scholarly journals From Early Morphometrics to Machine Learning—What Future for Cardiovascular Imaging of the Pulmonary Circulation?

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1004
Author(s):  
Deepa Gopalan ◽  
J. Simon R. Gibbs
Keyword(s):  
Pulmonary Circulation ◽  
New Technologies ◽  
Multimodality Imaging ◽  
Vascular Diseases ◽  
Blood Flow Imaging ◽  
New Information ◽  
Computational Flow Dynamics ◽  
To Come ◽  
Mathematical Analyses

Imaging plays a cardinal role in the diagnosis and management of diseases of the pulmonary circulation. Behind the picture itself, every digital image contains a wealth of quantitative data, which are hardly analysed in current routine clinical practice and this is now being transformed by radiomics. Mathematical analyses of these data using novel techniques, such as vascular morphometry (including vascular tortuosity and vascular volumes), blood flow imaging (including quantitative lung perfusion and computational flow dynamics), and artificial intelligence, are opening a window on the complex pathophysiology and structure–function relationships of pulmonary vascular diseases. They have the potential to make dramatic alterations to how clinicians investigate the pulmonary circulation, with the consequences of more rapid diagnosis and a reduction in the need for invasive procedures in the future. Applied to multimodality imaging, they can provide new information to improve disease characterization and increase diagnostic accuracy. These new technologies may be used as sophisticated biomarkers for risk prediction modelling of prognosis and for optimising the long-term management of pulmonary circulatory diseases. These innovative techniques will require evaluation in clinical trials and may in themselves serve as successful surrogate end points in trials in the years to come.

Integrating new technologies with embryology and animal production

2004 ◽  
Vol 16 (2) ◽  
pp. 113 ◽  
Author(s):  
Torben Greve ◽  
Henrik Callesen
Keyword(s):  
Embryo Transfer ◽  
New Technologies ◽  
Basic Research ◽  
Domestic Animal ◽  
Animal Production ◽  
New Information ◽  
Polymerase Chain Reaction Technology ◽  
Meaningful Context ◽  
To Come

The present review describes a range of selected farm animal embryo technologies used in embryological research and applied in animal breeding and production. Some of the techniques are driven by the breeder’s wish to obtain animals with higher breeding values, whereas others are primarily driven by the curiosity of researchers. The interaction between basic research and practical application in these areas is still a characteristic feature for people who contribute to the International Embryo Transfer Society (IETS) and has been an advantage for both researchers and breeders. One example of such an interaction is that detailed structural analyses have described quality differences between embryos of various origins and, following embryo transfer, the pregnancy results have confirmed the correlation between morphology and viability. Another example is that polymerase chain reaction technology has allowed detection of Y-specific sequences in male embryos and has become a tool in animal production today. Data from domestic animal genome sequencing will provide a great deal of new information. A major challenge for the years to come will be using this information in a physiologically meaningful context and to continue the efforts to convert the laboratory experience into use in practise. Finally, it is important to obtain societal acceptance for a wider application of many of the technologies, such as in vitro embryo production and cloning.

Physical Abuse of Children: An Update

1994 ◽  
Vol 15 (10) ◽  
pp. 394-399
Author(s):  
Andrew P. Sirotnak ◽  
Richard D. Krugman
Keyword(s):  
Child Abuse ◽  
Physical Abuse ◽  
Preventive Intervention ◽  
Mri Imaging ◽  
New Information ◽  
Health Practitioners ◽  
Medical Child Abuse ◽  
To Come ◽  
Thoracic And Abdominal

Now, more than ever, physicians must be willing to suspect child abuse and report their concerns. New information from the past decade warns us that reports of violence against children continue to increase. We are learning that MRI imaging of the head may, in some cases, help date subdural hematomas, but long-term developmental follow-up studies of "shaken" infants are lacking. Intentional thoracic and abdominal injuries carry a high mortality. Finally, new information in the field of child abuse—in particular, physical abuse—is slow to come. Lack of funding for basic medical child abuse research and lack of trained researchers in the field are the two most important barriers.20 Preventive intervention at the community and family level needs to be supported by both the pediatrician and the local and national government leaders. As the U.S. Advisory Board on Child Abuse and Neglect says, "We need to make it as easy for parents to pick up the telephone and get help before they abuse their child as it is now for their neighbor or physician to pick up the telephone and report them after it has happened." Child health practitioners may be in the best position to implement such a policy.

Principles of Low-Vacuum SEM

1992 ◽  
Vol 50 (2) ◽  
pp. 1304-1305
Author(s):  
Klaus-Ruediger Peters
Keyword(s):  
New Technologies ◽  
High Vacuum ◽  
Optical Microscope ◽  
Specimen Surface ◽  
Electrical Field ◽  
Gaseous Environment ◽  
New Information ◽  
Gas Molecules ◽  
New Interactions ◽  
Gas Pressures

Only recently it became possible to expand scanning electron microscopy to low vacuum and atmospheric pressure through the introduction of several new technologies. In principle, only the specimen is provided with a controlled gaseous environment while the optical microscope column is kept at high vacuum. In the specimen chamber, the gas can generate new interactions with i) the probe electrons, ii) the specimen surface, and iii) the specimen-specific signal electrons. The results of these interactions yield new information about specimen surfaces not accessible to conventional high vacuum SEM. Several microscope types are available differing from each other by the maximum available gas pressure and the types of signals which can be used for investigation of specimen properties.Electrical non-conductors can be easily imaged despite charge accumulations at and beneath their surface. At high gas pressures between 10-2 and 2 torr, gas molecules are ionized in the electrical field between the specimen surface and the surrounding microscope parts through signal electrons and, to a certain extent, probe electrons. The gas provides a stable ion flux for a surface charge equalization if sufficient gas ions are provided.

On Introducing New Information Technologies in Jurisprudence

2019 ◽  
pp. 82-86
Author(s):  
Aleksandr Mitin
Keyword(s):  
Information Technologies ◽  
New Technologies ◽  
Professional Competence ◽  
Comprehensive Analysis ◽  
Legal Services ◽  
Degree Programs ◽  
Creative Work ◽  
Electronic Trading ◽  
New Information ◽  
Legal Space

The article discusses the possibilities of automation of legal activities. Special attention is paid to the new branch of the business LegalTech, which allows providing legal services using information technology. Some projects in this area are briefly described: FreshDoc document designer, VideoContract app, and electronic trading platforms such as Legal Space and Pravoved.Ru. Although the legal community is not quite ready to work in such conditions, higher education institutions are already reforming their curricula, developing disciplines that allow gaining professional competence in introducing technologies that automate legal work, and so on. The author, in turn, offers using chat bots in legal clinics, gives examples of new disciplines for master’s degree programs, considers the idea of passing final examinations outside universities in certification centers, etc. It is emphasized that in jurisprudence there are a lot of typical situations in which typical decisions need to be made, and here artificial intelligence will be a good helper, and scientists will have more time to undertake a comprehensive analysis of law. Thus, even with the advent of new technologies, the creative work of lawyers will always be in demand.

Online Publication of Monuments

2020 ◽  
pp. 355-369
Author(s):  
Willeke Wendrich
Keyword(s):  
Peer Review ◽  
3D Modeling ◽  
Online Publication ◽  
New Technologies ◽  
3D Scanning ◽  
Architectural Drawings ◽  
3D Gis ◽  
Unity 3D ◽  
Long Term Preservation

This chapter outlines the advantages of digital epigraphy in the context of the original monuments. It analyzes the perception of epigraphic publication of monuments, taking into account new technologies. 3DVR models can be created using architectural drawings and measurements (CAD and 3D modeling), 3D scanning, and Structure for Motion (SfM). These systems present different advantages and challenges, which are discussed. Current options for publication include VSim, 3D GIS, and Unity 3D platforms. The issues of peer review of publications and long-term preservation of data are addressed. The chapter concludes with a consideration of the issue of potentially misleading impressions given by 3DVR representations.

scholarly journals The Infrared Absolute Radiance Interferometer (ARI) for CLARREO

2020 ◽  
Vol 12 (12) ◽  
pp. 1915
Author(s):  
Joe K. Taylor ◽  
Henry E. Revercomb ◽  
Fred A. Best ◽  
David C. Tobin ◽  
P. Jonathan Gero
Keyword(s):  
Brightness Temperature ◽  
New Technologies ◽  
Spectral Radiance ◽  
Overall Design ◽  
Societal Challenges ◽  
Ideal System ◽  
Uncertainty Estimates ◽  
Infrared Spectrometer ◽  
Global Coverage

The Absolute Radiance Interferometer (ARI) is an infrared spectrometer designed to serve as an on-orbit radiometric reference with the ultra-high accuracy (better than 0.1 K 3‑σ or k = 3 brightness temperature at scene brightness temperature) needed to optimize measurement of the long-term changes of Earth’s atmosphere and surface. If flown in an orbit that frequently crosses sun-synchronous orbits, ARI could be used to inter-calibrate the international fleet of infrared (IR) hyperspectral sounders to similar measurement accuracy, thereby establishing an observing system capable of achieving sampling biases on high-information-content spectral radiance products that are also < 0.1 K 3‑σ. It has been shown that such a climate observing system with <0.1 K 2‑σ overall accuracy would make it possible to realize times to detect subtle trends of temperature and water vapor distributions that closely match those of an ideal system, given the limit set by the natural variability of the atmosphere. This paper presents the ARI sensor's overall design, the new technologies developed to allow on-orbit verification and test of its accuracy, and the laboratory results that demonstrate its capability. In addition, we describe the techniques and uncertainty estimates for transferring ARI accuracy to operational sounders, providing economical global coverage. Societal challenges posed by climate change suggest that a Pathfinder ARI should be deployed as soon as possible.

scholarly journals EU Labor Market Inequalities and Sustainable Development Goals

2021 ◽  
Vol 13 (5) ◽  
pp. 2675
Author(s):  
Elena Jianu ◽  
Ramona Pîrvu ◽  
Gheorghe Axinte ◽  
Ovidiu Toma ◽  
Andrei Valentin Cojocaru ◽  
...  
Keyword(s):  
Sustainable Development ◽  
Labor Market ◽  
Policy Issue ◽  
Policy Makers ◽  
Public Policy Issue ◽  
Development Goals ◽  
To Come ◽  
Business Practitioners ◽  
The Eu

Reducing inequalities for EU citizens and promoting upward convergence is one of the priorities on the agenda of the European Commission and, certainly, inequality will be a very important public policy issue for years to come. Through this research we aim to investigate EU labor market inequalities, reflected by the specific indicators proposed for Goal 8 assumed by the 2030 Agenda for Sustainable Development, based on cluster analysis for all the 27 Member States. The research results showed encouraging results from the perspective of convergence in the EU labor market, but also revealed a number of analyzed variable effects that manifested regional inequalities that were generated in the medium and long term. Based on the observations made, we want to provide information for policy-makers, business practitioners, and academics so as to constitute solid ground for identifying good practices and proposing to implement policies aimed at reducing existing inequalities and supporting sustainable development.

scholarly journals Social distancing in public transport: mobilising new technologies for demand management under the Covid-19 crisis

2021 ◽  
Author(s):  
Daniel Hörcher ◽  
Ramandeep Singh ◽  
Daniel J. Graham
Keyword(s):  
Public Transport ◽  
Perceived Risk ◽  
Urban Areas ◽  
New Technologies ◽  
Demand Management ◽  
Single Point ◽  
Relevant Literature ◽  
Social Distancing ◽  
New Information ◽  
Occupancy Rates

AbstractDense urban areas are especially hardly hit by the Covid-19 crisis due to the limited availability of public transport, one of the most efficient means of mass mobility. In light of the Covid-19 pandemic, public transport operators are experiencing steep declines in demand and fare revenues due to the perceived risk of infection within vehicles and other facilities. The purpose of this paper is to explore the possibilities of implementing social distancing in public transport in line with epidemiological advice. Social distancing requires effective demand management to keep vehicle occupancy rates under a predefined threshold, both spatially and temporally. We review the literature of five demand management methods enabled by new information and ticketing technologies: (i) inflow control with queueing, (ii) time and space dependent pricing, (iii) capacity reservation with advance booking, (iv) slot auctioning, and (v) tradeable travel permit schemes. Thus the paper collects the relevant literature into a single point of reference, and provides interpretation from the viewpoint of practical applicability during and after the pandemic.

The Productivity of Unemployment and the Temporality of Employment-to-Come: Older Disadvantaged Job Seekers

2021 ◽  
pp. 136078042110095
Author(s):  
Jessica Gerrard ◽  
Juliet Watson
Keyword(s):  
Qualitative Research ◽  
Education And Training ◽  
Job Seekers ◽  
Voluntary Work ◽  
To Come ◽  
And Training

This article demonstrates how unemployment is made productive through workfare activities for older disadvantaged job seekers. We suggest that the requirement to look for work, engage in education and training, and participate in voluntary work blurs the boundaries between employment and unemployment. Drawing on in-depth qualitative research with older disadvantaged job seekers, we demonstrate how this obligatory productivity is lived and felt, characterised by shame and frustration and framed by the temporality of waiting and searching for work. We suggest that this experience of ‘productive’ unemployment can be described as a dissonant state of ‘transitional stasis’, whereby job seekers are expected to transition out of unemployment and poverty while experiencing the long-term and ongoing effects of immobility.

scholarly journals Scots pine (Pinus sylvestris) dynamics in the Welsh Marches during the mid to late-Holocene

The Holocene ◽  
2021 ◽  
pp. 095968362199465
Author(s):  
Dael Sassoon ◽  
William J Fletcher ◽  
Alastair Hotchkiss ◽  
Fern Owen ◽  
Liting Feng
Keyword(s):  
Pinus Sylvestris ◽  
Scots Pine ◽  
Late Holocene ◽  
British Isles ◽  
Loss On Ignition ◽  
Peat Core ◽  
New Information ◽  
Pine Trees ◽  
Pollen Records

Around 4000 cal yr BP, Scots pine ( Pinus sylvestris) suffered a widespread demise across the British Isles. This paper presents new information about P. sylvestris populations found in the Welsh Marches (western central Britain), for which the long-term history and origins are poorly known. Two new pollen records were produced from the Lin Can Moss ombrotrophic bog (LM18) and the Breidden Hill pond (BH18). The LM18 peat core is supported by loss-on-ignition, humification analysis and radiocarbon dating. Lead concentrations were used to provide an estimated timeframe for the recent BH18 record. In contrast to many other Holocene pollen records from the British Isles, analysis of LM18 reveals that Scots pine grains were deposited continuously between c. 6900–300 cal yr BP, at frequencies of 0.3–5.4%. It is possible that individual Scots pine trees persisted through the wider demise on thin soils of steep drought-prone crags of hills or the fringes of lowland bogs in the Welsh Marches. At BH18, the record indicates a transition from broadleaved to mixed woodland, including conifer species introduced around AD 1850 including Picea and Pinus. The insights from BH18 suggest that the current populations may largely be the result of planting. Comparison of the LM18 findings with other regional pollen records highlights consistent patterns, including a Mid-Holocene maximum (ca. 7000 cal yr BP), long-term persistence at low pollen percentages and a Late-Holocene minimum (ca. 3000 cal yr BP). These distinctive trends encourage further studies on refugial areas for Scots pine in this region and elsewhere.

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