scholarly journals Clinical Features and Prognoses of IgG4-Positive and IgG4-Negative Lacrimal Lymphomas

2021 ◽  
Vol 11 ◽  
Author(s):  
Rui Liu ◽  
Jinjin Wang ◽  
Nan Wang ◽  
Jing Li ◽  
Xin Ge ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Statistical Difference ◽  
Diagnostic Significance ◽  
Immunoglobulin G4 ◽  
Clinical Indicators ◽  
Cumulative Percentage ◽  
Department Of Ophthalmology ◽  
Serum Igg4 ◽  
The Mean ◽  
Male To Female

Purpose: The clinical characteristics and prognoses of immunoglobulin G4-positive (IgG4+) and IgG4-negative (IgG4−) lacrimal lymphomas were comparatively analyzed to screen for clinical indicators with differential diagnostic significance.Methods: This was a retrospective and single-center clinical study. From June 2011 to June 2018, clinical data of 39 patients with lacrimal lymphoma, diagnosed by histopathology were collected from the Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University.Results: According to inclusion and exclusion criteria, 30 (76.9%) were in the IgG4− group and 9 (23.1%) were in the IgG4+ group. In the IgG4+ group, the sex ratio of male to female was 2:1 and the mean age was 56.67 ± 13.29 years old. In the IgG4− group, the sex ratio of male to female was 3.29:1 and the mean age was 61.47 ± 12.87 years old. Statistical analysis of the clinical indicators showed significant differences between the two groups in affected eye, preoperative history of glucocorticoids, ocular nerve thickening, the expression of serum IgG4 and prognosis (P < 0.05). There was no significant statistical difference in laboratory indicators between the two groups, including C3, C4, RF, ASO, CRP, IgA, IgM, IgG, IgG1, IgG2, and IgG3 (P > 0.05). The event-free cumulative percentages at 3 and 5 years for the 39 lacrimal lymphomas were 81.1 and 62.4%, respectively, with recurrence and death as end events. In 34 lacrimal gland MALT lymphoma cases, the event-free cumulative percentages at 3 and 5 years were 84.4 and 69.1%, respectively. In the IgG4+ and IgG4− groups, the event-free cumulative percentages at 3 years were 75.0 and 87.7%, respectively. The event-free cumulative percentage at 5 years was 62.6% in the IgG4-group and insignificant in the IgG4+ group. There was no statistical difference in event-free cumulative percentage between the two groups (P = 0.983).Conclusion: The pathogenesis and disease characteristics of IgG4-positive lacrimal lymphoma may differ from IgG4-negative lacrimal lymphoma, but the positive expression of IgG4 may not have significant influence on the recurrence of lacrimal lymphoma.

scholarly journals On the fecundity and sex-ratio of Botia Dario (Hamilton) (Cypriniformes : Cobitidae)

1970 ◽  
Vol 26 ◽  
pp. 27-29 ◽  
Author(s):  
M Afzal Hussain ◽  
Mst Rehana Khatun ◽  
M Altaf Hossain
Keyword(s):  
Body Weight ◽  
Sex Ratio ◽  
Standard Length ◽  
Female Ratio ◽  
Ovary Weight ◽  
Total Length ◽  
Length Standard ◽  
The Mean ◽  
The Relationship ◽  
Male To Female

A total of 1183 Botia Dario (Hamilton) samples were collected from Rajshahi (Shaheb Bazar, Binodpur Bazar, Talaimari Bazar, Kazla Bazar and Godagari) during the period from January, 2002 to August, 2003 to study the fecundity, sex-ratio, relationship between fecundity and total length, standard length, body weight, ovary length as well as ovary weight. The mean fecundity was calculated as 31833.50±10313.42 with a range of 5245 to 53754 in fishes ranging in total length from 96 mm to 135 mm (mean 115.50±12.11 mm) and in body weight from 14.51 g to 43.29 g (mean 29.71±6.91 g). The relationship between the fecundity (F) and total length (TL), standard length (SL), body weight (BW), ovary length (OL) and ovary weight (OW) were found to be linear with the ‘r’ values 0.94, 0.94, 0.95, 0.92 and 0.98, respectively. The ovum diameter ranged from 0.3 to 0.72 mm and the mean diameter was calculated as 0.518±0.06 mm. The male to female ratio was 1:0.61. Key words: Botia dario, fecundity, sex-ratio. Univ. j. zool. Rajshahi Univ. Vol. 26, 2007. pp. 27-29

scholarly journals Pterygium Excision with Sutureless, Glueless Conjunctival Autograft

2021 ◽  
Vol 20 (1) ◽  
pp. 46-49
Author(s):  
Sachit Dhakal ◽  
Kamala Thapa ◽  
Niranjan Sharan
Keyword(s):  
Surgical Techniques ◽  
Autologous Serum ◽  
Common Condition ◽  
Hospital Data ◽  
Female Ratio ◽  
Post Surgery ◽  
Department Of Ophthalmology ◽  
Pterygium Surgery ◽  
The Mean ◽  
Male To Female

Introduction: Pterygium is a common condition and various surgical techniques have been described for its excision, of which autografting is seen to have very less recurrence. Graft fixation with fibrin glue is gaining popularity, but autologous serum might be a cheaper alternative. This study was planned to explore the efficacy of autologous serum as a stabilising agent for graft surgery in pterygium. Methods: The hospital data of patients who underwent pterygium surgery with autografting using autologous serum in the Department of Ophthalmology of Shree Birendra Hospital, Chhauni, Kathmandu, Nepal between Oct 2015 to Sept 2017 were retrospectively analysed. The graft stability post-surgery was studied. Results: 46 eyes of 46 patients underwent pterygium surgery with autograft using autologous serum. The male to female ratio was 1.08:1, and the mean age was 45 years. All the pterygium were nasal sided. Post-operatively the graft was stable in all of the cases. Conclusions: Autologous serum is a good stabilising agent for graft surgery in pterygium.

Determination some Immunological Aspects in Pulmonary Tuberculosis Patients in Qadisiyah Province

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Syoof Khowman Alramahy ◽  
Akram Hadi Hamza
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Statistical Difference ◽  
Positive Culture ◽  
Control Group ◽  
Tuberculosis Patients ◽  
Significant Difference ◽  
Lowenstein Jensen ◽  
The Mean ◽  
Igg Level

This study was carried out to study of some immunological aspects among the pulmonary Tuberculosis patients infected with causative agent, Mycobacterium tuberculosis. A Total of 200 sputum samples were collected from patients attending the consultant Clinic for Chest and Respiratory disease center, Diwaniya. Control group (No=15) also included. According to acid fast stain of sputum, the patients were classified as positive (No=91,45.5%) and negative (No=109,54.5, Lowenstein Jensen medium used for the cultivation of samples, on which 70% of sputum samples where positive culture for this microorganism. The grown microorganism were identified as M. tuberculosis, based on positive A.F.B, Niacin producers ,negative for catlase at 68c. The mean IgG level was l184.053±76.684 mg/100 ml in tuberculosis group compared with 1016.533 ± 44.882 mg/100ml in control group, rendering the statistical difference significant. For IgA and IgM levels, they were at mean of 315.880±38.552 mg/100 ml and 119.527±8.464 mg/100 ml in control group compared with 396.358±38.776 mg/100 ml and 134.207±11.696 mg/100 ml in patients group respectively with significant difference

scholarly journals Evaluate the Differences in CT Features and Serum IgG4 Levels between Lymphoma and Immunoglobulin G4-Related Disease of the Orbit

2020 ◽  
Vol 9 (8) ◽  
pp. 2425
Author(s):  
Wei-Hsin Yuan ◽  
Anna Fen-Yau Li ◽  
Shu-Yi Yu ◽  
Ying-Yuan Chen ◽  
Chia-Hung Wu ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Hounsfield Unit ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Serum Igg4 ◽  
Orbital Lymphoma ◽  
Serum Igg Levels ◽  
Igg Level ◽  
Ct Features ◽  
Higher Sensitivity

Background: Benign immunoglobulin G4 (IgG4)-related orbital disease (IgG4-ROD)—characterized as tumors mimicking malignant orbital lymphoma (OL)—responds well to steroids, instead of chemotherapy, radiotherapy and/or surgery of OL. The objective of this study was to report the differences in computed tomography (CT) features and- serum IgG4 levels of IgG4-ROD and OL. Methods: This study retrieved records for patients with OL and IgG4-ROD from a pathology database during an eight-year-and-five-month period. We assessed the differences between 16 OL patients with 27 lesions and nine IgG4-ROD patients with 20 lesions according to prebiopsy CT features of lesions and prebiopsy serum IgG4 levels and immunoglobulin G (IgG) levels This study also established the receiver-operating curves (ROC) of precontrast and postcontrast CT Hounsfield unit scales (CTHU), serum IgG4 levels, serum IgG levels and their ratios. Results: Significantly related to IgG4-ROD (all p < 0.05) were the presence of lesions with regular borders, presence of multiple lesions—involving both lacrimal glands on CT scans—higher median values of postcontrast CTHU, postcontrast CTHU/precontrast CTHU ratios, serum IgG4 levels and serum IgG4/IgG level ratios. Compared to postcontrast CTHU, serum IgG4 levels had a larger area under the ROC curve (0.847 [95% confidence interval (CI): 0.674–1.000, p = 0.005] vs. 0.766 [95% CI: 0.615–0.917, p = 0.002]), higher sensitivity (0.889 [95% CI: 0.518–0.997] vs. 0.75 [95% CI: 0.509–0.913]), higher specificity (0.813 [95% CI: 0.544–0.960] vs. 0.778 [95% CI: 0.578–0.914]) and a higher cutoff value (≥132.5 mg/dL [milligrams per deciliter] vs. ≥89.5). Conclusions: IgG4-ROD showed distinct CT features and elevated serum IgG4 (≥132.5 mg/dL), which could help distinguish IgG4-ROD from OL.

scholarly journals Sex-specific deaths in Norway and Sweden during the COVID-19 pandemic: Did mandates make a difference?

2021 ◽  
pp. 140349482110100
Author(s):  
Ralph Catalano
Keyword(s):  
Sex Ratio ◽  
Infection Control ◽  
Temporal Variation ◽  
Risky Behavior ◽  
Control Strategies ◽  
Sex Ratios ◽  
Female Mortality ◽  
All Cause Mortality ◽  
Societal Expectations ◽  
Male To Female

Aims: To determine whether differences between Norway’s and Sweden’s attempts to contain SARS-CoV-2 infection coincided with detectably different changes in their all-cause mortality sex ratios. Measuring temporal variation in the all-cause mortality sex ratio before and during the pandemic in populations exposed to different constraints on risky behavior would allow us to better anticipate changes in the ratio and to better understand its association with infection control strategies. Methods: I apply time Box–Jenkins modeling to 262 months of pre-pandemic mortality sex ratios to arrive at counterfactual values of 10 intra-pandemic ratios. I compare counterfactual to observed values to determine if intra-pandemic ratios differed detectably from those expected as well as whether the Norwegian and Swedish differences varied from each other. Results: The male to female mortality sex ratio in both Norway and Sweden increased during the pandemic. I, however, find no evidence that the increase differed between the two countries despite their different COVID-19 containment strategies. Conclusion: Societal expectations of who will die during the COVID-19 pandemic will likely be wrong if they assume pre-pandemic mortality sex ratios because the intra-pandemic ratios appear, at least in Norway and Sweden, detectably higher. The contribution of differences in policies to reduce risky behavior to those higher ratios appears, however, small.

scholarly journals Postoperative analgesia effects of sulfentanyl plus dexmedetomidine in patients received VATS

Pteridines ◽  
2020 ◽  
Vol 31 (1) ◽  
pp. 55-60
Author(s):  
Haoyu Jiang ◽  
Ying Zheng ◽  
Chang Liu ◽  
Ying Bao
Keyword(s):  
Statistical Difference ◽  
Control Group ◽  
Control Groups ◽  
Significant Statistical Difference ◽  
Post Surgery ◽  
Intravenous Analgesia ◽  
The Mean ◽  
Nsclc Patients ◽  
And Control ◽  
Time Point

AbstractBackground To evaluate sulfentanyl combined with dexmedetomidine hydrochloride on postoperative analgesia in patients who received video-assisted thoracic surgery (VATS) and its effects on serum norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), and prostaglandin (PGE2).Material and Methods Ninety-nine non-small cell lung cancer (NSCLC) patients who received VATS were included in the study. All the patients received intravenous inhalation compound anesthesia. Of the 99 cases, 49 subjects (control group) received sulfentanyl for patient controlled intravenous analgesia (PICA) and other 50 cases (experiment group) received sulfentanyl combined with dexmedetomidine hydrochloride for PICA after operation of VATS. The analgesic effects of the two groups were evaluated according to Visual Analogue Scales (VAS) and the Bruggrmann Comfort Scale (BCS). The serum pain mediator of NE, DA, 5-HT, and PGE2 were examined and compared between the two groups in the first 24 h post-surgery.Results The VAS scores for the experiment group were significant lower than that of control group on the time points of 8, 16, and 24 h post-surgery (pall<0.05), and the BCS scores of the experiment group in the time points of 8, 16, and 24 h were significantly higher than that of controls (p<0.05). However, the VAS and BCS scores were not statistical differently in the time point of 1, 2, and 4 h post-surgery (pall>0.05). The mean sulfentanyl dosage was 63.01 ± 5.14 μg and 67.12 ± 6.91 μg for the experiment and control groups respectively with significant statistical difference (p<0.05). The mean analgesic pump pressing times were 4.30 ± 1.31 and 5.31 ± 1.46 for experiment and control groups respectively with significant statistical difference (p<0.05). The serum NE, DA, 5-HT, and PGE2 levels were significantly lower in the experimental group compared to that of control group in the time point of 12 h post-surgery (pall<0.05). The side effects of nausea, vomiting, delirium, rash, and hypotension atrial fibrillation were not statistically different between the two groups (pall>0.05).Conclusion Patient controlled intravenous analgesia of sulfentanyl combined with dexmedetomidine hydrochloride was effective in reducing the VAS score and serum pain mediators in NSCLC patients who received VAST.

scholarly journals Immunoglobulin G4-related masses surrounding coronary arteries: a case report

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Takuya Nakamura ◽  
Yutaka Goryo ◽  
Takuya Isojima ◽  
Hiroyuki Kawata
Keyword(s):  
Coronary Artery ◽  
Coronary Angiography ◽  
Cardiovascular System ◽  
Coronary Arteries ◽  
Elevated Serum ◽  
High Serum ◽  
Immunoglobulin G4 ◽  
Coronary Arteritis ◽  
Serum Igg4 ◽  
Mass Formation

Abstract Background Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition with high serum IgG4 levels affecting various organs, such as the pancreas, lacrimal and salivary glands, thyroid, kidney, and lung. Typical cardiovascular manifestations of IgG4-RD include periaortitis, coronary arteritis, and pericarditis. However, reports of IgG4-RD associated with coronary arteritis are rare. Here, we report a case of IgG4-related masses surrounding the coronary arteries. Case summary A 59-year-old man was referred to our hospital because of mediastinal masses detected by computed tomography (CT). Coronary CT angiography revealed masses surrounding the right coronary artery and the left anterior descending coronary artery. An elevated serum level of IgG4 and histological findings led to the diagnosis of IgG4-related coronary arteritis with mass formation. Coronary angiography showed numerous feeding arteries to the masses, which were demonstrated as multiple microchannels in the intravascular ultrasound (IVUS) images. Discussion IgG4-RD involving the cardiovascular system has been reported. However, coronary artery disease associated with IgG4-RD is very rare, and the mechanism of mass formation in IgG4-related coronary arteritis is unclear. In our case, within the cardiovascular system, IgG4-RD was limited to the coronary arteries, suggesting that the affected coronary arteries may provide the necessary blood supply to the mass, thus, aiding its growth. These findings were supported by the images from coronary angiography and IVUS.

Population parameters of ringed seals (Phoca hispida Schreber, 1775) in the Svalbard area

1987 ◽  
Vol 65 (4) ◽  
pp. 1021-1027 ◽  
Author(s):  
Christian Lydersen ◽  
Ian Gjertz
Keyword(s):  
Sex Ratio ◽  
Ringed Seal ◽  
Adult Males ◽  
Population Parameters ◽  
Phoca Hispida ◽  
Age Class ◽  
Ringed Seals ◽  
Males And Females ◽  
The Mean ◽  
Sexually Mature

Samples were taken from 284 ringed seals (Phoca hispida) in the Svalbard area during April–July 1981 and March–April 1982. The age of 283 seals was determined by reading annuli in the cementum of the canine teeth. The mean age of the males was 11.3 years, and of the females, 14.9 years. Females were found to be significantly older than males. The mean length of sexually mature ringed seals was 128.9 cm for both sexes. The mean weight of adult males and females was 53.5 and 61.4 kg, respectively. Females were found to be significantly heavier than males. The sex ratio was 47.8% males and 52.2% females. Studies of microscopic sections of testis and epididymis from ringed seal males showed that 63, 75, and 80% of 5-, 6-, and 7-year-old animals, respectively, were sexually mature. The weights of testis and epididymis, diameters of tubuli, and the size of testis all showed a marked increase in the 5-year age-class. Macroscopic sections of ovaries from ringed seal females showed that 20, 60, and 80% of 3-, 4-, and 5-year-old animals, respectively, were sexually mature. The size of the ovaries showed a marked increase in the 5-year age-class. The ovulation rate of ringed seals from Svalbard was calculated to be 0.91.

scholarly journals Reproductive Biology of Round Sardinella (Sardinella Aurita) (Valenciennes, 1847) in Senegalese Coastal Waters

2018 ◽  
Vol 9 (1) ◽  
pp. 31
Author(s):  
Ismaïla NDIAYE ◽  
Alassane SARR ◽  
Alioune FAYE ◽  
Modou THIAW ◽  
Malick DIOUF ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Reproductive Biology ◽  
Coastal Waters ◽  
Sexual Maturity ◽  
Reproductive Parameters ◽  
Monthly Variation ◽  
Relative Fecundity ◽  
The Mean ◽  
Sardinella Aurita ◽  
Somatic Index

In this study, a total of 1068 specimens Sardinella aurita of which 553 females and 515 males were examined. The objectif of this study was to determine the reproductive parameters of Sardinella aurita. The sex ratio was significantly in favor of females (55%). The size at first sexual maturity was estimated at 18.9 cm for females and 18.0 cm for males. The monthly variation of sexual maturity stages and gonado-somatic index (GSI) allowed to locate the reproduction periods from February to June and from September to December. The mean absolute fecundity was estimated at 110.794 ± 7582 oocytes whereas relative fecundity was about 422 ± 26 oocytes per gram of female.

scholarly journals Biology and parasitic potential of Doryctobracon areolatuson Anastrepha fraterculus larvae

2011 ◽  
Vol 46 (6) ◽  
pp. 669-671 ◽  
Author(s):  
Adrise Medeiros Nunes ◽  
Dori Edson Nava ◽  
Fernanda Appel Müller ◽  
Rafael da Silva Gonçalves ◽  
Mauro Silveira Garcia
Keyword(s):  
Biological Control ◽  
Sex Ratio ◽  
Adult Emergence ◽  
Parasitism Rate ◽  
Anastrepha Fraterculus ◽  
The Mean ◽  
Parasitoid Development

The objective of this work was to study the biology and parasitic potential of Doryctobracon areolatus on larvae of Anastrepha fraterculus. The egg-adult period, the sex ratio, the longevity, the pupal viability, and the parasitism rate of D. areolatus were determined in laboratory, using A. fraterculus as host. The parasitoid development from oviposition to adult emergence required 25.00±1.70 days, the sex ratio was 0.62±0.09, and the mean longevity was 16.36±3.62 days for males and 10.24±1.71 days for females. The mean parasitism rate was 53.50±8.93%, varying from 41.60 to 68.60%, which shows the potential of this parasitoid for biological control of A. fraterculus.

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