scholarly journals COVID-19: The Disease, the Immunological Challenges, the Treatment with Pharmaceuticals and Low-Dose Ionizing Radiation

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2212
Author(s):  
Jihang Yu ◽  
Edouard I. Azzam ◽  
Ashok B. Jadhav ◽  
Yi Wang
Keyword(s):  
Low Dose ◽  
Vaccine Development ◽  
Health Workers ◽  
Low Dose Radiation ◽  
Effective Strategies ◽  
Advantages And Disadvantages ◽  
Life Threatening ◽  
History Of ◽  
History Books ◽  
Dose Radiation

The year 2020 will be carved in the history books—with the proliferation of COVID-19 over the globe and with frontline health workers and basic scientists worldwide diligently fighting to alleviate life-threatening symptoms and curb the spread of the disease. Behind the shocking prevalence of death are countless families who lost loved ones. To these families and to humanity as a whole, the tallies are not irrelevant digits, but a motivation to develop effective strategies to save lives. However, at the onset of the pandemic, not many therapeutic choices were available besides supportive oxygen, anti-inflammatory dexamethasone, and antiviral remdesivir. Low-dose radiation (LDR), at a much lower dosage than applied in cancer treatment, re-emerged after a 75-year silence in its use in unresolved pneumonia, as a scientific interest with surprising effects in soothing the cytokine storm and other symptoms in severe COVID-19 patients. Here, we review the epidemiology, symptoms, immunological alterations, mutations, pharmaceuticals, and vaccine development of COVID-19, summarizing the history of X-ray irradiation in non-COVID diseases (especially pneumonia) and the currently registered clinical trials that apply LDR in treating COVID-19 patients. We discuss concerns, advantages, and disadvantages of LDR treatment and potential avenues that may provide empirical evidence supporting its potential use in defending against the pandemic.

The Health Effects of Low-Dose Radiation on Atomic Workers

1980 ◽  
Vol 10 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Theodor D. Sterling
Keyword(s):  
Occupational Health ◽  
Health Effects ◽  
Low Dose ◽  
Organized Labor ◽  
Freedom Of Information ◽  
Low Dose Radiation ◽  
Negotiated Settlements ◽  
History Of ◽  
Exposure Levels ◽  
Dose Radiation

The 15-year history of a study on the health effects of low-dose radiation on workers at the Hanford Atomic Plant in Washington State demonstrates different facets of political control by employers over investigations of employee working conditions. Evidence obtained through the Freedom of Information Act shows that the original study, under the guidance of Dr. Thomas Mancuso, an experienced and respected occupational health epidemiologist, was funded even though its design was thought to be inadequate in order to furnish proof to employees that their exposure levels were safe. When it turned out that the study might show an increase in cancer rates among plant employees, its control was transferred to the employer. Public reports by scientists working for the employer are at variance with independent analyses of the same data. Lessons from these events are that it may be necessary for organized labor to negotiate the conduct of occupational health investigations as part of negotiated settlements and for legal means to be developed to make health scientists accountable for actions that influence public health policies.

scholarly journals Kelebihan dan kekurangan penggunaan radiasi dosis rendah (Low Doses Radiation: advantages and disadvantages)

2020 ◽  
Vol 4 (3) ◽  
pp. 117
Author(s):  
Lusi Epsilawati ◽  
Azhari Azhari ◽  
Bremmy Laksono ◽  
Haris Nasutianto ◽  
Eha Renwi Astuti
Keyword(s):  
Low Dose ◽  
The Body ◽  
Low Doses ◽  
Low Dose Radiation ◽  
Beneficial Effects ◽  
Advantages And Disadvantages ◽  
Long Time ◽  
Beneficial Response ◽  
Body Damage ◽  
Dose Radiation

Objectives: To inform and discuss the benefits and harms of low dose radiation. Literature Review: Low dose radiation (LDR) was often used, including for services in the field of dentistry. Several studies have studied this for a long time but the results are still not conclusively agreed. Some researchers found a variety of side effects that are not beneficial to the body, but some found no association with the body damage caused by this, and even some found that LDR has beneficial effects on the body. Conclusion: low doses of radiation cause significant changes in the body, although this condition is met with an adaptive reaction which is considered a beneficial response by the body. Therefore, no matter how small the radiation is given, it will still have an impact on the body so it is better to be wise in its use.  

scholarly journals A systematic review on the effect of low-dose radiation on hearing

2021 ◽  
Author(s):  
Srikanth Nayak ◽  
Arivudai Nambi ◽  
Sathish Kumar ◽  
P Hariprakash ◽  
Pradeep Yuvaraj ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Low Dose ◽  
Behavioral Symptoms ◽  
National Council ◽  
Low Dose Radiation ◽  
Cochlear Function ◽  
High Frequencies ◽  
Dose Radiation

AbstractNumerous studies have documented the adverse effects of high-dose radiation on hearing in patients. On the other hand, radiographers are exposed to a low dose of ionizing radiation, and the effect of a low dose of radiation on hearing is quite abstruse. Therefore, the present systematic review aimed to elucidate the effect of low-dose ionizing radiation on hearing. Two authors independently carried out a comprehensive data search in three electronic databases, including PUBMED/MEDLINE, CINAHL, and SCOPUS. Eligible articles were independently assessed for quality by two authors. Cochrane Risk of Bias tool was used assess quality of the included studies. Two articles met the low-dose radiation exposure criteria given by Atomic Energy Regulatory Board (AERB) and National Council on Radiation Protection (NCRP) guidelines. Both studies observed the behavioral symptoms, pure-tone hearing sensitivity at the standard, extended high frequencies, and the middle ear functioning in low-dose radiation-exposed individuals and compared with age and gender-matched controls. One study assessed the cochlear function using transient-evoked otoacoustic emissions (TEOAE). Both studies reported that behavioral symptoms of auditory dysfunction and hearing thresholds at extended high frequencies were higher in radiation-exposed individuals than in the controls. The current systematic review concludes that the low-dose ionizing radiation may affect the hearing adversely. Nevertheless, further studies with robust research design are required to explicate the cause and effect relationship between the occupational low-dose ionizing radiation exposure and hearing.

scholarly journals Double-layered fiber for lightweight flexible clothing providing shielding from low-dose natural radiation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Seon-Chil Kim ◽  
Jun Sik Son
Keyword(s):  
Low Dose ◽  
Layered Composite ◽  
Radiation Shielding ◽  
Flight Attendants ◽  
Low Dose Radiation ◽  
Natural Radiation ◽  
Composite Yarn ◽  
Materials Used ◽  
Fiber Fabric ◽  
Dose Radiation

AbstractNatural and medical radiation are the most frequent sources of daily low-dose radiation exposure for the general public, but these radiation levels are generally acceptable. Among various occupations, aviation crew members and medical workers are exposed to high levels of radiation from scattered rays. This study focused on developing clothing for shielding aviation crew members from natural radiation during air travel. Materials were selected considering their radiation-shielding properties. A tungsten double-layered composite yarn and a polyethylene terephthalate (PET) fiber fabric containing BaSO4 were manufactured. The characteristics and shielding performances of the products were analyzed. Prototypes of a protective scarf (for shielding the thyroid gland) and apron (for shielding the torso) for flight attendants were produced. A lightweight fabric was produced that neither restricts the movement of the wearer nor causes them skin discomfort. The shielding performances of the tungsten composite and PET fiber fabrics containing BaSO4 were 0.018 mmPb and 0.03 mmPb, respectively, demonstrating low-dose shielding that may be useful for protecting aviation crew members from scattered rays. The characteristics of the developed fibers are comparable to those of materials used in clothing production; therefore, low-dose radiation-shielding clothing could be manufactured for use in aviation, medical, and other industries.

Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53

2005 ◽  
Vol 97 (1) ◽  
pp. 142-150 ◽  
Author(s):  
Todd D. Tillmanns ◽  
Scott A. Kamelle ◽  
Suresh Guruswamy ◽  
Natalie S. Gould ◽  
Teresa L. Rutledge ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Retinoic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Low Dose ◽  
Cancer Cell Lines ◽  
Cervical Cancer Cell ◽  
Low Dose Radiation ◽  
Dose Radiation
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