scholarly journals Shifting Gears in Precision Oncology—Challenges and Opportunities of Integrative Data Analysis

Biomolecules ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1310
Author(s):  
Ka-Won Noh ◽  
Reinhard Buettner ◽  
Sebastian Klein
Keyword(s):  
Data Analysis ◽  
Patient Characteristics ◽  
Molecular Diagnostic ◽  
Precision Oncology ◽  
Integrative Data Analysis ◽  
Therapy Decision ◽  
Challenges And Opportunities ◽  
Optimal Treatment Regime ◽  
Diagnostic Modalities ◽  
The Individual

For decades, research relating to modification of host immunity towards antitumor response activation has been ongoing, with the breakthrough discovery of immune-checkpoint blockers. Several biomarkers with potential predictive value have been reported in recent studies for these novel therapies. However, with the plethora of therapeutic options existing for a given cancer entity, modern oncology is now being confronted with multifactorial interpretation to devise “the best therapy” for the individual patient. Into the bargain come the multiverse guidelines for established and emerging diagnostic biomarkers, as well as the complex interplay between cancer cells and tumor microenvironment, provoking immense challenges in the therapy decision-making process. Through this review, we present various molecular diagnostic modalities and techniques, such as genomics, immunohistochemistry and quantitative image analysis, which have the potential of becoming powerful tools in the development of an optimal treatment regime when analogized with patient characteristics. We will summarize the underlying complexities of these methods and shed light upon the necessary considerations and requirements for data integration. It is our hope to provide compelling evidence to emphasize on the need for inclusion of integrative data analysis in modern cancer therapy, and thereupon paving a path towards precision medicine and better patient outcomes.

Integrative Data Analysis from a Unifying Research Synthesis Perspective

2018 ◽  
Author(s):  
Eun-Young Mun ◽  
Anne E. Ray
Keyword(s):  
Data Analysis ◽  
Large Scale ◽  
Research Synthesis ◽  
Alcohol Intervention ◽  
Data Set ◽  
Integrative Data Analysis ◽  
Level Data ◽  
Model Complex ◽  
Wide Range ◽  
Individual Participant

Integrative data analysis (IDA) is a promising new approach in psychological research and has been well received in the field of alcohol research. This chapter provides a larger unifying research synthesis framework for IDA. Major advantages of IDA of individual participant-level data include better and more flexible ways to examine subgroups, model complex relationships, deal with methodological and clinical heterogeneity, and examine infrequently occurring behaviors. However, between-study heterogeneity in measures, designs, and samples and systematic study-level missing data are significant barriers to IDA and, more broadly, to large-scale research synthesis. Based on the authors’ experience working on the Project INTEGRATE data set, which combined individual participant-level data from 24 independent college brief alcohol intervention studies, it is also recognized that IDA investigations require a wide range of expertise and considerable resources and that some minimum standards for reporting IDA studies may be needed to improve transparency and quality of evidence.

scholarly journals MEASUREMENT PROPERTIES OF A STANDARDIZED ELICITED IMITATION TEST: AN INTEGRATIVE DATA ANALYSIS

2021 ◽  
pp. 1-27
Author(s):  
Daniel R. Isbell ◽  
Young-A Son
Keyword(s):  
Second Language ◽  
Data Analysis ◽  
Second Language Acquisition ◽  
Item Difficulty ◽  
Measurement Properties ◽  
Linguistic Features ◽  
Elicited Imitation ◽  
Integrative Data Analysis ◽  
Rater Severity ◽  
Study Participants

Abstract Elicited Imitation Tests (EITs) are commonly used in second language acquisition (SLA)/bilingualism research contexts to assess the general oral proficiency of study participants. While previous studies have provided valuable EIT construct-related validity evidence, some key gaps remain. This study uses an integrative data analysis to further probe the validity of the Korean EIT score interpretations by examining the performances of 318 Korean learners (198 second language, 79 foreign language, and 41 heritage) on the Korean EIT scored by five different raters. Expanding on previous EIT validation efforts, this study (a) examined both inter-rater reliability and differences in rater severity, (b) explored measurement bias across subpopulations of language learners, (c) identified relevant linguistic features which relate to item difficulty, and (d) provided a norm-referenced interpretation for Korean EIT scores. Overall, findings suggest that the Korean EIT can be used in diverse SLA/bilingualism research contexts, as it measures ability similarly across subgroups and raters.

Inequality in active ageing: evidence from a new individual-level index for European countries

2017 ◽  
Vol 39 (3) ◽  
pp. 541-567 ◽  
Author(s):  
MIKKEL BARSLUND ◽  
MARTEN VON WERDER ◽  
ASGHAR ZAIDI
Keyword(s):  
Age Groups ◽  
Positive Association ◽  
European Countries ◽  
Active Ageing ◽  
Unequal Distribution ◽  
Individual Level ◽  
Country Level ◽  
Challenges And Opportunities ◽  
Share Data ◽  
The Individual

ABSTRACTIn the context of emerging challenges and opportunities associated with population ageing, the study of inequality in active-ageing outcomes is critical to the design of appropriate and effective social policies. While there is much discussion about active ageing at the aggregate country level, little is known about inequality in active-ageing experiences within countries. Based on the existing literature on active ageing, this paper proposes an individual-level composite active ageing index based on Survey of Health, Ageing and Retirement in Europe (SHARE) data. The individual-level nature of the index allows us to analyse inequality in experiences of active ageing within selected European countries. One important motivation behind measuring active ageing at the individual level is that it allows for a better understanding of unequal experiences of ageing, which may otherwise be masked in aggregate-level measures of active ageing. Results show large differences in the distribution of individual-level active ageing across the 13 European countries covered and across age groups. Furthermore, there is a positive association between the country-level active ageing index and the equality of its distribution within a country. Hence, countries with the lowest average active ageing index tend to have the most unequal distribution in active-ageing experiences. For nine European countries, where temporal data are also available, we find that inequality in active-ageing outcomes decreased in the period 2004 to 2013.

GAMBARAN TINGKAT KECEMASAN ORANG TUA TERHADAP HOSPITALISASI ANAK DENGAN KEJANG DEMAM SELAMA ANAK DI RAWAT DI RUMAH SAKIT SANTA ELISABETH MEDAN TAHUN 2017

2017 ◽  
Vol 2 (2) ◽  
pp. 53-60
Author(s):  
Melky Rismando Damanik ◽  
Rusmauli Lumban Gaol
Keyword(s):  
Data Analysis ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Anxiety Level ◽  
Parental Anxiety ◽  
Subjective Experiences ◽  
High Anxiety ◽  
Specific Object ◽  
Anxiety Levels ◽  
The Individual

Anxiety is an unclear and widespread concern, associated with feelings of uncertainty and helplessness. This state of anxiety and emotion has no specific object but can affect behavior toward parents whose children are hospitalized. Parental anxiety levels are subjective experiences of the individual and can not be directly observed but consequently will affect the anxiety level of the parent. Hospitalization of children is a state of crisis in children, when children are sick and hospitalized, one of them in the febrile seizure disease is a seizure spasm that occurs in the rise in body temperature above 38 ° C this will result in anxiety level of parents increases. Goals: To know the description of anxiety level of parent to hospitalization of child with febrile seizure during child is treated in hospital of Elisabeth Elisabeth Medan. Method: The design used in this study is descriptive to describe the level of anxiety parents to hospitalization of children with febrile seizures during child care at Hospital Santa Elisabeth Medan Year 2017. Result: based on data collection found 10 respondents where 5 (50%) of respondents who experienced anxiety level in medium category and 5 (50%) respondents have low level anxiety level. Conclusion: Based on the research and data analysis that has been done in accordance with the objectives that have been determined can be concluded that all parents who care for their children in the hospital will experience anxiety level that is 5 respondents (50%) with moderate anxiety level, while 5 others (50% Low anxiety levels and high anxiety levels were not found.

scholarly journals ARE HEALTH EVENTS ASSOCIATED WITH PERSONALITY CHANGE? EVIDENCE FROM A 15 STUDY COORDINATED INTEGRATIVE DATA ANALYSIS

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 375-375
Author(s):  
E K Graham ◽  
S J Weston ◽  
A N Hall ◽  
Scott M Hofer ◽  
D K Mroczek
Keyword(s):  
Data Analysis ◽  
Personality Change ◽  
Integrative Data Analysis ◽  
Health Events

Searching for Sociability in the Stands: A Theory of Sports Spectating

1993 ◽  
Vol 7 (1) ◽  
pp. 44-60 ◽  
Author(s):  
Merrill J. Melnick
Keyword(s):  
Public Service ◽  
Intimate Relationships ◽  
Urban Structure ◽  
Social Forces ◽  
Social Psychological ◽  
The Social ◽  
Challenges And Opportunities ◽  
Interpersonal Competition ◽  
The Individual ◽  
Spectator Attendance

It is argued that the social forces of urbanization, individualism, interpersonal competition, technology, and geographical mobility have brought greater and greater numbers of strangers into people's everyday lives and have made the achievement of primary, social ties with relatives, friends, neighbors, and workmates more difficult. As a result, many are forced to satisfy their needs for sociability in less personal, less intimate, less private ways. It is proposed that sports spectating has emerged as a major urban structure where spectators come together not only to be entertained but to enrich their social psychological lives through the sociable, quasi-intimate relationships available. The changing nature of the sociability experience in America presents sport managers with interesting challenges and opportunities. A number of recommendations are offered for maximizing the gemeinschaft possibilities of sports spectating facilities. By giving greater attention to the individual and communal possibilities of their events, sport managers can increase spectator attendance while rendering an important public service.

Integrative Data Analysis and the Study of Global Health

2020 ◽  
pp. 121-158
Author(s):  
Andrea M. Hussong ◽  
Veronica T. Cole ◽  
Patrick J. Curran ◽  
Daniel J. Bauer ◽  
Nisha C. Gottfredson
Keyword(s):  
Data Analysis ◽  
Global Health ◽  
Integrative Data Analysis

scholarly journals Új célzott terápiás lehetőség az onkológiában: tropomiozin receptor-tirozin-kináz gátlók

2021 ◽  
Vol 162 (34) ◽  
pp. 1362-1369
Author(s):  
Edina Kiss ◽  
Zsuzsanna Pápai
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
First Generation ◽  
Kinase Inhibitor ◽  
Disease Free Survival ◽  
Diagnostic Methods ◽  
Molecular Diagnostic ◽  
Precision Oncology ◽  
Gene Fusions ◽  
Trk Inhibitors

Összefoglaló. A molekuláris diagnosztikai módszerek folyamatos fejlődésének köszönhetően egyre több onkogén genetikai eltérést azonosítanak. A neurotrofikus tropomiozin receptor-tirozin-kináz (NTRK-) génfúziók fontos precíziós onkológiai célpontok, melyek mindhárom NTRK-génben előfordulhatnak, onkogén-hajtóerőként viselkednek. A génfúziók különböző molekuláris diagnosztikai módszerekkel azonosíthatók, melyek közül a legpontosabb, legköltségesebb és legidőigényesebb meghatározást az újgenerációs szekvenálási technika jelenti. A tropomiozin receptor-tirozin-kináz (TRK-) fúziós fehérjék szelektív gátlása személyre szabott onkológiai kezelési lehetőséget jelent a tumor típusától, lokalizációjától és a beteg életkorától függetlenül. Az első generációs TRK-gátlók gyors, hatékony és tartós daganatellenes hatást biztosítanak kimutatott NTRK-fúzió-pozitív daganatok esetén, alacsony mellékhatásprofil mellett. Az első generációs TRK-gátlók mellett jelentkező ’on target’ rezisztenciát a második generációs TRK-gátlók oldják fel. Szekvenciális tirozin-kináz-inhibitor-kezeléssel tartós betegségmentes túlélés érhető el. Orv Hetil. 2021; 162(34): 1362–1369. Summary. Due to the continuous development of molecular diagnostic methods, more and more oncogenic genetic abnormalities are being identified. Neurotrophic tropomyosin receptor tyrosine kinase (NTRK) gene fusions are important precision oncology targets that can occur in all three NTRK genes and act as oncogenic drivers. Gene fusions can be identified by a variety of molecular diagnostic technologies, of which next-generation sequencing is the most accurate, costly and time-consuming determination. Selective inhibition of tropomyosin receptor tyrosine kinase (TRK) fusion proteins represents a personalized oncology treatment option regardless of tumour type, localization and patient age. First-generation TRK inhibitors provide rapid, efffective and long-lasting antitumor activity in NTRK fusion-positive tumors with a low side-effect profile. On target resistance to first-generation TRK inhibitors is resolved by second-generation TRK inhibitors. Durable disease-free survival can be achieved with sequential tyrosine kinase inhibitor therapies. Orv Hetil. 2021; 162(34): 1362–1369.

scholarly journals Data Analysis of Pile-free bike-sharing from Market Status to Operation Management Mode

2021 ◽  
Vol 251 ◽  
pp. 01052
Author(s):  
Jingyu Liang ◽  
Yiqing Zhu ◽  
Peixue Lin
Keyword(s):  
Data Analysis ◽  
Active Role ◽  
Urban Traffic ◽  
Management Mode ◽  
Future Research ◽  
Bike Sharing ◽  
Market Status ◽  
Subject Areas ◽  
The Individual ◽  
Operation And Management

Shared travel plays a more and more active role in the emergence of urban traffic, but there is no systematic and perfect combing and analysis on the study of bike-sharing without piles, especially on its operation and management mode. This paper will conduct a comprehensive data analysis on the research of bike-sharing without piles from the individual micro level and the enterprise government level, and explore the research focus and possible subject areas of future research.

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