scholarly journals Interventional Radiology Image-Guided Locoregional Therapies (LRTs) and Immunotherapy for the Treatment of HCC

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5797
Author(s):  
Pierpaolo Biondetti ◽  
Lorenzo Saggiante ◽  
Anna Maria Ierardi ◽  
Massimo Iavarone ◽  
Angelo Sangiovanni ◽  
...  
Keyword(s):  
Tumor Recurrence ◽  
Immune Status ◽  
The Other ◽  
Current Status ◽  
Antitumor Response ◽  
Image Guided ◽  
Locoregional Therapies ◽  
The One ◽  
Synergistic Relationship ◽  
Radiology Image

Image-guided locoregional therapies (LRTs) are a crucial asset in the treatment of hepatocellular carcinoma (HCC), which has proven to be characterized by an impaired antitumor immune status. LRTs not only directly destroy tumor cells but also have an immunomodulating role, altering the tumor microenvironment with potential systemic effects. Nevertheless, the immune activation against HCC induced by LRTs is not strong enough on its own to generate a systemic significant antitumor response, and it is incapable of preventing tumor recurrence. Currently, there is great interest in the possibility of combining LRTs with immunotherapy for HCC, as this combination may result in a mutually beneficial and synergistic relationship. On the one hand, immunotherapy could amplify and prolong the antitumoral immune response of LRTs, reducing recurrence cases and improving outcome. On the other hand, LTRs counteract the typical immunosuppressive HCC microenvironment and status and could therefore enhance the efficacy of immunotherapy. Here, after reviewing the current therapeutic options for HCC, we focus on LRTs, describing for each of them the technique and data on its effect on the immune system. Then, we describe the current status of immunotherapy and finally report the recently published and ongoing clinical studies testing this combination.

From ERP to Enterprise Service-Oriented Architecture

2011 ◽  
pp. 169-180
Author(s):  
Valentin Nicolescu ◽  
Holger Wittges ◽  
Helmut Krcmar
Keyword(s):  
Historical Development ◽  
Service Oriented Architecture ◽  
The Other ◽  
Current Status ◽  
Enterprise Software ◽  
Erp System ◽  
Modern Enterprise ◽  
Flexible Architecture ◽  
Service Oriented ◽  
The One

This chapter provides an overview of past and present development in technical platforms of ERP systems and its use in enterprises. Taking into consideration the two layers of application and technology, we present the classical scenario of an ERP system as a monolithic application block. As the demands of modern enterprise software cannot be met by this concept, the shift to a more flexible architecture like the service-oriented architecture (SOA) is the current status quo of modern companies. Keeping in mind the administrative complexity of such structures, we will discuss the new idea of business Webs. The purpose of our chapter is, on the one hand, to show the historical development of ERP system landscapes and, on the other hand, to show the comparison of the presented concepts with respect to application and technology view.

Empathy and Personality in Dentistry

Diogenes ◽  
2020 ◽  
Vol 28 (1) ◽  
Author(s):  
Borislav Vasilev ◽  
◽  
◽  
Keyword(s):  
Communication Skills ◽  
The Other ◽  
Current Status ◽  
Active Listening ◽  
Dental Practice ◽  
Good Communication ◽  
Successful Communication ◽  
Personal Qualities ◽  
The One ◽  
Empathic Process

The connection between empathy and communication on the dental practice is two-sided: on the one hand, empathy requires good communication skills (active listening, imagination, rich vocabulary) to be properly sensed and communicated to the other party in communication. Successful transmission of empathy is as important as the feeling itself. On the other hand, having empathy can greatly help the successful communication and transmission of the desired information by the sender. Through empathy, the sender can understand the current status of the addressee and thus convey the message more correctly. So it turns out that empathy alone is hardly enough. Personal qualities are also needed to establish contact during the empathic process.

Technology, Functionality, and Applicability of Portals in E-HRM

2009 ◽  
pp. 823-829
Author(s):  
Stefan Strohmeier
Keyword(s):  
Information Technologies ◽  
Service Providers ◽  
Access Point ◽  
The Other ◽  
Current Status ◽  
Specific Data ◽  
External Data ◽  
Front End ◽  
Major Application ◽  
The One

The application of electronic human resource management (e-HRM) does rest heavily on underlying information technologies (IT). Up until now, regularly numerous internal “back-end” systems, external data, and services were combined with different “front-end” systems in order to support and network different actors such as HR-professionals, managers, service providers, employees, and applicants (Walker, 2001). Concerning the success of any e-HRM implementation this technological heterogeneity is ambivalent. On the one hand, the merged functions of such heterogeneous application clusters are the essential enablers of e-HRM. On the other hand, such heterogeneous application clusters burden users with numerous incoherent technologies. For some time, portal technology is pledged to overcome this problem by providing a single access point to all specific data, applications, and services any user needs (e.g., Raoi, 2003). Therefore, this article examines whether portal technology is feasible in e-HRM and hence can serve as a measure of integration of heterogeneous HR systems. To do this, first the current status of e-HRM technologies is briefly reported. Subsequently, the technical blueprint (“architecture”) and the general functionality of portal technologies are assessed. Based on this, the applicability of portals is conceptually analyzed by discussing two major application scenarios in e-HRM.

International Administrative Tribunals: Current Status and Related Bibliography

1983 ◽  
Vol 11 (3-4) ◽  
pp. 130-142 ◽  
Author(s):  
Linda L. Thompson ◽  
Selma Rodriguez
Keyword(s):  
International Organizations ◽  
The Other ◽  
Current Status ◽  
International Forum ◽  
Staff Members ◽  
The Past ◽  
National Jurisdiction ◽  
The One

International administrative tribunals have gained in popularity during the past several years. These tribunals have been established as the need arose to adjudicate disputes between international organizations and their staff members. Since the disputes are internal in nature, the tribunals filled the lacunae between local or national jurisdiction on the one hand, and a global international forum on the other.

From ERP to Enterprise Service-Oriented Architecture

2009 ◽  
pp. 316-328
Author(s):  
Valentin Nicolescu ◽  
Holger Wittges ◽  
Helmut Krcmar
Keyword(s):  
Historical Development ◽  
Service Oriented Architecture ◽  
The Other ◽  
Current Status ◽  
Enterprise Software ◽  
Erp System ◽  
Modern Enterprise ◽  
Flexible Architecture ◽  
Service Oriented ◽  
The One

This chapter provides an overview of past and present development in technical platforms of ERP systems and its use in enterprises. Taking into consideration the two layers of application and technology, we present the classical scenario of an ERP system as a monolithic application block. As the demands of modern enterprise software cannot be met by this concept, the shift to a more flexible architecture like the service-oriented architecture (SOA) is the current status quo of modern companies. Keeping in mind the administrative complexity of such structures, we will discuss the new idea of business Webs. The purpose of our chapter is, on the one hand, to show the historical development of ERP system landscapes and, on the other hand, to show the comparison of the presented concepts with respect to application and technology view.

scholarly journals Computer-Assisted Pronunciation Training (CAPT): Current Issues and Future Directions

RELC Journal ◽  
2021 ◽  
pp. 003368822097740
Author(s):  
Pamela Mary Rogerson-Revell
Keyword(s):  
Teaching And Learning ◽  
Intelligent Tutoring ◽  
The Other ◽  
Current Status ◽  
Computer Assisted ◽  
Ubiquitous Learning ◽  
Future Directions ◽  
Key Issues ◽  
Automated Feedback ◽  
The One

This viewpoint essay considers the current status of computer-assisted pronunciation training (CAPT) before examining some of the current issues and future directions in the field. The underlying premise is the pedagogic potential of CAPT systems and resources for teaching and learning, and the need for greater synergy between technological design and functionality on the one hand, and pedagogic purpose on the other. Some of the key issues examined include providing accurate and individualised automated feedback for pronunciation, for both learning and assessment, and evaluating the effectiveness of CAPT tools and systems. When considering future directions, the discussion focuses on what aspects of pedagogy are likely to be at the forefront of developments, including ubiquitous learning; intelligent tutoring and authentic interaction; and goal-oriented, task-based learning.

GENETICS AND HUMAN CONGENITAL MALFORMATIONS

PEDIATRICS ◽  
1957 ◽  
Vol 19 (4) ◽  
pp. 749-754
Author(s):  
James V. Neel
Keyword(s):  
Congenital Malformations ◽  
Genetic Basis ◽  
Point Of View ◽  
The Other ◽  
Current Status ◽  
Simple Pattern ◽  
Clear Cut ◽  
Skeletal Malformations ◽  
The Subject ◽  
The One

A BRIEF SURVEY of the vast subject of "Genetics and Human Congenital Malformations" can scarcely be expected to be systematic. Accordingly, discussion of the subject will be limited to a series of more or less unrelated observations concerning genetics and the study of human teratology. The first portion of this discussion will be devoted to three general points concerning which there seems to be room for misunderstanding between the genetically and nongenetically oriented student of teratology. The latter portion of the discussion will be concerned with drawing attention to some general genetic approaches which may be profitable in specific areas. In approaching the material in this fashion, familiarity with the current status of work on human teratology is assumed. It is further assumed that the principal reason for this Conference on Teratology is to consider useful lines of attack on outstanding problems in this area. It is important at the outset to establish the fact that, from the genetic point of view, human malformations are a very "mixed bag" indeed. At the one extreme there are malformations which have a clear-cut and relatively simple genetic basis. Many of the skeletal malformations, such as the relatively benign brachydactyly or polydactyly, or the more serious ectrodactyly (split hand) or acheiropodia, fall into this category. At the other extreme there are a few malformations, such as tracheo-esophageal fistula1 which thus far have not been demonstrated to show a noteworthy tendency to concentrate in particular families. The majority of congenital malformations fall into neither of these extremes, showing clearly statistical tendencies to occur in certain families, but in these tendencies not following any simple pattern.

scholarly journals CONTRIBUTION TO A CARTOGRAPHIC AND PHYTOGEOGRAPHIC STUDY OF A LAVATERA MARITIMA MALVACEAEINTHETLEMCENCOAST

2021 ◽  
Vol 21 (no 1) ◽  
Author(s):  
Ghalem Sarra ◽  
Hassani faiçal ◽  
Bouayad Ibtissam Sarah ◽  
Zettam Amine
Keyword(s):  
Land Use ◽  
Plant Species ◽  
Present State ◽  
The Other ◽  
Current Status ◽  
Vegetation Map ◽  
Other Hand ◽  
The Mediterranean ◽  
Biogeographical Analysis ◽  
The One

This study allowed us to define on the one hand the biogeographical criteria, and on the other hand to develop a cartographic sketch of the physiognomy of Lavatera maritima in our study area. This work is devoted to the biogeographical analysis of Lavatera maritima in the Tlemcen Coast (Rachgoune 1 and 2, Béni-saf1 and 2 Oulhassa and Madrid). The biogeographic distribution shows the dominance of the Mediterranean element. A vegetation map can be viewed in different ways, as a physiognomy map showing the present state of vegetation, or as a land use map. The development of a cartographic test of the distribution of Lavatera maritima in the coast of Tlemcen aims to know the current status and range of this plant species.

Note on Selection of Coordinate Systems for Geodynamics

1975 ◽  
Vol 26 ◽  
pp. 395-407
Author(s):  
S. Henriksen
Keyword(s):  
Sea Level ◽  
The Other ◽  
Coordinate Systems ◽  
Mean Sea Level ◽  
The Earth ◽  
The One ◽  
Static Systems ◽  
Selection Of

The first question to be answered, in seeking coordinate systems for geodynamics, is: what is geodynamics? The answer is, of course, that geodynamics is that part of geophysics which is concerned with movements of the Earth, as opposed to geostatics which is the physics of the stationary Earth. But as far as we know, there is no stationary Earth – epur sic monere. So geodynamics is actually coextensive with geophysics, and coordinate systems suitable for the one should be suitable for the other. At the present time, there are not many coordinate systems, if any, that can be identified with a static Earth. Certainly the only coordinate of aeronomic (atmospheric) interest is the height, and this is usually either as geodynamic height or as pressure. In oceanology, the most important coordinate is depth, and this, like heights in the atmosphere, is expressed as metric depth from mean sea level, as geodynamic depth, or as pressure. Only for the earth do we find “static” systems in use, ana even here there is real question as to whether the systems are dynamic or static. So it would seem that our answer to the question, of what kind, of coordinate systems are we seeking, must be that we are looking for the same systems as are used in geophysics, and these systems are dynamic in nature already – that is, their definition involvestime.

Stories and the Self

2020 ◽  
Vol 32 (2) ◽  
pp. 47-58 ◽  
Author(s):  
Stefan Krause ◽  
Markus Appel
Keyword(s):  
Meta Analysis ◽  
The Self ◽  
The Other ◽  
Lower Degree ◽  
Contrast Effects ◽  
Self Perception ◽  
Self Perceptions ◽  
Other Hand ◽  
The One ◽  
Implicit And Explicit

Abstract. Two experiments examined the influence of stories on recipients’ self-perceptions. Extending prior theory and research, our focus was on assimilation effects (i.e., changes in self-perception in line with a protagonist’s traits) as well as on contrast effects (i.e., changes in self-perception in contrast to a protagonist’s traits). In Experiment 1 ( N = 113), implicit and explicit conscientiousness were assessed after participants read a story about either a diligent or a negligent student. Moderation analyses showed that highly transported participants and participants with lower counterarguing scores assimilate the depicted traits of a story protagonist, as indicated by explicit, self-reported conscientiousness ratings. Participants, who were more critical toward a story (i.e., higher counterarguing) and with a lower degree of transportation, showed contrast effects. In Experiment 2 ( N = 103), we manipulated transportation and counterarguing, but we could not identify an effect on participants’ self-ascribed level of conscientiousness. A mini meta-analysis across both experiments revealed significant positive overall associations between transportation and counterarguing on the one hand and story-consistent self-reported conscientiousness on the other hand.

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