Novel Prognostic Immunohistochemical Markers in Uveal Melanoma-Literature Review

Uveal melanoma is the most common primary intraocular neoplasm in adults. As there are currently no effective methods of treating the disease in the metastatic stage, there is a need to search for new prognostic factors that would enable a reliable assessment of the patient’s condition and constitute a possible therapeutic target. In this review, we have prepared the results of English-language studies on new prognostic factors determined with immunohistochemical methods. We found 64 articles in which the expression of various proteins was associated in a statistically significant manner with the histopathological and clinical prognostic factors identified by AJCC. The results of our work clearly show that the biology of uveal melanoma is extraordinarily complex. Numerous studies have shed new light on the complexity of the processes involved in the development of this cancer. Moreover, a careful analysis of the expression of individual proteins may allow the identification of homogeneous groups of patients requiring different treatment regimens.

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Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

Cancers ◽

10.3390/cancers13133142 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3142

Author(s):

Alissa Groenendijk ◽

Filippo Spreafico ◽

Ronald R. de Krijger ◽

Jarno Drost ◽

Jesper Brok ◽

...

Keyword(s):

Prognostic Factors ◽

Tumor Recurrence ◽

Wilms Tumor ◽

Clinicopathological Characteristics ◽

Copy Number Variations ◽

First Line ◽

Prognostic Variables ◽

Treatment Regimens ◽

International Collaborations ◽

Patients Experience

In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%. However, overall, 15% of patients experience tumor recurrence. The adverse prognostic factors currently used for risk stratification (advanced stage, high risk histology, and combined loss of heterozygosity at 1p and 16q in chemotherapy-naïve WTs) are present in only one third of these cases, and the significance of these factors is prone to change with advancing knowledge and improved treatment regimens. Therefore, we present a comprehensive, updated overview of the published prognostic variables for WT recurrence, ranging from patient-, tumor- and treatment-related characteristics to geographic and socioeconomic factors. Improved first-line treatment regimens based on clinicopathological characteristics and advancing knowledge on copy number variations unveil the importance of further investigating the significance of biological markers for WT recurrence in international collaborations.

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“Twenty Years of Studies in Sport Humanities – a Look at the Journal’s Archival Issues”

Studies in Sport Humanities ◽

10.5604/01.3001.0014.8904 ◽

2021 ◽

Vol 28 ◽

pp. 7-12

Author(s):

Joanna Basiaga-Pasternak ◽

Jan Blecharz

Keyword(s):

English Language ◽

Present Form ◽

International Studies ◽

Language Studies

In the text, it is shows how the journal – Studia Humanistyczne [Eng. Humanistic Studies] has changed, initially published as Zeszyty Naukowe [Eng. Scientifi c Notebooks], then as an independent periodical, to fi nally assume the form of the English-language Studies in Sport Humanities. The stages of the Journal’s operation, managed by successive Editors-in-Chief, were presented. It was showed who comprised the Editorial Board and what modifi cations the Journal underwent to fi nally take the present form of international Studies in Sport Humanities.

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Factors Which Facilitate or Impede Interpersonal Interactions and Relationships after Spinal Cord Injury: A Scoping Review with Suggestions for Rehabilitation

Rehabilitation Research and Practice ◽

10.1155/2016/9373786 ◽

2016 ◽

Vol 2016 ◽

pp. 1-13 ◽

Cited By ~ 2

Author(s):

Delena Amsters ◽

Sarita Schuurs ◽

Kiley Pershouse ◽

Bettina Power ◽

Yvonne Harestad ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Scoping Review ◽

English Language ◽

International Classification Of Functioning ◽

Interpersonal Interactions ◽

Self Image ◽

Language Studies ◽

Cord Injury ◽

Review Question

Interpersonal interactions and relationships can influence an individual’s perceptions of health and quality of life in the presence of disability. In the case of people with spinal cord injury (SCI), positive interpersonal interactions and relationships have been shown to contribute to resilience and adaptability. Understanding factors which facilitate or impede the development and maintenance of relationships after SCI may form the basis for proactive relationship support for people with SCI. To gain a broad insight into these factors, a scoping review was undertaken. Databases were searched for English language studies published between 2000 and 2015 that informed the review question. Sixty-two (62) studies were identified. Thematic analysis was conducted on data extracted from the studies and 51 factors which may facilitate relationships and 38 factors which may impede relationships after SCI were noted. The majority of factors could be categorized as environmental or personal according to the domains of the International Classification of Functioning, Disability, and Health (ICF). The facilitating factors included partner and social support, reciprocity in relationships, and presenting oneself positively. Impeding factors included physical environmental barriers, real and perceived social biases, and poor self-image. Factors identified may inform the provision of supportive, holistic rehabilitation for people with SCI.

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Fathers’ Views and Experiences of Creating a Smoke-Free Home: A Scoping Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16245164 ◽

2019 ◽

Vol 16 (24) ◽

pp. 5164 ◽

Cited By ~ 5

Author(s):

Rachel O’Donnell ◽

Kathryn Angus ◽

Peter McCulloch ◽

Amanda Amos ◽

Lorraine Greaves ◽

...

Keyword(s):

Gender Equity ◽

Scoping Review ◽

English Language ◽

Second Hand Smoke ◽

Language Studies ◽

Shs Exposure ◽

Gender Power ◽

Attitudes And Knowledge ◽

Successes And Challenges ◽

Children’S Exposure

Enabling parents to create a smoke-free home is one of the key ways that children’s exposure to second-hand smoke (SHS) can be reduced. Smoke-free home interventions have largely targeted mothers who smoke, and there is little understanding of the barriers and facilitators that fathers experience in creating a smoke-free home. Systematic searches combining terms for fathers, homes, and SHS exposure were run in April 2019 in Web of Science’s Citation Indices, PsycINFO, and PubMed for English-language studies published since 2008. The searches identified 980 records for screening, plus 66 records from other sources. Twelve studies reported in 13 papers were included in this scoping review. Eight of the studies were conducted in Asian countries (five in China, one in India, one in Japan, and one in Iran), three were conducted in Canada, and one in Turkey. Findings were extracted in verbatim text for thematic analysis. The review identified that attitudes and knowledge, cultural and social norms, gender power relations, and shifting perceptions and responsibilities related to fatherhood can impact on fathers’ views of their role in relation to creating and maintaining a smoke-free home. There were too few published studies that had assessed smoke-free home interventions with fathers to draw conclusions regarding effective approaches. Research is clearly needed to inform our understanding of fathers’ roles, successes and challenges in creating and maintaining a smoke-free home, so that father-inclusive rather than mother-led interventions can be developed to benefit entire households and improve gender equity as well as health.

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Prognostic Factors and Decision Tree for Long-Term Survival in Metastatic Uveal Melanoma

Cancer Research and Treatment ◽

10.4143/crt.2017.171 ◽

2018 ◽

Vol 50 (4) ◽

pp. 1130-1139 ◽

Cited By ~ 2

Author(s):

Daniel Lorenzo ◽

María Ochoa ◽

Josep Maria Piulats ◽

Cristina Gutiérrez ◽

Luis Arias ◽

...

Keyword(s):

Prognostic Factors ◽

Decision Tree ◽

Uveal Melanoma ◽

Term Survival ◽

Long Term Survival

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Health Beneficial Effects of Moomiaii in Traditional Medicine

Galen Medical Journal ◽

10.31661/gmj.v9i0.1743 ◽

2020 ◽

Vol 9 ◽

pp. 1743

Author(s):

Solmaz Rahmani Barouji ◽

Amir Saber ◽

Mohammadali Torbati ◽

Seyyed Mohammad Bagher Fazljou ◽

Ahmad Yari Khosroushahi

Keyword(s):

Traditional Medicine ◽

English Language ◽

Modern Medicine ◽

In Vivo Studies ◽

Beneficial Effects ◽

Anticancer Properties ◽

Language Studies ◽

Health Complications

raditional medicine (TM) that developed over the years within various societies consists of medical experimental knowledge and practices, which apply natural methods and compounds for general wellness and healing. Moomiaii as a pale-brown to blackish-brown natural exudate is one of the natural compounds in traditional medicine that has been used over 3000 years in many countries of the world especially in India, China, Russia, Iran, Mongolia, Kazakhstan and Kirgizstan. We reviewed all English-language studies about Moomiaii that we accessed them. In traditional medicine, many beneficial activities have been attributed to Moomiaii and to its main constituents, Humic acid and Fulvic acid, which are widely used to prevent and treatment of different diseases. Some modern scientific investigations showed that Moomiaii as a safe dietary supplement can be beneficial in various health complications. Even though the beneficial effects of Moomiaii have been confirmed in traditional and modern medicine, it seems that additional in-vitro/in-vivo studies and comprehensive clinical trials are necessary to explain the whole mechanisms of action and to determine the effective doses in various diseases. We discuss and clarify the claimed health beneficial effects of Moomiaii in some wide-spread diseases regarding its anti-ulcerogenic, immunomodulatory, antidiabetic, antioxidative and anticancer properties. [GMJ.2020;9:e1743]

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Lexical and semantic errors in the English language teaching in homogenious groups

Bulletin of the Karaganda University. Pedagogy series ◽

10.31489/2021ped2/141-149 ◽

2021 ◽

Vol 102 (2) ◽

pp. 141-149

Author(s):

G. Akhmetova ◽

◽

A. Bizhkenova ◽

Keyword(s):

English Language ◽

Language Teaching ◽

English Language Teaching ◽

Word Choice ◽

Homogeneous Groups ◽

Efl Learners ◽

Efl Teacher ◽

Semantic Errors ◽

Lexical Competence ◽

Incorrect Usage

The present research paper discusses the issues of identifying common lexical and semantic mistakes in Kazakh pre-intermediate EFL learners studying in homogeneous groups at university. Words are viewed as powerful tools and when used correctly, words may evoke different feelings and emotions and cause various actions. It’s important to learn how to spot difficult words, correct them timely, and master lexical competence teaching to use the words correctly. The data of the study were collected by learner’s EFL teacher from their final essays. Thirty-one essays were used as the instrument of the study to obtain real language from the participants. The authors of the study hope that the results of the conducted research would contribute to the understanding of the phenomenon of lexical and semantic errors in English language teaching which will help teachers to elaborate the differentiated tasks and ways of explaining new vocabulary preventing students’ misunderstanding. Furthermore, the results of the presented research can serve as guidance and be used in compiling EFL textbooks for Kazakhstani students. As a result, researchers managed to classify lexical and semantic errors in English language teaching, identified frequent errors, and described their causes. The findings of the research illustrate that the participants of the study make errors of word choice and incorrect collocations the most. Moreover, incorrect usage of the preposition and literal translation from L1 are included in the frequent mistakes

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Language in the Workplace Project and Workplace Communication for Skilled Migrants course at Victoria University of Wellington, New Zealand

10.26686/wgtn.12749651 ◽

2020 ◽

Author(s):

J de Bres ◽

J Holmes ◽

Angela Joe ◽

Meredith Marra ◽

Jonathan Newton ◽

...

Keyword(s):

New Zealand ◽

English Language ◽

Applied Linguistics ◽

Research Unit ◽

Deaf Studies ◽

Ongoing Research ◽

Language Studies ◽

Language Courses ◽

Set Up ◽

English Language Institute

The School of Linguistics and Applied Language Studies (LALS) at Victoria University of Wellington conducts research and teaching in Linguistics, Applied Linguistics, Writing and Deaf Studies. It incorporates a Deaf Studies Research Unit, which undertakes research on topics relating to deaf people and their language in New Zealand, and the New Zealand Dictionary Centre, set up in partnership with Oxford University Press, which provides a base for research into New Zealand lexicography and aspects of language in New Zealand. It also incorporates an English Language Institute, which specialises in teaching English language courses and teacher education programmes. A particular strength of the School's makeup is the opportunity to engage in research which benefits and is benefited by both theoretical and practical approaches to issues in linguistics and applied linguistics. This report describes one of a number of examples of the productive integration of language teaching and language research at LALS. We describe an ongoing research project that has developed organically over the past twelve years. The research involved first collecting and analysing authentic workplace interaction between native speakers, and then making use of it in explicit instruction aimed at developing socio-pragmatic proficiency in the workplace among skilled migrants with English as an Additional Language (EAL). We are now engaged in evaluating the results of the instruction, not only in the classroom, but also in workplaces where the migrants have been placed as interns.

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Development Factors of Region’s Foreign Economic Activity in the Context of Global Challenges

Economy of region ◽

10.17059/ekon.reg.2021-2-24 ◽

2021 ◽

Vol 17 (2) ◽

pp. 688-712

Author(s):

Yuliya G. Lavrikova ◽

Elena L. Andreeva ◽

Artem V. Ratner

Keyword(s):

Economic Activity ◽

English Language ◽

Energy Transition ◽

Business Community ◽

Homogeneous Groups ◽

Global Challenges ◽

Country Factors ◽

Federal Districts ◽

Production Technologies ◽

Organisational Factors

New global challenges such as COVID-19 pandemic, strengthening of protectionism, production technologies development, digitalisation and energy transition, require reinterpretation of regions’ foreign economic activity (FEA). In this context, the research aims to identify and classify development factors of such activity in regions described in the international scientific literature. We analysed works obtained from international (Scopus and Web of Science) and Russian (Elibrary.ru, journal websites) databases using the search terms “regional foreign economic activity”, “regional export”, “global challenges”, “export support”, “foreign investments”, etc. 143 Russian- and English-language articles and books published in the period 1980–2021 were chosen. Selected works, focused on Russian federal districts and regions, as well as advanced and emerging countries, describe various approaches to examining the specificity and development patterns of world regions. Based on the data, we performed structural analysis of foreign economic activity factors using the method of multi-parameter classification. The revealed factors were compared and divided into homogeneous groups with multilevel structures (macro-groups — groups — subgroups — individual factors). After analysing the variety of approaches, we identified five macro-groups of factors: 1) global challenges and partner country factors; 2) resource, industrial, transport and infrastructure potential; 3) organisational factors (finances, specialists’ skills, business community); 4) investment, innovation and image potential; 5) state support of foreign economic activity. The proposed classification considers the development of global, national, regional entities, as well as FEA participants and individuals, taking into account both direct and indirect factors. The research findings can be used for developing short-, medium- and long-term approaches, models and forecasts of regions’ foreign economic activity.

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