scholarly journals COL5A1 RS12722 Is Associated with Temporomandibular Joint Anterior Disc Displacement without Reduction in Polish Caucasians

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2423
Author(s):  
Bartosz Dalewski ◽  
Katarzyna Białkowska ◽  
Łukasz Pałka ◽  
Anna Jakubowska ◽  
Paweł Kiczmer ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Tennis Elbow ◽  
Cruciate Ligament ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Disc Displacement ◽  
Chi Square ◽  
Acl Injuries ◽  
Chi Square Test

Numerous reports describe the association between the single-nucleotide polymorphism (SNP) rs12722 and rs13946 in the COL5A1 gene and injuries, such as Achilles tendon pathology, anterior cruciate ligament (ACL) injuries, and tennis elbow. Hence, there were no studies investigating COL5A1 and temporomandibular joint (TMJ) pathology. The aim of this study is to evaluate the relationship between COL5A1 rs12722 and rs13946 SNPs and TMJ articular disc displacement without reduction (ADDwoR). In this case-control study, the study group consisted of 124 Caucasian patients of both sexes. Each patient had a history of ADDwoR no more than 3 months prior. The control group comprised 126 patients with no signs of TMD according to DC/TMD. Genotyping of the selected SNPs was performed by real-time PCR using TaqMan probes. The significance of the differences in the distribution of genotypes was analyzed using Pearson’s chi-square test. Logistic regression modeling was performed to analyze the influence of the 164 investigated SNPs on ADDwoR. The COL5A1 marker rs12722 turned out to be statistically significant (p-value = 0.0119), implying that there is a difference in the frequencies of TMJ ADDwoR. The distribution of rs12722 SNPs in the study group TT(66), CC(27), CT(31) vs. control group TT(45), CC(26), CT(51) indicates that patients with CT had an almost 2.4 times higher likelihood of ADDwoR (OR = 2.41) than those with reference TT (OR = 1), while rs13946 genotypes were shown to be insignificant, with a p-value of 0.1713. The COL5A1 rs12722 polymorphism is a risk factor for ADDwoR in the Polish Caucasian population.

scholarly journals Investigation of the Incidence of Coital Incontinence in Incontinent Women

2019 ◽  
pp. 1
Author(s):  
Omer Demir ◽  
Cihan Comba
Keyword(s):  
Urinary Incontinence ◽  
Urine Analysis ◽  
Stress Test ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Sexually Active ◽  
Chi Square ◽  
Coital Incontinence ◽  
Chi Square Test

<p><strong>Objective:</strong> Coital incontinence is the involuntary leakage of urine during sexual intercourse and is rarely reported in women with urinary incontinence. The aim of this study is to investigate the frequency of coital incontinence and its association with incontinence types.</p><p><strong>Study Design:</strong> All sexually active women with urinary incontinence (diagnosed as self-reported) attending the out-patient gynecology clinic of a regional state hospital were interviewed consecutively between September 2017 and September 2018 about their experience with regards to coital incontinence. The clinical evaluation consisted of medical history, physical examination, and urine analysis. The SPSS 20 program designed for Windows was used for statistical analysis. </p><p><strong>Results:</strong> Twenty-two of the 64 women who participated in the study were diagnosed with coital incontinence and the remaining 42 women were to be compared. 42 women were included in the control group, and 22 women were defined as the study group. The women with coital incontinence had significantly higher stress test positivity than the control group (p = 0.00). No significant differences in the frequency of coital incontinence between incontinence types were found. The chi-square test was applied, and the p-value was &gt;0.05 (p=0.110). So there was no statistically significant relationship between the type of incontinence and the frequency of coital incontinence.</p><p><strong>Conclusion:</strong> Coital incontinence is much more prevalent than expected and therefore patients with symptomatic urinary incontinence should be investigated for the presence of coital incontinence, as this may affect patient approach and treatment.</p>

scholarly journals Assessment Of Schoolchildren’s Temporomandibular Joint Sounds Associated With Bruxism

2019 ◽  
Vol 7 (1) ◽  
pp. 1-6
Author(s):  
Ahmed Fathy Arafa ◽  
Nawras Maher Mostafa ◽  
Shady Ahmed Moussa
Keyword(s):  
Temporomandibular Joint ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Chi Square ◽  
Dental Clinics ◽  
Chi Square Test ◽  
Manual Palpation ◽  
Level Of Significance ◽  
The Relationship

Many studies have explained temporomandibular joint (TMJ) sounds in children are frequent with TMJ disorder. In addition to multiple divergent findings are designed to evaluate the relationship between bruxism and TMJ disorder in children. Aim: study was designed and conducted to assess the possible relationship between bruxism and joint sounds in schoolchildren. Subjects and Methods: The sample comprised 60 schoolchildren participants between 6 to 10 years of age, of whom 30 children with bruxism as study group G1 and another 30 without bruxism as a control group G2 who were scheduled and randomly selected for treatment at (Outpatient Dental Clinics, Zagazig University Hospital). Examiner performed assessment who was blinded allocation of the groups. Assessment involved of (manual palpation, lateral and dorsal extra-auricular auscultation of TMJ by stethoscope for detecting of joint sounds, differentiating between joint sounds as a click/pop or crepitation) Three readings were performed on each participant. Collected data were checked, entered and statistically analyzed to test different variables by chi-square test with the level of significance (p< 0.05). Results: There were statistically significant association between joint sounds with regarding to bruxism and age, which showed the higher prevalence rates of joint sounds were found in children aged eight to ten years in comparison to those aged sex and seven years. However, there were statistically insignificant association between joints sounds and type in relation to gender. Conclusion: The bruxism in children may be associated with the symptoms of joint sounds with significant association regarding to age. Keywords: Bruxism; Temporomandibular Joint; Child; bruxism; TMJ sound

scholarly journals Anesthetic potential of lidocaine/prilocaine cream versus placebo before venepuncture

2018 ◽  
Vol 7 (12) ◽  
pp. 2401
Author(s):  
Varsha P. Gajbhiye ◽  
Y. R. Lamture
Keyword(s):  
Adult Patient ◽  
Normal Saline ◽  
Venous Blood ◽  
Blood Sampling ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Chi Square ◽  
Chi Square Test ◽  
Lidocaine Prilocaine

Background: Pain associated with venepuncture has long been accepted as an unavoidable consequence. Many studies show reducing pain during venepuncture after application of prilocaine/lignocaine, but there are few studies that has depicted, the depth of anesthesia produced by prilocaine/lignocaine tends to be too superficial for the reducing the pain during venepuncture. These two scenarios were debatable. Therefore, authors planned a study to assess anesthetic potential of lidocaine /prilocaine cream versus placebo before venepuncture with help of VAS in an adult patient who were drawn blood sample for investigation purposes.Methods: Prospective interventional study. All adult patient for blood sampling from surgery OPD to central laboratory were included in study. Site of venepuncture selected in both control and study group was left cubital fossa. 30 patients selected in study group received lignocaine/prilocaine locally, 30min prior to venepuncture which was later covered with occlusive tape, whereas 30 control group patient received normal saline locally as placebo. The extent of pain was assessed by patient on 10cm visual analogue scale (VAS) with end points of 0 cm rated as no pain and the points of 10cm as intolerable pain.Results: A total of 60 patient were randomly selected who were referred from surgery OPD for blood sampling. Other 30 patient were applied normal saline as placebo and 30 patient with lignocaine and prilocaine cream. In the control group there were 30 patients (5 female and 25 male). In the study group there were 30 patients (8 females and 22 males). The level of pain among study group is as follows: mild 22, moderate 7, worst 1 and in control group: no pain 0, mild 5, moderate 14 and worst pain 1. Statistical analysis between outcome of two groups done by calculating chi-square test. Chi- square test was 20.0263. P value is 0.000168. Hence the result is significant at p <0.05.Conclusions: The present study shows that prilocaine-lidocaine cream reduces the pain of needle puncture in adults and facilitates the procedure of venous blood sampling.

scholarly journals Maternal and fetal outcome in oligohydramnios after 34 weeks of gestation

2018 ◽  
Vol 7 (11) ◽  
pp. 4604
Author(s):  
Mahantappa A. Chiniwar ◽  
Joe Kaushik M. ◽  
Sharada B. Menasinkai
Keyword(s):  
Amniotic Fluid ◽  
Fetal Outcome ◽  
Morbidity And Mortality ◽  
Research Centre ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Perinatal Morbidity ◽  
Amniotic Fluid Index ◽  
Chi Square

Background: Oligohydramnios is one of the major causes of maternal and perinatal morbidity and mortality. It is a clinical condition characterized by Amniotic Fluid Index (AFI) ≤5 cm by sonographic assessment. The aim of present study is to know the maternal and fetal outcome in oligohydramnios after 34 weeks of gestation compared with women who had normal volume of amniotic fluid.Methods: Study was done for the period of 21 months from November 2014-July 2016 at Adichunchanagiri Institute of Medical Sciences, Hospital and Research Centre Bellur. 50 antenatal cases with > 34 weeks of gestation with AFI ≤5 cm by ultrasonographic estimation were included as study group and 50 women with normal AFI were included as control group. Maternal and fetal outcome of the women with oligohydramnios were analyzed and compared with control group.Results: Results were analyzed statistically using parameters like mean, SD, Chi Sq test, P value. Amniotic fluid was clear in 32% in study and 78% in control group, thin meconium stained in 30% in study group and 14%in control group and was thick meconium stained in 38% in study group and 8% in control group (Chi square =22.31, p<0.0001). Induction of labour was done in 54% in study group and 20% in control group. Cesarean delivery was done in 58% in study group women and 28% in control group women. Regarding the birth weight of babies 62% were < 2.5 kg in study group and 18% in control group with p<0.001. 10% of babies in study group required NICU admission and perinatal mortality was 2%.Conclusions: Due to increased perinatal morbidity and mortality and increased rate of LSCS, timely decision during labour is important to reduce perinatal morbidity and mortality.

scholarly journals Factors Related to the Incidence of Typhoid Fever in the Work Area Health Office of Jayawijaya Regency

2021 ◽  
Vol 5 (1) ◽  
pp. 49-56
Author(s):  
Rahmad Suryawan Ura ◽  
Yuly Peristiowati
Keyword(s):  
Typhoid Fever ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
District Health Office ◽  
District Health ◽  
Chi Square ◽  
Work Area ◽  
Chi Square Test ◽  
Test Result

Typhoid fever is a disease that is prone to occur in Indonesia, because of the characteristics of the climate that is very prone to diseases related to the seasons. The purpose of this study is to analyze factors related to the incidence of typhoid fever in the Working Area of the Jayawijaya District Health Office. The research design used is quantitative analytics method using quantitative data. The type of approach used is case control. The population is 74 patients with typhoid fever. The large sample taken as many as 37 respondents, with a large comparison of samples between the number of respondents in the case group is 37 respondents, and 37 respondents as a control group, so the total number of samples is 74 respondents. Sampling techniques used in this study is a simple random sampling technique. Based on the results of the study, it is known that there is no relationship between age and the incidence of typhoid fever in the Working Area of the Jayawijaya District Health Office. Chi-square test result obtained p-Value Sig (0.445) > α (0.05). While it is known that there is a relationship between the level of knowledge, the level of education, hygiene of individual respondents with the incidence of typhoid fever in the Work Area of the Health Office of Jayawijaya Regency. Chi-square test results obtained p- value (0.000) < α (0.05) and environmental sanitation with the incidence of Typhoid Fever in the Work Area of the Jayawijaya District Health Office. Chi-square test result obtained p-value (0.001) < α (0.05). Based on the results of the study is expected to increase kinship with patients as well as by providing health services visits to the patient's home.

scholarly journals Topical Application of Chlorhexidine Gel with Brush-On Technique in the Tailored Treatment of Plaque Induced Gingivitis

2020 ◽  
Vol 10 (17) ◽  
pp. 6014
Author(s):  
Gianna Maria Nardi ◽  
Roberta Grassi ◽  
Guglielmo Campus ◽  
Maria Letizia Pareti ◽  
Dario Di Stasio ◽  
...  
Keyword(s):  
Topical Application ◽  
Control Group ◽  
Study Group ◽  
Gingival Index ◽  
Chi Square ◽  
Plaque Score ◽  
Tailored Treatment ◽  
Chi Square Test ◽  
Chlorhexidine Gel

Aim: This study aimed to assess the action of a chlorhexidine-based brush-on gel application in the treatment of plaque-related gingivitis. Methods: The enrollment involved consecutive patients diagnosed with plaque-induced gingivitis. Each participant’s full mouth plaque score and gingival index were recorded at the first appointment (t0) and at follow ups after 1 week (t1), 2 weeks (t2) and 3 weeks (t4). All patients were randomly sorted into two groups: A study group, who was given instruction to brush their gums daily with a chlorhexidine gel, and a control group who received a placebo gel. The two groups’ data at baseline were compared using a chi-square test, while the t-Student and Mann–Whitney tests were employed to analyze the index’s trends, both separately and compared. Results: In total, 30 patients were enrolled, 15 referring to the study group and 15 to the control group. The study group had an 87% decrease in their plaque score and an 84% decrease in their gingival index (p < 0.05). The control group displayed a reduction in plaque score and gingival index of 74% and 84%, respectively (p < 0.05). The plaque score decreased statistically more significantly in the study group than in the control group. Conclusion: Topical employment of a chlorhexidine-containing brush-on gel appears to be a useful home tool in the treatment of plaque-induced gingivitis, associated with professional debridement.

scholarly journals Channa striata (Ikan Gabus) Extract and the Acceleration of Tuberculosis Treatment: A True Experimental Study

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Isa Ma’rufi ◽  
Khaidar Ali ◽  
Ign Arya Sedemen ◽  
P. Purwanto ◽  
Abu Khoiri
Keyword(s):  
Experimental Study ◽  
Intervention Group ◽  
International Health ◽  
Tuberculosis Treatment ◽  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
Channa Striata ◽  
True Experiment

Tuberculosis is international health problem, which is classified in Global Emergency disease since 1992. The objective of the study is to determine the effect of Channa striata extract toward the acceleration of tuberculosis treatment. The study used true experiment, in which the intervention of the study was Channa striata supplementation to respondent. In addition, Chi-square was used to analyze the data with SPSS version 22. The result is the proportion of respondent classified in negative category in intervention group within week 0, week 1, week 2, week 3, and week 4 being 10.7%, 35.9%, 56.3%, 70.9%, and 90.3%, respectively. Besides, the proportion of respondent classified in negative category in control group within week 0, week 1, week 2, week 3, and week 4 was 13.4%, 23.7%, 37.1%, 49.5%, and 68%, respectively. Based on Chi-square test, the P value of Channa striata supplementation toward the acceleration of tuberculosis treatment week 1, week 3, and week 4 is 0.045, 0.019, and 0.005 (P< α; α=0.05), respectively. It means that there were differences between Channa striata supplementation and acceleration of tuberculosis treatment among respondent. Therefore, Channa striata treatment was significantly related to the acceleration of tuberculosis recovery.

The Effect Of Oxytosin Massage Through The Back On The Production Of Breast Milk In Post Partum Mother In The Mother Of Permata Bunda Subdistrict Babat

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Dwi Kurnia purnama Sari
Keyword(s):  
Breast Milk ◽  
Milk Production ◽  
Health Workers ◽  
Statistical Tests ◽  
Post Partum ◽  
Significant Degree ◽  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test

Every minute of one baby indonesia died because they did not to obtain breast milk (BM) in the first hour of birth, problems in the provision of breastfeeding can because production breastfeeding not out.One way to overcome the incomplete milk production is by doing a massage of oxytocin through the back. This message can relax the mother’s so that stimulate oxcytocin reflex and milk production also smoothly. The purpose of this research to know the influence of massage oxytocin through the back to production breastfeeding on the post partum. This research using design Quasy experimental that involves 30 respondents taken with systematic random sampling. Respondents divided into 2 groups, namely the control group were 15 respondents and group experimental were 15 respondents.Data collection use observation checklist.Data analyzed using chi-square test with a significant degree α ≤ 0.05. The results of statistical tests chi square obtained p value = 0,028 (α< 0,05)thus H1 accepted that mean there are influence massage oxytocin through the back to production breastfeeding on the post partum. The research at the clinic Permata BundaSubdistrict Babat that is the massage oxytocin through the back to production breastfeeding. Because massage oxytocin through the back can stimulate reflexes oxytocin hormone. Expected for health workers can provide health education about massage oxytocin through the back to the community so later expected all the community be able to apply massage oxytocin through the back to overcome it swift sailboat production breastfeeding.

Association of CYP2B6 c.516G>T Polymorphism with Acute Lymphoblastic Leukemia Susceptibility

2014 ◽  
Vol 926-930 ◽  
pp. 1073-1076
Author(s):  
Zhong Hai Yuan ◽  
Yi Ju Hou ◽  
Chen Zhao ◽  
Yan Li
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Genomic Dna ◽  
Lymphoblastic Leukemia ◽  
Control Group ◽  
Study Group ◽  
Regression Analyses ◽  
Specific Primers ◽  
Blood Leukocytes ◽  
Chi Square ◽  
Chi Square Test

Abstract:Objective: To investigate whether any association exists between genetic polymorphism in CYP2B6 c.516G>T and individual susceptibility to acute lymphoblastic leukemia (ALL). Methods: Our study group consisted of 96 ALL patients(T-ALL 17 cases, B-ALL 79 cases) and 348 unrelated healthy newborn volunteers as a control group. Genomic DNA was extracted from peripheral blood and cord blood leukocytes. We genotyped CYP2B6 c.516G>T polymorphism by use of PCR with sequence-specific primers (PCR-SSP). The data were analyzed statistically using chi-square and logistic regression analyses. Results: The frequencies of GG genotype were 74.14%, 57.29%, 29.41% and 63.29%, and GT genotype were 23.85%, 37.50%, 64.71% and 31.65%, and TT genotype were 2.01%, 5.21%, 5.88% and 5.06% in control group, ALL, T-ALL, and B-ALL cases, respectively. Chi-square test showed a significant correlation between the CYP2B6 c.516G>T polymorphism GT genotype and ALL patients (OR=2.035, 95%CI=1.249-3.313, P=0.004); and T-ALL patients (OR=6.839, 95%CI=2.309-20.252, P=0.000); whereas and B-ALL patients (OR=1.554, 95%CI=0.906-2.667, P=0.108). Conclusions: This study revealed the CYP2B6 c.516GT genotype may be a risk factor to the development of ALL, especially T-ALL.

scholarly journals Small dose of ephedrine for prevention of hypotension following propofol and fentanyl administration during induction of general anesthesia

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Gamal Ejaimi ◽  
Abla Saab ◽  
Sittelnissa Ahmed ◽  
Areeg Ahmed ◽  
Hussain Abujamilah ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Small Dose ◽  
Elective Surgery ◽  
Statistical Significance ◽  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Arterial Blood ◽  
Chi Square Test ◽  
Study Participants

Induction of general anesthesia with propofol and fentanyl could result in hypotension and bradycardia. Various methods are being used to prevent these adverse effects. The aim of our study was to assess the efficacy and safety of a small dose of ephedrine in prevention of hypotension following administration of propofol and fentanyl. This prospective, randomized, comparative study was conducted among a total of 50 patients, both genders, age 18 years up to 60 years with ASA grade Ι and ΙΙ and some of class ΙΙΙ, presented for elective surgery under general anesthesia. Patients were randomly allocated into one of two groups (25 patients in each): CG (the control group), which received propofol in a dose of 2 mg/kg, intravenously, over 20–30 s mixed with 2 mL normal saline: and EphG (Ephedrine group), while received propofol in a dose of 2 mg/kg, intravenously, over 20–30 s mixed with 2 mL of ephedrine (10 mg). The Mean Arterial Blood Pressure (MAP) and Heart Rate (HR) were recorded before induction and then every 1 min up to 6 min after induction. The categorical data are presented as a number and percentage and were subjected to Fisher’s exact or Chi-square test for analysis. The statistical significance was p≤0.05. The significant differences in HR were observed in the 3rd,4th, and 5th minutes with P-value, 0.018, 0.000, 0.000, respectively. However, no patient in the study participants had bradycardia. The significant differences in MAP were observed in the 2nd, 3rd,4th, and 5th minutes with P-value, 0.035, 0.000, 0.000, and 0.000, respectively. The percentage of patient in CG who developed hypotension in the 3rd and 4th is 44% and 32% compared to 8% and 0% in EphG, with significant differences (P-value 0.004 and 0.002, respectively). Administration of small dose of ephedrine with propofol could attenuate propofol/fentanyl hypotensive and bradycardic effects.

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