scholarly journals The orexin neuropeptide system: physical activity and hypothalamic function throughout the aging process

Author(s):  
Anastasia N. Zink ◽  
Claudio Esteban Perez-Leighton ◽  
Catherine M. Kotz
2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Martha A. Sánchez-Rodríguez ◽  
Mariano Zacarías-Flores ◽  
Elsa Correa-Muñoz ◽  
Alicia Arronte-Rosales ◽  
Víctor Manuel Mendoza-Núñez

Oxidative stress (OS) increases during the human aging process, and the sedentary lifestyle could be a prooxidant factor. In this study, we determine the effect of sedentary lifestyle on OS during the aging process in Mexican women. A longitudinal study of two-year follow-up was carried out with 177 community-dwelling women (40-69 y) from Mexico City. We measured as OS markers plasma malondialdehyde, erythrocyte glutathione peroxidase (GPx) and superoxide dismutase (SOD), total plasma antioxidant status, uric acid level, antioxidant gap, and SOD/GPx ratio. To define OS using all the markers, we defined cut-off values of each parameter based on the 90th percentile of young healthy subjects and, we calculated a stress score (SS) ranging from 0 to 7, which represented the intensity of the marker modifications. All the women answered a structured questionnaire about prooxidant factors, including physical activity specially the type of activity, frequency, and duration, and they answered Spanish versions of self-assessment tests for establishing dysthymia and insomnia as potential confounders. Principal component and Poisson regression analysis were used as statistical tools, being two-year OS the primary outcome. The OS was considerate as SS ≥ 4 and sedentary lifestyle as <30 min/day of physical activity, beside several prooxidant factors and age that were covariables. SS is higher in sedentary lifestyle women after the two-year follow-up; although, the difference was statistically significant only in older women. Four principal components were associated with the OS, and 7 out of 8 prooxidant factors were important for the analysis, which were included in the Poisson model. The predictive factors for OS were the sedentary lifestyle (adjusted PR = 2.37, CI95%: 1.30–4.30, p < 0.01 ), and age, in which the risk increases 1.06 (CI95%:1.02–2.11, p < 0.01 ) by each year of age. Our findings suggest that a sedentary lifestyle increases the OS during the aging in Mexican women.


2015 ◽  
Vol 18 (4) ◽  
pp. 871-880 ◽  
Author(s):  
Mafalda Duarte ◽  
Constança Paúl

The present study is based on the conceptual model defined by Fried which explains phenotypic frailty through the presence of the following criteria: weight loss; exhaustion; low physical activity; slowness and weakness. The aim of the present study was to identify the behaviour of phenotypic frailty and outline the profile of the frail elderly person. In order to do this, a random stratified sample of 339 individuals residing in the community was obtained. A frailty protocol was developed, composed of measures related to the aging process and phenotypic frailty. The results indicated a high prevalence of this syndrome (34.9%). It occurs more frequently among women (40.9%) and at more advanced ages (60.4%). The criteria that appeared most frequently in association with frailty are low physical activity (88.9%) and slowness (86.4%). Frail elderly individuals were characterized by being widow/separated/divorced (46.7%); illiterate (71.1%); living within a family with some degree of dependence (41.6%); living in unsuitable conditions (44.9%); having limited social relations (54.2%) and not receiving social support (37.6%). It can be concluded that frailty is a prevalent condition, and that the profile of the frail individual is associated with a set of characteristics that result in greater vulnerability, which suggests possible areas of intervention to minimize and delay this syndrome.


2014 ◽  
Vol 155 (21) ◽  
pp. 817-821 ◽  
Author(s):  
Péter Apor ◽  
László Babai

Aging-related decline of muscle force, walking speed, locomotor coordination, aerobic capacity and endurance exert prognostic impact on life expectancy. Proper use of training may diminish the aging process and it may improve the quality of life of elderly persons. This paper provides a brief summary on the impact of training on aging-related decline of physical and cognitive functions. Orv. Hetil., 2014, 155(21), 817–821.


Author(s):  
Natalie Beausoleil ◽  
Geneviève Martin

ABSTRACTThis article discusses qualitative research conducted in minority Francophone communites in Ontario. The perceptions of and participation in physical activity by some thirty women are analysed with respect to sociological foundations and current views on aging. These views apply to individual responsibility for health; to the links between health, beauty, and aging; to participation in sports; to perceptions of masculinity and femininity; and, finally, to the obligation to remain physically active at all stages of life. The results of the study among women grouped into three age brackets reveal that, although these women have adopted a view of individual responsibility for health and the prevention of the harmful effects of aging through regular physical exercise, they may also be seen as subjects who find strategies in their daily lives to avoid falling prey to the pressures of health and beauty standards regarding aging, to face limitations, and to develop a healthy way of experiencing the aging process.


2017 ◽  
Vol 39 (01) ◽  
pp. 21-28 ◽  
Author(s):  
Mohamed Bouzid ◽  
Edith Filaire ◽  
Régis Matran ◽  
Sophie Robin ◽  
Claudine Fabre

AbstractThe hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise. There was no difference in resting antioxidant activities and lipid peroxidation between YS and OS. However, resting SOD and GR activities were higher in YA compared to OA (p<0.01 and p<0.05, respectively) and resting MDA level was higher in OA compared to YA (p<0.01). After exercise, a significant increase in SOD and GPX activities was observed in YS, YA and OA (p<0.01). Likewise, after exercise a significant increase of MDA level in YA, OS and OA (p<0.01) was observed. In addition, the comparison of YA to OA and YS to OA revealed similar antioxidant activities and lipid peroxidation between YS and OA, whereas antioxidant activities were higher in YA compared to OA. These data suggest that beneficial effects of regular physical activity in antioxidant defense and lipid peroxidation damage could be impaired by the aging process and that regular physical activity in older adults could maintain age-related decreases in antioxidant defense.


Author(s):  
Celia Maria Francisco ◽  
Marcia Abrantes Pinheiro

Os espaços de Convivência para o idoso no Brasil, destina-se ao segmento às pessoas com idade igual ou superior a 60 anos em situação de vulnerabilidade, risco pessoal e social. Assim, o objetivo do estudo foi conhecer os benefícios e as estratégias utilizadas nos Núcleos e Centros de Convivência para idosos. Foi realizada revisão integrativa nas bases SCIELO e LILACS. Para tal foi utilizado os descritores Convivência; Idoso, Isolamento. Os resultados demonstram que os idosos participantes de centro de convivência apresentam melhor equilíbrio, mobilidade funcional e qualidade de vida quando comparados aqueles que não frequentam o espaço. Conclui-se que os espaços de convivência não seja apenas um local para atividade física, lazer, diversão e prevenção a doenças associadas ao processo do envelhecimento, mas sim, um ambiente que contribui para o autonomia, independência e inclusão social da pessoa idosa.Descritores: Convivência, Idoso, Isolamento. Spaces of coexistence for elderly: benefits and strategiesAbstract: The retirement communities in Brazil, are aimed at the segment of people aged 60 or over in a situation of vulnerability, personal and social risk. Thus, the objective of the study was to know the benefits and strategies used in this retirement communities. An integrative review was carried out at the SCIELO and LILACS databases. To this end, the descriptors were used Coexistence; Old, Isolation. The results show that elderly people living in retirement communities have better balance, functional mobility and quality of life when compared to those who do not attend the space. It is concluded that the living spaces are not only a place for physical activity, leisure, fun and prevention of diseases associated with the aging process, but rather an environment that contributes to the autonomy, independence and social inclusion of the elderly person.Descriptors: Coexistence, Old, Isolation. Espacios de convivencia para anciano: beneficios y estrategiasResumen: Los espacios de Convivencia para el anciano en Brasil, se destina al segmento a las personas con edad igual o superior a 60 años en situación de vulnerabilidad, riesgo personal y social. Así, el objetivo del estudio fue conocer los beneficios y las estrategias utilizadas en los Núcleos y Centros de Convivencia para ancianos. Se realizó una revisión integrativa en las bases SCIELO y LILACS. Para ello se utilizaron los descriptores Convivencia; Ancianos, Aislamiento. Los resultados demuestran que los ancianos participantes de centro de convivencia presentan mejor equilibrio, movilidad funcional y calidad de vida cuando comparados aquellos que no frecuentan el espacio. Se concluye que los espacios de convivencia no son sólo un lugar para la actividad física, el ocio, la diversión y la prevención de las enfermedades asociadas al proceso del envejecimiento, sino un entorno que contribuye a la autonomía, independencia e inclusión social de la persona de edad.Descriptores: Convivencia, Ancianos, Aislamiento.


Author(s):  
Francisco José Gondim Pitanga ◽  
Cristiano Penas Seara Pitanga ◽  
Carmem Cristina Beck

Abstract Studies have shown reductions in the immune response capacity with the aging process (immunosenescence). Lifestyle factors (physical activity and diet) have been investigated as possible adjuvants to improve the effect of vaccines on the immune system in the elderly. The aim of this opinion article is to analyze studies on physical activity and the effect of influenza vaccines in an attempt to suggest that their results can also be found in future studies on physical activity and vaccines against COVID-19. Considering the results of the studies analyzed, it could be suggested that the practice of physical activity improves responses to the influenza vaccine. Thus, it could be assumed that, when transferring these findings to COVID-19, the importance of regular physical activity in the specific elderly population becomes extremely relevant during the COVID-19 pandemic.


2003 ◽  
Vol 11 (3) ◽  
pp. 370-387 ◽  
Author(s):  
Emily A. Roper ◽  
Douglas J. Molnar ◽  
Craig A. Wrisberg

In the sport, physical activity, and aging literature, much attention has been given to the importance of physical activity and sport involvement for the elderly. Most of the literature, however, has focused on the continuity of physical activity among older adults. The purpose of this study was to extend the understanding of older sport participants by conducting a case study of Max Springer, a male, White master runner (88 years old). We assumed that continuity in sport would represent a primary adaptive strategy for coping with the aging process. In addition to two in-depth interviews with Max, the authors interviewed various other “participants” regarding their perceptions of Max as an older runner. From deductive analysis of the interview material, the following themes emerged as figural to Max’s experience as an older runner: tradition of always being physically active, I’m not an athlete, being of senior age, meaning and philosophy of running, and significance of social support.


2014 ◽  
Vol 22 (3) ◽  
pp. 441-452 ◽  
Author(s):  
Anne O. Brady ◽  
Chad R. Straight ◽  
Ellen M. Evans

The aging process leads to adverse changes in body composition (increases in fat mass and decreases in skeletal muscle mass), declines in physical function (PF), and ultimately increased risk for disability and loss of independence. Specific components of body composition or muscle capacity (strength and power) may be useful in predicting PF; however, findings have been mixed regarding the most salient predictor of PF. The development of a conceptual model potentially aids in understanding the interrelated factors contributing to PF with the factors of interest being physical activity, body composition, and muscle capacity. This article also highlights sex differences in these domains. Finally, factors known to affect PF, such as sleep, depression, fatigue, and self-efficacy, are discussed. Development of a comprehensive conceptual model is needed to better characterize the most salient factors contributing to PF and to subsequently inform the development of interventions to reduce physical disability in older adults.


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