scholarly journals Comparison of Efficacy between Three-Dimensional Printing and Manual-Bending Implants for Inferomedial Orbital Fracture: A Retrospective Study

2021 ◽  
Vol 11 (17) ◽  
pp. 7971
Author(s):  
Jun-Hyeok Kim ◽  
Chae-Rim Lee ◽  
Deuk-Young Oh ◽  
Young-Joon Jun ◽  
Suk-Ho Moon
Keyword(s):  
Retrospective Study ◽  
Three Dimensional ◽  
Normal Structure ◽  
Orbital Fracture ◽  
Three Dimensional Printing ◽  
Normal Side ◽  
Lesion Side ◽  
Group A ◽  
3D Printed ◽  
Group B

The purpose of reconstruction of an orbital fracture is restoration of normal structure and volume without visible or functional complications. In a previous study, orbital implants were created using three-dimensional (3D) printing technology to restore orbital fractures. In the present study, the authors compared the efficacy of the conventional manual-bending implant and the 3D-printed standardized implant in order to verify the clinical utility of the fabricated 3D printed orbital implant. In this single-center, retrospective study, the authors evaluated medical records and 3D-CT scans of patients with inferomedial orbital fracture. Selected patients were divided into two groups. Group A underwent surgery with the 3D-printed standardized implant, while group B was treated using a manual technique to mold and trim the implant. A total of 32 patients was included in this study, 16 in each group. The volume of the preoperative lesion side was significantly different from that of the normal side or postoperative lesion side within each group. The volume of the postoperative lesion side was not statistically different from that of the normal side in Group A, but this volume was significantly different from that of the normal side in Group B. The 3D-printed standardized implant provides surgical efficacy to restore inferomedial orbital fracture and has superior surgical outcomes to the manual-bending implant.

scholarly journals 3D Printed Guides and Preoperative Planning for Uncemented Stem Anteversion Reconstruction during Hip Arthroplasty: A Pilot Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yingqi Zhang ◽  
Zhitao Rao ◽  
Jincheng Zhang ◽  
Shijie Li ◽  
Shimin Chang ◽  
...  
Keyword(s):  
Hip Arthroplasty ◽  
Preoperative Planning ◽  
Three Dimensional ◽  
Femoral Stem ◽  
Study Groups ◽  
Femoral Anteversion ◽  
Neck Fracture ◽  
Group A ◽  
3D Printed ◽  
Group B

Objective. To investigate if 3D printed guides and preoperative planning can accurately control femoral stem anteversion. Methods. A prospective comparative study was carried out from 2018 to 2020, including 53 patients who underwent hip arthroplasty for femoral neck fracture. The target rotation center of the femoral head is determined by three-dimensional planning. In group A, planning was made by 2D templates. In group B, preoperative 3D planning and 3D printed osteotomy/positioning guides were performed. After the operation, 3D model registration was performed to calculate the accuracy of anteversion restoration. Results. We screened 60 patients and randomized a total of 53 to 2 parallel study arms: 30 patients to the group A (traditional operation) and 23 patients to the group B (3D preoperative planning and 3D printed guide). There were no significant differences in demographic or perioperative data between study groups. The restoration accuracy of group A was 5.42 ° ± 3.65 ° and of group B was 2.32 ° ± 1.89 ° . The number and rate of abnormal cases was 15 (50%) and 2 (8.7%), respectively. Significant statistical differences were found in angle change, restoration accuracy, and number of abnormal cases. Conclusion. Three-dimensional preoperative planning and 3D printed guides can improve the accuracy of the restoration of femoral anteversion during hip arthroplasty.

scholarly journals Posterior surgery assisted by three dimensional printing technology in the treatment of sacroiliac joint tuberculosis

2020 ◽  
Author(s):  
Xinhua Yin ◽  
Liang Yan ◽  
Ding Jun Hao ◽  
Xiao Bin Yang ◽  
Zhongkai Liu
Keyword(s):  
Sacroiliac Joint ◽  
Three Dimensional ◽  
Printing Technology ◽  
Three Dimensional Printing ◽  
Posterior Surgery ◽  
Sacroiliac Screws ◽  
Group A ◽  
Group B ◽  
Posterior Debridement ◽  
Dimensional Printing

Abstract Background Three-dimensional (3D) printing is becoming increasingly important in spinal surgery, and few literatures have reported the surgical management for sacroiliac joint tuberculosis assisted by three dimensional printing technology. Purpose The study aim to assess the efficacy and feasibility of surgical treatment in sacroiliac joint tuberculosis (SJT) by posterior sacroiliac screws fixation, debridement and fusion, which assisted by three dimensional printing technology. Method Twenty-six patients with sacroiliac joint tuberculosis treated by surgery in our department between January 2008 and December 2015 . All the patients were divided into two group base on three dimensional printing technology: 11 cases in Group A underwent posterior debridement, fusion and sacroiliac screws fixation, and 15 cases in Group B underwent posterior debridement, bone graft, sacroiliac screws fixation, and three dimensional printing technology. Clinical and radiographic results for the two groups were analyzed and compared. Results All patients were followed up with an average 33.8±7.9 months (24–48 months). The sacroiliac joint tuberculosis was completely cured and the grafted bones were fused in all 26 patients. No injured nerve or other severe complications occurred in both groups. Group B achieved much better results in time of operation, intra-operative blood loss, and number of intra-operative fluoroscopy than group A ( p < 0.05). There were no significant differences between the two groups in ESR, fusion time, and VAS score in the last follow-up ( p >0.05). Conclusions The three dimensional printing technology can achieve the better effect in the treatment of sacroiliac joint tuberculosis. Posterior surgery assisted by three dimensional printing technology in the treatment of sacroiliac joint tuberculosis has the characteristics of shorter operative time, less bleeding, and less number of intra-operative fluoroscopy.

scholarly journals Osteogenesis of 3D-Printed PCL/TCP/bdECM Scaffold Using Adipose-Derived Stem Cells Aggregates; An Experimental Study in the Canine Mandible

2021 ◽  
Vol 22 (11) ◽  
pp. 5409
Author(s):  
Joon Seok Lee ◽  
Tae Hyun Park ◽  
Jeong Yeop Ryu ◽  
Dong Kyu Kim ◽  
Eun Jung Oh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intervention Group ◽  
Three Dimensional ◽  
Artificial Organs ◽  
Adipose Derived Stem Cells ◽  
Gene Expressions ◽  
Group A ◽  
3D Printed ◽  
Group B ◽  
Tissue Recovery

Three-dimensional (3D) printing is perceived as an innovative tool for change in tissue engineering and regenerative medicine based on research outcomes on the development of artificial organs and tissues. With advances in such technology, research is underway into 3D-printed artificial scaffolds for tissue recovery and regeneration. In this study, we fabricated artificial scaffolds by coating bone demineralized and decellularized extracellular matrix (bdECM) onto existing 3D-printed polycaprolactone/tricalcium phosphate (PCL/TCP) to enhance osteoconductivity and osteoinductivity. After injecting adipose-derived stem cells (ADSCs) in an aggregate form found to be effective in previous studies, we examined the effects of the scaffold on ossification during mandibular reconstruction in beagle dogs. Ten beagles were divided into two groups: group A (PCL/TCP/bdECM + ADSC injection; n = 5) and group B (PCL/TCP/bdECM; n = 5). The results were analyzed four and eight weeks after intervention. Computed tomography (CT) findings showed that group A had more diffuse osteoblast tissue than group B. Evidence of infection or immune rejection was not detected following histological examination. Goldner trichrome (G/T) staining revealed rich ossification in scaffold pores. ColI, Osteocalcin, and Runx2 gene expressions were determined using real-time polymerase chain reaction. Group A showed greater expression of these genes. Through Western blotting, group A showed a greater expression of genes that encode ColI, Osteocalcin, and Runx2 proteins. In conclusion, intervention group A, in which the beagles received the additional ADSC injection together with the 3D-printed PCL/TCP coated with bdECM, showed improved mandibular ossification in and around the pores of the scaffold.

Use of Three-dimensional Printing in the Development of Optimal Cardiac CT Scanning Protocols

2020 ◽  
Vol 16 (8) ◽  
pp. 967-977
Author(s):  
Zhonghua Sun
Keyword(s):  
Cardiovascular Disease ◽  
Cardiac Computed Tomography ◽  
Three Dimensional ◽  
Ct Scanning ◽  
Aortic Diseases ◽  
Clinical Value ◽  
Three Dimensional Printing ◽  
Doctor Patient Communication ◽  
Medical Education And Training ◽  
3D Printed

Three-dimensional (3D) printing is increasingly used in medical applications with most of the studies focusing on its applications in medical education and training, pre-surgical planning and simulation, and doctor-patient communication. An emerging area of utilising 3D printed models lies in the development of cardiac computed tomography (CT) protocols for visualisation and detection of cardiovascular disease. Specifically, 3D printed heart and cardiovascular models have shown potential value in the evaluation of coronary plaques and coronary stents, aortic diseases and detection of pulmonary embolism. This review article provides an overview of the clinical value of 3D printed models in these areas with regard to the development of optimal CT scanning protocols for both diagnostic evaluation of cardiovascular disease and reduction of radiation dose. The expected outcomes are to encourage further research towards this direction.

CONVENTIONAL VERSUS THREE-DIMENSIONAL CONFORMAL EXTERNAL RADIOTHERAPY IN CANCER CERVIX: A COMPARATIVE STUDY FOR COMPLIANCE, RESPONSE AND TOXICITY

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Richa Gupta ◽  
Piyush Kumar ◽  
D. P. Singh ◽  
Arvind Kumar Chauhan ◽  
Kamal Sahni
Keyword(s):  
Clinical Response ◽  
Three Dimensional ◽  
Common Side Effect ◽  
P Value ◽  
High Dose ◽  
Cancer Cervix ◽  
Conventional Radiotherapy ◽  
Radiation Fields ◽  
Group A ◽  
Group B

INTRODUCTION: Cervical cancer is the second most frequent cancer among Indian women. Radiotherapy is the cornerstone of treatment in all its stages. Three-dimensional conformal radiotherapy (3DCRT) combines multiple radiation fields to deliver precise dose of radiation to the affected area. Tailoring each of the radiation fields to focus on the tumor delivers a high dose of radiation to the tumor and avoids nearby healthy tissue. The present study is done to compare conventional radiotherapy versus 3DCRT in cancer cervix for compliance, clinical response and toxicity. MATERIAL AND METHODS: Fifty patients were enrolled and randomised into two radiotherapy plans with radical intent - Group A treated by conventional radiotherapy and group B treated by 3DCRT. Concurrent cisplatin was delivered on weekly (35mg/m2) or tri-weekly (75mg/m2) basis during external beam Radiotherapy and was followed by High Dose Radiotherapy Brachytherapy. Clinical response and complication assessment were evaluated.Collected data was analyzed using standard statistical methods and softwares to calculate level of significance using “p” value by chi square test. RESULTS: In this study mean age of the patients was 48 years (26-67 years). The anemia was the most common side effect seen in both groups (96% vs 88%, p=0.29). Neutropenia was more in group B (36% vs 44%, p= 0.56). Lower GI toxicity was seen only in patients in group A (20% vs 0%, p=0.018). In follow up there were no significant early rectal and bladder reactions in both groups and 2 patients in each group had late rectal reactions of grade I and II (p= 0.312). No significant skin, bladder and small intestinal toxicity were seen in both groups. CONCLUSION: Conventional radiotherapy gives equally efficacious response though accompanied by toxicities which were acceptable.

scholarly journals Three-dimensional printing for heart diseases: clinical application review

2021 ◽  
Author(s):  
Yanyan Ma ◽  
Peng Ding ◽  
Lanlan Li ◽  
Yang Liu ◽  
Ping Jin ◽  
...  
Keyword(s):  
3D Printing ◽  
Clinical Application ◽  
Heart Diseases ◽  
Three Dimensional ◽  
Convincing Evidence ◽  
Surgical Interventions ◽  
Three Dimensional Printing ◽  
Complex Anatomy ◽  
Precise Understanding ◽  
3D Printed

AbstractHeart diseases remain the top threat to human health, and the treatment of heart diseases changes with each passing day. Convincing evidence shows that three-dimensional (3D) printing allows for a more precise understanding of the complex anatomy associated with various heart diseases. In addition, 3D-printed models of cardiac diseases may serve as effective educational tools and for hands-on simulation of surgical interventions. We introduce examples of the clinical applications of different types of 3D printing based on specific cases and clinical application scenarios of 3D printing in treating heart diseases. We also discuss the limitations and clinically unmet needs of 3D printing in this context.

Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering

2021 ◽  
pp. 002199832098856
Author(s):  
Marcela Piassi Bernardo ◽  
Bruna Cristina Rodrigues da Silva ◽  
Luiz Henrique Capparelli Mattoso
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Poly Lactic Acid ◽  
Scanning Calorimetry ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.

scholarly journals Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 353
Author(s):  
Yanting Han ◽  
Qianqian Wei ◽  
Pengbo Chang ◽  
Kehui Hu ◽  
Oseweuba Valentine Okoro ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Biomedical Application ◽  
Three Dimensional ◽  
Antibacterial Properties ◽  
Natural Polymers ◽  
Three Dimensional Printing ◽  
3D Printed ◽  
Dental Applications ◽  
Hard Tissue Engineering

Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. In recent years, three-dimensional (3D) printing has been shown to provide a fast, precise, controllable, and scalable fabrication approach for the synthesis of HA-based scaffolds. This review therefore explores available 3D printing technologies for the preparation of porous HA-based nanocomposites. In the present review, different 3D printed HA-based scaffolds composited with natural polymers and/or synthetic polymers are discussed. Furthermore, the desired properties of HA-based composites via 3D printing such as porosity, mechanical properties, biodegradability, and antibacterial properties are extensively explored. Lastly, the applications and the next generation of HA-based nanocomposites for tissue engineering are discussed.

scholarly journals Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution

2021 ◽  
Vol 5 (1) ◽  
pp. 15
Author(s):  
Nuno Venâncio ◽  
Gabriela G. Pereira ◽  
João F. Pinto ◽  
Ana I. Fernandes
Keyword(s):  
Three Dimensional ◽  
Drug Dissolution ◽  
Fused Deposition Modelling ◽  
Three Dimensional Printing ◽  
Preliminary Results ◽  
Fused Deposition ◽  
3D Printed ◽  
Dimensional Printing ◽  
Hot Melt ◽  
Patient Centric

Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition modelling to produce tablets. Here, preliminary results evaluating the effect of infill geometry (cross, star, grid) on drug content and release are reported.

3D-Printed Conductive Filaments Based on Carbon Nanostructures Embedded in a Polymer Matrix

2021 ◽  
pp. 1725-1742
Author(s):  
Diogo José Horst ◽  
Pedro Paulo Andrade Junior
Keyword(s):  
Polymer Matrix ◽  
Carbon Nanostructures ◽  
Three Dimensional ◽  
Full Potential ◽  
Electrically Conductive ◽  
Three Dimensional Printing ◽  
Current State ◽  
3D Printed ◽  
The Subject ◽  
Dimensional Printing

Conductive and magnetic filaments are revolutionizing three-dimensional printing (3DP) to a new level. This review study presents the current state of the art on the subject, summarizing recent high impact studies about main advances regarding the application of 3DP filaments based on carbon nanostructures such as graphene, carbon fibers, nanotubes, and conductive carbon black embedded in a polymer matrix, by reviewing its main characteristics and showing the main producers and also the products available on the market. The availability of inexpensive, reliable, and electrically conductive material will be indispensable for the fabrication of circuits and sensors before the full potential of 3DP for customized products incorporating electrical elements can be fully explored.

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