scholarly journals Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome

2021 ◽  
Vol 11 (9) ◽  
pp. 1223
Author(s):  
Florence Lai ◽  
Nathaniel D. Mercaldo ◽  
Cassandra M. Wang ◽  
Micaela S. Hersch ◽  
Giovi G. Hersch ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Alzheimer Disease ◽  
Age Of Onset ◽  
Disease Onset ◽  
Age Groups ◽  
Positive Association ◽  
Early Age ◽  
Thyroid Function Tests ◽  
Logistic Regression Models ◽  
Chi Squared

Adults with Down syndrome (DS) have an exceptionally high frequency of Alzheimer disease (AD) with a wide variability in onset, from 40 to 70 years of age. Equally prevalent in DS is hypothyroidism. In this study, we sought to quantify the relationship between the two. A total of 232 adults with DS and AD were stratified into three AD onset age groups: early (<47 years), typical (48–59), and late (>59). Among patients with available data, differences in the distributions of demographics, hypothyroidism variables (presence, age of onset), thyroid function tests, thyroid autoantibodies, and APOE genotypes were assessed (e.g., chi-squared, Mann–Whitney tests). Spearman and partial Spearman correlations and ordinal logistic regression models were constructed to quantify the association between ages of AD and hypothyroidism onset with and without covariate adjustments. We observed a positive association between the ages of AD and hypothyroidism onset after accounting for APOE-Ɛ4 (correlation: 0.44, 0.24, 0.60; odds ratio: 1.09, 1.05–1.14). However, an early age of hypothyroidism onset and the presence of the APOE-Ɛ4 allele were independently associated with the early age of AD onset. Similar findings were observed when accounting for other factors. Our study provides evidence for the importance of hypothyroidism and associated pathological mechanisms for risk of AD in DS.

scholarly journals Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden

2016 ◽  
Vol 43 (10) ◽  
pp. 1777-1786 ◽  
Author(s):  
Amir I. Elshafie ◽  
Abdalla D. Elkhalifa ◽  
Sahwa Elbagir ◽  
Mawahib I.E. Aledrissy ◽  
Elnour M. Elagib ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Age Of Onset ◽  
Disease Onset ◽  
Age Groups ◽  
Central Africa ◽  
Immunoglobulin M ◽  
Laboratory Findings ◽  
American College Of Rheumatology ◽  
Highly Active ◽  
Higher Doses

Objective.To compare clinical characteristics and treatment between simultaneously investigated Sudanese and Swedish outpatients with rheumatoid arthritis (RA).Methods.Outpatients with RA from Sudan (n = 281) and Sweden (n = 542) diagnosed according to the 1987 American College of Rheumatology criteria were recruited between December 2008 and September 2010 and compared concerning clinical presentation, treatment, and laboratory findings, including immunoglobulin M with rheumatoid factor (IgM-RF).Results.Sudanese patients had lower inclusion age (median 49 vs 68 yrs), disease duration (48 vs 107 mos), and disease onset age (43 vs 56 yrs) as compared with Swedish patients (p < 0.0001 for all). When stratified concerning the age of inclusion, Swedish patients between 41–50 years had, however, a significantly lower age of onset, with a similar trend for all age groups above 30 years. The female preponderance was higher among Sudanese patients (89.3% vs 72.5%, p < 0.0001), and smoking was nonexistent among Sudanese female patients (p < 0.0001). Erythrocyte sedimentation rate levels and number of tender joints were significantly higher among Sudanese patients. The proportion of IgM-RF positivity was lower among Sudanese patients with RA (52.4% vs 75.5%, p < 0.0001). Higher proportions of Sudanese patients with RA were treated with methotrexate (MTX) and disease-modifying antirheumatic drug combinations, but none of them used biologics. Sudanese patients used lower doses of MTX and sulfasalazine (p < 0.0001) and higher doses of prednisolone (p < 0.0001) than Swedish patients.Conclusion.Sudanese patients with RA have significantly higher disease activity and are often IgM-RF–seronegative. Together with reports from Uganda and Cameroon, our data indicate a cluster of highly active and often seronegative RA in central Africa.

scholarly journals EVALUATION OF THYROID DISORDERS IN SUDANESE PATIENTS WITH DOWN SYNDROME

2020 ◽  
Vol 8 (12) ◽  
pp. 24-29
Author(s):  
Ayman FatahAlrahman ◽  
A. Babiker ◽  
Mosab .O. Khalid ◽  
Haghamad Allzain Allzain
Keyword(s):  
Down Syndrome ◽  
Significant Variation ◽  
Age Groups ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Thyroid Disorders ◽  
Thyroid Function Tests ◽  
Insignificant Difference ◽  
And Control

Down syndrome is the most common life compatible chromosomal disorder responsible for the majority of mental retardation and deaths in infancy and childhood. The current study intended to evaluate the thyroid disorders in Sudanese patients with Down syndrome by assessment of thyroid function tests (T3, T4 & TSH) . It was descriptive case control study, carried out in Khartoum, the capital of Sudan, from March to July 2018. It included fifty (50) participants, thirty (30) of them as case group with Down syndrome and twenty (20) normal healthy subjects as control group. Their ages ranged from seven (7) to twenty eight (28) years. The study findings showed significant variation in TSH level with mean  (2.66   ), (1.67 ) in case and control group respectively with P. value (0.001). There was also significant variation when compared children and adults mean TSH level (1.88   ),(2.59 ) with P. value of (0.03). There was insignificant differences in T3 level with mean  SD(1.04 .32),(1.11 ) between case and control group respectively with P. value of (0.08) . There was also insignificant difference in T4 level with mean  (6.09 ),(6.40 ) in case and control group respectively with P. value of (0.7). There were also insignificant differences in T4 and T3 levels between the age groups. As regard to the gender of the patients, there were insignificant differences of TSH, T4, and T3

scholarly journals An Intron 7 Polymorphism inAPPAffects the Age of Onset of Dementia in Down Syndrome

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Emma L. Jones ◽  
Clive G. Ballard ◽  
Vee P. Prasher ◽  
Matthew Arno ◽  
Stephen Tyrer ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amyloid Precursor Protein ◽  
Age Of Onset ◽  
Early Age ◽  
Tetranucleotide Repeat ◽  
Repeat Allele ◽  
Novel Treatment ◽  
Exciting Opportunity ◽  
Preliminary Study ◽  
The Impact

People with Down syndrome (DS) develop Alzheimer's disease (AD) with an early age of onset. A tetranucleotide repeat, attt5−8, in intron 7 of the amyloid precursor protein has been associated with the age of onset of AD in DS in a preliminary study. The authors examine the impact of this polymorphism in a larger cohort of individuals with DS. Adults with DS were genotyped for attt5−8andAPOE. The results were analysed with respect to the age of onset of dementia. The presence of three copies of the six-repeat allele resulted in onset of dementia seven years earlier than in the presence of other genotypes. Further study is essential to elucidate the mechanism by which this polymorphism functions, with an exciting opportunity to identify novel treatment targets relevant for people with DS and AD.

scholarly journals Pediatric household transmission of SARS-CoV-2 infection

2021 ◽  
Author(s):  
Lauren A Paul ◽  
Nick Daneman ◽  
Kevin L Schwartz ◽  
Michelle Science ◽  
Kevin A Brown ◽  
...  
Keyword(s):  
Index Case ◽  
Disease Onset ◽  
Age Groups ◽  
Algorithm Analysis ◽  
Sensitivity Analyses ◽  
Older Children ◽  
Secondary Transmission ◽  
Logistic Regression Models ◽  
Household Transmission ◽  
Index Cases

BACKGROUND: As a result of low numbers of pediatric cases early in the COVID-19 pandemic, pediatric household transmission of SARS-CoV-2 remains an understudied topic. This study sought to determine whether there are differences in the odds of household transmission for younger children compared to older children. METHODS: We assembled a cohort of all individuals in Ontario, Canada with laboratory-confirmed SARS-CoV-2 infection between June 1 and December 31, 2020. The cohort was restricted to individuals residing in private households (N=132,232 cases in 89,191 households), identified through an address matching algorithm. Analysis focused on households in which the index case was aged <18 years. Logistic regression models were fit to estimate the association between age group of pediatric index cases (0-3, 4-8, 9-13, and 14-17 years) and odds of household transmission. RESULTS: A total of 6,280 households had pediatric index cases, and 1,717 (27.3%) experienced secondary transmission. Children aged 0-3 years had the highest odds of household transmission compared to children aged 14-17 years (model adjusted for gender, month of disease onset, testing delay, and average family size: 1.43, 95% CI: 1.17-1.75). This association was similarly observed in sensitivity analyses defining secondary cases as 2-14 days or 4-14 days after the index case, and stratified analyses by presence of symptoms, association with a school/childcare outbreak, or school/childcare reopening. Children aged 4-8 years and 9-13 years also had increased odds of transmission (4-8: 1.40, 95% CI: 1.18-1.67; 9-13: 1.13, 95% CI: 0.97-1.32). CONCLUSIONS: This study suggests that younger children are more likely to transmit SARS-CoV-2 infection compared to older children, and the highest odds of transmission was observed for children aged 0-3 years. Differential infectivity of pediatric age groups has implications for infection prevention controls within households, as well as schools/childcare, to minimize risk of household secondary transmission.

scholarly journals Smoking, distress and COVID-19 in England: cross-sectional population surveys from 2016 to 2020

2020 ◽  
Author(s):  
Loren Kock ◽  
Lion Shahab ◽  
Jamie Brown ◽  
Graham Moore ◽  
Marie Horton ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Regression Models ◽  
Mental Health Problems ◽  
Middle Age ◽  
Age Groups ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Time Period ◽  
Chi Squared ◽  
Logistic Regressions

Background: Changes in the prevalence of mental health problems among smokers due to the COVID-19 pandemic in England have important implications for existing health inequalities. This study examined the prevalence of psychological distress among smokers following the onset of the pandemic compared with previous years. Methods: Cross-sectional data were used from a representative survey of smokers (18+) in England (n = 2,927) during four months (April to July) in 2016, 2017 and 2020. Adjusted logistic regressions estimated the associations between past-month psychological distress across two time periods (2016/17 and 2020), and age. Weighted proportions, chi-squared statistics and stratified logistic regression models were used to compare the distributions of minimal, moderate and severe distress, respectively, within socio-demographic and smoking characteristic categories in 2016/17 and 2020. Results: The prevalence of moderate and severe distress among past-year smokers was higher in 2020 (moderate: 28.79%, 95%CI 26.11-31.60; OR=2.08, 95%CI 1.34-3.25; severe: 11.04%, 9.30-13.12; OR=2.16, 1.13-4.07) than in 2016/17 (moderate: 20.66%, 19.02-22.43; severe: 8.23%, 7.16-9.47). While there was no overall evidence of an interaction between time period and age, young (16-24 years) and middle-age groups (45-54 years) may have experienced greater increases in moderate and older age groups (65+ years) in severe distress from 2016/17 to 2020. There were also increases in 2020 of moderate distress among those from more disadvantaged social grades and of both moderate and severe distress among women and those with low cigarette addiction. Conclusions: Between April-July 2016/17 and April-July 2020 in England there were increases in both moderate and severe distress among smokers. The distribution of distress differed between 2016/17 and 2020 and represents a widening of established inequalities, with increases in distress among socio-economically disadvantaged groups, women and diverging age groups.

Development of new predictive equations for basal metabolic rate in Iranian healthy adults: negligible effect of sex

2020 ◽  
pp. 1-10
Author(s):  
Bahareh Nikooyeh ◽  
Nastaran Shariatzadeh ◽  
Ali Kalayi ◽  
Maliheh Zahedirad ◽  
Tirang R. Neyestani
Keyword(s):  
Metabolic Rate ◽  
Thyroid Function ◽  
Basal Metabolic Rate ◽  
Age Groups ◽  
Thyroid Function Tests ◽  
Anthropometric Measures ◽  
Predictive Equations ◽  
Normal Thyroid Function ◽  
Asian People ◽  
Predictive Formulas

Abstract. Some studies have reported inaccuracy of predicting basal metabolic rate (BMR) by using common equations for Asian people. Thus, this study was undertaken to develop new predictive equations for the Iranian community and also to compare their accuracy with the commonly used formulas. Anthropometric measures and thyroid function were evaluated for 267 healthy subjects (18–60 y). Indirect calorimetry (InCal) was performed only for those participants with normal thyroid function tests (n = 252). Comparison of predicted RMR (both kcal/d and kcal.kg.wt−1.d−1) using current predictive formulas and measured RMR revealed that Harris-Benedict and FAO/WHO/UNU significantly over-estimated and Mifflin-St. Jeor significantly under-estimated RMR as compared to InCal measurements. In stepwise regression analysis for developing new equations, the highest r2 (=0.89) was from a model comprising sex, height and weight. However, further analyses revealed that unlike the subjects under 30 y, the association between age and the measured RMR in subjects 30 y and plus was negative (r = −0.241, p = 0.001). As a result, two separate equations were developed for these two age groups. Over 80 percent of variations were covered by the new equations. In conclusion, there were statistical significant under- and over-estimation of RMR using common predictive equations in our subjects. Using the new equations, the accuracy of the calculated RMR increased remarkably.

The Physician’s Task and the Problem of Documentation

1964 ◽  
Vol 03 (01) ◽  
pp. 11-19 ◽  
Author(s):  
A. Proppe
Keyword(s):  
Statistical Evaluation ◽  
Age Groups ◽  
Diagnostic Methods ◽  
Early Age ◽  
Case Histories ◽  
Lupus Vulgaris ◽  
Pathological Conditions ◽  
Clinical Methods ◽  
Corpus Hippocraticum ◽  
High Degree

SummaryCase histories suitable for statistical evaluation can be found even as far back as in the Corpus Hippocraticum. Such simple data as the patient’s age, body weight, size, the date of menarche, etc. are practically always included in the case records, and it is demonstrated that, when such data are recorded in a system of documentation suitable for mechanical sorting, it may enable us to draw conclusions of very great importance. Mechanical registration methods have revealed that, in the determination and recording of data as hitherto carried out. there has been a surprisingly large number of errors and a high degree of unreliability. This view has a considerable influence on modern clinical methods; it renders a more democratic relation between physician and patient necessary and makes clear the need for measures to enhance the reliability of diagnosis and treatment of pathological conditions. The author illustrates this view with reference to the mechanical falsification of the thesis of the proneness of early age groups to lupus vulgaris, furthermore with reference to the mechanical rationalization of modern routine diagnostic methods, to the constant surveillance of adverse effects on public health and to the protection against allergic reactions with the aid of recording systems of personal allergy and intolerance data with mechanical sorting and computer techniques.

scholarly journals Five reasons COVID-19 is less severe in younger age groups

2020 ◽  
Author(s):  
Paul W Turke
Keyword(s):  
Life History ◽  
Life History Theory ◽  
Age Of Onset ◽  
Age Groups ◽  
Medical Community ◽  
System Function ◽  
The Third ◽  
Immune System Function ◽  
Age Related ◽  
Younger Age

Abstract The severity of COVID-19 is age-related, with the advantage going to younger age groups. Five reasons are presented. The first two are well-known, are being actively researched by the broader medical community, and therefore are discussed only briefly here. The third, fourth, and fifth reasons derive from evolutionary life history theory, and potentially fill gaps in current understanding of why and how young and old age groups respond differently to infection with SARS-CoV-2. Age of onset of generalized somatic aging, and the timing of its progression, are identified as important causes of these disparities, as are specific antagonistic pleiotropic tradeoffs in immune system function.

Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint

Lupus ◽  
2021 ◽  
pp. 096120332110142
Author(s):  
Tamer A Gheita ◽  
Rasha Abdel Noor ◽  
Esam Abualfadl ◽  
Osama S Abousehly ◽  
Iman I El-Gazzar ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Age Of Onset ◽  
Wide Spectrum ◽  
Age At Onset ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Population Based ◽  
Systemic Lupus ◽  
Cross Sectional

Objective The aim of this study was to present the epidemiology, clinical manifestations and treatment pattern of systemic lupus erythematosus (SLE) in Egyptian patients over the country and compare the findings to large cohorts worldwide. Objectives were extended to focus on the age at onset and gender driven influence on the disease characteristics. Patients and method This population-based, multicenter, cross-sectional study included 3661 adult SLE patients from Egyptian rheumatology departments across the nation. Demographic, clinical, and therapeutic data were assessed for all patients. Results The study included 3661 patients; 3296 females and 365 males (9.03:1) and the median age was 30 years (17–79 years), disease duration 4 years (0–75 years) while the median age at disease onset was 25 years (4–75 years). The overall estimated prevalence of adult SLE in Egypt was 6.1/100,000 population (1.2/100,000 males and 11.3/100,000 females).There were 316 (8.6%) juvenile-onset (Jo-SLE) and 3345 adult-onset (Ao-SLE). Age at onset was highest in South and lowest in Cairo (p < 0.0001). Conclusion SLE in Egypt had a wide variety of clinical and immunological manifestations, with some similarities with that in other nations and differences within the same country. The clinical characteristics, autoantibodies and comorbidities are comparable between Ao-SLE and Jo-SLE. The frequency of various clinical and immunological manifestations varied between gender. Additional studies are needed to determine the underlying factors contributing to gender and age of onset differences.

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