scholarly journals Nanoparticle-Based FM-MCF LSPR Biosensor With Open Air-Hole

2021 ◽  
Vol 2 ◽  
Author(s):  
Chuanhao Yang ◽  
Shiyan Xiao ◽  
Qi Wang ◽  
Hongxia Zhang ◽  
Hui Yu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Biological Fluids ◽  
Coupling Efficiency ◽  
High Sensitivity ◽  
Localized Surface Plasmon ◽  
Nanoparticle Arrays ◽  
The Finite Element Method ◽  
Core Fiber ◽  
Simulation Results ◽  
Air Hole

A nanoparticle-based few-mode multi-core fiber (FM-MCF) localized surface plasmon resonance (LSPR) biosensor is proposed and analyzed using the finite element method (FEM). It’s critical to narrow the loss spectrum and improve the coupling efficiency, which makes it have high resolution and high sensitivity. With the aid of open air holes, the gold nanoparticles are easily assembled on the surface of this FM-MCF LSPR biosensor. Through multiple investigations, the performance of the sensor can be improved by properly setting gold nanoparticle configurations, such as radius, positions, shapes, and nanoparticle arrays. The simulation results show that when three circular gold nanoparticles with a radius of 150 nm are placed symmetrically in the open air hole and the angle between adjacent nanoparticles is 5°, the maximum sensitivity of 7,351.6 nm/RIU (LP02y mode na = 1.38) can be obtained in the sensing range of 1.33–1.38, which covers the refractive index (RI) of biological fluids, such as bovine serum albumin (BSA) solution and human Immunoglobulin G.

Micro-structured optical fiber magnetic field sensor based on magnetic fluid filling

2019 ◽  
Vol 33 (31) ◽  
pp. 1950380
Author(s):  
Jie Wang ◽  
Zhen Zhang ◽  
Shuguang Li ◽  
Shun Wang
Keyword(s):  
Magnetic Field ◽  
Magnetic Fluid ◽  
High Sensitivity ◽  
Magnetic Field Sensor ◽  
The Finite Element Method ◽  
Average Sensitivity ◽  
Magnetic Field Sensors ◽  
Hole Radius ◽  
Field Sensor ◽  
Air Hole

A novel micro-structured fiber magnetic field sensor based on magnetic fluid (MF) filling is proposed. The air hole radius in the cladding of fiber is reduced from inner layer to outer layer, and the numerical analysis is performed by the finite element method (FEM). For the [Formula: see text]-pol mode, the proposed sensor has an average sensitivity of 960.61 pm/Oe, and for the [Formula: see text]-pol mode, the average sensitivity can reach 884.85 pm/Oe. The sensor has the advantages of small size and high sensitivity and is competitive in magnetic field sensors.

Molecularly Imprinted Sensor for Ascorbic Acid Based on Gold Nanoparticles and Multiwalled Carbon Nanotubes

2020 ◽  
Vol 16 (7) ◽  
pp. 905-913
Author(s):  
Youyuan Peng ◽  
Qingshan Miao
Keyword(s):  
Carbon Nanotubes ◽  
Gold Nanoparticles ◽  
Ascorbic Acid ◽  
Multiwalled Carbon Nanotubes ◽  
Ph Value ◽  
Biological Fluids ◽  
Water Soluble ◽  
Multiwalled Carbon ◽  
Experimental Conditions ◽  
Molecularly Imprinted

Background: L-Ascorbic acid (AA) is a kind of water soluble vitamin, which is mainly present in fruits, vegetables and biological fluids. As a low cost antioxidant and effective scavenger of free radicals, AA may help to prevent diseases such as cancer and Parkinson’s disease. Owing to its role in the biological metabolism, AA has also been utilized for the therapy of mental illness, common cold and for improving the immunity. Therefore, it is very necessary and urgent to develop a simple, rapid and selective strategy for the detection of AA in various samples. Methods: The molecularly imprinted poly(o-phenylenediamine) (PoPD) film was prepared for the analysis of L-ascorbic acid (AA) on gold nanoparticles (AuNPs) - multiwalled carbon nanotubes (MWCNTs) modified glass carbon electrode (GCE) by electropolymerization of o-phenylenediamine (oPD) and AA. Experimental parameters including pH value of running buffer and scan rates were optimized. Scanning electron microscope (SEM), fourier-transform infrared (FTIR) spectra, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were utilized for the characterization of the imprinted polymer film. Results: Under the selected experimental conditions, the DPV peak currents of AA exhibit two distinct linear responses ranging from 0.01 to 2 μmol L-1 and 2 to 100 μmol L-1 towards the concentrations of AA, and the detection limit was 2 nmol L-1 (S/N=3). Conclusion: The proposed electrochemical sensor possesses excellent selectivity for AA, along with good reproducibility and stability. The results obtained from the analysis of AA in real samples demonstrated the applicability of the proposed sensor to practical analysis.

scholarly journals X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples

2021 ◽  
Vol 22 (7) ◽  
pp. 3691
Author(s):  
Oliver Schmutzler ◽  
Sebastian Graf ◽  
Nils Behm ◽  
Wael Y. Mansour ◽  
Florian Blumendorf ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Irradiation Time ◽  
High Sensitivity ◽  
Nanoparticle Uptake ◽  
X Ray ◽  
Functionalized Gold Nanoparticles ◽  
Uptake Measurement ◽  
Prostate Tumor Cells ◽  
Non Destructive

Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time.

scholarly journals High Sensitivity Plasmonic Sensor Based on Fano Resonance with Inverted U-Shaped Resonator

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1164
Author(s):  
Gongli Xiao ◽  
Yanping Xu ◽  
Hongyan Yang ◽  
Zetao Ou ◽  
Jianyun Chen ◽  
...  
Keyword(s):  
Fano Resonance ◽  
Figure Of Merit ◽  
High Sensitivity ◽  
Refractive Index Sensor ◽  
Multimode Interference ◽  
Geometrical Parameters ◽  
The Finite Element Method ◽  
Plasmonic Sensor ◽  
Coupled Mode ◽  
Plasmonic Nanosensor

Herein, we propose a tunable plasmonic sensor with Fano resonators in an inverted U-shaped resonator. By manipulating the sharp asymmetric Fano resonance peaks, a high-sensitivity refractive index sensor can be realized. Using the multimode interference coupled-mode theory and the finite element method, we numerically simulate the influences of geometrical parameters on the plasmonic sensor. Optimizing the structure parameters, we can achieve a high plasmonic sensor with the maximum sensitivity for 840 nm/RIUand figure of merit for 3.9 × 105. The research results provide a reliable theoretical basis for designing high sensitivity to the next generation plasmonic nanosensor.

scholarly journals Mid-infrared photoacoustic gas monitoring driven by a gas-filled hollow-core fiber laser

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yazhou Wang ◽  
Yuyang Feng ◽  
Abubakar I. Adamu ◽  
Manoj K. Dasa ◽  
J. E. Antonio-Lopez ◽  
...  
Keyword(s):  
Fiber Laser ◽  
Signal To Noise Ratio ◽  
High Sensitivity ◽  
Laser Source ◽  
High Signal ◽  
Mid Infrared ◽  
Raman Fiber Laser ◽  
Custom Made ◽  
Core Fiber ◽  
Detection Technologies

AbstractDevelopment of novel mid-infrared (MIR) lasers could ultimately boost emerging detection technologies towards innovative spectroscopic and imaging solutions. Photoacoustic (PA) modality has been heralded for years as one of the most powerful detection tools enabling high signal-to-noise ratio analysis. Here, we demonstrate a novel, compact and sensitive MIR-PA system for carbon dioxide (CO2) monitoring at its strongest absorption band by combining a gas-filled fiber laser and PA technology. Specifically, the PA signals were excited by a custom-made hydrogen (H2) based MIR Raman fiber laser source with a pulse energy of ⁓ 18 μJ, quantum efficiency of ⁓ 80% and peak power of ⁓ 3.9 kW. A CO2 detection limit of 605 ppbv was attained from the Allan deviation. This work constitutes an alternative method for advanced high-sensitivity gas detection.

Design and analysis of trench-assisted large-mode-field-area multi-core fiber with air-hole

2021 ◽  
Vol 127 (1) ◽  
Author(s):  
Yuqin Zhang ◽  
Yudong Lian ◽  
Yuhe Wang ◽  
Jingbo Wang ◽  
Mengxin Yang ◽  
...  
Keyword(s):  
Mode Field ◽  
Core Fiber ◽  
Field Area ◽  
Air Hole

scholarly journals Fabrication of Graphene Nanomesh FET Terahertz Detector

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 641
Author(s):  
Yuan Zhai ◽  
Yi Xiang ◽  
Weiqing Yuan ◽  
Gang Chen ◽  
Jinliang Shi ◽  
...  
Keyword(s):  
Room Temperature ◽  
Energy Gap ◽  
Coupling Efficiency ◽  
High Sensitivity ◽  
Fabrication Process ◽  
Monolayer Graphene ◽  
Terahertz Waves ◽  
Wet Process ◽  
Graphene Nanomesh ◽  
Thz Detector

High sensitivity detection of terahertz waves can be achieved with a graphene nanomesh as grating to improve the coupling efficiency of the incident terahertz waves and using a graphene nanostructure energy gap to enhance the excitation of plasmon. Herein, the fabrication process of the FET THz detector based on the rectangular GNM (r-GNM) is designed, and the THz detector is developed, including the CVD growth and the wet-process transfer of high quality monolayer graphene films, preparation of r-GNM by electron-beam lithography and oxygen plasma etching, and the fabrication of the gate electrodes on the Si3N4 dielectric layer. The problem that the conductive metal is easy to peel off during the fabrication process of the GNM THz device is mainly discussed. The photoelectric performance of the detector was tested at room temperature. The experimental results show that the sensitivity of the detector is 2.5 A/W (@ 3 THz) at room temperature.

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