scholarly journals Phytochemical Profile and Biological Activities of Tendrils and Leaves Extracts from a Variety of Vitis vinifera L.

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 373 ◽  
Author(s):  
Mirela L. Moldovan ◽  
Rahela Carpa ◽  
Ionel Fizeșan ◽  
Laurian Vlase ◽  
Cătălina Bogdan ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
Pathogenic Bacteria ◽  
Biological Activities ◽  
Vitis Vinifera L ◽  
Cytoprotective Effect ◽  
Antimicrobial Effects ◽  
Spectrophotometric Methods ◽  
Wide Range ◽  
Phytochemical Profile ◽  
Cellular Tests

Winery industry by-products have a great reuse potential in the pharmaceutical and cosmetic fields due to their bioactive compounds. This study investigates the phytochemical profile and the bioactivity of Vitis vinifera variety Fetească neagră tendrils extract (TE) and leaves extract (LE), intended to be used in oral hygiene products recommended in periodontal disease. The evaluation of the phenolic content was performed by colorimetric analysis. Liquid chromatography coupled with mass spectrometry was used to determine the chemical profile of the two extracts obtained from V. vinifera. Moreover, the antioxidant activity of the extracts was determined by spectrophotometric methods, as well as on human gingival fibroblasts (HGF) cell line. The cytocompatibility and cytoprotective effect against nicotine-induced cytotoxicity were tested, as well as the anti-inflammatory and antimicrobial effects. The TE showed higher total polyphenolic content, rich in rutin, compared to the leaves extract that displayed important amounts of isoquercitrin. The antioxidant effect was confirmed by both non-cellular and cellular tests. The cytocompatibility of the extracts was confirmed at a wide range of concentrations. The cytoprotective effect was demonstrated in HGF exposed to cytotoxic doses of nicotine; 300 µg/mL of both tested extracts decreased nicotine toxicity by approximately 20%. When challenged with E. coli polysaccharides, in HGF cells co-exposed to TE and LE, a reduction in the release of proinflammatory cytokines (IL-8, IL-6 and IL-1β) was observed. The extracts were both able to reduce the levels of reactive oxygen species and inflammatory cytokines, and had notable antimicrobial effects on pathogenic bacteria associated with periodontitis.

Enhanced phytochemical composition and biological activities of grape (Vitis vinifera L.) Stems growing in low altitude regions

2020 ◽  
Vol 265 ◽  
pp. 109248 ◽  
Author(s):  
Irene Gouvinhas ◽  
Rosa Pinto ◽  
Rafaela Santos ◽  
Maria José Saavedra ◽  
Ana Isabel Barros
Keyword(s):  
Vitis Vinifera ◽  
Biological Activities ◽  
Vitis Vinifera L ◽  
Phytochemical Composition ◽  
Low Altitude

scholarly journals Phenolic composition of vine leaves infusions produced from different Portuguese and Spanish Vitis vinifera L. varieties

2019 ◽  
Vol 12 ◽  
pp. 04004
Author(s):  
A.M. Jordão ◽  
J. Sousa ◽  
A.C. Correia ◽  
M.E. Valdés ◽  
F.M. Nunes ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Vitis Vinifera ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Total Phenolic ◽  
Vitis Vinifera L ◽  
Phenolic Composition ◽  
Alternative Source ◽  
Wide Range ◽  
Interesting Alternative

The main object of the present study was to analyze the phenolic composition of vine leaves infusions prepared from 8 different Portuguese (Fernão Pires, Touriga Franca, Tinta Roriz, Encruzado, Touriga Nacional, Rufete, Baga, and Siria) and Spanish (Pardina, Cayetana, Garnacha, Cigüente, Eva, Tempranillo, Macabeo and Verdelho) Vitis vinifera L. varieties. In general, a wide range of phenolic content were obtained from the vine leaves infusions according to the vine variety used. Thus, for total phenolic content the values ranged from 18 to 37 mg/L for the infusions produced from Portuguese varieties, while for Spanish varieties the values ranged from 14 to 37 mg/L. Vine leaves infusions obtained from Touriga Franca and Pardina varieties showed the highest total phenolic content. As a consequence of phenolic composition, chromatic characteristics (L*, a* and b*) of vine leaves infusions were also analyzed. Finally, it was also detected different individual phenolic compounds, such as, coutaric acid, trans-caftaric acid, quercetin-3-O-glucoside, rutin and 3 different anthocyanins from the different vine leaves infusions. All of the results obtained in this work show that vine leaves infusion may be an interesting alternative source of phenolic compounds for human diet.

scholarly journals Phytochemical Compounds and Pharmacological Activities of Vitis vinifera L.: An Updated Review

2021 ◽  
Vol 11 (6) ◽  
pp. 13829-13849
Keyword(s):  
Vitis Vinifera ◽  
Wound Care ◽  
Biological Activities ◽  
Vitis Vinifera L ◽  
Pharmacological Activities ◽  
Scientific Databases ◽  
Traditional Uses ◽  
Western Asia ◽  
Phytochemical Compounds ◽  
Nutritional Constituents

Grapes (Vitis vinifera L.) are commonly known grape species that belong to the Vitis genus in the Vitaceae family and come from western Asia and southern Europe. This review consists of traditional uses, phytochemical compounds, nutritional constituents, pharmacological activities, genotoxicological studies, and toxicity studies of V. vinifera. The data were obtained from scientific databases and search engines such as PubMed, Elsevier, Springer, Frontiers, Google Scholar, Scopus, Science Direct, and MDPI. In some countries, grapes used for traditional uses, such as drug therapy for blood-forming, anemia, allergies, wound care, colds and flu, carminative, bronchitis, diarrhea, and anti-phlegm. The main phytochemical compounds in V. vinifera are phenolic compounds, aromatic acids, flavonoids, proanthocyanidins, and stilbenoids. Nutritional constituents can be found in grapevines, i.e., proteins, lipids, carbohydrates, minerals, and vitamins. Parts of the grapevines had a wide variety of biological activities, i.e., antioxidant, antiviral, antiplatelet, antifungal, anticataract, antiobesity, anticholinergic, anti-sunburn, anti-inflammatory, and wound-healing activities. The phytochemical compounds content in each part of the grapevines were different. Each pharmacological activity depends on the grapevine's phytochemical compounds, components used, and extraction type. However, more studies are needed regarding the genotoxicity and toxicity of V. vinifera.

scholarly journals Plant thionins: structure, biological functions and potential use in biotechnology

2018 ◽  
Vol 22 (6) ◽  
pp. 667-675 ◽  
Author(s):  
T. I. Odintsova ◽  
M. P. Slezina ◽  
E. A. Istomina
Keyword(s):  
Pathogenic Bacteria ◽  
Plant Pathogens ◽  
Biological Activities ◽  
Three Dimensional ◽  
Amino Acid Sequences ◽  
Lipid Transfer ◽  
Human Pathogens ◽  
Candida Spp ◽  
Wide Range ◽  
Bacteria And Fungi

Antimicrobial peptides (AMPs) are important components of defense system in both plants and animals. They represent an ancient mechanism of innate immunity providing rapid first line of defense against pathogens. Plant AMPs are classified into several families: thionins, defensins, nonspecific lipid-transfer proteins, hevein- and knottin-type peptides, hairpinins and macrocyclic peptides (cyclotides). The review focuses on the thionin family. Thionins comprise a plant-specific AMP family that consists of short (~5 kDA) cysteine-rich peptides containing 6 or 8 cysteine residues with antimicrobial and toxic properties. Based on similarity in amino acid sequences and the arrangement of disulphide bonds, five structural classes of thionins are discriminated. The three-dimensional structures of a number of thionins were determined. The amphipathic thionin molecule resembles the Greek letter Г, in which the long arm is formed by two antiparallel α-helices, while the short one, by two parallel β-strands. The residues responsible for the antimicrobial activity of thionins were identified. Thionins are synthesized as precursor proteins consisting of a signal peptide, the mature peptide region and the C-terminal prodomain. Thionins protect plants from pathogenic bacteria and fungi acting directly on the membranes of microorganisms at micromolar concentrations, although their precise mode of action remains unclear. In addition to plant pathogens, thionins inhibit growth of a number of human pathogens and opportunistic microorganisms, such as Candida spp., Saccharomyces cerevisiae, Fusarium solani, Staphylococcus aureus and Escherichia coli. Thionins are toxic to different types of cells including mammalian cancer cell lines. Transgenic plants expressing thionin genes display enhanced resistance to pathogens. A wide range of biological activities makes thionins promising candidates for practical application in agriculture and medicine.

Temperature-based grapevine sugar ripeness modelling for a wide range of Vitis vinifera L. cultivars

2020 ◽  
Vol 285-286 ◽  
pp. 107902 ◽  
Author(s):  
Amber K. Parker ◽  
Iñaki García de Cortázar-Atauri ◽  
Laurence Gény ◽  
Jean-Laurent Spring ◽  
Agnès Destrac ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
Vitis Vinifera L ◽  
Wide Range

Validation Assay of p3_VvAGL11 Marker in a Wide Range of Genetic Background for Early Selection of Stenospermocarpy in Vitis vinifera L.

2013 ◽  
Vol 54 (3) ◽  
pp. 1021-1030 ◽  
Author(s):  
Carlo Bergamini ◽  
Maria Francesca Cardone ◽  
Angelo Anaclerio ◽  
Rocco Perniola ◽  
Arianna Pichierri ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
Genetic Background ◽  
Early Selection ◽  
Vitis Vinifera L ◽  
Wide Range ◽  
Selection Of

scholarly journals Antimicrobial Effects of Ethanol, Methanol and Ethyl Acetate Teucrium polium and Citrullus colocynthis extract on Pseudomonas aeruginosa

2021 ◽  
Vol 1 (01) ◽  
pp. 26-32
Author(s):  
Laleh Shahraki-Mojahed ◽  
Rezvaneh Behzadmehr ◽  
Zahra Beigomi
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Ethyl Acetate ◽  
Pathogenic Bacteria ◽  
Inhibitory Concentration ◽  
Citrullus Colocynthis ◽  
Intrinsic Resistance ◽  
Antimicrobial Effects ◽  
Wide Range ◽  
Teucrium Polium ◽  
Tract Infections

Pseudomonas aeruginosa is a common pathogen in a wide range of infections, from urinary tract infections to bacteremia. Intrinsic resistance to antimicrobial agents in this bacterium worsens the condition of the treatment of infections caused by it. The aim of this study was to investigate the antimicrobial effects of ethanol, methanol, and ethyl acetate Teucrium polium Extract and Citrullus colocynthis on a p. aeruginosa isolated from Zabol hospital. P. aeruginosa specimens were collected from Zabol city. Plant extracts were prepared using a rotary machine and the minimum inhibitory concentration and minimum trace concentration were determined by microdilution method. The lowest inhibitory concentration of methanolic extract of C. colocynthis against p. aeruginosa was 1.25 mg / ml while the lowest inhibitory concentration of ethyl acetate extract of C. colocynthis was 0.62 mg / ml, two strains were inhibited in this concentration and the highest inhibitory concentration was 5 mg, 6 strains of bacteria in this concentration has been restrained. The results of this study showed that watermelon extract of T. polium Extract and C. colocynthis have a significant antibacterial effect. Extract from this plant can be used to deal with specific pathogenic bacteria.

Impact of dehydration on retention of bioactive profile and biological activities of different grape (Vitis vinifera L.) pomace varieties

2018 ◽  
Vol 244 ◽  
pp. 116-127 ◽  
Author(s):  
Obert C. Chikwanha ◽  
Emiliano Raffrenato ◽  
Umezuruike L. Opara ◽  
Olaniyi A. Fawole ◽  
Mathabatha E. Setati ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
Biological Activities ◽  
Vitis Vinifera L

scholarly journals Evaluation of Seaweed Sulfated Polysaccharides As Natural Antagonists Targeting Salmonella typhi OmpF: Molecular Docking and Pharmacokinetic Profiling

2021 ◽  
Author(s):  
ARUN KUMAR MALAISAMY ◽  
Mahalakshmi Murugan ◽  
Ashok Kumar Vairamuthu ◽  
Manikka Kubendran Aravind ◽  
Sathaiah Gunaseelan ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Pathogenic Bacteria ◽  
Biological Activities ◽  
Salmonella Typhi ◽  
Sulfated Polysaccharides ◽  
Drug Resistant ◽  
Bacterial Strains ◽  
Microbial Diseases ◽  
Wide Range ◽  
Docking Approach

Abstract Background: Salmonella belongs to the Enterobacteriaceae family, a gram-negative, non-spore-forming, rod-shaped, motile, and pathogenic bacteria that transmit through unhygienic conditions. It is estimated that 21 million new infections arise every year, resulting in approximately 200,000 deaths. It is more prevalent among children, the old aged, and immunocompromised individuals. The frequent usage of classical antimicrobials has begun the increasing emergence of various drug-resistant pathogenic bacterial strains. Hence, this study was intended to evaluate the bioactive seaweed sulfated polysaccharides (SSP) against the ompF (outer membrane porin F) protein target of Salmonella typhi. SSP are sulfated compounds with a wide range of biological activities, such as anti-microbial, anti-allergy, anti-cancer, anti-coagulant, anti-inflammation, anti-oxidant, and anti-viral. Results: In this study, eleven compounds were targeted against S. typhi OmpF by molecular docking approach and were compared with two commercially available typhoid medications. The SSP showed good binding affinity compared to commercial drugs, particularly carrageenan/MIV-150, carrageenan lambda, fucoidan, and 3-Phenyllactate, ranked as top antagonists against OmpF. Further, pharmacokinetics and toxicology (ADMET) studies corroborated that SSP possessed drug-likeness and highly progressed in all parameters.Conclusion: AutoDockTools and Schrodinger's QikProp module results suggest that SSP could be a promising drug for extensively drug-resistant (XDR) S. typhi. To our best of knowledge, this is the first report on in-silico analysis of SSP against S. typhi OmpF. Thus, implying the capabilities of SSP's especially compounds like carrageenans, as a potential anti-microbial agent against Salmonella typhi infections. Eventually, advanced studies could corroborate SSPs to the next level of application in the crisis of XDR microbial diseases.

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