Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature

Background: Malignant odontogenic tumours (MOTs) arise either de novo from the tooth forming tissues, their developmental residues or from existing odontogenic epithelial or mesenchymal neoplasms in the jaws. Their management requires extensive surgery due to their infiltrative nature and risk of metastasis. There is a need to understand the clinical and pathological features of MOTs to inform both treatment algorithms and prognostication. This is an area of diagnostic pathology which presents substantial difficulties in diagnosis, compounded by inconsistent use of terminology. Thus, this systematic review aimed to describe the clinical and pathological features of MOTs with a view to consolidating the literature and defining problematic areas in diagnosis and classification.Methods: An electronic database search was conducted in Web of Science, PubMed/Medline, and Embase. Additionally, the grey literature and reference lists of selected papers searched for completeness. Nine hundred and sixty articles were initially identified. Following removal of duplicates and application of inclusion/exclusion criteria, 312 articles were included for qualitative analysis.Results: The 312 articles encompassed a total of 507 patients with most lesions located within the mandible (74.3%). The most common first histological diagnosis was ameloblastic carcinoma (25.7% of all diagnoses), but there is considerable variation in how and when various diagnostic terms are used, and several misdiagnoses were reported. An initial benign diagnosis was made in 24.7% of patients, followed by a later malignant diagnosis and in this sub-group, the most common benign first diagnosis was ameloblastoma (42.4%). Cervical lymph nodes were the most common site of metastasis (9.3% of patients). With respect to distant metastasis (DM), the lungs were the most common organ affected (11.2% of DM patients) with metastasising ameloblastoma the most commonly reported tumour which metastasised to the lungs. Overall, 26.8% of patients developed recurrence.Conclusion: Overall, the quality of the literature on MOTs is poor. This review of the literature has highlighted variations in diagnostic terms and criteria which has resulted in areas of confusion with potential for misdiagnosis. This consolidation of primary data has identified key areas for targeted research including further discussion on the malignant potential of ameloblastoma.

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Cannabis-associated arteritis

VASA ◽

10.1024/0301-1526/a000004 ◽

2010 ◽

Vol 39 (1) ◽

pp. 43-53 ◽

Cited By ~ 17

Author(s):

Grotenhermen

Keyword(s):

Systematic Review ◽

Case Reports ◽

Case Series ◽

Cardiovascular Effects ◽

Causative Factor ◽

Cannabis Use ◽

Thromboangiitis Obliterans ◽

Pathological Features ◽

Scientific Support ◽

Clinical And Pathological Features

Background: To investigate the hypothesis that cases of arteritis similar to thromboangiitis obliterans (TAO) and associated with the use of cannabis were caused by cannabis or THC (dronabinol), or that cannabis use is a co-factor of TAO. Patients and methods: A systematic review on case reports and the literature on so-called cannabis arteritis, TAO, and cardiovascular effects of cannabinoids was conducted. Results: Fifteen reports with 57 cases of an arteritis associated with the use of cannabis and two additional case series of TAO, in which some patients also used cannabis, were identified. Clinical and pathological features of cannabis-associated arteritis do not differ from TAO and the major risk factor of TAO, tobacco use, was present in most, if not in all of these cases. The proposed pathophysiological mechanisms for the development of an arteritis by cannabis use are not substantiated. Conclusions: The hypothesis of cannabis being a causative factor or co-factor of TAO or an arteritis similar to TAO is not supported by the available evidence. The use of the term cannabis arteritis should be avoided until or unless more convincing scientific support is forthcoming.

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Mortality of ethnic minority groups in the UK: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2019-034903 ◽

2020 ◽

Vol 10 (6) ◽

pp. e034903

Author(s):

Fiona Stanaway ◽

Naomi Noguchi ◽

Erin Mathieu ◽

Saman Khalatbari-Soltani ◽

Raj Bhopal

Keyword(s):

Systematic Review ◽

Ethnic Diversity ◽

Minority Groups ◽

Meta Analysis ◽

Grey Literature ◽

Primary Data ◽

Majority Population ◽

White Majority ◽

Newcastle Ottawa Scale ◽

The Uk

IntroductionGrowing ethnic diversity in the UK has made it increasingly important to determine the presence of ethnic health inequalities. There has been no systematic review that has drawn together research on ethnic differences in mortality in the UK.MethodsAll types of observational studies that compare all-cause mortality between major ethnic groups and the white majority population in the UK will be included. We will search Medline (OvidSP), Embase (OvidSP), Scopus and Web of Science and search the grey literature through conference proceedings and online thesis registries. Searches will be carried out from inception to 2 August 2019 with no language or other restrictions. Database searches will be repeated prior to publication to identify new articles published since the initial search. We will conduct forward and backward citation tracking of identified references and consult with experts in the field to identify further publications and ongoing or unpublished studies. Two reviewers will independently screen studies and extract data. Two reviewers will independently assess the quality of included studies using the Newcastle-Ottawa Scale. If at least two studies are located for each ethnic group and studies are sufficiently homogeneous, we will conduct a meta-analysis. If insufficient studies are located or if there is high heterogeneity we will produce a narrative summary of results.Ethics and disseminationAs no primary data will be collected, formal ethical approval is not required. The findings of this review will be disseminated through publication in peer reviewed journals and conference presentations.PROSPERO registration numberCRD42019146143.

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Effectiveness and feasibility of internet-based and mobile-based interventions for individuals experiencing bereavement: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2019-036034 ◽

2020 ◽

Vol 10 (4) ◽

pp. e036034

Author(s):

Melanie Luppa ◽

Margrit Löbner ◽

Alexander Pabst ◽

Christine Schlapke ◽

Janine Stein ◽

...

Keyword(s):

Systematic Review ◽

Mental Health Problems ◽

Grey Literature ◽

Complicated Grief ◽

Feasibility Studies ◽

Outcome Data ◽

Evaluation Methodology ◽

Management Tool ◽

Primary Data ◽

Cochrane Library

IntroductionInternet-based and mobile-based interventions (IMIs) provide an innovative and efficient self-management tool for mental health problems. This systematic review aims to summarise and critically evaluate studies addressing the effectiveness and feasibility of IMIs for normal and complicated grief in bereaved adults.Methods and analysisThe databases MEDLINE, Cochrane Library, PsycINFO, Embase and Web of Science and Google Scholar (for ‘grey’ literature) will be systematically searched for feasibility studies or randomised controlled trials of IMIs for bereaved adults who were experiencing normal/complicated grief. Data will be extracted and evaluated independently by two reviewers from studies eligible for inclusion. Quality of evidence will be assessed, and results will be synthesised qualitatively and pooled meta-analytically, if sufficient outcome data are available. Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards and Grades of Recommendation, Assessment, Development and Evaluation methodology will be used.Ethics and disseminationNo primary data will be collected; thus, ethical approval is not required. The results will be disseminated through a peer-reviewed publication and conference presentations.Trial registration numberCRD42019131428.

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Exploring different methods to evaluate the impact of basic income interventions: a systematic review

International Journal for Equity in Health ◽

10.1186/s12939-021-01479-2 ◽

2021 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Andrew D. Pinto ◽

Melissa Perri ◽

Cheryl L. Pedersen ◽

Tatiana Aratangy ◽

Ayu Pinky Hapsari ◽

...

Keyword(s):

Systematic Review ◽

Evaluation Method ◽

Grey Literature ◽

Primary Data ◽

Multiple Time ◽

Basic Income ◽

Team Members ◽

Health And Social Care ◽

Multiple Time Points ◽

The Impact

Abstract Background Persistent income inequality, the increase in precarious employment, the inadequacy of many welfare systems, and economic impact of the COVID-19 pandemic have increased interest in Basic Income (BI) interventions. Ensuring that social interventions, such as BI, are evaluated appropriately is key to ensuring their overall effectiveness. This systematic review therefore aims to report on available methods and domains of assessment, which have been used to evaluate BI interventions. These findings will assist in informing future program and research development and implementation. Methods Studies were identified through systematic searches of the indexed and grey literature (Databases included: Scopus, Embase, Medline, CINAHL, Web of Science, ProQuest databases, EBSCOhost Research Databases, and PsycINFO), hand-searching reference lists of included studies, and recommendations from experts. Citations were independently reviewed by two study team members. We included studies that reported on methods used to evaluate the impact of BI, incorporated primary data from an observational or experimental study, or were a protocol for a future BI study. We extracted information on the BI intervention, context and evaluation method. Results 86 eligible articles reported on 10 distinct BI interventions from the last six decades. Workforce participation was the most common outcome of interest among BI evaluations in the 1960–1980 era. During the 2000s, studies of BI expanded to include outcomes related to health, educational attainment, housing and other key facets of life impacted by individuals’ income. Many BI interventions were tested in randomized controlled trials with data collected through surveys at multiple time points. Conclusions Over the last two decades, the assessment of the impact of BI interventions has evolved to include a wide array of outcomes. This shift in evaluation outcomes reflects the current hypothesis that investing in BI can result in lower spending on health and social care. Methods of evaluation ranged but emphasized the use of randomization, surveys, and existing data sources (i.e., administrative data). Our findings can inform future BI intervention studies and interventions by providing an overview of how previous BI interventions have been evaluated and commenting on the effectiveness of these methods. Registration This systematic review was registered with PROSPERO (CRD 42016051218).

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Factors influencing the readiness to tackle the burden of ischaemic heart disease in India: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2020-047464 ◽

2021 ◽

Vol 11 (8) ◽

pp. e047464

Author(s):

Shuvarthi Bhattacharjee ◽

Nima Yaghmaei ◽

Cao Tran Le Phuong ◽

Dinesh Neupane

Keyword(s):

Systematic Review ◽

Heart Disease ◽

Ischaemic Heart Disease ◽

Grey Literature ◽

Primary Data ◽

Eligibility Criteria ◽

Design Data ◽

Factors Influencing ◽

Open Government Data ◽

The Government

IntroductionIschaemic heart disease (IHD) is one of the leading causes of death and disease burden in India affecting all age groups. To reduce the deaths and tackle the burden of existing IHD, the government approach has been mostly through the National Health Policy (2017) and National Programme for Prevention and Control of Diabetes, Cardiovascular diseases and Stroke. This paper offers a protocol for the systematic review of studies exploring the factors influencing service readiness of the public health system of India to tackle the burden of IHD.Methods and analysisElectronic databases of Embase (Ovid), AMED (Ovid), HMIC (Ovid), BNI (ProQuest), CINAHL (EBSCO), EMCARE (Ovid), PsycINFO (ProQuest), MEDLINE/PubMed and Web of Science (Clarivate Analytics) will be searched till 2020 for primary studies. Grey literature will be accessed through OpenGrey, TRIP Medical, WHO database, MoHFW website, Open Government Data (OGD) Platform of India and Google Scholar (between 2010 and 2020). Primary studies meeting the eligibility criteria and grey literature published in English between 2010 and 2020 will be included. Data will be analysed through a conceptual framework, and the primary outcome will constitute both quantitative and qualitative data. The quality of included studies will be assessed based on study design. Data will be managed on the COVIDENCE platform. All authors will be involved in data extraction, quality appraisal, data synthesis and formulation of the final draft.Ethics and disseminationThis study, being a systematic review, does not involve any clinical trial, primary data collection or empirical study involving humans or animals. Therefore, no ethical permissions were sought by reviewers.PROSPERO registration numberCRD42020219490.

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Gender-specific design and effectiveness of non-pharmacological interventions against cognitive decline and dementia–protocol for a systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0256826 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0256826

Author(s):

Andrea E. Zuelke ◽

Steffi G. Riedel-Heller ◽

Felix Wittmann ◽

Alexander Pabst ◽

Susanne Roehr ◽

...

Keyword(s):

Systematic Review ◽

Cognitive Decline ◽

Meta Analysis ◽

Grey Literature ◽

Primary Data ◽

Subjective Cognitive Decline ◽

Cochrane Central Register ◽

Specific Design ◽

Meta Analyses ◽

Gender Specific

Introduction Dementia is a public health priority with projected increases in the number of people living with dementia worldwide. Prevention constitutes a promising strategy to counter the dementia epidemic, and an increasing number of lifestyle interventions has been launched aiming at reducing risk of cognitive decline and dementia. Gender differences regarding various modifiable risk factors for dementia have been reported, however, evidence on gender-specific design and effectiveness of lifestyle trials is lacking. Therefore, we aim to systematically review evidence on gender-specific design and effectiveness of trials targeting cognitive decline and dementia. Methods and analysis We will conduct a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Databases MEDLINE (PubMed interface), PsycINFO, Web of Science Core Collection, Cochrane Central Register of Controlled Trials (CENTRAL) and ALOIS will be searched for eligible studies using a predefined strategy, complemented by searches in clinical trials registers and Google for grey literature. Studies assessing cognitive function (overall measure or specific subdomains) as outcome in dementia-free adults will be included, with analyses stratified by level of cognitive functioning at baseline: a) cognitively healthy b) subjective cognitive decline 3) mild cognitive impairment. Two reviewers will independently evaluate eligible studies, extract data and determine methodological quality using the Scottish Intercollegiate Guidelines Network (SIGN)-criteria. If sufficient data with regards to quality and quantity are available, a meta-analysis will be conducted. Ethics and dissemination No ethical approval will be required as no primary data will be collected. PROSPERO registration number CRD42021235281.

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Biopsychosocial factors associated with non-recovery after a minor transport-related injury: protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2017-016314 ◽

2017 ◽

Vol 7 (9) ◽

pp. e016314 ◽

Cited By ~ 3

Author(s):

Stella Samoborec ◽

Rasa Ruseckaite ◽

Lorena Romero ◽

Sue M Evans

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Grey Literature ◽

Road Transport ◽

Primary Data ◽

Cochrane Central Register ◽

Post Traumatic Stress ◽

Factors Associated ◽

Quantitative And Qualitative Research ◽

Meta Analyses

IntroductionGlobally, road transport accidents contribute substantially to the number of deaths and also to the burden of disability. Up to 50 million people suffer a transport-related non-fatal injury each year, which often leads to long-term disability. It has been shown that substantial number of people with minor injuries struggle to recover and the reasons are still not well explored.Despite the high prevalence, little is known about the factors hindering recovery following minor traffic-related injuries. The aim of this paper is to present a protocol for the systematic review aiming to understand biopsychosocial factors related to non-recovery and identify current gaps in the literature.Methods and analysisThe review will be conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol guidelines. A search of the electronic databases, MEDLINE, EMBASE, Cochrane Central Register of Controlled trials, will be undertaken, in addition to Google Scholar and grey literature to identify studies in period from 2006 to 2016. Quantitative and qualitative research articles describing and identifying biopsychosocial factors associated with non-recovery and health outcomes such as pain, disability, functional recovery, health-related quality of life, post-traumatic stress disorder, depression, anxiety and return to work will be included. A conceptual framework developed to identify biopsychosocial factors will be applied to assure defined criterion.At present, there is little anticipation for meta-analyses due to the heterogeneity of factors and outcomes assessed. Therefore, a narrative synthesis based on study findings will be conducted.Ethics and disseminationEthical approval is not required as primary data will not be collected. Review results will be published as a part of thesis, peer-reviewed journal and conferences.Trialregistration numberPROSPEROregistration number: CRD42016052276.

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Settlement Service Literacy and the Relationship Between Service Utilisation and Wellbeing Among Newly Arrived Migrants: A Mixed Methods Systematic Review Protocol

Social Science Protocols ◽

10.7565/ssp.2020.2801 ◽

2020 ◽

Vol 3 ◽

pp. 1-7

Author(s):

Kerry Woodward ◽

Michael Polonsky ◽

Julie Green ◽

Julianne Abood ◽

Andre Renzaho

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Service Providers ◽

Grey Literature ◽

Well Being ◽

Primary Data ◽

Service Utilisation ◽

Publication Type ◽

Settlement Services ◽

The Relationship

Background: Settlement service literacy refers to the ability of migrants to access, understand and critically navigate settlement services. In Australia, increasing numbers of culturally and linguistically diverse migrants require settlement services to assist their transition. However, there are barriers to migrant’s ability to utilise settlement services which are related to their level of settlement service literacy. This review aims to shed light on how settlement service literacy influences new migrant’s utilisation of settlement services, and the consequences that it has for health, well-being and sense of belonging. Methods: The review will follow the guidelines laid out by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Literature searches will be undertaken in CINAHL, EMBASE, PubMed, PsycINFO, Scopus, Web of Science, Sociological Abstracts, SocIndex, ProQuest Social Science Database, and Google Scholar. Grey literature and relevant government bodies, non-government organisations, service providers and research institutes will also be searched. Studies included will report primary data (qualitative and quantitative) on new migrant’s (under five years) ability to utilise settlement services in high income countries. Studies that meet the inclusion criteria will be imported to Covidence, two researchers will screen the studies in a two part process (title and introduction scan; and full text) for relevance. Data extracted will include general publication information (author, country, year, and publication), type of study, participants, type of settlement service, measured outcomes, and the study aims, methods and results. Finally, data will be synthesised using a narrative approach. Discussion: The review will provide insight into the relationship between settlement service literacy and service utilisation and wellbeing for new migrants. The review will also provide data to inform settlement service policy to better cater for the needs of migrants. Systematic review registration:This protocol has been submitted to international prospective register of systematic reviews and meta-analysis (PROSPERO) and is currently under review.

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Estimating the global cost of vision impairment and its major causes: protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2019-036689 ◽

2020 ◽

Vol 10 (9) ◽

pp. e036689

Author(s):

Ana Patricia Marques ◽

Jacqueline Ramke ◽

John Cairns ◽

Thomas Butt ◽

Justine H Zhang ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Grey Literature ◽

Well Being ◽

Open Science ◽

Vision Impairment ◽

Primary Data ◽

Costs Of Illness ◽

Eye Health ◽

Global Cost

IntroductionVision impairment (VI) places a burden on individuals, health systems and society in general. In order to support the case for investing in eye health services, an updated cost of illness study that measures the global impact of VI is necessary. To perform such a study, a systematic review of the literature is needed. Here we outline the protocol for a systematic review to describe and summarise the costs associated with VI and its major causes.Methods and analysisWe will systematically search in Medline (Ovid) and the Centre for Reviews and Dissemination database which includes the National Health Service Economics Evaluation Database. No language or geographical restriction will be applied. Additional literature will be identified by reviewing the references in the included studies and by contacting field experts. Grey literature will be considered. The review will include any study published from 1 January 2000 to November 2019 that provides information about costs of illness, burden of disease and/or loss of well-being in participants with VI due to an unspecified cause or due to one of the seven leading causes globally.Two reviewers will independently screen studies and extract relevant data from included studies. Methodological quality of economic studies will be assessed based on the British Medical Journal checklist for economic submissions adapted to costs of illness studies. This protocol has been prepared following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocols and has been published prospectively in Open Science Framework.Ethics and disseminationFormal ethical approval is not required, as primary data will not be collected in this review. The findings of this study will be disseminated through peer-reviewed publications, stakeholder meetings and inclusion in the ongoing Lancet Global Health Commission on Global Eye Health.Registration detailshttps://osf.io/9au3w (DOI 10.17605/OSF.IO/6F8VM).

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Towards sustainable healthcare system performance in the 21st century in high-income countries: a protocol for a systematic review of the grey literature

BMJ Open ◽

10.1136/bmjopen-2018-025892 ◽

2019 ◽

Vol 9 (1) ◽

pp. e025892 ◽

Cited By ~ 4

Author(s):

Jeffrey Braithwaite ◽

Yvonne Zurynski ◽

Kristiana Ludlow ◽

Joanna Holt ◽

Hanna Augustsson ◽

...

Keyword(s):

Systematic Review ◽

Healthcare System ◽

English Language ◽

Grey Literature ◽

Healthcare Delivery ◽

Healthcare Systems ◽

High Income ◽

Primary Data ◽

Healthcare Delivery System ◽

Policy Makers

IntroductionThere is wide recognition that, if healthcare systems continue along current trajectories, they will become harder to sustain. Ageing populations, accelerating rates of chronic disease, increasing costs, inefficiencies, wasteful spending and low-value care pose significant challenges to healthcare system durability. Sustainable healthcare systems are important to patients, society, policy-makers, public and private funders, the healthcare workforce and researchers. To capture current thinking about improving healthcare system sustainability, we present a protocol for the systematic review of grey literature to capture the current state-of-knowledge and to compliment a review of peer-reviewed literature.Methods and analysisThe proposed search strategy, based on the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines, includes Google Advanced Search, snowballing techniques and targeted hand searching of websites of lead organisations such as WHO, Organisation for Economic Cooperation and Development, governments, public policy institutes, universities and non-government organisations. Documents will be selected after reviewing document summaries. Included documents will undergo full-text review. The following criteria will be used: grey literature document; English language; published January 2013–March 2018; relevant to the healthcare delivery system; the content has international or national scope in high-income countries. Documents will be assessed for quality, credibility and objectivity using validated checklists. Descriptive data elements will be extracted: identified sustainability threats, definitions of sustainability, attributes of sustainable healthcare systems, solutions for improvement and outcome measures of sustainability. Data will be analysed using novel text-mining methods to identify common concept themes and meanings. This will be triangulated with the more traditional analysis and concept theming by the researchers.Ethics and disseminationNo primary data will be collected, therefore ethical approval will not be sought. The results will be disseminated in peer-reviewed literature, as conference presentations and as condensed summaries for policy-makers and health system partners.PROSPERO registration numberCRD42018103076.

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