scholarly journals Cold Atmospheric Plasma Cancer Treatment, a Critical Review

2021 ◽  
Vol 11 (16) ◽  
pp. 7757
Author(s):  
Dayun Yan ◽  
Alisa Malyavko ◽  
Qihui Wang ◽  
Li Lin ◽  
Jonathan H. Sherman ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanisms ◽  
Critical Evaluation ◽  
Atmospheric Plasma ◽  
Physical Factors ◽  
Atmospheric Conditions ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer ◽  
Biological Impacts ◽  
Indirect Treatment

Cold atmospheric plasma (CAP) is an ionized gas, the product of a non-equilibrium discharge at atmospheric conditions. Both chemical and physical factors in CAP have been demonstrated to have unique biological impacts in cancer treatment. From a chemical-based perspective, the anti-cancer efficacy is determined by the cellular sensitivity to reactive species. CAP may also be used as a powerful anti-cancer modality based on its physical factors, mainly EM emission. Here, we delve into three CAP cancer treatment approaches, chemically based direct/indirect treatment and physical-based treatment by discussing their basic principles, features, advantages, and drawbacks. This review does not focus on the molecular mechanisms, which have been widely introduced in previous reviews. Based on these approaches and novel adaptive plasma concepts, we discuss the potential clinical application of CAP cancer treatment using a critical evaluation and forward-looking perspectives.

The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

2018 ◽  
Vol 18 (6) ◽  
pp. 769-775 ◽  
Author(s):  
Dayun Yan ◽  
Jonathan H. Sherman ◽  
Michael Keidar
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Current Status ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer ◽  
Long Time ◽  
Key Topics ◽  
The Common

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

scholarly journals Cold atmospheric plasma, a novel promising anti-cancer treatment modality

Oncotarget ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 15977-15995 ◽  
Author(s):  
Dayun Yan ◽  
Jonathan H. Sherman ◽  
Michael Keidar
Keyword(s):  
Cancer Treatment ◽  
Treatment Modality ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer

scholarly journals The Cell Activation Phenomena in the Cold Atmospheric Plasma Cancer Treatment

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Dayun Yan ◽  
Wenjun Xu ◽  
Xiaoliang Yao ◽  
Li Lin ◽  
Jonathan H. Sherman ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cell Activation ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

Exploring the Effects of Direct and Indirect Treatment Of Human Cells with Cold Atmospheric Plasma Devices

2021 ◽  
Author(s):  
Cian Madigan ◽  
Fiona O'Neill ◽  
Denis O’Sullivan ◽  
Darren F. Kavanagh ◽  
Liam O’Neill
Keyword(s):  
Human Cells ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Indirect Treatment

scholarly journals Comparative Study between Direct and Indirect Treatment with Cold Atmospheric Plasma on In Vitro and In Vivo Models of Wound Healing

2018 ◽  
Vol 8 (4) ◽  
pp. 379-401 ◽  
Author(s):  
Constance Duchesne ◽  
Nadira Frescaline ◽  
Jean-Jacques Lataillade ◽  
Antoine Rousseau
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Atmospheric Plasma ◽  
In Vivo Models ◽  
Cold Atmospheric Plasma ◽  
Indirect Treatment

scholarly journals On the Anti-Cancer Effect of Cold Atmospheric Plasma and the Possible Role of Catalase-Dependent Apoptotic Pathways

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2330
Author(s):  
Charlotta Bengtson ◽  
Annemie Bogaerts
Keyword(s):  
Mathematical Model ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Cancer Cell Death ◽  
Anti Cancer ◽  
Apoptotic Pathways ◽  
Cell Signaling Pathways

Cold atmospheric plasma (CAP) is a promising new agent for (selective) cancer treatment, but the underlying cause of the anti-cancer effect of CAP is not well understood yet. Among different theories and observations, one theory in particular has been postulated in great detail and consists of a very complex network of reactions that are claimed to account for the anti-cancer effect of CAP. Here, the key concept is a reactivation of two specific apoptotic cell signaling pathways through catalase inactivation caused by CAP. Thus, it is postulated that the anti-cancer effect of CAP is due to its ability to inactivate catalase, either directly or indirectly. A theoretical investigation of the proposed theory, especially the role of catalase inactivation, can contribute to the understanding of the underlying cause of the anti-cancer effect of CAP. In the present study, we develop a mathematical model to analyze the proposed catalase-dependent anti-cancer effect of CAP. Our results show that a catalase-dependent reactivation of the two apoptotic pathways of interest is unlikely to contribute to the observed anti-cancer effect of CAP. Thus, we believe that other theories of the underlying cause should be considered and evaluated to gain knowledge about the principles of CAP-induced cancer cell death.

scholarly journals PO-041 Cold atmospheric plasma: a potentially selective and non-inflammatory anti-cancer therapy

2018 ◽  
Author(s):  
R Silva-Teixeira ◽  
M Laranjo ◽  
C Almeida-Ferreira ◽  
G Brites ◽  
AM Abrantes ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer

scholarly journals Micro-Sized Cold Atmospheric Plasma Source for Brain and Breast Cancer Treatment

2018 ◽  
Vol 8 (2) ◽  
pp. 203-215 ◽  
Author(s):  
Zhitong Chen ◽  
Li Lin ◽  
Qinmin Zheng ◽  
Jonathan H. Sherman ◽  
Jerome Canady ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Plasma Source ◽  
Breast Cancer Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Gillian E. Conway ◽  
Zhonglei He ◽  
Ana Lacramioara Hutanu ◽  
George Paul Cribaro ◽  
Eline Manaloto ◽  
...  
Keyword(s):  
Cell Death ◽  
Glioblastoma Multiforme ◽  
Plasma Treatment ◽  
Acridine Orange ◽  
Molecular Mechanisms ◽  
Confocal Imaging ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Rapid Accumulation ◽  
Lysosomal Accumulation

Abstract Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as the mode of cell death in various cancer cells. We have previously demonstrated a caspase-independent mechanism of cell death in p53-mutated glioblastoma multiforme (GBM) cells exposed to plasma. The purpose of this study was to elucidate the molecular mechanisms involved in caspase-independent cell death induced by plasma treatment. We demonstrate that plasma induces rapid cell death in GBM cells, independent of caspases. Accumulation of vesicles was observed in plasma treated cells that stained positive with acridine orange. Western immunoblotting confirmed that autophagy is not activated following plasma treatment. Acridine orange intensity correlates closely with the lysosomal marker Lyso TrackerTM Deep Red. Further investigation using isosurface visualisation of confocal imaging confirmed that lysosomal accumulation occurs in plasma treated cells. The accumulation of lysosomes was associated with concomitant cell death following plasma treatment. In conclusion, we observed rapid accumulation of acidic vesicles and cell death following CAP treatment in GBM cells. We found no evidence that either apoptosis or autophagy, however, determined that a rapid accumulation of late stage endosomes/lysosomes precedes membrane permeabilisation, mitochondrial membrane depolarisation and caspase independent cell death.

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