Laser Therapy in the Treatment of Peri-Implantitis: State-of-the-Art, Literature Review and Meta-Analysis

(1) Background: The treatment of the peri-implantitis is still challenging, and no consensus was found in the literature on which is the best treatment protocol. In recent years, numerous authors have proposed the use of the dental laser as an alternative and effective method for decontaminating the surface of infected implants. Therefore, the aim of this work was to examine the state-of-the-art on the use of lasers in the treatment of peri-implantitis through the literature. (2) Methods: An electronic search was conducted through the PubMed database; we selected and reviewed articles that evaluated the effects of laser irradiation in the treatment of peri-implantitis. (3) Results: The use of lasers seems to provide similar results if compared with conventional mechanical therapy. The included studies were divided into three groups based on the active medium of the laser used for the treatments being tested (Erbium: Yttrium Aluminum Garnet, CO2 and diode laser). (4) Conclusions: The lasers showed positive results, on average, after 6 months of follow-up. Comparative clinical trials conducted with the aim to test the efficiency of laser irradiation, in addition to conventional therapy, indicate that this technique can induce similar results if compared to conventional therapy alone.

Download Full-text

Abstract 523: Ultrasound Assisted Thrombolysis Versus Catheter Directed Thrombolysis: A Meta-Analysis

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.37.suppl_1.523 ◽

2017 ◽

Vol 37 (suppl_1) ◽

Author(s):

Syed Imran M Zaidi ◽

Abdul Ahad Khan ◽

Hemang B Panchal ◽

Zulfiqar Qutrio Baloch ◽

Enambir Josan ◽

...

Keyword(s):

Success Rate ◽

Meta Analysis ◽

Ultrasonic Energy ◽

Short Term ◽

Bleeding Events ◽

Thrombolytic Agents ◽

Catheter Directed Thrombolysis ◽

Pubmed Database ◽

Ultrasound Assisted

Introduction: Deep venous thrombosis (DVT) and pulmonary embolism (PE) have many methods of treatment including anti-coagulation, thrombectomy and thrombolysis. Thrombolysis can be achieved via systemic or local thrombolytic agents, with standard local thrombolysis achieved via catheter insertion in proximity to the thrombus and delivery of thrombolytic agents. Ultrasound-assisted catheter thrombolysis (UAT) is a relatively newer form of thrombolysis which utilizes ultrasonic energy, along with local thrombolytics to help in thrombus breakdown. The objective of our meta-analysis is to compare UAT and catheter directed thrombolysis (CDT) for treatment of DVT and PE. Methods: PubMed database was searched through January 2017. Three studies (n=156) comparing UAT (n=99) and CDT (n=57) for thrombolysis were included. End points were > 50% thrombus lysis, bleeding (moderate and severe), and mortality on short term follow up (<1 year). The relative risk (RR) or mean difference (MD) with 95% confidence interval (CI) was computed and p<0.05 was considered as a level of significance. Results: Thrombolysis success rate was similar with UAT and CDT (RR 1.06, CI 0.89-1.27, p=0.49). Moderate and severe bleeding events were similar with both groups (RR 0.71, CI 0.27-1.87, p=0.49). Mortality on short term follow up was significantly lower in UAT as compared to CDT (RR 0.47, CI 0.23-0.95, p=0.04). Conclusions: The results of our meta-analysis demonstrated no difference in thrombolysis success rate or bleeding events when using UAT Vs CDT, however short term mortality was significantly lower with UAT. Further controlled trials with larger sample sizes are required to assess the possible benefit of using ultrasonic energy for venous thrombolysis.

Download Full-text

Non-Adhesive Liquid Embolic Agents in Extra-Cranial District: State of the Art and Review of the Literature

Journal of Clinical Medicine ◽

10.3390/jcm10214841 ◽

2021 ◽

Vol 10 (21) ◽

pp. 4841

Author(s):

Filippo Piacentino ◽

Federico Fontana ◽

Marco Curti ◽

Edoardo Macchi ◽

Andrea Coppola ◽

...

Keyword(s):

State Of The Art ◽

Case Reports ◽

Meta Analysis ◽

Review Of The Literature ◽

Time Period ◽

Embolic Agents ◽

Liquid Embolic ◽

Data Heterogeneity ◽

New Generation

This review focuses on the use of “new” generation of non-adhesive liquid embolic agents (NALEA). In literature, non-adhesive liquid embolic agents have mainly been used in the cerebral district; however, multiple papers describing the use of NALEA in the extracranial district have been published recently and the aim of this review is to explore and analyze this field of application. There are a few NALEA liquids such as Onyx, Squid, and Phil currently available in the market, and they are used in the following applications: mainly arteriovenous malformations, endoleaks, visceral aneurysm or pseudoaneurysm, presurgical and hypervascular lesions embolization, and a niche of percutaneous approaches. These types of embolizing fluids can be used alone or in combination with other embolizing agents (such as coils or particles) so as to enhance its embolizing effect or improve its possible defects. The primary purpose of this paper is to evaluate the use of NALEAs, predominantly used alone, in elective embolization procedures. We did not attempt a meta-analysis due to the data heterogeneity, high number of case reports, and the lack of a consistent follow-up time period.

Download Full-text

Acupuncture for Alcohol Use Disorder: A Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/7823278 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Na Young Shin ◽

Young Jin Lim ◽

Chae Ha Yang ◽

Cheongtag Kim

Keyword(s):

Alcohol Use ◽

Alcohol Use Disorder ◽

Meta Analysis ◽

Inclusion Criteria ◽

Control Intervention ◽

Acupuncture Intervention ◽

Pubmed Database ◽

Significant Difference ◽

And Behaviors

Empirical research has produced mixed results regarding the effects of acupuncture on the treatment of alcohol use disorder in humans. Few studies have provided a comprehensive review or a systematic overview of the magnitude of the treatment effect of acupuncture on alcoholism. This study investigated the effects of acupuncture on alcohol-related symptoms and behaviors in patients with this disorder. The PubMed database was searched until 23 August 2016, and reference lists from review studies were also reviewed. Seventeen studies were identified for a full-text inspection, and seven (243 patients) of these met our inclusion criteria. The outcomes assessed at the last posttreatment point and any available follow-up data were extracted from each of the studies. Our meta-analysis demonstrated that an acupuncture intervention had a stronger effect on reducing alcohol-related symptoms and behaviors than did the control intervention (g=0.67). A beneficial but weak effect of acupuncture treatment was also found in the follow-up data (g=0.29). Although our analysis showed a significant difference between acupuncture and the control intervention in patients with alcohol use disorder, this meta-analysis is limited by the small number of studies included. Thus, a larger cohort study is required to provide a firm conclusion.

Download Full-text

Clinical Study of Pingyangmycin Combined with Nd:YAG Laser to Treat Venous Malformations in the Oral and Maxillofacial Region

Open Access Journal of Dental Sciences ◽

10.23880/oajds-16000288 ◽

2021 ◽

Vol 6 (1) ◽

Author(s):

Yongsheng Li

Keyword(s):

Laser Irradiation ◽

Nd:Yag Laser ◽

Yttrium Aluminum Garnet ◽

Control Group ◽

Venous Malformations ◽

Maxillofacial Region ◽

Yttrium Aluminum ◽

Oral And Maxillofacial Region ◽

Experimental Group

Purpose: To explore the efficacy of pingyangmycin (PYM) combined with Neodymium yttrium aluminum garnet (Nd:YAG) laser to treat venous malformations in the oral and maxillofacial region. Methods: Eighty-six patients were randomly divided into two groups. Forty-two patients were allocated to the experimental group and were injected with PYM at the lesion site, followed by Nd:YAG laser irradiation two days later. Forty-four patients were allocated to the control group and received only Nd:YAG laser irradiation (15-30W of power). All patients came back for a follow-up examination one month later. Results: Twenty-eight patients in the experimental group (66.67%) and 16 patients in the control group (36.31%) had no lesions after one treatment. Additionally, 10 patients in the experimental group (23.81%) and nine patients in the control group (20.45%) showed significant improvement at one month post-treatment. Compared to the control group, the experimental group demonstrated superior outcomes and shorter treatment durations. The between-group difference was significant (p<0.05). Conclusion: PYM combined with Nd:YAG laser is an effective treatment of venous malformations in the oral and maxillofacial region, potentially shortening treatment durations.

Download Full-text

Stevens–Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

Journal of Wound Care ◽

10.12968/jowc.2021.30.12.1012 ◽

2021 ◽

Vol 30 (12) ◽

pp. 1012-1019

Author(s):

Khosrow S Houschyar ◽

Christian Tapking ◽

Mimi R Borrelli ◽

Behrus Puladi ◽

Mark Ooms ◽

...

Keyword(s):

Systematic Review ◽

Toxic Epidermal Necrolysis ◽

Clinical Studies ◽

English Language ◽

Meta Analysis ◽

Treatment Protocol ◽

Stevens Johnson Syndrome ◽

Inclusion Criteria ◽

Johnson Syndrome ◽

Pubmed Database

Objective: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and severe skin and mucosal reactions that are associated with high mortality. Despite the severity, an evidence-based treatment protocol for SJS/TEN is still lacking. Method: In this systematic review and meta-analysis, the PubMed database was searched using the following terms: [Stevens–Johnson syndrome] OR [toxic epidermal necrolysis] AND [therapy] OR [treatment] over a 20-year period (1999–2019) in the German and English language. All clinical studies reporting on the treatment of SJS/TEN were included, and epidemiological and diagnostic aspects of treatment were analysed. A meta-analysis was conducted on all comparative clinical studies that met the inclusion criteria. Results: A total of 88 studies met the inclusion criteria, reporting outcomes in 2647 patients. Treatment was either supportive or used systemic corticosteroid, intravenous immunoglobulin, plasmapheresis, cyclosporine, thalidomide or cyclophosphamide therapy. The meta-analysis included 16 (18%) studies, reporting outcomes in 976 (37%) patients. Systemic glucocorticoids showed a survival benefit for SJS/TEN patients in all analyses compared with other forms of treatment. Cyclosporine treatment also showed promising results, despite being used in a small cohort of patients. No beneficial effects on mortality could be demonstrated for intravenous immunoglobulins. Conclusion: Glucocorticoids and cyclosporine may be tentatively recommended as the most promising immunomodulatory therapies for SJS/TEN, but these results should be investigated in future prospective controlled trials.

Download Full-text

Clinical efficacy of chlorhexidine as an adjunct to mechanical therapy of peri-implant disease: a systematic review and meta-analysis.

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00213 ◽

2020 ◽

Author(s):

Pengfei Zhao ◽

Qian Wang ◽

Peng Zhang ◽

Xinyi Zhou ◽

Lulingxiao Nie ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Clinical Results ◽

Cochrane Central Register ◽

Clinical Attachment Level ◽

Probing Depth ◽

Central Register ◽

Mechanical Therapy ◽

Attachment Level

The aim of this systematic review and meta-analysis was to determine the efficacy of chlorhexidine (CHX) as an adjunctive therapy to mechanical debridement in the treatment of peri-implant diseases. Five databases (PubMed, EMBASE, Cochrane Central Register of Controlled Trails, Web of Science, and ClinicalTrials.gov) were searched. Randomized controlled trials (RCTs) comparing mechanical debridement combined with CHX to mechanical debridement alone for patients with peri-implant disease were identified. The trial investigators evaluated factors indicating inflammatory levels, including bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL). Six RCTs with 207 patients were ultimately included in this review. Low- to moderate-quality evidence demonstrated that the adjunctive CHX therapy had no significant effect on BOP reduction within 1 month (mean difference [MD], 0.10; 95% confidence interval [CI], -0.06 to 0.25), 3 to 4 months (MD, 0.06; 95% CI, -0.03 to 0.15), and 6 to 8 months (MD, 0.06; 95% CI, -0.03 to 0.14) follow-up. Significant differences in PD reduction and CAL gain were also not found. However, one subgroup analysis revealed a significant result for the use of CHX solution, but it was clinically slight (MD, 0.09; 95%CI, 0.01 to 0.18). Based on available evidence, adding CHX to mechanical debridement, compared to mechanical debridement alone, did not significantly enhance the clinical results. Therefore, clinicians should consider the negligible effect of adjunctive CHX.

Download Full-text

Could Early Surgery Get Beneficial in Adult Patients with Active Native Infective Endocarditis? A Meta-Analysis

BioMed Research International ◽

10.1155/2017/3459468 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7

Author(s):

Liqun Jia ◽

Zanxin Wang ◽

Qiang Fu ◽

Huaien Bu ◽

Minxin Wei

Keyword(s):

Infective Endocarditis ◽

Meta Analysis ◽

Early Surgery ◽

Pubmed Database ◽

Efficacy Criteria ◽

Embase Database ◽

Native Infective Endocarditis ◽

Related Mortality

After a thorough search through the database as PubMed database and Embase database, the clinical experimental articles have been selected out on the effects of early surgery on the treatment of active native infective endocarditis. The quality of the trials included in this study was assessed by researcher according to the Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0. A meta-analysis was carried out in terms of clinical efficacy criteria by RevMan 5.3 software. Based on the results, we cautiously conclude that early surgery used for active native infective endocarditis could reduce in-hospital mortality, follow-up mortality, and IE-related mortality.

Download Full-text

Efficacy and Safety of Safflower Yellow in Early Diabetic Nephropathy: A Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/8065376 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Xiuze Jin ◽

Liuyan Shi ◽

Feng Chang ◽

Yun Lu

Keyword(s):

Conventional Therapy ◽

Urinary Albumin Excretion ◽

Meta Analysis ◽

Fasting Blood Glucose ◽

Effective Rate ◽

Urinary Albumin ◽

Efficacy And Safety ◽

Randomized Controlled ◽

Excretion Rates

Background. Diabetic nephropathy (DN) is a major cause of end-stage renal disease. In order to palliate renal function impairment and reduce kidney related mortality, it is crucial to treating DN patients at the early stage. This study aims to assess the efficacy and safety of conventional therapy combined with safflower yellow versus conventional therapy alone in early DN patients. Methods. A meta-analysis of randomized controlled trials that compared safflower yellow plus conventional therapy with conventional therapy alone in early DN patients was conducted. Papers were searched using the electronic databases and reference lists. Two reviewers working independently extracted relevant data and carried out risk-of-bias assessments. Statistical analysis was undertaken in Review Manager 5.3. Results. Fourteen trials (1,072 patients) were included in the meta-analysis. Conventional therapy combined with safflower yellow was associated with a higher effective rate (RD, 0.24; 95% CI, 0.17 to 0.30) and a greater decline in urinary albumin excretion rates (SMD, -1.34; 95% CI, -1.77 to -0.92), fasting blood glucose (MD, -0.57; 95% CI, -0.98 to -0.16), serum creatinine (MD, -12.36; 95% CI, -14.66 to -10.06), and blood urea nitrogen (SMD, -0.93; 95% CI, -1.13 to -0.73) in the subgroup with a follow-up time > 15 days. The incidence of adverse events did not differ significantly between these two regimens (RD, -0.01; 95% CI, -0.03 to 0.01). Findings were similar in the subgroup with a follow-up time < 15 days. Conclusions. Conventional therapy combined with safflower yellow had a more beneficial effect than conventional therapy alone in early DN patients. There were significant differences in effective rate, urinary albumin excretion rates, fasting blood glucose, serum creatinine, and blood urea nitrogen between the two regimens and no significant difference in adverse events. More randomized controlled research using standardized protocols would be needed in the future to compare these two regimens.

Download Full-text

Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades

Pathogens ◽

10.3390/pathogens7030065 ◽

2018 ◽

Vol 7 (3) ◽

pp. 65 ◽

Cited By ~ 9

Author(s):

Silvia Fabiani ◽

Simona Fortunato ◽

Fabrizio Bruschi

Keyword(s):

Meta Analysis ◽

Immunosuppressive Agents ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Parasitic Infections ◽

Solid Organ ◽

Number Of Patients ◽

Pubmed Database ◽

High Level

The aim of this study was to evaluate the occurrence of parasitic infections in solid organ transplant (SOT) recipients. We conducted a systematic review of literature records on post-transplant parasitic infections, published from 1996 to 2016 and available on PubMed database, focusing only on parasitic infections acquired after SOT. The methods and findings of the present review have been presented based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. From data published in the literature, the real burden of parasitic infections among SOT recipients cannot really be estimated. Nevertheless, publications on the matter are on the increase, probably due to more than one reason: (i) the increasing number of patients transplanted and then treated with immunosuppressive agents; (ii) the “population shift” resulting from immigration and travels to endemic areas, and (iii) the increased attention directed to diagnosis/notification/publication of cases. Considering parasitic infections as emerging and potentially serious in their evolution, additional strategies for the prevention, careful screening and follow-up, with a high level of awareness, identification, and pre-emptive therapy are needed in transplant recipients.

Download Full-text

Coffee consumption and hip fracture risk: a meta-analysis

Journal of Nutritional Science ◽

10.1017/jns.2013.13 ◽

2013 ◽

Vol 2 ◽

Cited By ~ 3

Author(s):

Xin-li Li ◽

Jiu-hong Xu

Keyword(s):

Hip Fracture ◽

Fracture Risk ◽

Random Effects ◽

Meta Analysis ◽

Coffee Consumption ◽

Hip Fracture Risk ◽

Pubmed Database ◽

Increased Risk ◽

Subgroup Analyses

AbstractTo investigate the effect of coffee consumption on hip fracture risk, a meta-analysis was conducted. The PubMed database was screened for all published studies about coffee consumption and hip fracture through to November 2011. Reviews, PubMed option ‘related articles’ and references of retrieved papers were also searched for potentially relevant papers. Only studies that contained OR with 95 % CI for the association between coffee consumption and hip fracture risk were included. The summary risk estimates were calculated by fixed- and random-effects models. Subgroup analyses were carried out stratified by study designs and participant characteristics, respectively. A total of six prospective cohort studies and six case–control studies were included in the final analysis. The pooled OR displayed increased risk of hip fracture by 29·7 % (95 % CI 0·960, 1·751; P = 0·09) for the highest compared with the lowest coffee consumption by the random-effects model (P for heterogeneity = 0·000; I2 = 84·0 %), but the result had no statistical significance. Subgroup analyses showed that coffee consumption significantly increased hip fracture risk by 54·7 % (95 % CI 1·152, 2·077; P = 0·004) among women, by 40·1 % (95 % CI 1·015, 1·935; P = 0·040) for elderly participants aged over 70 years, and by 68·3 % for Northern Americans (95 % CI 1·492, 1·899; P = 0·000). Other subgroup analyses according to data published before the year 2000 showed a positive association between coffee and hip fracture risk, and follow-up duration also positively affected hip fracture risk, especially when the follow-up length was less than 13 years. Although our meta-analysis has provided insufficient evidence that coffee consumption significantly increases hip fracture risk, coffee intake may increase hip fracture risk among women, elderly participants and Northern Americans. No dose–response pattern was observed.

Download Full-text