scholarly journals Stress Response and Hearing Loss Differentially Contribute to Dynamic Alterations in Hippocampal Neurogenesis and Microglial Reactivity in Mice Exposed to Acute Noise Exposure

2021 ◽  
Vol 15 ◽  
Author(s):  
Qian Li ◽  
Hong Li ◽  
Xiuting Yao ◽  
Conghui Wang ◽  
Haiqing Liu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Stress Response ◽  
Time Course ◽  
Noise Exposure ◽  
Neurological Diseases ◽  
Noise Pollution ◽  
Modern Society ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Serum Corticosterone

Noise-induced hearing loss (NIHL) is one of the most prevalent forms of acquired hearing loss, and it is associated with aberrant microglial status and reduced hippocampal neurogenesis; however, the nature of these associations is far from being elucidated. Beyond its direct effects on the auditory system, exposure to intense noise has previously been shown to acutely activate the stress response, which has increasingly been linked to both microglial activity and adult hippocampal neurogenesis in recent years. Given the pervasiveness of noise pollution in modern society and the important implications of either microglial activity or hippocampal neurogenesis for cognitive and emotional function, this study was designed to investigate how microglial status and hippocampal neurogenesis change over time following acoustic exposure and to analyze the possible roles of the noise exposure-induced stress response and hearing loss in these changes. To accomplish this, adult male C57BL/6J mice were randomly assigned to either a control or noise exposure (NE) group. Auditory function was assessed by measuring ABR thresholds at 20 days post noise exposure. The time-course profile of serum corticosterone levels, microglial status, and hippocampal neurogenesis during the 28 days following noise exposure were quantified by ELISA or immunofluorescence staining. Our results illustrated a permanent moderate-to-severe degree of hearing loss, an early but transient increase in serum corticosterone levels, and time-dependent dynamic alterations in microglial activation status and hippocampal neurogenesis, which both present an early but transient change and a late but enduring change. These findings provide evidence that both the stress response and hearing loss contribute to the dynamic alterations of microglia and hippocampal neurogenesis following noise exposure; moreover, noise-induced permanent hearing loss rather than noise-induced transient stress is more likely to be responsible for perpetuating the neurodegenerative process associated with many neurological diseases.

scholarly journals Noise Pollution and Its Correlations with Occupational Noise-Induced Hearing Loss in Cement Plants in Vietnam

2021 ◽  
Vol 18 (8) ◽  
pp. 4229
Author(s):  
Tinh Thai ◽  
Petr Kučera ◽  
Ales Bernatik
Keyword(s):  
Hearing Loss ◽  
Noise Level ◽  
Noise Exposure ◽  
Noise Pollution ◽  
Noise Induced Hearing Loss ◽  
Exposure Limit ◽  
Global Issue ◽  
Exposed Workers ◽  
Almost All ◽  
Cement Grinding

Noise-Induced Hearing Loss (NIHL) is a global issue that is caused by many factors. The purpose of this study was to survey noise level to identify NIHL and its relationship with other factors in cement plants in Vietnam. Noise level was measured at one cement plant and three cement grinding stations located in the South of Vietnam. The audiometric data of exposed workers were surveyed to determine NIHL. Finally, the relationship between NIHL and noise level in cement plants was determined. The results show that noise level in almost all processes exceeded the permissible exposure limit (PEL). In this study, 42 cases (10% of exposed workers) with occupational NIHL were found with mean age (SD) of 49 (9.0) years. All NIHL cases were found in the departments in which the noise level exceeded the PEL, which included quarry (n = 16), maintenance (n = 12), production (n = 10), co-waste processing (n = 3) and quality assurance (n = 1). There was a positive and significant correlation between the NIHL and the excessive noise exposure in the cement plants (r = 0.89, p = 0.04).

Permanent Threshold Shift Associated With Overamplification by Hearing Aids

1991 ◽  
Vol 34 (2) ◽  
pp. 403-414 ◽  
Author(s):  
John H. Macrae
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Hearing Aids ◽  
Time Course ◽  
Noise Exposure ◽  
High Volume ◽  
Normal Hearing ◽  
Sensorineural Hearing ◽  
Threshold Shift ◽  
Volume Control

Humes and Jesteadt have proposed that the Modified Power Law (MPL) provides a means of predicting permanent threshold shift (PTS) due to noise exposure in subjects with preexisting sensorineural hearing loss. Data concerning PTS attributed to overamplification by hearing aids in 8 children with severe sensorineural hearing loss were used to evaluate the MPL hypothesis. The excessive amplification was partly due to use by the children of very high volume-control settings instead of mid-range volume-control settings. The PTS tended to be flat across frequency. Its course in time was a miniature version of the time course of PTS that would be induced by a similar noise exposure in a person with normal hearing. It began to occur soon after the start of hearing aid use and its rate of development was slower than that which would occur in a person with normal hearing. The growth of PTS could be predicted from the estimated real ear output levels of the children’s hearing aids by means of the MPL combined with the logarithmic equation proposed by Kraak for predicting the effect of noise exposure on hearing.

scholarly journals Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective

2021 ◽  
Author(s):  
A. Surget ◽  
C. Belzung
Keyword(s):  
Stress Response ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Pattern Separation ◽  
Brain Areas ◽  
Functional Involvement ◽  
Different Dimensions ◽  
Stressful Experiences ◽  
The Brain

AbstractAdult hippocampal neurogenesis (AHN) represents a remarkable form of neuroplasticity that has increasingly been linked to the stress response in recent years. However, the hippocampus does not itself support the expression of the different dimensions of the stress response. Moreover, the main hippocampal functions are essentially preserved under AHN depletion and adult-born immature neurons (abGNs) have no extrahippocampal projections, which questions the mechanisms by which abGNs influence functions supported by brain areas far from the hippocampus. Within this framework, we propose that through its computational influences AHN is pivotal in shaping adaption to environmental demands, underlying its role in stress response. The hippocampus with its high input convergence and output divergence represents a computational hub, ideally positioned in the brain (1) to detect cues and contexts linked to past, current and predicted stressful experiences, and (2) to supervise the expression of the stress response at the cognitive, affective, behavioral, and physiological levels. AHN appears to bias hippocampal computations toward enhanced conjunctive encoding and pattern separation, promoting contextual discrimination and cognitive flexibility, reducing proactive interference and generalization of stressful experiences to safe contexts. These effects result in gating downstream brain areas with more accurate and contextualized information, enabling the different dimensions of the stress response to be more appropriately set with specific contexts. Here, we first provide an integrative perspective of the functional involvement of AHN in the hippocampus and a phenomenological overview of the stress response. We then examine the mechanistic underpinning of the role of AHN in the stress response and describe its potential implications in the different dimensions accompanying this response.

scholarly journals Hearing Loss Due to Traffic Noise-in Una Town.

10.29007/bngd ◽  
2018 ◽  
Author(s):  
Alpesh Sankhat ◽  
C. B. Mishra ◽  
Shailesh Parmar
Keyword(s):  
Hearing Loss ◽  
Noise Exposure ◽  
Road Traffic ◽  
Traffic Noise ◽  
Noise Pollution ◽  
Threshold Shift ◽  
Road Traffic Noise ◽  
Negative Effects ◽  
High Level ◽  
Audiometric Test

Road traffic noise is likely the most thorough and inescapable kind of noise pollution and is in charge of negative effects that are destructive to nature and the nature of group health of mankind. Residential area/towns close by roads are additionally casualty of the issue, extraordinarily have the high danger of hearing loss due to the traffic noise exposure. The Objectives of the present review were to concentrate the attributes of hearing loss and survey the predominance of hearing loss because of traffic on 52 people working 8 to 12 hours close to the periphery of NH 8E going through Una Town by performing audiometric test. Consequence of the present study demonstrates that hearing impairment are common in people persistently exposed to traffic noise. The effect of high-level traffic noise leads to temporary threshold shift and if any person is exposed to such noisy environment may suffer from permanent threshold shift after long period of time.

scholarly journals The Avian Hippocampal Formation and the Stress Response

2017 ◽  
Vol 90 (1) ◽  
pp. 81-91 ◽  
Author(s):  
Tom V. Smulders
Keyword(s):  
Electrical Stimulation ◽  
Stress Response ◽  
Glucocorticoid Receptors ◽  
Hippocampal Formation ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Functional Specialization ◽  
Chronic Stressors ◽  
Temporal Pole ◽  
Hippocampal Lesions

Though widely studied for its function in memory and navigation, the hippocampal formation (HF) in mammals also plays an important role in regulating the stress response. If this is an ancestral feature of the hippocampus, then it is likely that the avian HF plays a similar role. Indeed, the avian HF strongly expresses both mineralocorticoid and glucocorticoid receptors, and has indirect projections to the paraventricular nucleus of the hypothalamus, which controls the hypothalamic-pituitary-adrenal (HPA) axis. Hippocampal lesions increase HPA activity, while electrical stimulation suppresses it. In addition, adult hippocampal neurogenesis in birds is reduced in response to different acute and chronic stressors, as it is in mammals. Because the mammalian hippocampus is functionally specialized along its septotemporal axis, with the temporal pole playing a more important role in the stress response, the hypothesis is put forward that a similar functional specialization exists in birds along the rostrocaudal hippocampal axis. Some, though not all, of the evidence supports a rostrocaudal functional gradient. The evidence for whether this is equivalent to the mammalian septotemporal organization is currently ambiguous at best and needs to be more extensively investigated.

scholarly journals Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer’s disease

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Fabiola Paciello ◽  
Marco Rinaudo ◽  
Valentina Longo ◽  
Sara Cocco ◽  
Giulia Conforto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hearing Loss ◽  
Mouse Model ◽  
Cognitive Decline ◽  
Time Course ◽  
Noise Exposure ◽  
Sensory Deprivation ◽  
Model Of Alzheimer’S Disease ◽  
The Impact

Although association between hearing impairment and dementia has been widely documented by epidemiological studies, the role of auditory sensory deprivation in cognitive decline remains to be fully understood. To address this issue we investigated the impact of hearing loss on the onset and time-course of cognitive decline in an animal model of Alzheimer’s disease (AD), that is the 3×Tg-AD mice and the underlying mechanisms. We found that hearing loss induced by noise exposure in the 3×Tg-AD mice before the phenotype is manifested caused persistent synaptic and morphological alterations in the auditory cortex. This was associated with earlier hippocampal dysfunction, increased tau phosphorylation, neuroinflammation, and redox imbalance, along with anticipated memory deficits compared to the expected time-course of the neurodegenerative phenotype. Our data suggest that a mouse model of AD is more vulnerable to central damage induced by hearing loss and shows reduced ability to counteract noise-induced detrimental effects, which accelerates the neurodegenerative disease onset.

Hearing: The Effects of Noise

1992 ◽  
Vol 106 (6) ◽  
pp. 669-676 ◽  
Author(s):  
William W. Clark
Keyword(s):  
Hearing Loss ◽  
Auditory System ◽  
Noise Exposure ◽  
Modern Society ◽  
Noisy Environments ◽  
Permanent Damage ◽  
Department Of Labor ◽  
The Past ◽  
The U.S ◽  
Excessive Noise

We live in a noisy world. The clamor and din of modern society has increased in variety, if not in prevalence and intensity, In the past decades, making noise America's most widespread nuisance. Excessive noise exposure annoys individuals, produces stress, Impairs the ability to communicate, Interferes with work and play activities, and, in high enough doses, produces permanent damage to the auditory system, which leads to significant hearing loss. Noise exposure associated with the workplace has been known to produce hearing loss for centuries. More than 20 years ago the U.S. Department of Labor promulgated regulations designed to protect the hearing of employees who work in noisy environments. However, these regulations failed to consider noise exposures outside the workplace, and recent evidence suggests that these exposures are potentially hazardous for millions of Americans. The most important sources of nonoccupational noise exposure are hunting and target shooting, listening to amplified music through headphones, and attendance at rock concerts. For each source, an assessment of risk of hearing loss is made.

scholarly journals Innovative Approaches to Noise Reduction

2020 ◽  
Author(s):  
Mia Suhanek ◽  
Sanja Grubesa
Keyword(s):  
Quality Of Life ◽  
Noise Reduction ◽  
Noise Exposure ◽  
Harmful Effect ◽  
Noise Pollution ◽  
Modern Society ◽  
Daily Basis ◽  
Long Period ◽  
Acoustic Environments

Nowadays, each individual is exposed to noise on a daily basis, and noise is often referred as in literature as a plague of modern society. Noise pollution is often overlooked when compared to other environmental pollutions (e.g. air, water, soil pollution). However, same as the all aforementioned pollutions, noise exposure has an accumulating character, meaning that the harmful effect of noise is detected only after a long period of time. Long exposure to noise pollution can be displayed as a bad mood, fatigue, insomnia, headache and loss of concentration, which causes reduced work ability and ultimately permanent hearing impairment. The goal of this chapter is to present two different approaches (traditional and contemporary) in noise reductions. The aim of both approaches is to link objective and subjective acoustic parameters, in order to plan future urban infrastructures while keeping in mind the existing acoustic environments, and to create and implement new solutions that will design, preserve and improve acoustic environments. Thus, we can conclude this chapter will be oriented towards human health and overall quality of life in terms of noise reduction.

Sign in / Sign up

Export Citation Format

Share Document