scholarly journals Effects of Lactobacillus plantarum FZU3013-Fermented Laminaria japonica on Lipid Metabolism and Gut Microbiota in Hyperlipidaemic Rats

2021 ◽  
Vol 8 ◽  
Author(s):  
Jin-Peng Hu ◽  
Ting-Ting Zheng ◽  
Bin-Fen Zeng ◽  
Man-Ling Wu ◽  
Rui Shi ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Lactobacillus Plantarum ◽  
Metabolic Pathways ◽  
High Fat Diet ◽  
Lipid Droplets ◽  
Short Chain Fatty Acid ◽  
Laminaria Japonica ◽  
Mrna Levels ◽  
High Fat ◽  
Positive Effect

In this study, we explored the effect of Lactobacillus plantarum FZU3013-fermented Laminaria japonica (LPLJ) supplementation to prevent hyperlipidaemia in rats fed with a high-fat diet (HFD). The results indicate that LPLJ supplementation improved serum and hepatic biochemical indicators (p < 0.05), elevated short-chain fatty acid levels, reduced HFD-induced accumulation of lipid droplets in the liver, modulated the relative abundance of some microbial phylotypes, and reduced hyperlipidaemia in HFD-fed rats by adjusting the aminoacyl-tRNA, phenylalanine, tyrosine, and tryptophan biosynthetic pathways, as well as the phenylalanine, D-glutamine and D-glutamate, and glutathione metabolic pathways. Additionally, hepatic mRNA levels of the genes involved in lipid metabolism and bile acid homeostasis were significantly reduced by LPLJ intervention (p < 0.05). These results suggest that LPLJ has a positive effect on modulating lipid metabolism and has the potential to be a functional food that can help prevent hyperlipidaemia.

Abstract 023: Inducible Deletion of Adipocyte Prorenin Receptor Reverses Obesity Related Hypertension

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Eva Gatineau ◽  
Dianne Cohn ◽  
Ming Gong ◽  
Frédérique Yiannikouris
Keyword(s):  
Blood Pressure ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Fat Mass ◽  
High Fat Diet ◽  
Standard Diet ◽  
Mrna Levels ◽  
High Fat ◽  
Elevated Systolic Blood Pressure ◽  
Prorenin Receptor

Obesity contributes to approximatively 2.5 million deaths every year and is associated with life threatening conditions including hypertension. Recently, we found that constitutive deletion of adipocyte (pro)renin-receptor (PRR) prevented high-fat diet-induced obesity through a drastic decrease in fat mass. However, adipocyte PRR deficient mice were characterized by a fatty liver and by an elevated systolic blood pressure (SBP), classic features of models of lipodystrophy. The purpose of this study was to investigate whether the temporally-controlled deletion of adipocyte PRR in obese mice reverses obesity related hypertension. After 18 weeks of high fat diet, inducible adipocyte-PRR deficient ( PRR ERT ) and control ( PRR fl/Y ) male mice (n=7-11 mice/ group) were injected intraperitoneally with tamoxifen (TMX) for 5 consecutive days. Body weight, body composition and blood pressure, measured by radiotelemetry in a subgroup of mice (n=2-4 mice/ group), were recorded before and after TMX injection. The inducible deletion of adipocyte PRR in PRR ERT mice decreased significantly body weights ( PRR fl/fl , 46.6 ± 1.3 g; PRR ERT , 42.1 ± 1.4 g, P<0.05) and fat mass ( PRR fl/fl , 15.8 ± 1.0 g; PRR ERT , 8.1 ± 0.7 g, P<0.05) compared to control mice. PPARγ, FABP4 and FAS mRNA levels were significantly decreased by 68% (6.8 out 10), 80% (8 out 10) and 68% (6.8 out 10) respectively in white adipose tissues of PRR ERT mice suggesting that PRR positively regulated adipogenesis and lipid metabolism in adipose tissue. In addition, the inducible deletion of adipocyte PRR in PRR ERT mice decreased significantly SBP compared to control mice ( PRR fl/fl , -4.3 ± 3.2 g; PRR ERT , -10.2 ± 2.4 g, P<0.05). Interestingly, adipocyte angiotensinogen mRNA abundance was significantly decreased in adipose tissue of PRR ERT mice fed a standard diet suggesting that the decrease in blood pressure might be mediated by a local renin angiotensin system (RAS). The measurement of local (liver, kidney, adipose tissue and brain) and systemic RAS in HF-fed mice is under investigation. Taken together, our results highlight a new signaling pathway in which PRR regulates adipogenesis, lipid metabolism and blood pressure. PRR could represent a new potential therapeutic target for obesity and hypertension.

Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease

2014 ◽  
Vol 5 (12) ◽  
pp. 3216-3223 ◽  
Author(s):  
Chuan Li ◽  
Shao-Ping Nie ◽  
Ke-Xue Zhu ◽  
Qiao Ding ◽  
Chang Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Liver Function ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Possible mechanisms underlying how Lactobacillus plantarum NCU116 improves lipid metabolism in rats with high fat diet induced NAFLD.

scholarly journals The Effects of TwoLactobacillus plantarumStrains on Rat Lipid Metabolism Receiving a High Fat Diet

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Rastislav Salaj ◽  
Jana Štofilová ◽  
Alena Šoltesová ◽  
Zdenka Hertelyová ◽  
Emília Hijová ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Ldl Cholesterol ◽  
Body Weight Gain ◽  
Diet Group ◽  
High Fat ◽  
Probiotic Strains ◽  
Total Bile Acids

The aim of our study was to evaluate the effects of the different probiotic strains,Lactobacillus plantarumLS/07 andLactobacillus plantarumBiocenol LP96, on lipid metabolism and body weight in rats fed a high fat diet. Compared with the high fat diet group, the results showed thatLactobacillus plantarumLS/07 reduced serum cholesterol and LDL cholesterol, butLactobacillus plantarumBiocenol LP96 decreased triglycerides and VLDL, while there was no change in the serum HDL level and liver lipids. Both probiotic strains lowered total bile acids in serum. Our strains have no significant change in body weight, gain weight, and body fat. These findings indicate that the effect of lactobacilli on lipid metabolism may differ among strains and that theLactobacillus plantarumLS/07 andLactobacillus plantarumBiocenol LP96 can be used to improve lipid profile and can contribute to a healthier bowel microbial balance.

The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet

2020 ◽  
Vol 11 (6) ◽  
pp. 5024-5039 ◽  
Author(s):  
Yujun Liu ◽  
Yuan Gao ◽  
Fenglian Ma ◽  
Mengying Sun ◽  
Guangqing Mu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Lipid Metabolism ◽  
Oral Administration ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Intestinal Transit ◽  
Obese Mice ◽  
High Fat ◽  
Ameliorative Effect ◽  
Transit Tolerance

In our previous studies, Lactobacillus plantarum Y44 showed antioxidant activity and favorable gastric and intestinal transit tolerance.

Regulating effect of Lactobacillus plantarum CQPC03 on lipid metabolism in high‐fat diet‐induced obesity in mice

2020 ◽  
Vol 44 (11) ◽  
Author(s):  
Yi Gan ◽  
Hong Chen ◽  
Xian‐Rong Zhou ◽  
Ling‐Ling Chu ◽  
Wan‐Ting Ran ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

The beneficial effects of Lactobacillus brevis FZU0713-fermented Laminaria japonica on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed a high-fat diet

2021 ◽  
Author(s):  
Qing Zhang ◽  
xiaoyun fan ◽  
Ying-Jia Cao ◽  
Ting-Ting Zheng ◽  
Wenjian Cheng ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Oral Administration ◽  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Laminaria Japonica ◽  
Lactobacillus Brevis ◽  
High Fat ◽  
Beneficial Effects

This study aimed to investigate the beneficial effects of oral administration of Lactobacillus brevis FZU0713-fermented Laminaria japonica (FLJ) on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed a high-fat...

Effect of Mixture of Lactobacillus plantarum CECT 7527, 7528, and 7529 on Obesity and Lipid Metabolism in Rats Fed a High-fat Diet

2014 ◽  
Vol 43 (10) ◽  
pp. 1484-1490 ◽  
Author(s):  
Dae Hwan Kim ◽  
Mi-Ran Choi ◽  
Ji Eun Hong ◽  
Jae-Yong Lee ◽  
Soon Im Lee ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
High Fat

Anti‐obesity effect of Lactobacillus plantarum CQPC01 by modulating lipid metabolism in high‐fat diet‐induced C57BL/6 mice

2020 ◽  
Vol 44 (12) ◽  
Author(s):  
Yi Gan ◽  
Ming‐Wei Tang ◽  
Fang Tan ◽  
Xian‐Rong Zhou ◽  
Ling Fan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
High Fat
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