PD-L1 Expression Correlated with p53 Expression in Pediatric Glioblastoma Multiforme
Keyword(s):
High-grade gliomas are infrequent in the pediatric population compared to adults, nevertheless, mortality and morbidity caused by malignant gliomas in this group of patients remain significant. PD-L1 and PD-1 Immune checkpoints (IC) molecules maintain immunological balance between activation and suppression. Eighteen patients with a histopathological diagnosis of pediatric glioblastoma multiforme (GBM, WHO IV) were studied. In total, PD-L1 expression was detected in 8 patients (44%). The molecular aspect of IC and immunotherapy targeted on PD-1/PD-L1 axis in pediatric population may be a promising adjuvant therapy in pediatric glioblastoma multiform treatment, however, this subject requires further investigation.
2017 ◽
Vol 43
(1)
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pp. 108-119
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2019 ◽
Vol 49
(5)
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pp. 1547-1554
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2002 ◽
Vol 20
(24)
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pp. 4684-4691
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