scholarly journals Long-Term Effects of a Soft Robotic Suit on Gait Characteristics in Healthy Elderly Persons

2019 ◽  
Vol 9 (9) ◽  
pp. 1957 ◽  
Author(s):  
Shanhai Jin ◽  
Xiaogang Xiong ◽  
Dejin Zhao ◽  
Changfu Jin ◽  
Motoji Yamamoto
Keyword(s):  
Gait Training ◽  
Assistive Device ◽  
Elderly Subjects ◽  
Elderly Persons ◽  
Long Term Effects ◽  
Initial State ◽  
Healthy Elderly ◽  
Gait Characteristics ◽  
Repeated Use

As a walking assistive device for elderly persons, one of the major aims should be to improve and rehabilitate gait characteristics after long-term repeated use of the device. However, most of the existing research on walking assistive devices only emphasize their immediate effects, and there is limited research indicating the long-term effects. To address this gap, this paper experimentally validates the effects of our soft wearable robotic suit on gait characteristics of elderly persons after repeated use of the device for six weeks. Experimental results on four elderly subjects (age = 74.8 ± 5.0 year) show that, after six weeks of gait rehabilitation training by the robotic suit, the gait characteristics of the subjects were improved, leading to an increased walk ratio with an average of 9.8% compared with the initial state. The results of this research will benefit the potential use of the robotic suit in gait training and rehabilitation for elderly persons and also will be useful to the establishment of practical guidelines that maximize the training and rehabilitation effectiveness of the robotic suit.

scholarly journals Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Rosa Casas ◽  
Mireia Urpi-Sardà ◽  
Emilio Sacanella ◽  
Sara Arranz ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Plasma Concentrations ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Inflammatory Biomarkers ◽  
Elderly Persons ◽  
Long Term Effects ◽  
Plaque Development ◽  
Atheroma Plaque

Objective.To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease.Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®.Results.At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β(P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group.Conclusions. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.

1P-0308 Long-term exercise improves postprandial response to fat in healthy elderly subjects

2003 ◽  
Vol 4 (2) ◽  
pp. 87
Author(s):  
H. Sone ◽  
K. Saito ◽  
H. Murakami ◽  
M. Shu ◽  
S. Maeda ◽  
...  
Keyword(s):  
Elderly Subjects ◽  
Healthy Elderly ◽  
Postprandial Response ◽  
Healthy Elderly Subjects

scholarly journals Determining Whether Tai Chi Chuan is Related to the Updating Function in Older Adults: Differences Between Experts and Novices

2021 ◽  
Author(s):  
Yuan Yang ◽  
Tingting Chen ◽  
Xiaoxia Yuan ◽  
Xiaoke Zhong ◽  
Shoufu Yan ◽  
...  
Keyword(s):  
Older Adults ◽  
Tai Chi ◽  
The Elderly ◽  
Elderly Subjects ◽  
Cross Sectional ◽  
Tai Chi Chuan ◽  
Novice Group ◽  
Healthy Elderly ◽  
Back Task

Abstract Background: Tai Chi Chuan (TCC) is one effective method used to delay cognitive decline in older adults. However, the relationship between the long-term practice of TCC and the crucial working memory updating function of the brain in the elderly has not been comprehensively researched.Objective: This cross-sectional study explores how behavioral performance in a laboratory setting is related to long term practice of TCC on the updating function in older people using reaction times (RTs) of N-back tasks. Methods: 26 healthy elderly people participated in this experiment. According to the length of time TCC was practiced, 13 subjects in the TCC group had more than 5 years’ experience of TCC exercise, and 13 elderly subjects who had not been systematically exposed to mind-body exercise were assigned to the novice group. The N-back task was administered to every participant to evaluate the updating function. Results: The TCC group had faster RTs compared to the novice group (p<0.05); For the 1-back task, the TCC group showed faster RTs than the novice group. For the 2-back task, the novice group exhibited faster RTs than the TCC group. Conclusions: TCC experts exhibit greater updating function as compared to TCC novices. Long-term TCC appears to be positive associated with the updating function of older adults, making it an effective exercise to maintain cognitive function in the elderly.

scholarly journals Long-term vitamin status and dietary intake of healthy elderly subjects

1979 ◽  
Vol 42 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Ingrid H. E. Rutishauser ◽  
C. J. Bates ◽  
Alison A. Paul ◽  
Alison E. Black ◽  
A. R. Mandal ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Limited Range ◽  
Dietary Factors ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Biochemical Status ◽  
Dietary Record ◽  
Activation Coefficient ◽  
Healthy Elderly Subjects

1. Long-term clinical and biochemical riboflavin status and dietary intake of riboflavin were monitored for 18 months in a group of twenty-three relatively-healthy elderly subjects living at home in the north of England.2. Both dietary intake and biochemical status, as measured by the activation coefficient (stimulated: basal activity) of NAD(P)H2: glutathione oxidoreductase (EC 1.6.4.2), remained fairly constant for each individual and for most subjects the usual intake and biochemical status were characterized quite accurately by a single week's intake dietary record and a single measurement of the activation coefficient.The expected relationship between biochemical status and dietary intake was present, but not strongly evident. There was a significant within-subject correlation between α values and the immediately preceding dietary intake; however the between-subject correlation between α values and dietary intake approached zero if the two subjects receiving long-term riboflavin supplements were omitted. Over the limited range of intakes observed in unsupplemented subjects, non-dietary factors evidently obscure the relationship.4. Although eight subjects had average values above 1.2 for the activation coefficient, no excessively high values were observed, and no subject showed any clear-cut clinical deficiency symptoms.

scholarly journals Liver damage while Covid-19: problems of pathogenesis and treatment

2021 ◽  
pp. 178-185
Author(s):  
E. A. Lyalyukova ◽  
I. V. Dolgalev ◽  
E. N. Chernysheva ◽  
I. V. Druk ◽  
G. M. Konovalova ◽  
...  
Keyword(s):  
Liver Damage ◽  
Liver Diseases ◽  
Scientific Information ◽  
Organ Damage ◽  
Chronic Liver Diseases ◽  
Long Term Effects ◽  
Initial State ◽  
Cytopathogenic Effect ◽  
Optimal Patient Management

The purpose of the review is to present an analysis of the current literature data on the pathogenesis and therapy of liver damage in Covid-19. Liver damage in COVID-19 patients can be caused by the direct cytopathogenic effect of SARS-CoV-2, an uncontrolled immune response, sepsis, severe hypoxia, or drug damage. In addition, COVID-19 can exacerbate and decompensate previously formed chronic liver diseases with the development of acute liver failure. Physicians should carefully assess the initial state of the liver, and after prescribing therapy, intensify monitoring of its functional state, especially in patients with severe COVID-19. In each clinical case, the doctor needs to establish the possible mechanisms of organ damage in order to select the most optimal patient management tactics, which would take into account all aspects of the COVID-19 course and liver damage. Currently, additional scientific information is required to uncover the features of liver damage during SARS-CoV-2 infection and in the postcovid period. Patients who have undergone COVID-19 need further monitoring to assess the long-term effects of the disease.

scholarly journals Prolonged Rest, Long-Term Dynamic Balance, and Gait in a Mouse Ankle-Sprain Model

2019 ◽  
Vol 54 (7) ◽  
pp. 801-807
Author(s):  
Erik A. Wikstrom ◽  
Tricia Hubbard-Turner ◽  
Ashley Duncan ◽  
Jason Cline ◽  
Michael J. Turner
Keyword(s):  
Ankle Instability ◽  
Dynamic Balance ◽  
Return To Sport ◽  
Human Model ◽  
Future Research ◽  
Ankle Sprains ◽  
Long Term Effects ◽  
Gait Characteristics ◽  
Short And Long Term

Context Lateral ankle sprains (LASs) result in short- and long-term adaptations in the sensorimotor system that are thought to contribute to the development of chronic ankle instability and posttraumatic ankle osteoarthritis. Debate continues as to the appropriateness of rapid return to sport after LASs given the prevalence of long-term consequences. Objective To examine the short- and long-term effects of prolonged rest, as a model of immobilization, on dynamic balance and gait outcomes after a severe LAS in a mouse model. Design Controlled laboratory study. Setting Research laboratory. Intervention(s) At 7 weeks of age, 18 male mice (CBA/J) had their right anterior talofibular and calcaneofibular ligaments transected. Mice were then randomized to 1 of 3 groups representing when access to a running wheel postsurgery was gained: at 3 days, 1 week, and 2 weeks. Main Outcome Measure(s) Dynamic balance and spatial gait characteristics were quantified before surgery (baseline) and at 3 days and 1, 2, 4, 6, 12, 18, 24, 30, 36, 42, 48, and 54 weeks postinjury. Results Relative to prolonged rest, resting for only 3 days resulted in worse dynamic balance during the later assessment points (42–54 weeks postinjury, P &lt; .01). Mice that underwent a prolonged rest period of 2 weeks crossed the balance beam faster than the group that rested for only 3 days when averaged across all time points (P &lt; .012). Spatial gait characteristics did not differ among the groups (P &gt; .05). Conclusions Relative to 3 days of rest, prolonged rest (1 and 2 weeks) after a severe LAS in mice positively affected balance. The apparent benefit of prolonged rest was noted on both dynamic-balance outcomes and performance. Stride length was not altered by the duration of rest after a surgically induced severe LAS in mice. Future research is needed to determine if these results translate to a human model.

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