scholarly journals Future Prospective of Oral Microbiome Research

2021 ◽  
Vol 12 (1) ◽  
pp. 55
Author(s):  
Yoshiaki Nomura ◽  
Ayako Okada ◽  
Nobuhiro Hanada
Keyword(s):  
Older Adults ◽  
Human Health ◽  
Complex Structure ◽  
Oral Microbiome ◽  
Oral Diseases ◽  
Beneficial Bacteria ◽  
Concise Review ◽  
Microbiome Research

Oral microbiome has complex structure. It consisted of more than 700 species of bacteria. These bacteria contains pathogens for human health. In contrast, some beneficial bacteria were included. Perspective of oral microbiome is not still elucidated. In this paper, information regarding oral microbiome of health older adults and oral diseases are included. Additionally, concise review of oral microbiome are presented.

scholarly journals Consumer Safety Considerations of Skin and Oral Microbiome Perturbation

2019 ◽  
Vol 32 (4) ◽  
Author(s):  
Andrew J. McBain ◽  
Catherine A. O’Neill ◽  
Alejandro Amezquita ◽  
Laura J. Price ◽  
Karoline Faust ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Microbiome ◽  
Personal Care ◽  
Oral Diseases ◽  
Microbial Risk Assessment ◽  
Microbial Risk ◽  
Consumer Safety ◽  
Microbiome Research ◽  
Axillary Odor ◽  
Safety Considerations

SUMMARY Microbiomes associated with human skin and the oral cavity are uniquely exposed to personal care regimes. Changes in the composition and activities of the microbial communities in these environments can be utilized to promote consumer health benefits, for example, by reducing the numbers, composition, or activities of microbes implicated in conditions such as acne, axillary odor, dandruff, and oral diseases. It is, however, important to ensure that innovative approaches for microbiome manipulation do not unsafely disrupt the microbiome or compromise health, and where major changes in the composition or activities of the microbiome may occur, these require evaluation to ensure that critical biological functions are unaffected. This article is based on a 2-day workshop held at SEAC Unilever, Sharnbrook, United Kingdom, involving 31 specialists in microbial risk assessment, skin and oral microbiome research, microbial ecology, bioinformatics, mathematical modeling, and immunology. The first day focused on understanding the potential implications of skin and oral microbiome perturbation, while approaches to characterize those perturbations were discussed during the second day. This article discusses the factors that the panel recommends be considered for personal care products that target the microbiomes of the skin and the oral cavity.

scholarly journals Understanding Oral Diseases: Exploring Opportunities from Filipino Oral Microbiome Research

2021 ◽  
Author(s):  
Marilen P. Balolong ◽  
Michael Antonio F. Mendoza
Keyword(s):  
Soft Tissues ◽  
Selective Constraint ◽  
Current Control ◽  
Oral Microbiome ◽  
Policy Framework ◽  
Oral Microbiota ◽  
Oral Diseases ◽  
Microbiome Research ◽  
Health And Disease ◽  
And Function

The human mouth houses the second most diverse microbial community in the body, with almost 700 species of bacteria colonizing the hard surfaces of teeth and the soft tissues of the oral mucosa. To compete in the relatively exposed oral cavity, resident microbes must avoid being replaced by newcomers. This selective constraint, coupled with pressure on the host to cultivate a beneficial microbiome, has rendered a commensal oral microbiota that displays colonization resistance, protecting the human host from invasive species, including pathogens. Current control of dental plaque-related diseases is non-specific and is centered on the removal of plaque by mechanical means. Several new methods based on the modulation of the microbiome that aim at maintaining and re-establishing a healthy oral ecosystem have been developed and has greatly expanded our knowledge of the composition and function of the oral microbiome in health and disease. Promoting a balanced microbiome is therefore important to effectively maintain or restore oral health. This review provides an updated body of knowledge on oral microbiome in health and disease and discusses the implications for modern-day oral healthcare. Filipino Oral Microbiome Research to develop a policy framework for microbiome-based management of dental diseases and opportunities will be discussed.

scholarly journals Human Fecal Metabolome Reflects Differences in Body Mass Index, Physical Fitness, and Blood Lipoproteins in Healthy Older Adults

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 717
Author(s):  
Mengni Cui ◽  
Alessia Trimigno ◽  
Josue L. Castro-Mejía ◽  
Søren Reitelseder ◽  
Jacob Bülow ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Physical Fitness ◽  
Glutamic Acid ◽  
Human Health ◽  
Body Mass ◽  
Gut Microbiome ◽  
Density Lipoprotein ◽  
Healthy Older Adults ◽  
Lipoprotein Particles

This study investigated how body mass index (BMI), physical fitness, and blood plasma lipoprotein levels are related to the fecal metabolome in older adults. The fecal metabolome data were acquired using proton nuclear magnetic resonance spectroscopy and gas chromatography–mass spectrometry on 163 healthy older adults (65–80 years old, 80 females and 83 males). Overweight and obese subjects (BMI ≥ 27) showed higher levels of fecal amino acids (AAs) (valine, alanine, and phenylalanine) compared to normal-weight subjects (BMI ≤ 23.5). Adults classified in the high-fitness group displayed slightly lower concentrations of fecal short-chain fatty acids, propionic acid, and AAs (methionine, leucine, glutamic acid, and threonine) compared to the low-fitness group. Subjects with lower levels of cholesterol in low-density lipoprotein particles (LDLchol, ≤2.6 mmol/L) displayed higher fecal levels of valine, glutamic acid, phenylalanine, and lactic acid, while subjects with a higher level of cholesterol in high-density lipoprotein particles (HDLchol, ≥2.1 mmol/L) showed lower fecal concentration of isovaleric acid. The results from this study suggest that the human fecal metabolome, which primarily represents undigested food waste and metabolites produced by the gut microbiome, carries important information about human health and should be closely integrated to other omics data for a better understanding of the role of the gut microbiome and diet on human health and metabolism.

scholarly journals Evaluating Mechanisms of Change in an Oral Hygiene Improvement Trial With Older Adults

2021 ◽  
Author(s):  
Jean Schensul ◽  
Susan Reisine ◽  
Apoorva Salvi ◽  
Toan Ha ◽  
James Grady ◽  
...  
Keyword(s):  
Older Adults ◽  
Oral Health ◽  
Locus Of Control ◽  
Low Income ◽  
Oral Hygiene ◽  
Perceived Risk ◽  
Mechanisms Of Change ◽  
Oral Diseases ◽  
Counseling Intervention ◽  
Group Randomized Trial

Abstract Objectives. This paper examines the relationship between theoretically-driven mediators and clinical outcomes of a group randomized trial to improve oral health and hygiene of older adults in subsidized housing were compared. Methods. Six low-income senior residences were paired and randomized into two groups. The first received a face to face counseling intervention (AMI) and the second, a peer-facilitated health campaign (three oral health fairs) both based on Fishbein’s Integrated Model. 331 participants were recruited at baseline and 306 completed the post-assessment one month after intervention. Clinical outcome s were Gingival Index (GI) and Plaque score (PS), collected by calibrated dental hygienists. Surveys obtained data on patient background characteristics, and ten oral health beliefs, attitudes, norms and behaviors. GLMM assessed the effects of time, intervention arm, moderators and mediators and intervention by time interactions. Results. Baseline moderators were similar. Both outcomes improved significantly. GI scores changed from baseline mean of 0.38 (sd=.032) to .26 (sd=.025) and PS scores changed from baseline mean of 71.4 (sd=18%) to 59.1% (sd=21%). Fears, intentionality, norms, worries, flossing and sugar consumption improved significantly in both interventions from baseline to post intervention. Self-efficacy, perceived risk of oral health problems, locus of control and brushing improved significantly only in the counseling intervention. Mechanisms predicting GI improvement were intentionality, locus of control, brushing and flossing in association with the counseling intervention. Mechanisms predicting PS improvement were worries about oral hygiene self-management and fear of oral diseases in association with the AMI intervention. In the trimmed final models, only locus of control (predicting GI) and fears of oral diseases (predicting PS) were significant. Conclusions. GI and PS improved more in response to the counseling intervention than the campaign. The counseling intervention had a greater impact on mechanisms of change than the campaign. Locus of control, a key concept in oral hygiene interventions including the IM was the main contributing mechanism for GI. Fear, an emotional response drove improvement in PS reinforcing the importance of cognitive/emotional mechanisms in oral hygiene interventions. Improvements in mediators across both interventions suggest a closer examination of the campaign intervention impact on outcomes over time. Trial Registration: Clinicaltrials.gov NCT02419144, first posted April 17, 2015

scholarly journals Computational Modeling of the Human Microbiome

2020 ◽  
Vol 8 (2) ◽  
pp. 197
Author(s):  
Shomeek Chowdhury ◽  
Stephen S. Fong
Keyword(s):  
Computational Modeling ◽  
Human Health ◽  
Large Scale ◽  
Human Microbiome ◽  
Human Microbiome Project ◽  
Microbial Composition ◽  
Site Specific ◽  
Microbiome Research ◽  
High Level ◽  
The Impact

The impact of microorganisms on human health has long been acknowledged and studied, but recent advances in research methodologies have enabled a new systems-level perspective on the collections of microorganisms associated with humans, the human microbiome. Large-scale collaborative efforts such as the NIH Human Microbiome Project have sought to kick-start research on the human microbiome by providing foundational information on microbial composition based upon specific sites across the human body. Here, we focus on the four main anatomical sites of the human microbiome: gut, oral, skin, and vaginal, and provide information on site-specific background, experimental data, and computational modeling. Each of the site-specific microbiomes has unique organisms and phenomena associated with them; there are also high-level commonalities. By providing an overview of different human microbiome sites, we hope to provide a perspective where detailed, site-specific research is needed to understand causal phenomena that impact human health, but there is equally a need for more generalized methodology improvements that would benefit all human microbiome research.

scholarly journals ORAL CANCER SCREENING IN NON-INSTITUTIONALIZED OLDER ADULTS LIVING IN RURAL COMMUNITIES OF SOUTHEAST GEORGIA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S883-S884
Author(s):  
Swaha Pattanaik ◽  
Bettye Apenteng ◽  
Adrienne L Cohen ◽  
Georgia Dounis ◽  
Raymona Lawrence
Keyword(s):  
Older Adults ◽  
Cancer Screening ◽  
Rural Communities ◽  
Oral Cancer ◽  
Well Being ◽  
The United States ◽  
Oral Diseases ◽  
Key Informants ◽  
Oral Cancer Screening ◽  
Common Sign

Abstract The older population in the United States is growing at an unprecedented rate. Oral diseases such as oral cancer can affect physical, psychological, and social well-being in older adults. Oral cancer screening can prevent development of the disease in high-risk individuals. The purpose of this research was to assess determinants of preventive oral health behavior including oral cancer screening in noninstitutionalized older adults living in rural/medically underserved communities of southeast Georgia. A mixed methods sequential explanatory design was used. Surveys were administered to 206 individuals aged 50 and older. Phone interviews were conducted with 22 individuals from the survey sample and 11 key informants. The majority of the participants (83.01%) said they had never been examined for oral cancer by a doctor or a dentist. Those who correctly recognized the most common sign of oral cancer were about three times more likely (OR=3.75; 95% CI: 1.04 – 13.50) to have had an exam for oral cancer (p=0.04). The survey participants who lived alone were more likely (OR = 4.39; 95% CI = 0.95 – 20.26) to have been examined for oral cancer (p = 0.05). During the interview, older adult participants rarely mentioned oral cancer with regards to an unhealthy mouth. The interview participants revealed that living alone gave them more time to pay attention to their health. For the older adults, prevention of oral diseases was grounded in the autonomy in their own behaviors, while the key informants saw more macro community and systems- level factors as the solution.

scholarly journals Single-Cell Genomics and the Oral Microbiome

2020 ◽  
Vol 99 (6) ◽  
pp. 613-620 ◽  
Author(s):  
M. Balachandran ◽  
K.L. Cross ◽  
M. Podar
Keyword(s):  
Microbial Community ◽  
Single Cell ◽  
Single Cells ◽  
Oral Bacteria ◽  
Oral Microbiome ◽  
Oral Microbiota ◽  
Oral Diseases ◽  
Interspecies Interactions ◽  
Single Cell Genomics

The human oral cavity is one of the first environments where microbes have been discovered and studied since the dawn of microbiology. Nevertheless, approximately 200 types of bacteria from the oral microbiota have remained uncultured in the laboratory. Some are associated with a healthy oral microbial community, while others are linked to oral diseases, from dental caries to gum disease. Single-cell genomics has enabled inferences on the physiology, virulence, and evolution of such uncultured microorganisms and has further enabled isolation and cultivation of several novel oral bacteria, including the discovery of novel interspecies interactions. This review summarizes some of the more recent advances in this field, which is rapidly moving toward physiologic characterization of single cells and ultimately cultivation of the yet uncultured. A combination of traditional microbiological approaches with genomic-based physiologic predictions and isolation strategies may lead to the oral microbiome being the first complex microbial community to have all its members cultivable in the laboratory. Studying the biology of the individual microbes when in association with other members of the community, in controlled laboratory conditions and in vivo, should lead to a better understanding of oral dysbiosis and its prevention and reversion.

scholarly journals The Oral and Gut Bacterial Microbiomes: Similarities, Differences, and Connections

2020 ◽  
Vol 23 (1) ◽  
pp. 7-20
Author(s):  
Katherine A. Maki ◽  
Narjis Kazmi ◽  
Jennifer J. Barb ◽  
Nancy Ames
Keyword(s):  
Gut Microbiome ◽  
Alpha Diversity ◽  
Oral Microbiome ◽  
Taxonomic Resolution ◽  
Future Research ◽  
Sequencing Analysis ◽  
Systemic Diseases ◽  
Shotgun Metagenomics ◽  
Healthy Humans ◽  
Microbiome Research

Background: The oral cavity is associated with local and systemic diseases, although oral samples are not as commonly studied as fecal samples in microbiome research. There is a gap in understanding between the similarities and differences in oral and gut microbiomes and how they may influence each other. Methods: A scoping literature review was conducted comparing oral and gut microbiome communities in healthy humans. Results: Ten manuscripts met inclusion criteria and were examined. The oral microbiome sites demonstrated great variance in differential bacterial abundance and the oral microbiome had higher alpha diversity as compared to the gut microbiome. Studies using 16S rRNA sequencing analysis resulted in overall community differences between the oral and gut microbiomes when beta diversity was analyzed. Shotgun metagenomics sequencing increased taxonomic resolution to strain level (intraspecies) and demonstrated a greater percentage of shared taxonomy and oral bacterial translocation to the gut microbiome community. Discussion: The oral and gut microbiome bacterial communities may be more similar than earlier research has suggested, when species strain is analyzed through shotgun metagenomics sequencing. The association between oral health and systemic diseases has been widely reported but many mechanisms underlying this relationship are unknown. Although future research is needed, the oral microbiome may be a novel interventional target through its downstream effects on the gut microbiome. As nurse scientists are experts in symptom characterization and phenotyping of patients, they are also well posed to lead research on the connection of the oral microbiome to the gut microbiome in health and disease.

scholarly journals The Current and Future State of Department of Defense (DoD) Microbiome Research: a Summary of the Inaugural DoD Tri-Service Microbiome Consortium Informational Meeting

mSystems ◽  
2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Sarah Glaven ◽  
Kenneth Racicot ◽  
Dagmar H. Leary ◽  
J. Philip Karl ◽  
Steven Arcidiacono ◽  
...  
Keyword(s):  
Human Health ◽  
Air Force ◽  
Department Of Defense ◽  
Collaborative Research ◽  
Research Policy ◽  
Future Directions ◽  
Research Activities ◽  
Future State ◽  
Microbiome Research ◽  
And Performance

ABSTRACT The Tri-Service Microbiome Consortium (TSMC) was recently established to enhance collaboration, coordination, and communication of microbiome research among Department of Defense (DoD) organizations. The TSMC aims to serve as a forum for sharing information related to DoD microbiome research, policy, and applications, to monitor global advances relevant to human health and performance, to identify priority objectives, and to facilitate Tri-Service (Army, Navy, and Air Force) collaborative research. The inaugural TSMC workshop held on 10 to 11 May 2017 brought together almost 100 attendees from across the DoD and several key DoD partners. The meeting outcomes informed attendees of the scope of current DoD microbiome research efforts and identified knowledge gaps, collaborative/leveraging opportunities, research barriers/challenges, and future directions. This report details meeting presentations and discussions with special emphasis on Tri-Service labs’ current research activities.

The Role of Bacterial Biofilms in Dental Caries and Periodontal and Peri-implant Diseases: A Historical Perspective

2019 ◽  
Vol 98 (4) ◽  
pp. 373-385 ◽  
Author(s):  
A.P.V. Colombo ◽  
A.C.R. Tanner
Keyword(s):  
Deep Understanding ◽  
Oral Microbiome ◽  
Oral Diseases ◽  
Oral Infections ◽  
Microbial Biofilms ◽  
Holistic Concept ◽  
Dental Diseases ◽  
The One ◽  
Associated Species ◽  
Clinical Conditions

Over the last hundred years, groundbreaking research in oral microbiology has provided a broad and deep understanding about the oral microbiome, its interactions with our body, and how the community can affect our health, be protective, or lead to the development of dental diseases. During this exciting journey, hypotheses were proposed, and concepts were established, discarded, and later revisited from updated perspectives. Dental plaque, previously considered a polymicrobial community of unspecific pathogenicity, is recognized as microbial biofilms with healthy, cariogenic, or periodontopathogenic profiles, resulting from specific ecologic determinants and host factors. The “one pathogen, one disease” paradigm of oral infections has been replaced by a holistic concept of a microbial community as the entity of pathogenicity. Cutting-edge technology can now explore large microbial communities related to different clinical conditions, which has led to finding several novel disease-associated species and potential pathobionts and pathobiomes. This vast amount of data generated over time has widened our view of the etiology of caries and periodontal and peri-implant diseases and has promoted updated strategies to treat and prevent the oral diseases.

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