Posterior Mediastinal Epithelioid Angiosarcoma Arising in Schwannoma: A Case Report and Review of the Literature

Epithelioid angiosarcoma arising in schwannoma is an extremely rare mesenchymal tumor that accounts for only 1 to 2% of all sarcomas. This type of tumor occurs in all parts of the body, most often in the skin and soft tissues and rarely in the mediastinum. The present study describes the case of an asymptomatic, 58-year-old male who presented with epithelioid angiosarcoma in the posterior mediastinum during a physical examination. Enhanced computed tomography of the chest revealed a 3.5 × 3.1-cm mass in the posterior mediastinum. Thoracoscopic mediastinal mass resection was performed under general anesthesia due to the possibility that the tumor was malignant. Pathological examination revealed the presence of angiosarcoma and schwannoma components. Immunohistochemical staining for cluster of differentiation (CD) 31, CD34, early growth response (EGR), vimentin, Sry-related HMG box (SOX)-10 and S-100 was strongly positive. The patient recovered and was discharged on postoperative day 5. Two months postsurgery, the patient returned for evaluation, and no evidence of tumor recurrence was observed.

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A giant posterior mediastinal malignant peripheral nerve sheath tumor and benign neurofibroma in body surface: a case report

BMC Surgery ◽

10.1186/s12893-021-01122-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yan Zhang ◽

Hongfei Cai ◽

Guangchao Lv ◽

Yang Li

Keyword(s):

Peripheral Nerve ◽

Neurofibromatosis Type ◽

Posterior Mediastinum ◽

Pathological Examination ◽

Nerve Sheath Tumor ◽

Tumor Type ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Tumor ◽

Nerve Sheath ◽

Posterior Mediastinal

Abstract Background Neurofibromatosis comprises neurofibromatosis type 1 (NF1) and type 2 (NF2). Major tumor type of NF1 are neurofibroma recognized as benign peripheral nerve tumor, malignant peripheral nerve sheath tumor (MPNST), and glioma. Case presentation We report a woman with a special condition, whose tumors in body surfaces were benign neurofibroma and tumors in posterior mediastinum are MPNST. The chest-enhanced CT suggested a round soft tissue density in posteriormediastium. The diagnosis was established by pathology and immunohistochemistry. A single-stage thoracoscopic mediastinal mass resection was performed. The whole operation went smoothly and the CT scan of lungs did not show relapse of tumor three months later. Conclusions The appearance of neurofibroma should draw particular attention to the possibility of developing MPNST. More careful imaging examinations should be carried out, and pathological examination could diagnose it.

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A Case of Giant Posterior Mediastinal Mass: Gastrointestinal Stromal Tumor Developed in Neurofibromatosis Type 1 Patient.

10.21203/rs.3.rs-748331/v1 ◽

2021 ◽

Author(s):

Volkan ASLAN ◽

Fatih Gürler ◽

ozan yazıcı ◽

özlem erdem ◽

ali çelik ◽

...

Keyword(s):

Histopathological Examination ◽

Genetic Disorders ◽

Neurofibromatosis Type ◽

Skin Lesions ◽

Posterior Mediastinum ◽

Pathological Examination ◽

Imatinib Treatment ◽

First Case ◽

Posterior Mediastinal

Abstract Introduction: Gastrointestinal Stromal Tumors mostly located in the stomach and esophageal GIST is extremely rare. Various genetic disorders increase the risk of developing GIST, among these, NF-1 is the most common. A case of posterior mediastial GIST developing in the neurofibromatosis patient has not been reported yet.Case: A 48-year-old male patient is being evaluated with complaints of dyspnea and progressive dysphagia. Computed tomography detected a cystic, lobulated contour mass that was located at the posterior mediastinum and measuring 11 x 14x12 cm. The giant semisolid mass has been dissected from adjacent the vertebra, the esophagus, pericardium and inferior pulmonary vein and Histopathological examination revealed GİST. Pathological examination of skin lesions confirmed NF-1. Finally, NF-1-associated posterior mediastinal GIST was diagnosed and adjuvant imatinib treatment was initiated. Conclusion: To the best our knowledge, this patient was the first case, who diagnosed with posterior mediastinal GIST developing on the basis of NF-1.

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Spontaneous hematoma of posterior mediastinum with an uncommon cause: a case report and review of the literature

Clinics and Practice ◽

10.4081/cp.2016.838 ◽

2016 ◽

Vol 6 (1) ◽

Author(s):

Xiaowei Li ◽

Leilei Liu ◽

Dianbo Cao ◽

Yutian Sun

Keyword(s):

Bronchial Artery ◽

Left Gastric Artery ◽

Posterior Mediastinum ◽

Gastric Artery ◽

Mediastinal Hematoma ◽

Satisfactory Outcome ◽

Contrast Enhanced ◽

Feeding Vessels ◽

Posterior Mediastinal ◽

Enhanced Computed Tomography

Spontaneous mediastinal hematoma is exceedingly rare. We described such a case of a 61-year-old male with a posterior mediastinal hematoma from ruptured small aneurysm, which was ascertained <em>via</em> contrast-enhanced computed tomography examination. Subsequent super-selective angiography of left gastric artery revealed a ruptured aneurysm with contrast medium leakage, feeding vessels respectively from caudal and cranial artery. The left gastric artery branch caudally feeding aneurysm was successfully occluded, while cranially feeding artery from the branch of left bronchial artery failed to embolize due to complex anatomic factor. Our management still yields to a satisfactory outcome.

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Posterior Mediastinal Hyperfunctioning Insular Thyroid Carcinoma

Tumori Journal ◽

10.1177/030089160509100415 ◽

2005 ◽

Vol 91 (4) ◽

pp. 358-360 ◽

Cited By ~ 1

Author(s):

Rocco Bellantone ◽

Celestino Pio Lombardi ◽

Maurizio Bossola ◽

Guido Fadda ◽

Massimo Salvatori ◽

...

Keyword(s):

Computed Tomography ◽

Thyroid Carcinoma ◽

Mediastinal Mass ◽

Thyroid Tissue ◽

Posterior Mediastinum ◽

Pathological Examination ◽

Posterior Mediastinal Mass ◽

Posterior Mediastinal ◽

Poorly Differentiated ◽

The Right

A case is presented of a posterior mediastinal mass arising in a 57-year-old woman with severe compressive cervical symptoms and hyperthyroidism. Computed tomography showed intrathoracic thyroid tissue that displaced the trachea towards the front and the right and invaded the posterior mediastinum. Pathological examination showed features of a poorly differentiated (insular) thyroid carcinoma. To the best of our knowledge, this is the first reported case of a posterior mediastinal insular thyroid carcinoma with thyroid hyperfunction.

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Monocyte as an Emerging Tool for Targeted Drug Delivery: A Review

Current Pharmaceutical Design ◽

10.2174/1381612825666190102104642 ◽

2019 ◽

Vol 24 (44) ◽

pp. 5296-5312 ◽

Cited By ~ 5

Author(s):

Fakhara Sabir ◽

Rai K. Farooq ◽

Asim.ur.Rehman ◽

Naveed Ahmed

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

The Body ◽

Carrier System ◽

Bone Marrow Precursor ◽

Extensive Introduction ◽

Cancer Inflammation ◽

Targeted Drug ◽

Cluster Of Differentiation

Monocytes are leading component of the mononuclear phagocytic system that play a key role in phagocytosis and removal of several kinds of microbes from the body. Monocytes are bone marrow precursor cells that stay in the blood for a few days and migrate towards tissues where they differentiate into macrophages. Monocytes can be used as a carrier for delivery of active agents into tissues, where other carriers have no significant access. Targeting monocytes is possible both through passive and active targeting, the former one is simply achieved by enhanced permeation and retention effect while the later one by attachment of ligands on the surface of the lipid-based particulate system. Monocytes have many receptors e.g., mannose, scavenger, integrins, cluster of differentiation 14 (CD14) and cluster of differentiation 36 (CD36). The ligands used against these receptors are peptides, lectins, antibodies, glycolipids, and glycoproteins. This review encloses extensive introduction of monocytes as a suitable carrier system for drug delivery, the design of lipid-based carrier system, possible ways for delivery of therapeutics to monocytes, and the role of monocytes in the treatment of life compromising diseases such as cancer, inflammation, stroke, etc.

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Ovarian epithelioid angiosarcoma complicating pregnancy: a case report and review of the literature

Journal of International Medical Research ◽

10.1177/03000605211019641 ◽

2021 ◽

Vol 49 (5) ◽

pp. 030006052110196

Author(s):

Xiaotong Peng ◽

Zhi Duan ◽

Hongling Yin ◽

Furong Dai ◽

Huining Liu

Keyword(s):

Adverse Events ◽

Soft Tissues ◽

Malignant Tumors ◽

Cystic Teratoma ◽

Abdominal Distension ◽

Epithelioid Angiosarcoma ◽

History Of ◽

New Ideas ◽

The Right ◽

Clinical Awareness

Epithelioid angiosarcoma is a rare and highly aggressive soft tissue angiosarcoma most commonly arising in the deep soft tissues. Given that abundant vascular cavities anastomose with each other, most angiosarcomas prone to metastasis recur quickly, and the overall prognosis is poor. We report a 25-year-old woman at 24 weeks’ gestation who presented with a 1-month history of abdominal distension. Ultrasonography suggested a mass in the right adnexa, and she underwent two operations owing to uncontrolled intraperitoneal bleeding with progressive anemia. The right ovarian tumor and right adnexa were removed successively. Biopsy yielded a diagnosis of primary epithelioid angiosarcoma with mature cystic teratoma. The patient died from uncontrolled progressive bleeding 1 week after the second operation. This case revealed that epithelial angiosarcoma is a highly malignant endothelial cell tumor. The results of surgery and chemoradiotherapy tend to be poor, and the recurrence rate is high. The purpose of this study is to raise clinical awareness of epithelial angiosarcoma and its adverse events and to provide new ideas for the treatment of these adverse events. Immunohistochemical staining of pathological specimens can facilitate diagnosis. Pregnancy with malignant tumors may lead to rapid disease progression, extensive lesions, and a poor prognosis.

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A Case of Incidental Schwannoma Mimicking Necrotic Metastatic Lymph Node from Bladder Cancer

Medicina ◽

10.3390/medicina57070728 ◽

2021 ◽

Vol 57 (7) ◽

pp. 728

Author(s):

Jeong-Hyouk Choi ◽

Koo-Han Yoo ◽

Dong-Gi Lee ◽

Gyeong-Eun Min ◽

Gou-Young Kim ◽

...

Keyword(s):

Histopathological Examination ◽

Metastatic Lymph Node ◽

Imaging Study ◽

Surgical Excision ◽

The Body ◽

Pathological Examination ◽

Cystic Tumor ◽

Complete Surgical Excision ◽

Ultrasound Computed Tomography ◽

Retroperitoneal Schwannoma

Background and Objectives: Retroperitoneal schwannoma is a very rare case of schwannoma which commonly occurs in the other part of the body. However, it is difficult to distinguish schwannoma from other tumors before pathological examination because they do not show specific characteristics on imaging study such as ultrasound, computed tomography (CT), and magnetic resonance image (MRI). Case summary: A 60-year-old male showed a retroperitoneal cystic tumor which is found incidentally during evaluation of coexisted bladder tumor. Neurogenic tumor was suspicious for the retroperitoneal tumor through pre-operative imaging study. Finally, a schwannoma was diagnosed by immunohistochemical examination after complete surgical excision laparoscopically. Conclusion: As imaging technology is developed, there may be more chances to differentiate schwannoma from other neoplasm. However, still surgical resection and histopathological examination is feasible for diagnosis of schwannoma.

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Magnetic Resonance Imaging in the Diagnosis of Disruption of the Posterior Tibial Tendon

Foot & Ankle ◽

10.1177/107110078700800307 ◽

1987 ◽

Vol 8 (3) ◽

pp. 144-147 ◽

Cited By ~ 26

Author(s):

Ian J. Alexander ◽

Kenneth A. Johnson ◽

Thomas H. Berquist

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Soft Tissues ◽

Diagnostic Technique ◽

Clinical Findings ◽

The Body ◽

Posterior Tibial Tendon ◽

Resonance Imaging ◽

Posterior Tibial ◽

Magnetic Resonance Imaging Mri

Magnetic resonance imaging (MRI), a useful technique of studying soft tissues of the body, can be very effective in assessing the integrity of tendons. Usually a patient with a complete tear of the posterior tibial tendon has characteristic physical findings. In the patient presented, MRI demonstrated a complete disruption of the posterior tibial tendon, despite the absence of the commonly associated clinical findings. In view of the difficulties encountered with attempted tenography of the completely torn posterior tibial tendon, MRI provides a sensitive alternative diagnostic technique.

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Computerized Tomography: A Perspective in the Pediatric Patient

PEDIATRICS ◽

10.1542/peds.59.2.305 ◽

1977 ◽

Vol 59 (2) ◽

pp. 305-308

Author(s):

Derek Harwood-Nash ◽

Herman Grossman ◽

Alvin Felman ◽

John Kirkpatrick ◽

Leonard Swischuk

Keyword(s):

Computerized Tomography ◽

Soft Tissues ◽

Conventional Radiography ◽

The United States ◽

The Body ◽

Whole Body ◽

Central Research ◽

X Ray ◽

Whole Body Ct

Computerized tomography (CT), a technique conceptualized by Oldendorf in 19611 and developed by Hounsfield2 of EMI-Tronics Inc. (EMI) Central Research Laboratories, has proven to be a successful innovation in neuroradiology. Reviews by Ambrose3 in England and by Baker et al.4 and by New et al.5 in the United States have clearly demonstrated the value of this new modality in neuroradiological diagnosis. In 1975 Houser et al.6 and Harwood-Nash et al.7 provided the initial clinical and radiological data about CT in infants and children. More recently this technique has been extended to the study of tissues and organs in the body other than those in the head. This has been accomplished by modification of the original machine into a whole-body CT system. Early reviews by Ledley et al.8 and by Alfidi et al.9 suggest a significant potential for diagnosis of lesions in the abdomen, pelvis, and thorax. The advantages of CT are that it is less invasive than standard special diagnostic radiological procedures and that for the first time it provides in vivo information regarding the content and the characteristics of tissue composing organs and masses. DESCRIPTION OF EQUIPMENT In conventional radiography an image is made on radiographic film by an attenuated X-ray beam. In passing through a core of tissue, each ray of the beam is attenuated as it is absorbed and scattered by the tissue in its path. The intensity of the transmitted ray depends on the sum total of X-ray attenuation by all the different soft tissues in its path.

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The reaction of the soft tissues of the anterior abdominal wall to various suture material

Kazan medical journal ◽

10.17816/kazmj62327 ◽

1982 ◽

Vol 63 (4) ◽

pp. 72-74

Author(s):

V. P. Nefedov ◽

R. M. Ramazanov

Keyword(s):

Foreign Body ◽

Abdominal Wall ◽

Soft Tissues ◽

Suture Material ◽

Anterior Abdominal Wall ◽

The Body ◽

Reactive Changes ◽

Healing Processes

The healing processes of sutured wounds of soft tissues in most cases depend on the type and quality of the suture material. Any kind of suture material in the tissues of the body is a foreign body that causes various reactive changes from the tissues. The nature of these changes, all other things being equal, is mainly determined by the type of suture material, its thickness and the method of sterilization of the tissues on which the sutures are applied, the trauma of surgery, the infection of the wound and the irritating effect of the threads on the tissues.

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