scholarly journals Does PRGF Work? A Prospective Clinical Study in Dogs with a Novel Polylactic Acid Scaffold Injected with PRGF Using the Modified Maquet Technique

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2404
Author(s):  
Victoria Valiño-Cultelli ◽  
Óscar Varela-López ◽  
Antonio González-Cantalapiedra
Keyword(s):  
Clinical Study ◽  
Polylactic Acid ◽  
Recovery Time ◽  
Patellar Ligament ◽  
Prospective Clinical Study ◽  
Control Groups ◽  
Biodegradable Scaffold ◽  
Negative Results ◽  
Metallic Implants ◽  
And Control

Tibial tuberosity advancement is a surgical technique to restore the dynamical stability in the knee by advancing the insertion of the patellar ligament, for which it is necessary to advance the tibial crest, being maintained in the desired position usually by a cage and metallic implants. The purpose of this study was to replace the cage with a polylactic acid biodegradable scaffold designed for each patient by 3D printing, inserting platelet-rich in growth factors (PRGF) to demonstrate its osteoinductive properties. To this end, we used the modified Maquet technique to reduce the amount of metal to a minimum. Fifty-three dogs finished the study. The control and PRGF groups did not present any statistically significant differences in terms of ossification degree (p > 0.001) but they demonstrated satisfactory ossification compared to previous publications, although in the PRGF group three of the scaffolds suffered complete reabsorption. The PRGF and control groups did not show any statistically significant differences in terms of lameness degree (p > 0.001). However, the PRGF group showed at the first control some analgesic and anti-inflammatory properties but they were not enough for reducing the functional recovery time in a significant way. The PRGF group did not show any complications or negative results associated with their use.

scholarly journals Effectiveness of a Selective Etching Technique in Reducing White Spots Formation around Lingual Brackets: A Prospective Cohort Clinical Study

Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 572
Author(s):  
Domenico Dalessandri ◽  
Marino Bindi ◽  
Francesca Massetti ◽  
Gaetano Isola ◽  
Marco Migliorati ◽  
...  
Keyword(s):  
Clinical Study ◽  
Difficulty Level ◽  
Prospective Clinical Study ◽  
White Spot Lesions ◽  
Etching Technique ◽  
White Spots ◽  
Accumulation Index ◽  
One Year ◽  
Lingual Brackets ◽  
And Control

The risk of developing white spot lesions (WSLs) after orthodontic treatment with lingual brackets is generally considered lower than with labial ones, even if plaque accumulation is frequently higher due to the increased difficulty level in oral hygiene maintenance. In this prospective clinical study, selective enamel etching technique effectiveness in reducing plaque accumulation and WSLs was tested. Thirty patients were bonded with a split-mouth approach: two randomly selected opposite quadrants were used as the test sides, using customized plastic etching guides, and the other two as control sides, applying traditional direct etching methods. The plaque presence around the braces was recorded after 1, 3, 6, and 12 months according to a lingual plaque accumulation index (LPAI), as was the presence of WSLs. PAI measured values were significantly higher in the control sides during the observation period. Test and control sides differed significantly for new WSL onset only after 12 months of treatment. Therefore, the present research demonstrated that this guided enamel etching technique allowed for significant reduction in plaque accumulation around the lingual brackets and reduced onset of white spots after one year of treatment.

scholarly journals Khat Chewing and Smoking Effect on Oral Mucosa: A Clinical Study

2009 ◽  
Vol 52 (4) ◽  
pp. 155-158 ◽  
Author(s):  
Essam Halboub ◽  
Essam Dhaifullah ◽  
Mahmoud Abdulhuq
Keyword(s):  
Clinical Study ◽  
Oral Mucosa ◽  
Smoking Habit ◽  
Clinical Findings ◽  
Control Group ◽  
Control Groups ◽  
Catha Edulis ◽  
Khat Chewing ◽  
Clinical Relationship ◽  
And Control

Khat (Catha Edulis Forskal) is widely cultivated in Yemen and East of Africa. The habit of chewing tender leaves and twigs of khat is deep-rooted in Yemen. Our study investigates the chronic khat chewing and smoking effect on oral mucosa. The sample (n=79) consists of two main groups, khat chewers (n=54) and control groups (n=25). Khat chewers group is divided into 4 subgroups according to duration of khat chewing and smoking habit. The control group is divided into 2 subgroups according to smoking habit. Whitening with mild corrugation, frictional keratosis and frictional keratosis with mild or sever corrugation were the clinical findings. One hundred percent of clinical findings were present on buccal mucosa of chewing side of both smokers and non-smokers whatever the duration of khat chewing period. On the vestibular and mucobuccal fold mucosa, (100 % and 73.3 %) and (60 % and 43.7 %) of the khat chewers group had clinical findings on chewing side of smokers and non-smokers according to khat chewing duration respectively. There was clinical relationship between these lesions and khat chewing, but not smoking. Khat chewing causes oral white lesions on the chewing side and it is found that smoking, clinically, does not exacerbate such lesions.

Effect of Removable Orthodontic Appliance on Taste and Flavor Perception – A Clinical Study

2007 ◽  
Vol 32 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Amitha Hegde ◽  
Swati Dwivedi
Keyword(s):  
Clinical Study ◽  
Orthodontic Appliances ◽  
Age Group ◽  
Marked Variation ◽  
Control Groups ◽  
Orthodontic Appliance ◽  
Food And Beverages ◽  
Flavor Perception ◽  
Removable Orthodontic Appliances ◽  
And Control

Removable orthodontic appliances are known to be the cause of various complaints related to oral handling of food and beverages, phonation and vocalization. To evaluate the complaint regarding appliance and its effect on taste and flavor perception ,100 volunteers were selected for the study. Two groups (I and II) of 50 children each were divided as study and control groups between the age group of 8- 13 years. Selected volunteers were given taste and flavor stimuli and were asked to score as per their perception in different testing sessions. The overall results revealed that volunteers from both study and control groups, irrespective of the use of removable orthodontic appliances showed marked variation in the estimation of the taste and flavor stimuli in different testing sessions. However, the results obtained were statistically not significant.

Adverse events when treating XDR tuberculosis

MedAlliance ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 16-24
Keyword(s):  
Clinical Study ◽  
Adverse Events ◽  
Adverse Reactions ◽  
Main Group ◽  
The Other ◽  
Control Group ◽  
Aminosalicylic Acid ◽  
Control Groups ◽  
Drug Induced ◽  
And Control

The article presents the results of a clinical study on the frequency and spectrum of adverse events (AEs) that occur during treatment with an anti-tuberculosis drug (thioureidoiminomethylpyridinium perchlorate, Tpp). The purpose of the study was to determine the frequen-cy and nature of adverse events when TPP is included in the treatment regimen and to develop an algorithm for the prevention of adverse reactions. Materials and methods: 125 (N=125) patients with MDR and XDR tu-berculosis were examined. 70.4% (88) patients developed adverse events. Results and discussion: At the same time, adverse reactions occurred in 58.3% (35) of the main group, and in 69.2% (45) of the control group. There were no significant differences in the frequency of adverse events between the main and control groups (2=1.608, 95% CI 0.298-1.298, p>0.05). In the control group, diges-tive and hepatobiliary AEs were more frequent (up by 8.6% and 3.5%, respectively). On the other hand, derma-tological reactions prevailed in the main group (up by 3.8%). Tpp was not shown to be the main cause of drug induced hypothyroidism, it can jointly reinforce thyrotox-ic effect when used in combination with protionamide and/or PASA (para-aminosalicylic acid). Statistic analy-sis showed no significant differences in any class of AEs between the groups (p>0.05 for all AE categories). Up to 68% of adverse reactions were mild (1 and 2 grade). Con-clusion. Thioureidoiminomethylpyridinium perchlorate is not the main cause of drug induced hypothyroidism, it can jointly reinforce thyrotoxic effect when used in combina-tion with protionamide and/or PASA.

scholarly journals The effects of rapid maxillary expansion on voice function

2016 ◽  
Vol 87 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Gizem Yurttadur ◽  
Faruk Ayhan Bascıftcı ◽  
Kayhan Ozturk
Keyword(s):  
Clinical Study ◽  
Acoustic Analysis ◽  
Rapid Maxillary Expansion ◽  
Control Group ◽  
Maxillary Expansion ◽  
Control Groups ◽  
Vocal Function ◽  
Vocal Quality ◽  
And Control ◽  
Controlled Clinical Study

ABSTRACT Objective: To evaluate the effects of rapid maxillary expansion (RME) on vocal function in patients with bilateral maxillary crossbite. Materials and Methods: We designed our research as a prospective, controlled, clinical study. The treatment group and the control group each had 20 subjects for a total of 40 subjects. Acoustic voice samples were recorded from all patients at T1 and T2 by the Multi-Dimensional Voice Program (MDVP Model 5105) for acoustic analysis in Computerized Speech Lab (CSL). Results: No statistically significant differences were found between the treatment and control groups in the means of any parameters. Conclusions: RME does not change vocal quality or resonance, so it can be safely used with patients.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

The Prospects and Risks Connected with Increasing the Level of Self-Organisation in Students

2020 ◽  
pp. 75-81
Author(s):  
Svetlana Alexandrovna Kosareva ◽  
Keyword(s):  
Higher Education ◽  
Professional Competence ◽  
Initial Level ◽  
Education Institution ◽  
Diagnostic Methods ◽  
Study Guide ◽  
Learning Approaches ◽  
Control Groups ◽  
Self Organisation ◽  
And Control

The paper describes the method for increasing the level of self-organisation in students which has been developed by the author. It also contains the method testing results and presents the prospects and risks teachers could face while applying the method in a higher education institution. The purpose of this study is to find out the prospects and risks of applying the method for increasing the level of self-organisation in students and to determine the ways of reducing the risks. Methodology. The author points out the learning approaches which were the basis of developing the method and describes diagnostic methods for determining students’ self-organisation levels. The work focused on increasing each student’s initial level consists of a theoretical and a practical part and includes project activities on creating a study guide. The results of the study. The method developed proved to be effective. It was established by diagnosing the final level of self-organisation in students in the experimental and control groups. The paper considers the advantages of the method among which there is universal character, flexibility, improvements to teacher’s and students’ professional competence, etc. At the same time it is necessary to be aware of the risks due to the increased amount of teacher’s work and the fact that students’ work within the project tends to be monotonous. In conclusion, the prospects of the method for increasing the level of self-organisation in students are related to its advantages and the final results of the work. The risks of its use can be reduced with the help of the measures proposed in the paper.

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