scholarly journals Serum Malondialdehyde is Associated with Non-Alcoholic Fatty Liver and Related Liver Damage Differentially in Men and Women

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 578 ◽  
Author(s):  
Shira Zelber-Sagi ◽  
Dana Ivancovsky-Wajcman ◽  
Naomi Fliss-Isakov ◽  
Michal Hahn ◽  
Muriel Webb ◽  
...  
Keyword(s):  
Vitamin E ◽  
Fatty Liver ◽  
Liver Damage ◽  
Thiobarbituric Acid ◽  
Abdominal Ultrasound ◽  
Cross Sectional Study ◽  
High Serum ◽  
Dietary Vitamin ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver

Background: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are associated with increased oxidative stress and lipid peroxidation, but large studies are lacking. The aim was to test the association of malondialdehyde (MDA), as a marker of oxidative damage of lipids, with NAFLD and liver damage markers, and to test the association between dietary vitamins E and C intake and MDA levels. Methods: A cross-sectional study was carried out among subjects who underwent blood tests including FibroMax for non-invasive assessment of NASH and fibrosis. MDA was evaluated by reaction with Thiobarbituric acid and HPLC-fluorescence detection method. NAFLD was diagnosed by abdominal ultrasound. Findings: MDA measurements were available for 394 subjects. In multivariate analysis, the odds for NAFLD were higher with the rise of MDA levels in a dose–response manner, adjusting for age, gender, BMI, and lifestyle factors. Only among men, higher serum MDA was associated of higher odds for NAFLD and NASH and/or fibrosis (OR = 2.59, 95% CI 1.33–5.07, P = 0.005; OR = 2.04, 1.02–4.06, P = 0.043, respectively). Higher vitamin E intake was associated with lower odds of high serum MDA level (OR = 0.28 95% CI 0.13–0.62, P = 0.002). In conclusion, serum MDA is associated with NAFLD and markers of NASH or fibrosis among men. Dietary vitamin E may be protective among women.

scholarly journals Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children

2021 ◽  
Vol 10 (13) ◽  
pp. 2812
Author(s):  
Cristina Bellarosa ◽  
Giorgio Bedogni ◽  
Annalisa Bianco ◽  
Sabrina Cicolini ◽  
Diana Caroli ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Serum Bilirubin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Obese Children ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.

scholarly journals OC49 Non-alcoholic fatty liver disease in obese and overweight iranian children: a cross sectional study

2019 ◽  
Author(s):  
Farzad Maleki ◽  
Marjan Hosseinpour ◽  
Bahman Mansouri motlagh ◽  
Hadi Esmaeili Gouvarchin Ghaleh ◽  
Shahsanam Gheibi
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Iranian Children ◽  
Alcoholic Fatty Liver Disease

scholarly journals Low Urine pH Is Associated with Non-alcoholic Fatty Liver Disease: A Community-based Cross-sectional Study

2018 ◽  
Vol 57 (19) ◽  
pp. 2799-2805 ◽  
Author(s):  
Teruki Miyake ◽  
Sakiko Yoshida ◽  
Shin Yamamoto ◽  
Shinya Furukawa ◽  
Osamu Yoshida ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Urine Ph ◽  
Community Based ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Association between sitting time and non-alcoholic fatty liver disease in South Korean population: a cross-sectional study: a cross-sectional study

2020 ◽  
Author(s):  
Jae Hong Joo ◽  
Hwi Jun Kim ◽  
Eun-Cheol Park ◽  
Sung-In Jang
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Korean Population ◽  
Sitting Time ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
South Korean ◽  
Alcoholic Fatty Liver Disease

Abstract Background: To examine the association between sitting time and non-alcoholic fatty liver disease among South Koreans aged ≥20 years. Methods : Data from the 2016–2018 Korea National Health and Nutrition Examination Survey were used for the analysis. Non-alcoholic fatty liver disease was diagnosed according to a hepatic steatosis index of >36. Sitting time was categorized into as < 5, 5 -7, 8 – 10, and > 10 hours. Multiple logistic regression analysis was used to examine the association between sitting time and non-alcoholic fatty liver disease in South Korean population. Results : A total of 13,518 participants were enrolled. The odds for having NAFLD in 5 – 7, 8 – 10, and > 10 sitting hours were 1.04 (CI: 0.85-1.28), 1.23(CI: 1.01-1.51), and 1.33(CI: 1.10-1.62), respectively. The odds ratio increased in magnitude with longer hours of sitting time (test for trend: P-value = 0.0009). Conclusion : Advising physical exercises and discouraging sedentary activities may help to alleviate NAFLD among the South Korean population.

scholarly journals Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhening Liu ◽  
Jinghua Wang ◽  
Shenghui Chen ◽  
Chengfu Xu ◽  
Yu Zhang
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Negatively Associated ◽  
Smoking Group ◽  
Alcoholic Fatty Liver Disease ◽  
The U.S

Abstract Background Acrylamide (AA) is a toxicant to humans, but the association between AA exposure and the risk of non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, our objective is to examine the cross-sectional association between AA exposure and the risk of NAFLD in American adults. Methods A total of 3234 individuals who took part in the National Health and Nutrition Examination Survey (NHANES) 2003–2006 and 2013–2016 were enrolled in the study. NAFLD was diagnosed by the U.S. Fatty Liver Index. Multivariable logistic regression models were applied to estimate the association between AA and NAFLD in the whole group and the non-smoking group. Results We discovered that in the whole group, serum hemoglobin adducts of AA (HbAA) were negatively associated with the prevalence of NAFLD after adjustment for various covariables (P for trend < 0.001). Compared with individuals in the lowest HbAA quartiles, the odds ratios (ORs) with 95% confidence intervals (CIs) in the highest HbAA quartiles were 0.61 (0.46–0.81) and 0.57 (0.36–0.88) in the whole group and the non-smoking group, respectively. In contrast, HbGA/HbAA showed a significantly positive correlation with the prevalence of NAFLD in both groups (P for trend < 0.001). In addition, HbGA was not significantly associated with NAFLD in the whole group or the non-smoking group. Conclusions HbAA is negatively associated with NAFLD whereas HbGA/HbAA is positively associated with NAFLD in adults in the U.S. Further studies are needed to clarify these relationships.

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