Side Effects ◽  
Pain Intensity ◽  
Active Treatment ◽  
Spinal Manipulation ◽  
Active Treatment Group ◽  
Text Messages ◽  
Control Group ◽  
Fixed Sequence

Abstract BackgroundTo investigate the effectiveness of chiropractic spinal manipulation versus sham manipulation in children aged 7-14 with recurrent headaches.MethodsDesign: A two-arm randomised superiority single-blinded clinical trial.Setting: One chiropractic clinic and one paediatric specialty practice in Denmark Participants: 199 children aged 7 to 14 years, who experienced at least one episode of headache per week for the previous 6 months and with at least one musculoskeletal dysfunction identified. Interventions: All participants and parents received standard oral and written advice to reduce headaches. In addition, children in the active treatment group received chiropractic spinal manipulation and children in the control group received sham manipulation for a period of 4 months. The number and frequency of treatments were based on the chiropractor’s individual evaluation in the active treatment group, and the children in the control group received approximately eight visits during the treatment period.Primary outcome measures: ‘Number of days with headache’, ‘pain intensity’ and ‘medication’ were reported weekly by text messages, and global perceived effect by text message after 4 months. A planned fixed sequence strategy based on an initial outcome data analysis was used to prioritize outcomes. ‘Number of days with headache’ and ‘pain intensity’ were chosen as equally important outcomes of highest priority, followed by global perceived effect and medication. The significance level for the first two outcomes was fixed to 0.025 to take multiplicity into account.ResultsChiropractic spinal manipulation resulted in significantly fewer days with headaches (reduction of 0.81 vs. 0.41, p=0.019, NNT=7) and better global perceived effect (2.63 vs. 3.24, p<0.001, NNT=5) compared with a sham manipulation procedure. There was no difference between groups for pain intensity during headache episodes. Due to methodological shortcomings, no conclusions could be drawn about medication use.Conclusions Chiropractic spinal manipulation resulted in fewer headaches and higher global perceived effect, with only minor side effects. It did not lower the intensity of the headaches.Since the treatment is easily applicable, of low cost and minor side effects, chiropractic spinal manipulation might be considered as a valuable treatment option for children with recurrent headaches.Trial registrationClinicalTrials.gov, identifier NCT02684916, registered 02/18/2016 – retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT02684916

scholarly journals Effectiveness of chiropractic manipulation versus sham manipulation for recurrent headaches in children aged 7-14 years. A randomised clinical trial

2020 ◽  
Author(s):  
Susanne Lynge ◽  
Kristina Boe Dissing ◽  
Werner Vach ◽  
Henrik Wulf Christensen ◽  
Lise Hestbaek
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Pain Intensity ◽  
Active Treatment ◽  
Spinal Manipulation ◽  
Controlled Trial ◽  
Active Treatment Group ◽  
Text Messages ◽  
Control Group ◽  
Fixed Sequence

Abstract Background: To investigate the effectiveness of chiropractic spinal manipulation versus sham manipulation in children aged 7-14 with recurrent headaches. Methods: Design: A two-arm , single - blind, superiority randomised superiority single-blinded clinical controlled trial. Setting: One chiropractic clinic and one paediatric specialty practice in Denmark Participants : 199 children aged 7 to 14 years, who experienced at least one episode of headache per week for the previous 6 months and with at least one musculoskeletal dysfunction identified. Interventions: All participants and parents received standard oral and written advice to reduce headaches. In addition, children in the active treatment group received chiropractic spinal manipulation and children in the control group received sham manipulation for a period of 4 months. The n N umber and frequency of treatments were based on the chiropractor’s individual evaluation in the active treatment group, and the children in the control group received approximately eight visits during the treatment period. Primary outcome measures: ‘Number of days with headache’, ‘pain intensity’ and ‘medication’ were reported weekly by text messages, and global perceived effect by text message after 4 months. A planned fixed sequence strategy based on an initial outcome data analysis was used to prioritize outcomes. ‘Number of days with headache’ and ‘pain intensity’ were chosen as equally important outcomes of highest priority, followed by global perceived effect and medication. The significance level for the first two outcomes was fixed to 0.025 to take multiplicity into account. Results: Chiropractic spinal manipulation resulted in significantly fewer days with headaches (reduction of 0.81 vs. 0.41, p=0.019, NNT=7 for 20% improvement ) and better global perceived effect ( dichotomized into improved/not improved, OR= 2.8 (95% CI: 1.5-5.3) 2.63 vs. 3.24 , p<0.001 , NNT=5) compared with a sham manipulation procedure. There was no difference between groups for pain intensity during headache episodes. Due to methodological shortcomings, no conclusions could be drawn about medication use. Conclusions: Chiropractic spinal manipulation resulted in fewer headaches and higher global perceived effect, with only minor side effects. It did not lower the intensity of the headaches. Since the treatment is easily applicable, of low cost and minor side effects, chiropractic spinal manipulation might be considered as a valuable treatment option for children with recurrent headaches.

scholarly journals Pengaruh Terapi Progressive Muscle Relaxation Terhadap Kecemasan Dan Kualitas Hidup Pada Pasien Diabetes Mellitus Tipe 2 Di RS Muhammadiyah Lamongan

2018 ◽  
Vol 2 (1) ◽  
pp. 45
Author(s):  
Adbul Rokhman ◽  
Lilik Supriati
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Treatment Group ◽  
Muscle Relaxation ◽  
Progressive Muscle Relaxation ◽  
Control Group ◽  
Relaxation Therapy

ABSTRAKPenyakit diabetes mellitus yang tidak bisa disembuhkan secara total sering berdampak pada terjadinya kecemasan dan penurunan kualitas hidup. Untuk menurunkan kecemasan dan meningkatkan kualitas hidup pasien dapat dilakukan terapi progressive muscle relaxation. Penelitian ini bertujuan untuk mengetahui pengaruh terapi PMR (Progressive Muscle Relaxation) terhadap kecemasan dan kualitas hidup pada pasien diabetes mellitus tipe 2 di RS Muhammadiyah Lamongan. Metode quasi eksperimental dengan pendekatan pre-post test control group design dengan simple random sampling. Jumlah sampel 50 orang dibagi menjadi 2 kelompok perlakuan dan kontrol masing-masing 25 orang. Alat ukur menggunakan kuisioner HARS untuk kecemasan dan DQOL (Diabetes Quality of Life) untuk kualitas hidup. Hasil analisis kecemasan dengan uji t pada kelompok perlakuan p 0,000, kelompok kontrol p 0,746. Analisis kualitas hidup pada kelompok perlakuan nilai p 0,000 dan kelompok kontrol p 0,098. Perbedaan kecemasan pada kelompok perlakuan dan kontrol p 0,019. Perbedaan kualitas hidup pada kelompok perlakuan dan kontrol p 0,076. Pengaruh faktor pendidikan terhadap kualitas hidup pada pasien DM tipe 2 sesudah diberikan terapi progressive muscle relaxation sebesar 4,9 % setelah dikontrol variabel lain. Terapi progressive muscle relaxation efektif untuk menurunkan kecemasan dan efektif untuk meningkatkan kualitas hidup pasien DM tipe 2. Terapi progressive muscle relaxation dapat dimasukkan kedalam intervensi keperawatan pada pelayanan rumah sakit. Kata Kunci: Diabetes Mellitus tipe 2, Kecemasan, Kualitas Hidup, Terapi Progressive Muscle Relaxation ABSTRACTDiabetes mellitus which cannot be cured completely often have an impact on the occurrence of anxiety and reduced quality of life. To reduce anxiety and improve the quality of life of patients can use progressive muscle relaxation therapy. This study aims to determine the effect of PMR therapy (Progressive Muscle Relaxation) in anxiety and quality of life in patients with type 2 diabetes mellitus in Lamongan Muhammadiyah Hospital. Quasi-experimental method with the approach of pre-posttest control group design with simple random sampling. Number of samples 50  people  were   divided  into   two   treatment   groups  and   control  each   25   people.  HARS questionnaire instrument used for measuring anxiety and DQOL (Diabetes Quality of Life) for measuring quality of life. Results of the analysis by the t-test anxiety in the experimental group p0.000, 0.746 p control group. Analysis of the quality of life in the treatment group p values of 0.000 and 0.098 p control group. Anxiety differences in the treatment group and the control p0.019. Differences in the quality of life in the treatment group and the control p 0.076. Results of the analysis by the t-test anxiety in the experimental group p 0.000, 0.746 p control group. Analysis of the quality of life in the treatment group p values of 0.000 and 0.098 p control group. Anxiety differences in the treatment group and the control p 0.019. Differences in the quality of life in the treatment group and the control p 0.076. Educational factors influence the quality of life in patients with type 2 diabetes mellitus after progressive muscle relaxation therapy by 4.9% after controlling other variables. Progressive muscle relaxation therapy is effective to reduce anxiety and effective to improve the quality of life of patients with type 2 diabetes. Progressive muscle relaxation therapy can be incorporated into nursing interventions on hospitals.Keyword : Type 2 Diabetes Mellitus, anxiety, quality of life, progressive muscle relaxation therapy

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