scholarly journals The Role of Sumoylation in the Response to Hypoxia: An Overview

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2359 ◽  
Author(s):  
Chrysa Filippopoulou ◽  
George Simos ◽  
Georgia Chachami
Keyword(s):  
Cellular Response ◽  
Therapeutic Interventions ◽  
Covalent Attachment ◽  
Glucose And Lipid Metabolism ◽  
Different Types ◽  
Cancer Tumor ◽  
Molecular Therapeutic ◽  
And Oxidative Stress ◽  
The Way

Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular response to different types of stress including osmotic, hypoxic and oxidative stress. Hypoxia can occur under physiological or pathological conditions, such as ischemia and cancer, as a result of an oxygen imbalance caused by low supply and/or increased consumption. The hypoxia inducible factors (HIFs), and the proteins that regulate their fate, are critical molecular mediators of the response to hypoxia and modulate procedures such as glucose and lipid metabolism, angiogenesis, erythropoiesis and, in the case of cancer, tumor progression and metastasis. Here, we provide an overview of the sumoylation-dependent mechanisms that are activated under hypoxia and the way they influence key players of the hypoxic response pathway. As hypoxia is a hallmark of many diseases, understanding the interrelated connections between the SUMO and the hypoxic signaling pathways can open the way for future molecular therapeutic interventions.

Depression, Anhedonia, and Psychomotor Symptoms: The Role of Dopaminergic Neurocircuitry

CNS Spectrums ◽  
2008 ◽  
Vol 13 (7) ◽  
pp. 561-565 ◽  
Author(s):  
Dan J. Stein
Keyword(s):  
Major Depression ◽  
Dopaminergic System ◽  
Therapeutic Interventions ◽  
Gene Variants ◽  
Characteristic Features ◽  
Psychomotor Symptoms ◽  
Affective Disturbances ◽  
The Way

ABSTRACTThe heterogeneity of major depression suggests that multiple neurocircuits and neurochemicals are involved in its pathogenesis. Anhedonia and psychomotor symptoms are, however, particularly characteristic features of major depression and may provide insights into its underlying psychobiology. Importantly, these symptoms appear to be mediated by dopaminergic mesolimbic and mesostriatal projections, the function of which is, in turn, influenced by key gene variants and environment stressors. Indeed, there is growing evidence of the way in which the dopaminergic system is associated with cognitive-affective disturbances in depression, and provides a useful target for therapeutic interventions. At the same time, a range of other systems are likely to contribute to the psychobiology of this condition.

scholarly journals Face masks as layers of meaning in times of COVID-19

2020 ◽  
pp. 1354067X2095754
Author(s):  
Luca Tateo
Keyword(s):  
University Students ◽  
Everyday Life ◽  
Cultural Psychology ◽  
Meaning Making ◽  
Face Mask ◽  
The Other ◽  
Different Types ◽  
The Face ◽  
The Way

The pandemic of COVID-19 has brought to the front a particular object: the face mask. I have explored the way people make-meaning of an object generally associated with the medical context that, under exceptional circumstances, can become a presence in everyday life. Understanding how people make meaning of their use is important. Using cultural psychology, I analyse preferences toward different types of face masks people would wear in public. The study involved 2 groups, 44 Norwegian university students and 60 international academics. In particular, I have focused on the role of the mask in regulating people affective experience. The mask evokes safety and fear, it mediates in the auto-dialogue between “I” and “Me” through the “Other”, and in the hetero-dialogue between “I” and the “Other” through “Me” The dialogue is characterized by a certain ambivalence, as expected. Meaning-making is indeed the way to deal with the ambivalence of human existence.

scholarly journals Management Control for Stimulating Different Types of Creativity: The Role of Budgets

2017 ◽  
Vol 29 (3) ◽  
pp. 1-21 ◽  
Author(s):  
Martine Cools ◽  
Kristof Stouthuysen ◽  
Alexandra Van den Abbeele
Keyword(s):  
Control System ◽  
Comparative Study ◽  
Creative Process ◽  
Management Control ◽  
Management Control System ◽  
Diagnostic Use ◽  
Different Types ◽  
Per Se ◽  
The Way

ABSTRACT In this paper, we examine the role of budgets as a central instrument within the management control system (MCS) in a creative context. In particular we investigate whether creative firms characterized by different kinds of creativity use their budgets in a similar way. We hereby distinguish between expected creativity (for open, self-discovered problems) and responsive creativity (for closed, presented problems) (Unsworth 2001) and investigate the interactive versus diagnostic use of budgets (Simons 1990, 1991, 1995). Based on a comparative study involving four creative firms, we find that creative firms, being mainly characterized by expected creativity, use their budgets in a more interactive way. In creative firms in which responsive creativity is most important, the budgets are used in a rather diagnostic way. This study contributes to the management control literature by acknowledging that a diagnostic use of budgets does not per se stifle creativity. Instead, it is important to understand that the specific creative context might have implications for the way in which MCS instruments are used to sustain the creative process.

scholarly journals The Bifurcations of the Critical Points and the Role of Depth in a Symmetric Caldera Potential Energy Surface

2021 ◽  
Vol 31 (11) ◽  
pp. 2130034
Author(s):  
Y. Geng ◽  
M. Katsanikas ◽  
M. Agaoglou ◽  
S. Wiggins
Keyword(s):  
Potential Energy ◽  
Potential Energy Surface ◽  
Critical Points ◽  
Energy Surface ◽  
The Other ◽  
Different Types ◽  
Before And After ◽  
The One ◽  
The Way

In this work, we continue the study of the bifurcations of the critical points in a symmetric Caldera potential energy surface. In particular, we study the influence of the depth of the potential on the trajectory behavior before and after the bifurcation of the critical points. We observe two different types of trajectory behavior: dynamical matching and the nonexistence of dynamical matching. Dynamical matching is a phenomenon that limits the way in which a trajectory can exit the Caldera based solely on how it enters the Caldera. Furthermore, we discuss two different types of symmetric Caldera potential energy surface and the transition from the one type to the other through the bifurcations of the critical points.

The use of the simple present in the speech of two three-year-olds: Normativity not subjectivity

1986 ◽  
Vol 15 (4) ◽  
pp. 501-535 ◽  
Author(s):  
Julie (Gee) Gerhardt ◽  
Iskender Savasir
Keyword(s):  
American English ◽  
Present Report ◽  
Social Effects ◽  
Ongoing Activity ◽  
Different Types ◽  
Activity Types ◽  
Verb Inflections ◽  
The Way

ABSTRACTIn our research, we wish to illuminate different types of discursive intentions which are structured into discourse via the verb inflections and auxiliaries, together with their entailed social effects. In the present report, we examine the use of the simple present by two three-year-olds, and argue that analyses in terms of tense or aspect are not adequate to account for its use. One needs to recognize the way in which the form implicitly refers to norms and thereby entails a type of impersonal motivation – especially as it is just this feature of the use of this form that structures the ongoing activity into a nondialogic, normative activity. (Simple present, normativity, subjectivity, activity-types, nondialogic discourse, the constitutive role of language, American English)

scholarly journals Different Types of Cellular Stress Affect the Proteome Composition of Small Extracellular Vesicles: A Mini Review

Proteomes ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 23 ◽  
Author(s):  
Agata Abramowicz ◽  
Piotr Widłak ◽  
Monika Pietrowska
Keyword(s):  
Extracellular Vesicles ◽  
Cellular Response ◽  
Stress Factors ◽  
Functional Importance ◽  
Different Types ◽  
Response To Stress ◽  
Experimental Works ◽  
Stressed Cells

Extracellular vesicles (EVs) are well-known mediators of the cellular response to different stress factors, yet the exact mechanism of their action remains unclear. Hence, the characterization of their cargo, consisting of proteins, nucleic acids, and different classes of metabolites, helps to elucidate an understanding of their function in stress-related communication. The unexpected diversity and complexity of these vesicles requires the incorporation of multiple technologically advanced approaches in EV-oriented studies. This mini review focuses on the invaluable role of proteomics, especially mass spectrometry-based tools, in the investigation of the role of small EVs in their response to stress. Though relatively few experimental works address this issue to date, the available data indicate that stress conditions would affect the composition of protein cargo of vesicles released by stressed cells, as evidenced by the functional importance of such changes in the context of the response of recipient cells.

scholarly journals Facebook as an instrument of election campaigning and voters’ engagement: Comparing Czechia and Poland

2018 ◽  
Vol 34 (2) ◽  
pp. 121-141 ◽  
Author(s):  
Vaclav Stetka ◽  
Paweł Surowiec ◽  
Jaromír Mazák
Keyword(s):  
Strong Predictor ◽  
Parliamentary Election ◽  
Election Campaigns ◽  
Internet Users ◽  
Different Types ◽  
And Gender ◽  
The Comparative Study ◽  
The Relationship ◽  
The Way

Adding to the growing scholarship on the use and role of social media in election campaigning, this article examines and compares the character and determinants of Internet users’ engagement with political party communication in 2013 and 2015 Parliamentary election campaigns in Czechia and Poland. Apart from the relationship between the thematic focus of party-produced content and the level of users’ interactivity, the study also explores the way the tonality of users’ comments is influenced by different types of party communication, as well as by users’ gender. The results suggest that the level of support for a party status is largely independent of the content of the message in both countries. The type of content has, however, an effect on the intensity of criticism by the users, with policy-related subjects generating more negativity than mobilization- or campaign-oriented statuses. Finally, the study points to both gender gaps and gender as a strong predictor of user negativity, as female users – while constituting a minority of participants in both countries – tend to be significantly less negative in their comments towards the home party. Overall, the comparative study reveals both similarities and differences in the way Czech and Polish parties utilize Facebook as campaign platform, as well as in their respective Internet users’ engagement with parties messages.

Effect of different types of noises on the formations of swarming systems: the sensing-noise and the acting-noise

2014 ◽  
Vol 28 (23) ◽  
pp. 1450186 ◽  
Author(s):  
Wen-Qiang Tian ◽  
Dan Gao ◽  
Ju-Feng Luo ◽  
Wei-Yi Zhang ◽  
Ying-Guan Wang
Keyword(s):  
Decision Making ◽  
Numerical Simulations ◽  
Negative Impact ◽  
Neighbor Distance ◽  
Different Types ◽  
Decision Making Processes ◽  
The Difference ◽  
The Way

In this paper, different types of noises, the sensing-noise and the acting-noise, are brought into the extended adaptive Attractive/Repulsive (A/R) swarming models to explore the role of noise in swarming formations. The difference between these two extended A/R models consists in the way in which the noise is introduced. The sensing-noise is added to the inputs of the swarming system which results in the uncertainty of the sensed information for agents, and it affects the whole processes of the swarming system. The acting-noise is added to the outputs of the swarming system, which does not affect the information-sensing and decision-making processes of the system, but it directly affects the action of swarms. With numerical simulations and analyses, the results show that the convergence of the expected swarming formation and the cohesiveness of the swarms may be affected to various degrees and suffered from certain negative impact due to the interference of different noises. We conclude that both the convergence and the cohesiveness are much more sensitive to the sensing-noise, and the model with acting-noise will be robust compared with the model with sensing-noise. Meanwhile we point out that, in the model with the interference of sensing-noise, too strong noises will lead to erroneous judgments of A/R function for agents. The sensed neighbor distance may fall into the zone of attraction, the zone of repulsion, or it may even fall into the zone of Non-A/R area. The original definite A/R function which is determined by the definite neighbor distance will evolve into the indefinite A/R function which is determined by the indefinite sensed neighbor distance. Along with the increase of the probability of such misjudgments, the effect of the A/R model will be progressively weakened. However, such phenomenon does not exist in the A/R model with the interference of acting-noise, in which the strong acting-noise leads the agents move randomly and spread apart gradually.

scholarly journals Pro-Tumorigenic Macrophage Infiltration in Oral Squamous Cell Carcinoma and Possible Macrophage-Aimed Therapeutic Interventions

2021 ◽  
Vol 11 ◽  
Author(s):  
Flavia Bruna ◽  
Pablo Scodeller
Keyword(s):  
Squamous Cell ◽  
Stromal Cells ◽  
State Of The Art ◽  
Clinical Stage ◽  
Squamous Cell Carcinomas ◽  
Therapeutic Interventions ◽  
Preclinical Studies ◽  
Different Types ◽  
Epidermal Growth

In Oral Squamous Cell Carcinomas (OSCC), as in other solid tumors, stromal cells strongly support the spread and growth of the tumor. Macrophages in tumors (tumor-associated macrophages or “TAMs”), can swing between a pro-inflammatory and anti-tumorigenic (M1-like TAMs) state or an anti‐inflammatory and pro-tumorigenic (M2-like TAMs) profile depending on the tumor microenvironment cues. Numerous clinical and preclinical studies have demonstrated the importance of macrophages in the prognosis of patients with different types of cancer. Here, our aim was to review the role of M2-like TAMs in the prognosis of patients with OSCC and provide a state of the art on strategies for depleting or reprogramming M2-like TAMs as a possible therapeutic solution for OSCC. The Clinical studies reviewed showed that higher density of CD163+ M2-like TAMs associated with worse survival and that CD206+ M2-TAMs are involved in OSCC progression through epidermal growth factor (EGF) secretion, underlining the important role of CD206 as a marker of OSCC progression and as a therapeutic target. Here, we provide the reader with the current tools, in preclinical and clinical stage, for depleting M2-like TAMs, re-educating them towards M1-like TAMs, and exploiting TAMs as drug delivery vectors.

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