scholarly journals Factors Affecting Voriconazole Trough Concentration and Optimal Maintenance Voriconazole Dose in Chinese Children

Antibiotics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1542
Author(s):  
Yi-Chang Zhao ◽  
Yang Zou ◽  
Jing-Jing Hou ◽  
Chen-Lin Xiao ◽  
Bi-Kui Zhang ◽  
...  
Keyword(s):  
Influencing Factors ◽  
Trough Concentration ◽  
Maintenance Dose ◽  
Chinese Children ◽  
Direct Bilirubin ◽  
Drug Label ◽  
Urea Nitrogen ◽  
Factors Affecting ◽  
Treatment And Prevention ◽  
Retrospective Clinical Study

Voriconazole is a triazole antifungal agent commonly used for the treatment and prevention of invasive aspergillosis (IA). However, the study of voriconazole's use in children is limited. The present study was performed to explore maintenance dose to optimize voriconazole dosage in children and the factors affecting voriconazole trough concentration. This is a non-interventional retrospective clinical study conducted from 1 January 2016 to 31 December 2020. The study finally included 94 children with 145 voriconazole trough concentrations. The probability of achieving a targeted concentration of 1.0–5.5 µg/mL with empiric dosing increased from 43 (45.3%) to 78 (53.8%) after the TDM-guided adjustment. To achieve targeted concentration, the overall target maintenance dose for the age group of less than 2, 2 to 6, 6 to 12, and 12 to 18 years old was approximately 5.71, 6.67, 5.08 and 3.31 mg·kg−1/12 h, respectively (p < 0.001). Final multivariate analysis found that weight (p = 0.019), dose before sampling (p < 0.001), direct bilirubin (p < 0.001), urea nitrogen (p = 0.038) and phenotypes of CYP2C19 were influencing factors of voriconazole trough concentration. These factors can explain 36.2% of the variability in voriconazole trough concentration. Conclusion: In pediatric patients, voriconazole maintenance doses under the target concentration tend to be lower than the drug label recommended, but this still needs to be further studied. Age, body weight, dose, direct bilirubin, urea nitrogen and phenotypes of CYP2C19 were found to be influencing factors of voriconazole concentration in Chinese children. The influence of these factors should be taken into consideration during voriconazole use.

Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders

2020 ◽  
Vol 17 (3) ◽  
pp. 238-258 ◽  
Author(s):  
Michal Prendecki ◽  
Marta Kowalska ◽  
Ewa Toton ◽  
Wojciech Kozubski
Keyword(s):  
Lewy Bodies ◽  
Hepatic Metabolism ◽  
New Drugs ◽  
Glutamate Excitotoxicity ◽  
Factors Affecting ◽  
Treatment And Prevention ◽  
Expression Of Genes ◽  
Dementia Risk ◽  
Antidementia Drugs ◽  
Butyrylcholinesterase Activity

: Dementia is an important issue in western societies, and in the following years, this problem will also rise in the developing regions, such as Africa and Asia. The most common types of dementia in adults are Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD) and Vascular Dementia (VaD), of which, AD accounts for more than half of the cases. : The most prominent symptom of AD is cognitive impairment, currently treated with four drugs: Donepezil, rivastigmine, and galantamine, enhancing cholinergic transmission; as well as memantine, protecting neurons against glutamate excitotoxicity. Despite ongoing efforts, no new drugs in the treatment of AD have been registered for the last ten years, thus multiple studies have been conducted on genetic factors affecting the efficacy of antidementia pharmacotherapy. The researchers investigate the effects of variants in multiple genes, such as ABCB1, ACE, CHAT, CHRNA7, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP3A7, NR1I2, NR1I3, POR, PPAR, RXR, SLC22A1/2/5, SLC47A1, UGT1A6, UGT1A9 and UGT2B7, associated with numerous pathways: the development of pathological proteins, formation and metabolism of acetylcholine, transport, metabolism and excretion of antidementia drugs and transcription factors regulating the expression of genes responsible for metabolism and transport of drugs. The most promising results have been demonstrated for APOE E4, dementia risk variant, BCHE-K, reduced butyrylcholinesterase activity variant, and CYP2D6 UM, ultrarapid hepatic metabolism. Further studies investigate the possibilities of the development of emerging drugs or genetic editing by CRISPR/Cas9 for causative treatment. : In conclusion, the pharmacogenetic studies on dementia diseases may improve the efficacy of pharmacotherapy in some patients with beneficial genetic variants, at the same time, identifying the carriers of unfavorable alleles, the potential group of novel approaches to the treatment and prevention of dementia.

scholarly journals Aphid–Plant–Phytovirus Pathosystems: Influencing Factors from Vector Behaviour to Virus Spread

Agriculture ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 502
Author(s):  
Junior Corneille Fingu-Mabola ◽  
Frédéric Francis
Keyword(s):  
Influencing Factors ◽  
Virus Transmission ◽  
Physical Factors ◽  
Factors Affecting ◽  
Vector Borne Diseases ◽  
Vector Behaviour ◽  
Crop Fields ◽  
Host Seeking ◽  
The Impact ◽  
Vector Efficiency

Aphids are responsible for the spread of more than half of the known phytovirus species. Virus transmission within the plant–aphid–phytovirus pathosystem depends on vector mobility which allows the aphid to reach its host plant and on vector efficiency in terms of ability to transmit phytoviruses. However, several other factors can influence the phytoviruses transmission process and have significant epidemiological consequences. In this review, we aimed to analyse the aphid behaviours and influencing factors affecting phytovirus spread. We discussed the impact of vector host-seeking and dispersal behaviours mostly involved in aphid-born phytovirus spread but also the effect of feeding behaviours and life history traits involved in plant–aphid–phytovirus relationships on vector performances. We also noted that these behaviours are influenced by factors inherent to the interactions between pathosystem components (mode of transmission of phytoviruses, vector efficiency, plant resistance, …) and several biological, biochemical, chemical or physical factors related to the environment of these pathosystem components, most of them being manipulated as means to control vector-borne diseases in the crop fields.

scholarly journals The role of serum β-trophin and endostatin in patients with polycystic ovary syndrome: Are they correlated?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wei Gong ◽  
Aikmu Bilixzi ◽  
Xinmei Wang ◽  
Yanli Lu ◽  
Li Wan ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Influencing Factors ◽  
Polycystic Ovary ◽  
Pearson Correlation ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Ovary Syndrome ◽  
Factors Affecting ◽  
Main Factors

Abstract Background It’s necessary to investigate the serum β-trophin and endostatin (ES) level and its influencing factors in patients with newly diagnosed polycystic ovary syndrome (PCOS). Methods Newly diagnosed PCOS patients treated in our hospital were selected, and healthy women who took physical examination during the same period as healthy controls. We detected and compared the related serum indicators between two groups, Pearson correlation were conducted to identify the factors associated with β-trophin and ES, and the influencing factors of β-trophin and ES were analyzed by logistic regression. Results A total of 62 PCOS patients and 65 healthy controls were included. The BMI, WHI, LH, FSH, TT, FAI, FBG, FINS, HOMA-IR, TC, TG, LDL, ES in PCOS patients were significantly higher than that of healthy controls, while the SHBG and HDL in PCOS patients were significantly lower than that of healthy controls (all p < 0.05). β-trophin was closely associated with BMI (r = 0.427), WHR (r = 0.504), FBG (r = 0.385), TG (r = 0.405) and LDL (r = 0.302, all p < 0.05), and ES was closely associated with BMI (r = 0.358), WHR (r = 0.421), FBG (r = 0.343), TC (r = 0.319), TG (r = 0.404, all p < 0.05). TG, BMI, WHR and FBG were the main factors affecting the serum β-trophin levels (all p < 0.05). FBG, TC and BMI were the main factors affecting the serum ES levels (all p < 0.05). The TG, β-trophin, ES level in PCOS patients with insulin resistance (IR) were significantly higher than that of those without IR (all p < 0.05). Conclusion Increased β-trophin is closely associated with increased ES in patients with PCOS, which may be the useful indicators for the management of PCOS.

scholarly journals Grey Relational Grade Based Quantitative Analysis of the Factors Influencing the Load Characteristics of A Power Grid

2018 ◽  
Vol 53 ◽  
pp. 01012 ◽  
Author(s):  
Wei Pan ◽  
Caijia Lei ◽  
Wei Jia ◽  
Hui Gao ◽  
Binghua Fang
Keyword(s):  
Quantitative Analysis ◽  
Influencing Factors ◽  
Power Grid ◽  
Grey System Theory ◽  
Grey System ◽  
Factors Affecting ◽  
Grey Relational Grade ◽  
Load Characteristics ◽  
Grey Relational ◽  
Main Factor

Regarding analysis of load characteristics of a power grid, there are multiple factors that influence the variation of load characteristics. Among these factors, the influence of different ones on the change of load characteristic is somewhat different, thus the degree of influence of various factors needs to be quantified to distinguish the main and minor factors of load characteristics. Based on this, the grey relational analysis in the grey system theory is employed as the basis of mathematical model in this paper. Firstly, the main factors affecting the load characteristics of a power grid are analysed. Then, the principle of quantitative analysis of the influencing factors by using grey relational grade is introduced. Lastly, the load of Guangzhou power grid is selected as the research object, thereby the main factor of temperature affecting the load characteristics is quantitatively analysed, such that the correlation between temperature and load is established. In this paper, by investigating the influencing factors and the degree of influence of load characteristics, the law of load characteristics changes can be effectively revealed, which is of great significance for power system planning and dispatching operation.

scholarly journals Factors Affecting the Occurrence of Out-of-Hospital Sudden Cardiac Arrest

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Izabella Uchmanowicz ◽  
Wiesław Bartkiewicz ◽  
Jarosław Sowizdraniuk ◽  
Joanna Rosińczuk
Keyword(s):  
Risk Factors ◽  
Cardiac Arrest ◽  
Rapid Assessment ◽  
Sudden Cardiac Arrest ◽  
International Classification Of Diseases ◽  
Medical Emergency ◽  
Endocrine Disorders ◽  
Factors Affecting ◽  
Emergency Procedures ◽  
Treatment And Prevention

Objective. This paper aims to discover the risk factors for sudden cardiac arrest (out-of-hospital sudden cardiac arrest (OHSCA)) which significantly affect the decision about prioritizing emergency interventions before dispatching medical emergency teams, risk of deterioration of the patient’s condition at the scene, and emergency procedures.Methods. A retrospective study taking into account the international classification of diseases ICD-10 based on an analysis of medical records of Emergency Medical Service in Wroclaw (Poland).Results. The main risk factor of OHSCA is coexistence of external cause leading to illness or death (ICD Group V-10) as well as the occurrence of diseases from the group of endocrine disorders (group E), in particular diabetes. The increase in the risk of OHSCA incidence is affected by nervous system diseases (group G), especially epilepsy of various etiologies, respiratory diseases (group J), mainly COPD, and bronchial asthma or mental and behavioral disorders (group F), with particular emphasis on the drugs issue. The procedure for receiving calls for Emergency Notification Centre does not take into account clinical risk factors for sudden cardiac arrest (SCA).Conclusion. Having knowledge of OHSCA risk factors can increase the efficiency of rescue operations from rapid assessment and provision of appropriate medical team, through effective performance of medical emergency treatment and prevention of SCA or finally reducing the costs.

Investigation on Polymer Adsorption and Retention in a Polymer Flooded Reservoir

2013 ◽  
Vol 734-737 ◽  
pp. 1200-1203
Author(s):  
Shu Qiang Liu ◽  
Ji Cheng Zhang ◽  
Jin Cheng Xu
Keyword(s):  
Polymer Solution ◽  
Influencing Factors ◽  
Polymer Adsorption ◽  
Solution Concentration ◽  
Injection Rate ◽  
The Other ◽  
Injection Time ◽  
Factors Affecting ◽  
Dynamic Factors ◽  
Polymer Retention

During polymer flooding, certain amount of polymer would be lost. Polymer retention causes sweep volume expanding on one side, it also causes polymer loss on the other. Therefore, it is a very important topic to study the influencing factors of polymer retention. There are many factors affecting polymer retention process. This paper mainly studied the influence from dynamic factors such as polymer solution concentration, injection rate, injection time, injected pv number. This paper investigated the influence of these factors on polymer retention process, and optimized these factors to minimize polymer loss in reservoir.

What is access to radiation therapy? A conceptual framework and review of influencing factors

2016 ◽  
Vol 40 (1) ◽  
pp. 11 ◽  
Author(s):  
Puma Sundaresan ◽  
Martin R. Stockler ◽  
Christopher G. Milross
Keyword(s):  
Radiation Therapy ◽  
Health Services ◽  
Conceptual Framework ◽  
Influencing Factors ◽  
International Literature ◽  
Access To Treatment ◽  
Access Methods ◽  
Factors Affecting ◽  
Detailed Review ◽  
Factors Influencing

Objectives Optimal radiation therapy (RT) utilisation rates (RURs) have been defined for various cancer indications through extensive work in Australia and overseas. These benchmarks remain unrealised. The gap between optimal RUR and actual RUR has been attributed to inadequacies in ‘RT access’. We aimed to develop a conceptual framework for the consideration of ‘RT access’ by examining the literature for existing constructs and translating it to the context of RT services. We further aimed to use this framework to identify and examine factors influencing ‘RT access’. Methods Existing models of health care access were reviewed and used to develop a multi-dimensional conceptual framework for ‘RT access’. A review of the literature was then conducted to identify factors reported to affect RT access and utilisation. The electronic databases searched, the host platform and date range of the databases searched were Ovid MEDLINE, 1946 to October 2014 and PsycINFOvia OvidSP,1806 to October 2014. Results The framework developed demonstrates that ‘RT access’ encompasses opportunity for RT as well as the translation of this opportunity to RT utilisation. Opportunity for RT includes availability, affordability, adequacy (quality) and acceptability of RT services. Several factors at the consumer, referrer and RT service levels affect the translation of this opportunity for RT to actual RT utilisation. Conclusion ‘Access’ is a term that is widely used in the context of health service related research, planning and political discussions. It is a multi-faceted concept with many descriptions. We propose a conceptual framework for the consideration of ‘RT access’ so that factors affecting RT access and utilisation may be identified and examined. Understanding these factors, and quantifying them where possible, will allow objective evaluation of their impact on RT utilisation and guide implementation of strategies to modify their effects. What is known about the topic? It is well documented that the use of RT in Australia is well below evidence-based benchmarks. The shortfall in the use of RT has been attributed to problems with access to treatment services. Although considerable attention has been directed (rightly) towards addressing infrastructure needs, access to RT is more than just supply of services. There is currently no specific framework for RT access to comprehensively consider and examine other factors influencing the use of RT. The existing international literature addresses some of the influencing factors. However, there is a need for a detailed review of all actual and potential influencers of RT utilisation. What does this paper add? This paper presents a conceptual framework for the specific consideration of access to RT. A detailed review of various factors affecting access and utilisation of RT has been performed using the aforementioned conceptual framework. To our knowledge this is the first such review and hence we are confident that it adds to the existing international literature on this subject. What are the implications for practitioners? The topic of improving consumers’ access to RT is of relevance locally, in Australia, as well as internationally. We feel that the RT access framework proposed herein will be of interest and use to those involved in health services research, delivery and policy, especially those involved with the planning and delivering of cancer services. In addition to compiling evidence on the subject, the review of factors influencing RT utilisation highlights and proposes areas for future translational and implementation research in the areas of health services and treatment-related decision making.

scholarly journals FACTORS AFFECTING DISPOSITION EFFECT IN EQUITY INVESTMENT: A SOCIAL NETWORK ANALYSIS APPROACH

2020 ◽  
Vol 5 (3) ◽  
pp. 64-86
Author(s):  
K. Kajol ◽  
Prasita Biswas ◽  
Ranjit Singh ◽  
Sana Moid ◽  
Amit Kumar Das
Keyword(s):  
Social Network ◽  
Social Network Analysis ◽  
Network Analysis ◽  
Stock Market ◽  
Influencing Factors ◽  
Social Trust ◽  
Complete Analysis ◽  
Disposition Effect ◽  
Factors Affecting ◽  
The Relationship

The study aims at identifying the factors influencing the disposition effect acting on equity investors and further identifying the relationship between the influencing factors. The study aims at conducting a complete analysis of the influencing factors along with measuring their impact on disposition effect using Social Network Analysis (SNA).The factors affecting disposition effect on investors were identified through the literature review. Experts’ opinions were sought for determining the relationship among the factors and finally, the importance of those factors was analyzed using Social Network Analysis (SNA). It was found that social trust, investor emotion are the two most important factors affecting the other factors of disposition effect and consequently disposition effect finally. Besides, mental accounting; regret aversion, trading intensity, trading volume, and portfolio performance strongly influence the effect of disposition on investors because of their higher in-degree and out-degree. Therefore, the policymakers need to impart training to the investors to understand the mechanism of the stock market so that they can evaluate their standing in the stock market which, in the long run, will be reflected in their investment behavior. 

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