scholarly journals The Effect of Artemisinin-Based Drugs vs Non-artemisinin-based Drugs on Gametophyte Carrying in the Body After the Treatment of Uncomplicated Falciparum Malaria: A Systematic Review and Meta-analysis

2022 ◽  
Vol 12 ◽  
Author(s):  
Yuanyuan Zou ◽  
Nadia Julie ◽  
Shiyuan Guo ◽  
Yexiao Tang ◽  
Hongying Zhang ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Meta Analysis ◽  
Clinical Malaria ◽  
The Body ◽  
Control Group ◽  
Therapeutic Effects ◽  
Serious Adverse Events ◽  
Intervention Measures ◽  
Significant Difference ◽  
The Difference

The WHO recommends Artemisinin-based combination therapy (ACTs) as the first-line treatment for malaria. This meta-analysis aims to analyze the effects of artemisinin and its derivatives as well as non-artemisinin drugs on the gametophytes in the host during the treatment of falciparum malaria. Fourteen studies were included in this analysis, and the artemisinin combination drugs involved were: artemether-lumefantrine (AL), artemisinin (AST), artemether-benflumetol (AB), dihydroartemisinin-piperaquine + trimethoprim + primaquine (CV8), amodiaquine + sulfadoxine-pyrimethamine (ASP), pyronaridine-phosphate + dihydroartemisinin (PP-DHA), dihydroartemisinin (DHA), and mefloquine + artesunate (MA), with 1702 patients. The control intervention measures involved the following: sulfadoxine-pyrimethamine (SP), mefloquine (MQ), atovaquone-proguanil (AT-PG), chloroquine + sulfadoxine-pyrimethamine (C-SP), quinine (Q), pyronaridine-phosphate (PP), pyronaridine (PN), and mefloquine + primaquine (MP), with 833 patients. The effect of ACTs was more obvious (OR = 0.37, 95%CI: 0.22–0.62, p < 0.05). In the control group of second malaria attacks, the difference between the two groups was not statistically significant (RD = 1.16, 95%CI: 0.81–1.66, p < 0.05); there was no significant difference in treatment failure during follow-up (RD = -0.01, 95%CI: 0.04–0.03, p < 0.05). There were also very few serious adverse events in both groups. ACTs showed good therapeutic effects in preventing gametocythemia but did not control the recrudescence rate and overall cure, which indicated the effectiveness of the combination of antimalarial drugs. Further research is required to explore which compatibility method is most conducive to the development of clinical malaria control.

scholarly journals Digit ratio (2D:4D) and transgender identity: new original data and a meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Eva-Maria Siegmann ◽  
Tobias Müller ◽  
Isabelle Dziadeck ◽  
Christiane Mühle ◽  
Bernd Lenz ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Original Data ◽  
Control Group ◽  
Convenience Sample ◽  
Left Hand ◽  
Transgender Identity ◽  
Significant Difference ◽  
The Difference ◽  
Prenatal Androgen ◽  
Male To Female

Abstract Previously reported associations between second-to-fourth digit length ratio (2D:4D), a proxy for prenatal androgen load, and transgender identity have been inconsistent. The objectives of the present study were to provide additional original data and an updated meta-analysis concerning this association. In a study of 464 participants, we compared the 2D:4D of transgender individuals with age- and sex-matched controls. Patients were recruited at a specialized psychiatrist’s medical office, whereas controls were hired via flyers, advertisements, and as convenience sample. A random-effects meta-analysis of the literature (17 samples, n = 3674) also quantifies the overall magnitude of the difference in 2D:4D between transgender individuals and controls. In our study providing new original data, we found a significantly higher (i.e. feminized) left-hand 2D:4D in the male-to-female transgender (MtF) identity [mean age: 32.3 (18; 61)] than in the male control group [mean age: 34.5 (18; 65)] with a Cohen’s d = 0.271. Concordantly, the meta-analytic results suggest a significant difference in 2D:4D among MtF individuals compared to male controls [g = 0.153; 95% CI (0.063; 0.243)], which was even more pronounced when individuals had been diagnosed by a clinician instead of self-identified as transgender [g = 0.193; 95% CI (0.086; 0.300)]. In both studies, no significant results were revealed for female-to-male transgender individuals [mean age: 26.1 (18; 53)] versus female controls [mean age: 27.2 (18; 55)]. This original investigation and the updated meta-analysis clarify the association between transgender identity and 2D:4D indicating the influence of prenatal androgen on the development of gender identity in subjects born as males.

scholarly journals Effect of kinesio taping on low back pain during pregnancy: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiali Xue ◽  
Yan Chen ◽  
Xiaorong Mao ◽  
Huan Tu ◽  
Xinwei Yang ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Future Research ◽  
Control Group ◽  
Low Back ◽  
Kinesio Taping ◽  
Significant Difference ◽  
The Difference

Abstract Background Low back pain during pregnancy affects the normal daily activities of pregnant women to a certain extent. Current studies have shown that Kinesio Taping (KT) may be a treatment for low back pain during pregnancy, but there is still a lack of key evidence. The purpose of this study is to evaluate the efficacy and safety of KT in the treatment of low back pain during pregnancy. Methods PubMed, Web of Science, The Cochrane Library, Scopus, Embase, Wanfang Data, CNKI, and VIP databases were searched to collect randomized controlled trials (RCTs) of the efficacy of KT intervention on low back pain in women during pregnancy. The retrieval time limit is from the establishment of the database to April 2021. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies. Meta-analysis was performed using RevMan5.3 software. Results A total of 7 RCTs were included, including 444 patients. Meta-analysis results showed that: Compared with the control group, KT intervention could significantly improve low back pain and dysfunction, VAS score (− 1.62, 95%CI − 2.08 to − 1.16, P < 0.00001, I2 = 77%), RMDQ score (− 1.00, 95%CI − 1.54 to − 0.46, P = 0.0003, I2 = 80%); The results of the meta-analysis of the subgroup showed that compared with the control group, the KT intervention was less than or equal to 1 week, and the waist pain and dysfunction were improved, with statistically significant differences. The difference in the improvement of low back pain was statistically significant after KT intervention for more than 1 week, but there was no statistically significant difference in RMDQ score (− 1.25, 95%CI − 2.66 to 0.15, P = 0.08, I2 =77%). Compared with the control group, KT intervention improved low back pain in the second and third trimesters, and the difference was statistically significant. Conclusion KT has a positive effect on the improvement of low back pain during pregnancy, KT intervention can significantly improve pregnant women’s low back pain and dysfunction problems, improve the quality of life. It is suggested that future research should focus on the prevention and treatment of low back pain during pregnancy to provide more research data for improving women’s health.

scholarly journals The safety and efficacy of mesenchymal stem cells in the treatment of COVID-19-associated pneumonia: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Junwu Wang ◽  
Pengzhi Shi ◽  
Dong Chen ◽  
Shuguang Wang ◽  
Pingchuan Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adverse Events ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Control Group ◽  
Serious Adverse Events ◽  
Safe Method ◽  
Radiographic Outcomes ◽  
The Difference

Mesenchymal stem cells (MSCs) therapy is considered one of the most promising treatments in the context of the coronavirus disease 2019 (COVID-19) pandemic. However, the safety and effectiveness of MSCs in the treatment of COVID-19-associated pneumonia patients need to be systematically reviewed and analyzed. Two independent researchers searched for the relevant studies published between October 2019 and April 2021 in PubMed, Embase, Cochrane Library, WAN FANG, and CNKI databases. A total of 22 studies involving 371 patients were included in the present study. MSCs were administered in 247 participants, and MSCs were allogeneic from umbilical cord, adipose tissue, menstrual blood, placenta, Wharton's jelly, or unreported sources. Combined results found that MSCs group significantly reduced the incidence of adverse events (OR = 0.43, 95%CI. = 0.22~0.84, P = 0.01) and mortality (OR = 0.17, 95%CI. = 0.06~0.49, P < 0.01), and the difference compared with control group was statistically significant. No MSCs treat-related serious adverse events were reported. The lung function and radiographic outcomes, and biomarker levels of inflammation and immunity all showed improvement trends. Therefore, MSCs therapy is an effective and safe method in the treatment of COVID-19-associated pneumonia and shows advantages in less adverse events and mortality. However, a standard and effective MSCs treatment program needs to be developed.

scholarly journals Perbedaan Tekanan Darah Sebelum dan Sesudah Exercise Intradialysis Pada Pasien Hemodialisis di Unit Hemodialisis Rumah Sakit Panti Rahayu Gunung Kidul

2021 ◽  
Vol 2 (2) ◽  
pp. 156-169
Author(s):  
Christina Murni Yuliastuti ◽  
Th.Tatik Pujiastuti ◽  
Sr. Lucilla Suparmi, CB
Keyword(s):  
Blood Pressure ◽  
Intervention Group ◽  
The Body ◽  
Control Group ◽  
Cardiovascular Exercise ◽  
Significant Difference ◽  
Before And After ◽  
Quasi Experimental ◽  
The Difference ◽  
Intradialytic Exercise

ABSTRACT Background:Hemodialysis defines as a process of cleaning the blood from waste substances through a filtering process outside the body. Patients with chronic renal failure undergoing hemodialysis often experience complications including hypotension. Several references state an alternative intervention to prevent complications of hypotension in hemodialysis patients with an Intradialytic exercise. Intradialytic exercise is a planned and gradual form of exercise that includes various stages of flexibility exercise, strengthening exercise and cardiovascular exercise performed during hemodialysis. Intradialytic exercise is aimed to improve the work of the heart, respiration and improve hemodialysis regulation for the better. Objective:This study was aimed to determine the difference in blood pressure before and after intradialytic exercise in patients undergoing hemodialysis. Methods:This research design used a quasi-experimental design with pre-test and post-test with control design. The samples were 38 respondents who taken by total sampling at the Hemodialysis Unit of Panti Rahayu Hospital. The samples were divided into the intervention group who undertook intradialytic exercise for 4 weeks, each respondent experiences twice a week, while the control group who did routine hemodialysis and independent exercise. Results:The results showed that the distribution of the characteristics of the respondents was 51-54 years old (18.41%) the sex was mostly male (63.2%) Most of them (55.3%) underwent hemodialysis for less than 2 years. Statistically, it was known that there was no significant difference in blood pressure before and after intradialytic exercise inside patient’s body of the control and intervention groups. There was no significant difference in blood pressure between the intervention group compared to the control group, but there was a dynamic difference in blood pressure in patients who did intradialytic exercise. Conclusion:There was dynamics of differences in blood pressure in patients undergoing intradialytic exercise, it is recommended that hemodialysis nurses at Panti Rahayu Hospital take care patients during hemodialysis so that these interventions are routinely carried out.

scholarly journals PERBEDAAN POLA MAKAN PADA BALITA STUNTING DAN TIDAK STUNTING DI KECAMATAN TEON NILA SERUA (TNS) KABUPATEN MALUKU TENGAH

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Trixie Leunupun ◽  
Ani Margawati ◽  
Annastasia Ediati
Keyword(s):  
Child Growth ◽  
The Body ◽  
Control Group ◽  
Case Group ◽  
Research Subjects ◽  
Chi Square ◽  
Significant Difference ◽  
Chi Square Test ◽  
Good Energy ◽  
The Difference

Stunting is a condition that describes the growth of children due to long-term malnutrition. Stunting according to WHO is based on the index of the body length compared to age (PB/U) or height compared to the age (TB/U) with the Z-score limit of less than-2 SD. The age of toddlers is an age where child growth and development happens very quickly. In that age toddlers often experience health problems especially nutritional problems. Insufficient nutritional intake can cause stunting and can inhibit children's development. Design of observational analytic research with case-control design in toddlers aged 2-3 years. The population of this research is all toddlers who reside in the working area of Puskesmas Layeni subdistrict of Central Maluku district. Sample research is done using the Lameshow formula. The study used the ratio of 1:1 so that the number of research subjects in the case group was equivalent to the number of research subjects in the control group (i.e. 30 children per group), resulting in a total subject of 60 children. Analysis of the data used to see the difference between variables using the chi-square test. Variable dependent events are stunting and independent dietary variables. The results of the chi-square test show that there is no difference between the diet (the level of energy and protein adequacy) in a stunting toddler and not stunting the value (p > 0.05). The conclusion of the diet (adequacy of energy and protein) respectively in the group of cases is not too much of a significant difference. But in the control group more toddlers with good energy and protein adequacy levels. Keywords: toddler, diet, stunting

Perbedaan Tekanan Darah Sebelum dan Sesudah Exercise Intradialysis Pada Pasien Hemodialisis di Unit Hemodialisis Rumah Sakit Panti Rahayu Gunung Kidul

2021 ◽  
Vol 2 (2) ◽  
pp. 156-169
Author(s):  
Christina Murni Yuliastuti ◽  
Th.tatik Pujiastuti ◽  
Sr. Lucilla Suparmi, CB
Keyword(s):  
Blood Pressure ◽  
Intervention Group ◽  
The Body ◽  
Control Group ◽  
Cardiovascular Exercise ◽  
Significant Difference ◽  
Before And After ◽  
Quasi Experimental ◽  
The Difference ◽  
Intradialytic Exercise

ABSTRACT Background: Hemodialysis defines as a process of cleaning the blood from waste substances through a filtering process outside the body. Patients with chronic renal failure undergoing hemodialysis often experience complications including hypotension. Several references state an alternative intervention to prevent complications of hypotension in hemodialysis patients with an Intradialytic exercise. Intradialytic exercise is a planned and gradual form of exercise that includes various stages of flexibility exercise, strengthening exercise and cardiovascular exercise performed during hemodialysis. Intradialytic exercise is aimed to improve the work of the heart, respiration and improve hemodialysis regulation for the better. Objective: This study was aimed to determine the difference in blood pressure before and after intradialytic exercise in patients undergoing hemodialysis. Methods: This research design used a quasi-experimental design with pre-test and post-test with control design. The samples were 38 respondents who taken by total sampling at the Hemodialysis Unit of Panti Rahayu Hospital. The samples were divided into the intervention group who undertook intradialytic exercise for 4 weeks, each respondent experiences twice a week, while the control group who did routine hemodialysis and independent exercise. Results: The results showed that the distribution of the characteristics of the respondents was 51-54 years old (18.41%) the sex was mostly male (63.2%) Most of them (55.3%) underwent hemodialysis for less than 2 years. Statistically, it was known that there was no significant difference in blood pressure before and after intradialytic exercise inside patient’s body of the control and intervention groups. There was no significant difference in blood pressure between the intervention group compared to the control group, but there was a dynamic difference in blood pressure in patients who did intradialytic exercise. Conclusion: There was dynamics of differences in blood pressure in patients undergoing intradialytic exercise, it is recommended that hemodialysis nurses at Panti Rahayu Hospital take care patients during hemodialysis so that these interventions are routinely carried out.

scholarly journals TL 18141 - Isolated gastrocnemius tightness

2019 ◽  
Vol 13 (Supl 1) ◽  
pp. 90S
Author(s):  
Kelly Cristina Stéfani ◽  
Leonardo Vinicius De Matos Moraes ◽  
Vinícius Quadros Borges ◽  
Gabriel Ferraz Ferreira
Keyword(s):  
Plantar Fasciitis ◽  
Plantar Flexion ◽  
Age Groups ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Calcaneal Tendon ◽  
Significant Difference ◽  
The Mean ◽  
The Difference

Introduction: The objective of this study was to evaluate the difference in muscle strength between flexion and ankle extension to test the hypothesis that this predisposes to a dynamic equine and, thus, to evaluate this correlation with pain in the forefoot (metatarsalgias) and hindfoot (plantar fasciitis, tendinopathy of the tendon insertional and non-insertional calcaneus). Methods: In this prospective cohort study, 50 patients were consecutively diagnosed with forefoot pain (metatarsalgias) or pain in the hindfoot (plantar fasciitis, tendonopathy of the insertional and non-insertional calcaneal tendon), and 50 patients had no foot diseases. The body mass index (BMI) was evaluated, and IGT was evaluated through the Silfverskiöld test. The parameter of gastrocnemius contracture was considered in cases of limitation of ankle extension <10. The intervention was to measure flexion strength and ankle extension with a manual dynamometer, evaluating isometric contraction based on the method suggested by Kahn et al. Results: One hundred patients participated in the study, with 50 patients in the study group and 50 in the control group. The mean age was 63.42 years, and the mean BMI was 28.53 in the study group and 62.26 and 28.84 in the control group, with no difference in distribution between age groups (p = 0.634) and for BMI (p = 0.709). The difference was significant between the groups in relation to the Silfverskiöld test (p = 0.019), the ankle force variation in dynamometry (p <0.001) and normalized variation (p <0.001). In addition, a significant difference between groups was observed in the dynamometry of plantar flexion (p <0.001). Conclusion: The hypothesis of causes for sural triceps shortening considered as idiopathic are as follows. The difference in strength between the dorsiflexion musculature and the one that performs the plantar flexion, the delay in neuromuscular activation of the dorsiflexors, or even a combination of these two factors. We demonstrated the possibility of the evaluation of the force through a manual dynamometer that can be used in routine outpatient visits, which proved to be effective and reproducible.

scholarly journals Peculiarities of the body of a young sheep under biophysical methods of exposure

2021 ◽  
Vol 13 ◽  
pp. 14-24
Author(s):  
M.A. Afanasyev ◽  
◽  
S.N. Shlykov ◽  
S.S. Bobryshov ◽  
R.S. Omarov ◽  
...  
Keyword(s):  
Laser Radiation ◽  
Infrared Region ◽  
The Body ◽  
Breast Development ◽  
Control Group ◽  
Low Intensity ◽  
Group I ◽  
Significant Difference ◽  
The Difference ◽  
Intensity Laser

Aim. Study the effect of low-intensity laser radiation on the genotype's young sheep (poll Dorset x North Caucasian meat-wool) and their exterior. Material and Methods. Zootechnical, biophysical, statistical and other methods were used in research. Experimental animals were exposed to an STP laser apparatus, the action of which is based on the use of low-intensity laser radiation in the infrared region of the spectrum. The study of measurements of animals at the age of 5 and 7 months was carried out and physique indices were calculated. Results. Comparing measurements in the studied animals at 5 months of age revealed the advantage of lambs of groups II and III over the control, in almost all main parameters. However, the experimental groups' young animals were characterized by higher rates of breast measurements. Thus, the superiority of lambs of groups II and III over animals of the control group were: in chest depth 2.1-3.3%, width – 4.4-7.1%, girth – 1.2-4.1% (P < 0.001). A similar trend was established due to measurements of the studied animals' physique at the age of 7 months. At the same time, a clear advantage in terms of measurements characterizing breast development was found in young animals of the second and, especially, in the third group: in chest depth by 3.8-7.4%, width by 4.8-9.1%, girth – 3,7-9.0%, with a significant difference (P < 0.05; P < 0.001). It was also found that the greatest value of the breast index at 5 months of age was typical for animals of groups II and III (77.6-78.6%), which is 1.8-2.8 abs. percent (P < 0.001). However, with age, the difference in the value of this indicator between the groups decreased. Therefore, at the age of 7 months, young animals of groups II and III surpassed animals of group I in this indicator by 0.8-1.5 abs. percent. Conclusion. Thus, it was found that the best ratio of most body articles and body build indices, characterizing them as animals with well-pronounced meat forms, were animal groups II and III.

scholarly journals Effect of Kinesio Taping on Low Back Pain During Pregnancy: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Xiali Xue ◽  
Yan Chen ◽  
Xiaorong Mao ◽  
Huan Tu ◽  
Xinwei Yang ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Future Research ◽  
Control Group ◽  
Low Back ◽  
Kinesio Taping ◽  
Significant Difference ◽  
The Difference

Abstract Background: Low back pain during pregnancy affects the normal daily activities of pregnant women to a certain extent. Current studies have shown that Kinesio Taping(KT) may be a treatment for low back pain during pregnancy, but there is still a lack of key evidence. The purpose of this study is to evaluate the efficacy and safety of KT in the treatment of low back pain during pregnancy.Methods: PubMed, Web of Science, The Cochrane Library, Wanfang Data, CNKI, and VIP databases were searched to collect randomized controlled trials (RCTs) of the efficacy of KT intervention on low back pain in women during pregnancy. The retrieval time limit is from the establishment of the database to April 2021. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies. Meta-analysis was performed using RevMan5.3 software.Results:A total of 7 RCTs were included, including 444 patients. Meta-analysis results showed that: Compared with the control group, KT intervention could significantly improve low back pain and dysfunction, VAS score (-1.62, 95%CI -2.08 to -1.16, P<0.00001, I2=77%), RMDQ score (-1.00, 95%CI -1.54 to -0.46, P=0.0003, I2=80%); The results of the meta-analysis of the subgroup showed that compared with the control group, the KT intervention was less than or equal to one week, and the waist pain and dysfunction were improved, with statistically significant differences. The difference in the improvement of low back pain was statistically significant after KT intervention for more than one week, but there was no statistically significant difference in RMDQ score (-1.25, 95%CI -2.66 to 0.15, P=0.08, I2=77%). Compared with the control group,KT intervention improved low back pain in the second and third trimesters, and the difference was statistically significant.Conclusion:KT has a positive effect on the improvement of low back pain during pregnancy, KT intervention can significantly improve pregnant women's low back pain and dysfunction problems, improve the quality of life.It is suggested that future research should focus on the prevention and treatment of low back pain during pregnancy to provide more research data for improving women's health.

scholarly journals The Effectiveness of Convalescent Plasma for the Treatment of Novel Corona Virus Disease 2019: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Huiling Cao ◽  
Li Ming ◽  
Long Chen ◽  
Xingwang Zhu ◽  
Yuan Shi
Keyword(s):  
Hospital Stay ◽  
Virus Disease ◽  
Meta Analysis ◽  
Length Of Hospital Stay ◽  
Conclusive Evidence ◽  
Cochrane Library ◽  
Control Group ◽  
Inflammatory Factor ◽  
Serious Adverse Events ◽  
Significant Difference

Background: Coronavirus disease 2019 (COVID-19), sweeping across the world, has created a worldwide pandemic. Effective treatments of COVID-19 are extremely urgent.Objective: To analyze the efficacy and safety of convalescent plasma (CCP) on patients with COVID-19.Methods: All the relevant studies were searched from PubMed, EMBASE,Cochrane library, Scopus, Web of Science, CBM, CNKI, Wan fang, VIP, Medrxiv, Biorxiv, and SSRN on July 19, 2021. PICOS criteria were as follows: (P) the study interests were human subjects with the infection of COVID-19; (I) the intervention of interest was CCP; (C) comparator treatments contained placebo, sham therapy, and standard treatment; (O) the primary outcome was mortality rates by the novel coronavirus. The secondary outcomes included the incidence of serious adverse events, the rate of ICU admission and mechanical ventilation (MV); the length of hospital stay; the duration of MV and ICU stay; the antibody levels, inflammatory factor levels, and viral loads. (S) Only randomized controlled trials (RCTs) of CCP were included. Subanalysis, quality assessment, sensitive analysis, and publication bias were conducted by two reviewers independently.Results: Sixteen RCTs were included and enrolled a total of 16,296 participants in this meta-analysis. The pooled data showed that no significant difference was observed in reducing the rate of overall mortality between CCP treatment group and placebo group (OR 0.96; 95% CI 0.90 to 1.03; p = 0.30; I2 = 6%). According to the results of subgroup analysis, severe or critical patients with CCP showed significant difference in reducing the 28-day mortality of compared with placebo (OR 0.58, 95% CI 0.36 to 0.93, p = 0.02, I2 = 0%). CCP groups have a significantly shorter duration of MV compared with the control group (weighted MD −1.00, 95% CI −1.86 to −0.14 d p = 0.02, I2 = 0%). No significant difference was observed in the length of hospital stay, the duration of ICU, and the rate of ICU and MV. There is no conclusive evidence about the safety of CCP.Conclusion: Convalescent plasma can significantly reduce the 28-day mortality of severe or critical COVID-19 patients and the duration of MV. However, more evidence was needed to prove the safety of convalescent plasma.

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