scholarly journals Nonwoven Textiles from Hyaluronan for Wound Healing Applications

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 16
Author(s):  
Jolana Kubíčková ◽  
Tomáš Medek ◽  
Jarmila Husby ◽  
Jana Matonohová ◽  
Hana Vágnerová ◽  
...  
Keyword(s):  
Wound Healing ◽  
Moisture Absorption ◽  
High Capacity ◽  
Synthetic Polymers ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Fibre Structure ◽  
Monocyte Activation ◽  
Textile Technology ◽  
Nonwoven Textiles

Nonwoven textiles are used extensively in the field of medicine, including wound healing, but these textiles are mostly from conventional nondegradable materials, e.g., cotton or synthetic polymers such as polypropylene. Therefore, we aimed to develop nonwoven textiles from hyaluronan (HA), a biocompatible, biodegradable and nontoxic polysaccharide naturally present in the human body. For this purpose, we used a process based on wet spinning HA into a nonstationary coagulation bath combined with the wet-laid textile technology. The obtained HA nonwoven textiles are soft, flexible and paper like. Their mechanical properties, handling and hydration depend on the microscale fibre structure, which is tuneable by selected process parameters. Cell viability testing on two relevant cell lines (3T3, HaCaT) demonstrated that the textiles are not cytotoxic, while the monocyte activation test ruled out pyrogenicity. Biocompatibility, biodegradability and their high capacity for moisture absorption make HA nonwoven textiles a promising material for applications in the field of wound healing, both for topical and internal use. The beneficial effect of HA in the process of wound healing is well known and the form of a nonwoven textile should enable convenient handling and application to various types of wounds.

Effect of coagulation bath parameters on the morphology and absorption behavior of a skin–core filament based on biomedical polyurethane and native silk fibroin microparticles

2019 ◽  
Vol 90 (3-4) ◽  
pp. 460-468 ◽  
Author(s):  
Yan Zhuang ◽  
Han Wang ◽  
Linfeng Wang ◽  
Changjun Liu ◽  
Yuan Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Water Absorption ◽  
Silk Fibroin ◽  
Controlled Drug Release ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Electron Microscopy Analysis ◽  
Potential Applications ◽  
Spinning Process ◽  
Biomedical Polyurethane

This study investigates the effect of the constituents and temperature of a coagulation bath on the morphology and water absorption behavior of a skin–core filament, which has potential application in the field of controlled drug release, based on biomedical polyurethane (BPU) and native silk fibroin microparticles (NSFPs). BPU solution and BPU/NSFP blend solution were extruded from the cortex and core channel of a coaxial double injector into a coagulation bath with different constituents and at different temperatures to form filaments. Scanning electron microscopy analysis of the skin–core filament prepared by wet-spinning revealed that the addition of ethanol decreased the exchange speed between the solvent and non-solvent and led to the formation of micropores on the surface. Meanwhile, the interface between the cortex and core became pronounced and the water absorption capability of the filament decreased with increasing ethanol concentration in the coagulation bath. The high temperature of the coagulation bath also improved the exchange speed between the solvent and non-solvent; however, its effect on the morphology of the filament was weak. Thus, a skin–core filament with different morphologies and water absorption behaviors was fabricated by controlling the constituents and temperature of the coagulation bath during the wet-spinning process. This skin–core filament has potential applications in controlled drug release.

scholarly journals Preparation of CdTe/Alginate Textile Fibres with Controllable Fluorescence Emission through a Wet-Spinning Process and Application in the Trace Detection of Hg2+ Ions

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 570 ◽  
Author(s):  
Zhihui Zhao ◽  
Cunzhen Geng ◽  
Xihui Zhao ◽  
Zhixin Xue ◽  
Fengyu Quan ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Resonance Energy Transfer ◽  
Fluorescence Emission ◽  
Resonance Energy ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Trace Detection ◽  
Metallic Ions ◽  
Textile Fibres ◽  
Cdte Nanocrystals

Fluorescent textile fibres (FTFs) are widely used in many industrial fields. However, in addition to fibres with good fluorescence, fibres with excellent colour controllability, structural stability and appropriate mechanical strength still need to be developed. In this work, CdTe/alginate composite FTFs are prepared by taking advantage of the interactions between CdTe nanocrystals (NCs) and alginate macromolecules via a wet-spinning machine with a CaCl2 aqueous solution as the coagulation bath. CdTe NCs were chemically fixed in the fibre due to the interactions among surface ligands, macromolecules and coagulators (calcium ions), which ensured the excellent dispersity and good stability of the fibres. Förster resonance energy transfer (FRET) between NCs in the fibre was found to be restricted, which means that the emission colour of the fibres was totally controllable and could be predicted. Other properties of alginate fibres, such as flame retardance and mechanical strength, were also well preserved in the fluorescent fibres. Finally, FTFs showed good selectivity toward trace Hg2+ ions over other metallic ions, and the detection could be identified by the naked eye.

Preparation and Characterization of Alginate/Polyvinyl Alcohol Composite Fibers Containing Copper Ions

2013 ◽  
Vol 652-654 ◽  
pp. 1562-1565 ◽  
Author(s):  
Jing Guo ◽  
Qian He Chen ◽  
Yu Yan Zhang ◽  
Yu Mei Gong ◽  
Hong Zhang
Keyword(s):  
Tensile Strength ◽  
Polyvinyl Alcohol ◽  
Copper Ions ◽  
Fiber Surface ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Composite Fibers ◽  
Pseudoplastic Fluid ◽  
Cu Ions

Alginate/polyvinyl alcohol (PVA) composite fibers containing copper ions were prepared by wet spinning. The spinning solution and manufacturing process were researched. The composite fibers were characterized by Tensile Strength Tester, SEM and TGA. This report shows that the spinning solution is a typical kind of pseudoplastic fluid. Adding boric acid to coagulation bath and putting Cu ions into composite fibers can improve the strength. The structure of composite fibers with Cu ions is denser and there are grooves on the fiber surface. In addition, the thermal property of composite fibers is steady.

scholarly journals Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 389 ◽  
Author(s):  
Mónica C. Guadarrama-Acevedo ◽  
Raisa A. Mendoza-Flores ◽  
María L. Del Prado-Audelo ◽  
Zaida Urbán-Morlán ◽  
David M. Giraldo-Gomez ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Clinical Performance ◽  
Ex Vivo ◽  
High Capacity ◽  
Wound Dressings ◽  
In Vivo Studies ◽  
Potential Use

Non-biodegradable materials with a low swelling capacity and which are opaque and occlusive are the main problems associated with the clinical performance of some commercially available wound dressings. In this work, a novel biodegradable wound dressing was developed by means of alginate membrane and polycaprolactone nanoparticles loaded with curcumin for potential use in wound healing. Curcumin was employed as a model drug due to its important properties in wound healing, including antimicrobial, antifungal, and anti-inflammatory effects. To determine the potential use of wound dressing, in vitro, ex vivo, and in vivo studies were carried out. The novel membrane exhibited the diverse functional characteristics required to perform as a substitute for synthetic skin, such as a high capacity for swelling and adherence to the skin, evidence of pores to regulate the loss of transepidermal water, transparency for monitoring the wound, and drug-controlled release by the incorporation of nanoparticles. The incorporation of the nanocarriers aids the drug in permeating into different skin layers, solving the solubility problems of curcumin. The clinical application of this system would cover extensive areas of mixed first- and second-degree wounds, without the need for removal, thus decreasing the patient’s discomfort and the risk of altering the formation of the new epithelium.

Fabrication of the Colored PMIA Fibers by Wet Spinning: Effect of Spinning Parameters on the Coagulation Process

2014 ◽  
Vol 9 (1) ◽  
pp. 155892501400900
Author(s):  
Liqi Liu ◽  
Lei Chen ◽  
Zuming Hu ◽  
Junrong Yu ◽  
Jing-Zhu ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Aromatic Polyamide ◽  
Stretch Ratio ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Ultrasonic Oscillation ◽  
Coagulation Process ◽  
Polyamide Fiber ◽  
Spinning Process ◽  
Oscillation Method

The poly (m-phenylene isophthalamide) (PMIA) fiber, which can be prepared by wet spinning, is a kind of aromatic polyamide fiber. The spinning parameters could influence the performance and structure of the colored PMIA fiber such as the diffusion coefficient and coagulation bath. In this study, the PMIA spinning solutions doped with Color Inde purple 120 were first commixed in a pressurizer and then spun into a coagulation bath under a pressure about 0.3 MPa. In the coagulation bath, the pure or dope-dyed PMIA fibers were prepared by wet spinning at 323 K, and then the as-spun fibers were extracted by an ultrasonic oscillation method. The effects of jet stretch ratio, temperature, and concentration of the coagulation bath on the ratio of diffusion coefficient of solvent to coagulator were analyzed during the spinning process of dope-dyed PMIA fibers. The properties and structures of the colored PMIA fibers were characterized by SEM. Finally the most optimized spinning technology of the dope-dyed PMIA fiber was obtained and the dope-dyed PMIA fibers were successfully fabricated through wet spinning.

Preparation of R-BABP Polyimide Fibers via Wet Spinning of Polyamide Acid

2020 ◽  
Vol 869 ◽  
pp. 266-272
Author(s):  
Gleb Vaganov ◽  
Andrei Didenko ◽  
Elena Ivan’kova ◽  
Elena Popova ◽  
Vladimir Elokhovskii ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Ethylene Glycol ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Structure And Properties ◽  
Polyimide Fibers ◽  
Thermal Imidization ◽  
Morphology And Mechanical Properties

A polyamide acid (PAA) based on diamine 4,4'-bis (4-aminophenoxy) diphenyl and 1,3-bis (3',4-dicarboxyphenoxy) benzene dianhydride was synthesized. PAA fibers were obtained by wet spinning. Then, these fibers were converted into polyimide by thermal imidization. Dependence of the structure and properties of fibers on the die drawing and the composition of the coagulation bath was studied. It is shown that the composition of the coagulation bath has a significant effect on the morphology and mechanical properties of polyimide (PI) fibers. To obtain defect-free fibers, a coagulation bath consisting of ethylene glycol/ethanol at 50/50 vol. % was found to be optimal. An increase in the die drawing of fibers from 1 to 2 times leads to an increase in tensile strength and strain at break of the polyimide fibers.

Effect of DMSO/H2O coagulation bath on the structure and property of polyacrylonitrile fibers during wet-spinning

2007 ◽  
Vol 105 (3) ◽  
pp. 1221-1227 ◽  
Author(s):  
Xing-Guang Dong ◽  
Cheng-Guo Wang ◽  
Yu-Jun Bai ◽  
Wei-Wei Cao
Keyword(s):  
Coagulation Bath ◽  
Wet Spinning ◽  
Structure And Property

Polymer-Based Nanotherapeutics for Burn Wounds

2021 ◽  
Vol 22 ◽  
Author(s):  
Rewati Raman Ujjwal ◽  
Awesh Yadav ◽  
Shourya Tripathi ◽  
S.T.V. Sai Krishna
Keyword(s):  
Wound Healing ◽  
Research Effort ◽  
Synthetic Polymers ◽  
Wound Dressings ◽  
High Porosity ◽  
Natural Polymers ◽  
Burn Wound ◽  
Burn Treatment ◽  
Mortality And Morbidity ◽  
Burn Wounds

: Burn wounds are complex and intricate injuries that have become a common cause of trauma leading to significant mortality and morbidity every year. Dressings are applied to burn wounds with the aim of promoting wound healing, preventing burn infection and restoring skin function. The dressing protects the injury and contributes to recovery of dermal and epidermal tissues. Polymer-based nanotherapeutics are increasingly being exploited as burn wound dressings. Natural polymers such as cellulose, chitin, alginate, collagen, gelatin and synthetic polymers like poly (lactic-co-glycolic acid), polycaprolactone, polyethylene glycol, and polyvinyl alcohol are being obtained as nanofibers by nanotechnological approaches like electrospinning and have shown wound healing and re-epithelialization properties. Their biocompatibility, biodegradability, sound mechanical properties and unique structures provide optimal microenvironment for cell proliferation, differentiation, and migration contributing to burn wound healing. The polymeric nanofibers mimic collagen fibers present in extracellular matrix and their high porosity and surface area to volume ratio enable increased interaction and sustained release of therapeutics at the site of thermal injury. This review is an attempt to compile all recent advances in the use of polymer-based nanotherapeutics for burn wounds. The various natural and synthetic polymers used have been discussed comprehensively and approaches being employed have been reported. With immense research effort that is currently being invested in this field and development of proper characterization and regulatory framework, future progress in burn treatment is expected to occur. Moreover, appropriate preclinical and clinical research will provide evidence for the great potential that polymer-based nanotherapeutics hold in the management of burn wounds.

scholarly journals Temperature Effect of Water Coagulation Bath on Chitin Fiber Prepared through Wet-Spinning Process

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1909
Author(s):  
Khoa Dang Nguyen
Keyword(s):  
Phase Inversion ◽  
Room Temperature ◽  
Biomedical Application ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Crab Shell ◽  
Shell Waste ◽  
Different Temperatures ◽  
Spinning Process ◽  
Crab Shell Waste

Chitin was chemically extracted from crab shell waste and dissolved in N,N-dimethyl acetamine/5% lithium chloride (DMAc/5% LiCl) at room temperature to obtain 1% and 2% concentrations of chitin solution. Chitin fibers were prepared by phase inversion at different temperatures of water coagulation bath at 5, 20, and 60 °C. The deconvolution of FTIR spectra indicated that the area portion of the intermolecular hydrogen bonding NH…OC increased at 60 °C due to the higher density of the chitin segment in the fiber. As a result, scanning electron microscope (SEM) measurement suggests that a denser structure of the chitin fiber was observed when the temperature of the coagulation bath increased. In addition, the resultant chitin fibers generated better mechanical properties relative to the amount of chitin concentration and temperature. At 2% of chitin solution, the tensile strength significantly increased from 80 to 182 MPa for the fiber obtained at temperatures of 5 and 60 °C of the water coagulation bath, respectively. Meanwhile, the water content in the fiber significantly decreased from 1101% to 335%. This green synthesis route has high potential for the fabrication of the fiber as future material of interest for biomedical application.

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